{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:13:35Z","timestamp":1760955215202},"reference-count":51,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2010,12,1]],"date-time":"2010-12-01T00:00:00Z","timestamp":1291161600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Spine Journal"],"published-print":{"date-parts":[[2010,12]]},"DOI":"10.1016\/j.spinee.2010.08.030","type":"journal-article","created":{"date-parts":[[2010,10,13]],"date-time":"2010-10-13T07:38:45Z","timestamp":1286955525000},"page":"1078-1085","source":"Crossref","is-referenced-by-count":13,"title":["High-frequency loading of lumbar ligaments increases proinflammatory cytokines expression in a feline model of repetitive musculoskeletal disorder"],"prefix":"10.1016","volume":"10","author":[{"given":"Sarah E.","family":"Pinski","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen B.","family":"King","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bradley S.","family":"Davidson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bing He","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moshe","family":"Solomonow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.spinee.2010.08.030_bib1","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1080\/00140130120716","article-title":"Theories of musculoskeletal injury causation","volume":"44","author":"Kumar","year":"2001","journal-title":"Ergonomics"},{"key":"10.1016\/j.spinee.2010.08.030_bib2","first-page":"779","article-title":"Hand wrist cumulative trauma disorders in industry","volume":"43","author":"Silverstein","year":"1986","journal-title":"Br J Ind Med"},{"key":"10.1016\/j.spinee.2010.08.030_bib3","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.jelekin.2003.09.015","article-title":"Work related musculoskeletal disorders: the epidemiologic evidence and the debate","volume":"14","author":"Punnett","year":"2004","journal-title":"J Electromyogr Kinesiol"},{"key":"10.1016\/j.spinee.2010.08.030_bib4","doi-asserted-by":"crossref","first-page":"3087","DOI":"10.1097\/00007632-200012010-00018","article-title":"Flexion and rotation of the trunk and lifting at work are risk factors for low back pain: results of a prospective cohort study","volume":"25","author":"Hoogendoorn","year":"2000","journal-title":"Spine"},{"key":"10.1016\/j.spinee.2010.08.030_bib5","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1080\/001401300409080","article-title":"Occupational low back disorder causation and control","volume":"43","author":"Marras","year":"2000","journal-title":"Ergonomics"},{"key":"10.1016\/j.spinee.2010.08.030_bib6","doi-asserted-by":"crossref","first-page":"2426","DOI":"10.1097\/00007632-199912010-00003","article-title":"Biomechanics of increased exposure to lumbar injury due to cyclic loading: I. Loss of reflexive muscular stabilization","volume":"24","author":"Solomonow","year":"1999","journal-title":"Spine"},{"key":"10.1016\/j.spinee.2010.08.030_bib7","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0268-0033(99)00062-5","article-title":"Bi-exponential recovery model of lumbar viscoelastic creep and reflexive muscular activity after prolonged cyclic loading","volume":"15","author":"Solomonow","year":"2000","journal-title":"Clin Biomech"},{"key":"10.1016\/j.spinee.2010.08.030_bib8","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/s10439-005-1742-x","article-title":"Human lumbar spine creep during cyclic and static flexion: creep rate, biomechanics, and facet joint capsule strain","volume":"33","author":"Little","year":"2005","journal-title":"Ann Biomed Eng"},{"key":"10.1016\/j.spinee.2010.08.030_bib9","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1016\/j.clinbiomech.2007.06.003","article-title":"An in vivo assessment of the low back response to prolonged flexion: interplay between active & passive tissues","volume":"22","author":"Shin","year":"2007","journal-title":"Clin Biomech"},{"key":"10.1016\/j.spinee.2010.08.030_bib10","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/0268-0033(92)90007-Q","article-title":"Creep response of the lumbar spine to prolonged full flexion","volume":"17","author":"McGill","year":"1992","journal-title":"Clin Biomech"},{"key":"10.1016\/j.spinee.2010.08.030_bib11","doi-asserted-by":"crossref","first-page":"379","DOI":"10.3233\/BIR-1982-19302","article-title":"Mechanical properties of tendons and ligaments. II. The relationships of exercise in tissue remodeling","volume":"19","author":"Woo","year":"1982","journal-title":"Biorheology"},{"key":"10.1016\/j.spinee.2010.08.030_bib12","first-page":"15","article-title":"Normal ligament properties and ligament healing","volume":"96","author":"Frank","year":"1985","journal-title":"Clin Orthop Rel Res"},{"key":"10.1016\/j.spinee.2010.08.030_bib13","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1002\/jor.20722","article-title":"Subrupture tendon fatigue damage","volume":"27","author":"Fung","year":"2009","journal-title":"J Orthop Res"},{"key":"10.1016\/j.spinee.2010.08.030_bib14","series-title":"Sports induced inflammation: clinical and basic science concepts","article-title":"An introduction to sports induced soft tissue inflammation","author":"Leadbetter","year":"1990"},{"key":"10.1016\/j.spinee.2010.08.030_bib15","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/S1050-6411(03)00045-2","article-title":"Muscular dysfunction elicited by creep of lumbar viscoelastic tissues","volume":"13","author":"Solomonow","year":"2003","journal-title":"J Electromyogr Kinesiol"},{"key":"10.1016\/j.spinee.2010.08.030_bib16","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1016\/j.clinbiomech.2009.07.011","article-title":"High magnitude cyclic load triggers inflammatory response in lumbar ligaments","volume":"24","author":"King","year":"2009","journal-title":"Clin Biomech"},{"key":"10.1016\/j.spinee.2010.08.030_bib17","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1007\/s00586-010-1371-4","article-title":"Pro-Inflammatory cytokines expression increase following low and high magnitudes cyclic loading of lumbar ligaments","volume":"19","author":"D\u2019Ambrosia","year":"2010","journal-title":"Eur Spine J"},{"key":"10.1016\/j.spinee.2010.08.030_bib18","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1002\/mus.10318","article-title":"Neuromuscular disorder elicited by cyclic lumbar flexion","volume":"27","author":"Claude","year":"2003","journal-title":"Muscle Nerve"},{"key":"10.1016\/j.spinee.2010.08.030_bib19","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1002\/mus.20629","article-title":"High repetition of cyclic loading is a risk factor for lumbar disorders","volume":"34","author":"Navar","year":"2006","journal-title":"Muscle Nerve"},{"key":"10.1016\/j.spinee.2010.08.030_bib20","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1097\/JOM.0b013e318046eb0b","article-title":"Cyclic load magnitude is a risk factor for cumulative low back disorder","volume":"49","author":"Le","year":"2007","journal-title":"J Occup Environ Med"},{"key":"10.1016\/j.spinee.2010.08.030_bib21","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.clinbiomech.2007.03.010","article-title":"Short rest between cyclic flexion periods is a risk factor for lumbar disorder","volume":"22","author":"Hoops","year":"2007","journal-title":"Clin Biomech"},{"key":"10.1016\/j.spinee.2010.08.030_bib22","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/j.clinbiomech.2004.05.007","article-title":"Flexion-relaxation response to cyclic lumbar flexion","volume":"19","author":"Olson","year":"2004","journal-title":"Clin Biomech"},{"key":"10.1016\/j.spinee.2010.08.030_bib23","doi-asserted-by":"crossref","first-page":"2545","DOI":"10.1016\/j.jbiomech.2005.09.009","article-title":"Flexion-relaxation response to gravity","volume":"39","author":"Olson","year":"2006","journal-title":"J Biomech"},{"key":"10.1016\/j.spinee.2010.08.030_bib24","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.jelekin.2007.06.011","article-title":"Interaction of viscoelastic tissue compliance with lumbar muscles during passive cyclic flexion-extension","volume":"19","author":"Olson","year":"2009","journal-title":"J Electromyogr Kinesiol"},{"key":"10.1016\/j.spinee.2010.08.030_bib25","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/S1050-6411(03)00041-5","article-title":"Trunk muscle activation in low-back pain patients, an analysis of the literature","volume":"13","author":"van Dieen","year":"2003","journal-title":"J Electromyogr Kinesiol"},{"key":"10.1016\/j.spinee.2010.08.030_bib26","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.clinbiomech.2009.10.013","article-title":"Torso muscles EMG profile differences between\u00a0patients of back pain and control","volume":"25","author":"Kumar","year":"2010","journal-title":"Clin Biomech"},{"key":"10.1016\/j.spinee.2010.08.030_bib27","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1097\/00007632-198205000-00003","article-title":"Physiologic strains in the lumbar spinal ligaments","volume":"7","author":"Panjabi","year":"1982","journal-title":"Spine"},{"key":"10.1016\/j.spinee.2010.08.030_bib28","doi-asserted-by":"crossref","first-page":"2916","DOI":"10.1097\/00007632-200011150-00014","article-title":"Multifidus spasms elicited by prolonged lumbar flexion","volume":"25","author":"Williams","year":"2000","journal-title":"Spine"},{"key":"10.1016\/j.spinee.2010.08.030_bib29","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/S0268-0033(01)00007-9","article-title":"High speed sub failure stretch of rabbit ACL: changes in elastic failure and viscoelastic characteristics","volume":"16","author":"Panjabi","year":"2001","journal-title":"Clin Biomech"},{"key":"10.1016\/j.spinee.2010.08.030_bib30","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.jelekin.2003.09.011","article-title":"Ligaments: a source of work related musculoskeletal disorder","volume":"14","author":"Solomonow","year":"2004","journal-title":"J Electromyogr Kinesiol"},{"key":"10.1016\/j.spinee.2010.08.030_bib31","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/j.jbiomech.2003.11.023","article-title":"Frequency dependent changes in neuromuscular response to cyclic lumbar flexion","volume":"37","author":"Lu","year":"2004","journal-title":"J Biomech"},{"key":"10.1016\/j.spinee.2010.08.030_bib32","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1002\/mus.21019","article-title":"High frequency cyclic flexion is a risk factor for a lumbar disorder","volume":"38","author":"Lu","year":"2008","journal-title":"Muscle Nerve"},{"key":"10.1016\/j.spinee.2010.08.030_bib33","doi-asserted-by":"crossref","first-page":"2552","DOI":"10.1097\/00007632-199812010-00010","article-title":"The ligamento-muscular stabilizing system of the spine","volume":"23","author":"Solomonow","year":"1998","journal-title":"Spine"},{"key":"10.1016\/j.spinee.2010.08.030_bib34","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.cytogfr.2008.11.006","article-title":"Cytokine and cytokine receptor gene polymorphisms and their functionality","volume":"20","author":"Smith","year":"2009","journal-title":"Cytokine Growth Factor Rev"},{"key":"10.1016\/j.spinee.2010.08.030_bib35","first-page":"203","article-title":"Purified interleukin-1 (IL-1) from human monocytes stimulates acute-phase protein synthesis by rodent hepatocytes in vitro","volume":"60","author":"Gauldie","year":"1987","journal-title":"Immunology"},{"key":"10.1016\/j.spinee.2010.08.030_bib36","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/S0736-0266(02)00141-9","article-title":"IL-1 beta induces COX2, MMP-1, -3 and -13, ADAMTS-4, IL-1 beta and IL-6 in human tendon cells","volume":"21","author":"Tsuzaki","year":"2003","journal-title":"J Orthop Res"},{"key":"10.1016\/j.spinee.2010.08.030_bib37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/eji.1830170102","article-title":"Interleukin 1 and poly(rI).poly(rC) induce production of a hybridoma growth factor by human fibroblasts","volume":"17","author":"Van Damme","year":"1987","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.spinee.2010.08.030_bib38","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1172\/JCI113921","article-title":"Synovium as a source of interleukin 6 in vitro. Contribution to local and systemic manifestations of arthritis","volume":"83","author":"Guerne","year":"1989","journal-title":"J Clin Invest"},{"issue":"Suppl 2","key":"10.1016\/j.spinee.2010.08.030_bib39","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1186\/ar1918","article-title":"Interleukin-6 and rheumatic diseases","volume":"8","author":"Lipsky","year":"2006","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.spinee.2010.08.030_bib40","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1084\/jem.167.3.988","article-title":"B cell precursor growth-promoting activity. Purification and characterization of a growth factor active on lymphocyte precursors","volume":"167","author":"Namen","year":"1988","journal-title":"J Exp Med"},{"key":"10.1016\/j.spinee.2010.08.030_bib41","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1007\/BF02231778","article-title":"Interleukin-8 (IL-8) in synovial fluid of rheumatoid and nonrheumatoid joint effusions","volume":"12","author":"Verburgh","year":"1993","journal-title":"Clin Rheumatol"},{"key":"10.1016\/j.spinee.2010.08.030_bib42","doi-asserted-by":"crossref","first-page":"2811","DOI":"10.1016\/j.febslet.2006.04.033","article-title":"The logic of TGF [beta] signaling","volume":"580","author":"Massague","year":"2006","journal-title":"FEBS Lett"},{"key":"10.1016\/j.spinee.2010.08.030_bib43","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/S1050-6411(97)00006-0","article-title":"The development of an EMG assisted model to assess spine loading during whole body free dynamic lifting","volume":"7","author":"Marras","year":"1997","journal-title":"J Electromyogr. Kinesiol"},{"key":"10.1016\/j.spinee.2010.08.030_bib44","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1097\/00007632-198403000-00008","article-title":"Measurement of loads on the lumbar spine under isometric and isokinetic conditions","volume":"7","author":"Marras","year":"1984","journal-title":"Spine"},{"key":"10.1016\/j.spinee.2010.08.030_bib45","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1002\/jor.1100080607","article-title":"Muscle activation during asymmetric trunk muscular acceleration","volume":"8","author":"Marras","year":"1990","journal-title":"J Orthop Res"},{"key":"10.1016\/j.spinee.2010.08.030_bib46","first-page":"67","article-title":"Pain generation in lumbar and cervical facet joints","volume":"63","author":"Cavanaugh","year":"2006","journal-title":"J Bone Joint Surg Am"},{"key":"10.1016\/j.spinee.2010.08.030_bib47","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S1058-2746(00)90033-8","article-title":"Neer Award 1999. Overuse activity injures the supraspinatus tendon in an animal model: a histologic and biomechanical study","volume":"9","author":"Soslowsky","year":"2000","journal-title":"J Shoulder Elbow Surg"},{"key":"10.1016\/j.spinee.2010.08.030_bib48","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0736-0266(02)00086-4","article-title":"Chronic repetitive reaching and grasping results in decreased motor performance and widespread tissue responses in rat model of MSD","volume":"21","author":"Barbe","year":"2003","journal-title":"J Orthop Res"},{"key":"10.1016\/j.spinee.2010.08.030_bib49","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1177\/036354658601400114","article-title":"Strains within the anterior cruciate ligament during hamstring and quadriceps activity","volume":"14","author":"Renstrom","year":"1986","journal-title":"Am J Sports Med"},{"key":"10.1016\/j.spinee.2010.08.030_bib50","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1097\/00007632-198005000-00007","article-title":"The resistance to flexion of the lumbar intervertebral joint","volume":"5","author":"Adams","year":"1980","journal-title":"Spine"},{"key":"10.1016\/j.spinee.2010.08.030_bib51","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.spinee.2007.07.391","article-title":"Determination of torque limits for human and cat lumbar spine specimen during displacement controlled physiological motions","volume":"9","author":"Ianuzzi","year":"2009","journal-title":"Spine J"}],"container-title":["The Spine Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1529943010011496?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1529943010011496?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,6,5]],"date-time":"2019-06-05T08:16:27Z","timestamp":1559722587000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1529943010011496"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,12]]},"references-count":51,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2010,12]]}},"alternative-id":["S1529943010011496"],"URL":"https:\/\/doi.org\/10.1016\/j.spinee.2010.08.030","relation":{},"ISSN":["1529-9430"],"issn-type":[{"value":"1529-9430","type":"print"}],"subject":[],"published":{"date-parts":[[2010,12]]}}}