{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T23:41:06Z","timestamp":1792712466988,"version":"4.5.0"},"reference-count":24,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2014,3,1]],"date-time":"2014-03-01T00:00:00Z","timestamp":1393632000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Spine Journal"],"published-print":{"date-parts":[[2014,3]]},"DOI":"10.1016\/j.spinee.2013.09.045","type":"journal-article","created":{"date-parts":[[2013,10,25]],"date-time":"2013-10-25T06:37:43Z","timestamp":1382683063000},"page":"445-454","source":"Crossref","is-referenced-by-count":14,"title":["A novel strategy of spine defect repair with a degradable bioactive scaffold preloaded with adipose-derived stromal cells"],"prefix":"10.1016","volume":"14","author":[{"given":"Haixiang","family":"Liang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xudong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam L.","family":"Shimer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary","family":"Balian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francis H.","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.spinee.2013.09.045_bib1","doi-asserted-by":"crossref","first-page":"4240","DOI":"10.1016\/j.biomaterials.2007.06.023","article-title":"A tissue engineering approach to bone repair in large animal models and in clinical practice","volume":"28","author":"Cancedda","year":"2007","journal-title":"Biomaterials"},{"key":"10.1016\/j.spinee.2013.09.045_bib2","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/S0142-9612(01)00137-5","article-title":"Tissue engineered microsphere-based matrices for bone repair: design and evaluation","volume":"23","author":"Borden","year":"2002","journal-title":"Biomaterials"},{"key":"10.1016\/j.spinee.2013.09.045_bib3","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/S0142-9612(02)00374-5","article-title":"Structural and human cellular assessment of a novel microsphere-based tissue engineered scaffold for bone repair","volume":"24","author":"Borden","year":"2003","journal-title":"Biomaterials"},{"key":"10.1016\/j.spinee.2013.09.045_bib4","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1163\/156856296X00435","article-title":"Three-dimensional degradable porous polymer-ceramic matrices for use in bone repair","volume":"7","author":"Devin","year":"1996","journal-title":"J Biomater Sci Polym Ed"},{"key":"10.1016\/j.spinee.2013.09.045_bib5","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.spinee.2006.03.006","article-title":"Osteogenic differentiation of adipose-derived stromal cells treated with GDF-5 cultured on a novel three-dimensional sintered microsphere matrix","volume":"6","author":"hen","year":"2006","journal-title":"Spine J"},{"key":"10.1016\/j.spinee.2013.09.045_bib6","doi-asserted-by":"crossref","first-page":"4777","DOI":"10.1016\/j.biomaterials.2003.11.051","article-title":"Characterization of surface property of poly(lactide-co-glycolide) after oxygen plasma treatment","volume":"25","author":"Wan","year":"2004","journal-title":"Biomaterials"},{"key":"10.1016\/j.spinee.2013.09.045_bib7","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.bone.2010.05.023","article-title":"Use of a bioactive scaffold for the repair of bone defects in a novel reproducible vertebral body defect model","volume":"47","author":"Liang","year":"2010","journal-title":"Bone"},{"key":"10.1016\/j.spinee.2013.09.045_bib8","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1159\/000081088","article-title":"Osteogenic potential of human adipose tissue-derived stromal cells as an alternative stem cell source","volume":"178","author":"Hattori","year":"2004","journal-title":"Cells Tissues Organs"},{"key":"10.1016\/j.spinee.2013.09.045_bib9","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.1089\/ten.2006.12.1891","article-title":"Mouse adipose-derived stem cells undergo multilineage differentiation in\u00a0vitro but primarily osteogenic and chondrogenic differentiation in\u00a0vivo","volume":"12","author":"Zheng","year":"2006","journal-title":"Tissue Eng"},{"key":"10.1016\/j.spinee.2013.09.045_bib10","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.yexcr.2005.04.029","article-title":"Functional studies of mesenchymal stem cells derived from adult human adipose tissue","volume":"308","author":"Dicker","year":"2005","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.spinee.2013.09.045_bib11","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1080\/03008200600980769","article-title":"Recombinant growth\/differentiation factor-5 stimulates osteogenic differentiation of fat-derived stromal cells in\u00a0vitro","volume":"47","author":"Zeng","year":"2006","journal-title":"Connect Tissue Res"},{"key":"10.1016\/j.spinee.2013.09.045_bib12","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.bone.2006.09.022","article-title":"Growth and differentiation factor-5 (GDF-5) stimulates osteogenic differentiation and increases vascular endothelial growth factor (VEGF) levels in fat-derived stromal cells in\u00a0vitro","volume":"40","author":"Zeng","year":"2007","journal-title":"Bone"},{"key":"10.1016\/j.spinee.2013.09.045_bib13","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1002\/jbm.a.30575","article-title":"Improvement in hydrophilicity of PHBV films by plasma treatment","volume":"76","author":"Wang","year":"2006","journal-title":"J Biomed Mater Res A"},{"key":"10.1016\/j.spinee.2013.09.045_bib14","first-page":"357","article-title":"Cell and platelet adhesions on plasma glow discharge-treated poly(lactide-co-glycolide)","volume":"7","author":"Khang","year":"1997","journal-title":"Biomed Mater Eng"},{"key":"10.1016\/j.spinee.2013.09.045_bib15","doi-asserted-by":"crossref","first-page":"32204","DOI":"10.1063\/1.3466882","article-title":"Oxygen plasma treatment for reducing hydrophobicity of a sealed polydimethylsiloxane microchannel","volume":"4","author":"Tan","year":"2010","journal-title":"Biomicrofluidics"},{"key":"10.1016\/j.spinee.2013.09.045_bib16","doi-asserted-by":"crossref","first-page":"7","DOI":"10.4047\/jap.2010.2.1.7","article-title":"Angiogenic factor-enriched platelet-rich plasma enhances in\u00a0vivo bone formation around alloplastic graft material","volume":"2","author":"Kim","year":"2010","journal-title":"J Adv Prosthodont"},{"key":"10.1016\/j.spinee.2013.09.045_bib17","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1038\/labinvest.2010.39","article-title":"Local transplantation of human multipotent adipose-derived stem cells accelerates fracture healing via enhanced osteogenesis and angiogenesis","volume":"90","author":"Shoji","year":"2010","journal-title":"Lab Invest"},{"key":"10.1016\/j.spinee.2013.09.045_bib18","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1080\/03008200701692743","article-title":"Modulation of VEGF expression in rat bone marrow stromal cells by GDF-5","volume":"48","author":"Sena","year":"2007","journal-title":"Connect Tissue Res"},{"key":"10.1016\/j.spinee.2013.09.045_bib19","doi-asserted-by":"crossref","first-page":"30","DOI":"10.22203\/eCM.v019a04","article-title":"VEGF incorporated into calcium phosphate ceramics promotes vascularisation and bone formation in\u00a0vivo","volume":"19","author":"Wernike","year":"2010","journal-title":"Eur Cell Mater"},{"key":"10.1016\/j.spinee.2013.09.045_bib20","doi-asserted-by":"crossref","first-page":"306","DOI":"10.3109\/08977194.2010.484423","article-title":"VEGF and BMP-6 enhance bone formation mediated by cloned mouse osteoprogenitor cells","volume":"28","author":"Cui","year":"2010","journal-title":"Growth Factors"},{"key":"10.1016\/j.spinee.2013.09.045_bib21","doi-asserted-by":"crossref","first-page":"9656","DOI":"10.1073\/pnas.152324099","article-title":"Vascular endothelial growth factor stimulates bone repair by promoting angiogenesis and bone turnover","volume":"99","author":"Street","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.spinee.2013.09.045_bib22","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1369\/jhc.4A6280.2005","article-title":"Behavior of transplanted bone marrow-derived GFP mesenchymal cells in osteochondral defect as a simulation of autologous transplantation","volume":"53","author":"Oshima","year":"2005","journal-title":"J Histochem Cytochem"},{"key":"10.1016\/j.spinee.2013.09.045_bib23","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1302\/0301-620X.86B8.14267","article-title":"Tissue-engineered bone formation in\u00a0vivo using a novel sintered polymeric microsphere matrix","volume":"86","author":"Borden","year":"2004","journal-title":"J\u00a0Bone Joint Surg Br"},{"key":"10.1016\/j.spinee.2013.09.045_bib24","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1002\/jcp.22313","article-title":"Adipose tissue-derived progenitors for engineering osteogenic and vasculogenic grafts","volume":"225","author":"Scherberich","year":"2010","journal-title":"J Cell Physiol"}],"container-title":["The Spine Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1529943013015878?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1529943013015878?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,7,31]],"date-time":"2019-07-31T08:59:11Z","timestamp":1564563551000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1529943013015878"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3]]},"references-count":24,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,3]]}},"alternative-id":["S1529943013015878"],"URL":"https:\/\/doi.org\/10.1016\/j.spinee.2013.09.045","relation":{},"ISSN":["1529-9430"],"issn-type":[{"value":"1529-9430","type":"print"}],"subject":[],"published":{"date-parts":[[2014,3]]}}}