{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T15:00:48Z","timestamp":1784300448645,"version":"3.55.0"},"reference-count":26,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2014,12,1]],"date-time":"2014-12-01T00:00:00Z","timestamp":1417392000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["thespinejournalonline.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Spine Journal"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1016\/j.spinee.2014.03.043","type":"journal-article","created":{"date-parts":[[2014,4,4]],"date-time":"2014-04-04T03:30:10Z","timestamp":1396582210000},"page":"2835-2840","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":69,"title":["Spinal instability as defined by the spinal instability neoplastic score is associated with radiotherapy failure in metastatic spinal disease"],"prefix":"10.1016","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2289-7130","authenticated-orcid":false,"given":"Merel","family":"Huisman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne M.","family":"van der Velden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"van Vulpen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurice A.A.J.","family":"van den Bosch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward","family":"Chow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. Cumhur","family":"\u00d6ner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"Yee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena M.","family":"Verkooijen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorrit-Jan","family":"Verlaan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.spinee.2014.03.043_bib1","doi-asserted-by":"crossref","first-page":"589","DOI":"10.3928\/0147-7447-19920501-10","article-title":"Evaluation, prognosis, and medical treatment considerations of metastatic bone tumors","volume":"15","author":"Brage","year":"1992","journal-title":"Orthopedics"},{"issue":"8 Suppl","key":"10.1016\/j.spinee.2014.03.043_bib2","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.1002\/(SICI)1097-0142(19971015)80:8+<1588::AID-CNCR9>3.0.CO;2-G","article-title":"Skeletal complications of malignancy","volume":"80","author":"Coleman","year":"1997","journal-title":"Cancer"},{"key":"10.1016\/j.spinee.2014.03.043_bib3","doi-asserted-by":"crossref","first-page":"E1221","DOI":"10.1097\/BRS.0b013e3181e16ae2","article-title":"A novel classification system for spinal instability in neoplastic disease: an evidence-based approach and expert consensus from the Spine Oncology Study Group","volume":"35","author":"Fisher","year":"2010","journal-title":"Spine"},{"key":"10.1016\/j.spinee.2014.03.043_bib4","doi-asserted-by":"crossref","first-page":"2186","DOI":"10.1097\/01.brs.0000180401.06919.a5","article-title":"A revised scoring system for preoperative evaluation of metastatic spine tumor prognosis","volume":"30","author":"Tokuhashi","year":"2005","journal-title":"Spine"},{"key":"10.1016\/j.spinee.2014.03.043_bib5","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/S0140-6736(05)66954-1","article-title":"Direct decompressive surgical resection in the treatment of spinal cord compression caused by metastatic cancer: a randomised trial","volume":"366","author":"Patchell","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.spinee.2014.03.043_bib6","doi-asserted-by":"crossref","first-page":"2028","DOI":"10.1200\/JCO.2005.00.067","article-title":"Systematic review of the diagnosis and management of malignant extradural spinal cord\u00a0compression: the Cancer Care Ontario Practice Guidelines Initiative's Neuro-Oncology Disease Site Group","volume":"23","author":"Loblaw","year":"2005","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.spinee.2014.03.043_bib7","doi-asserted-by":"crossref","first-page":"3072","DOI":"10.1200\/JCO.2010.34.3897","article-title":"Spinal instability neoplastic score: an analysis of reliability and validity from the spine oncology study group","volume":"29","author":"Fourney","year":"2011","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.spinee.2014.03.043_bib8","doi-asserted-by":"crossref","first-page":"e282","DOI":"10.3747\/co.v18i6.797","article-title":"Inter-rater reliability between musculoskeletal radiologists and orthopedic surgeons on computed tomography imaging features of spinal metastases","volume":"18","author":"Khan","year":"2011","journal-title":"Curr Oncol"},{"key":"10.1016\/j.spinee.2014.03.043_bib9","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1097\/00007632-199702010-00002","article-title":"Risk factors and probability of vertebral body collapse in metastases of the thoracic and lumbar spine","volume":"22","author":"Taneichi","year":"1997","journal-title":"Spine"},{"key":"10.1016\/j.spinee.2014.03.043_bib10","unstructured":"R Core Team (2012). R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. Available at: http:\/\/www.R-project.org\/. Accessed April 23, 2014."},{"key":"10.1016\/j.spinee.2014.03.043_bib11","unstructured":"Therneau T (2012). A Package for Survival Analysis in S. R package version 2.36-12. Available at: http:\/\/CRAN.R-project.org\/package=survival. Accessed April 23, 2014."},{"key":"10.1016\/j.spinee.2014.03.043_bib12","first-page":"CD004721","article-title":"Palliation of metastatic bone pain: single fraction versus multifraction radiotherapy: a systematic review of the randomised trials","author":"Sze","year":"2004","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.spinee.2014.03.043_bib13","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.clon.2011.11.004","article-title":"Update on the systematic review of palliative radiotherapy trials for bone metastases","volume":"24","author":"Chow","year":"2012","journal-title":"Clin Oncol (R Coll Radiol)"},{"issue":"20 pt 2","key":"10.1016\/j.spinee.2014.03.043_bib14","doi-asserted-by":"crossref","first-page":"6243s","DOI":"10.1158\/1078-0432.CCR-06-0931","article-title":"Clinical features of metastatic bone disease and risk of skeletal morbidity","volume":"12","author":"Coleman","year":"2006","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.spinee.2014.03.043_bib15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0304-3959(96)03267-8","article-title":"Malignant bone pain: pathophysiology and treatment","volume":"69","author":"Mercadante","year":"1997","journal-title":"Pain"},{"key":"10.1016\/j.spinee.2014.03.043_bib16","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1097\/00007632-200102010-00016","article-title":"Surgical strategy for spinal metastases","volume":"26","author":"Tomita","year":"2001","journal-title":"Spine"},{"key":"10.1016\/j.spinee.2014.03.043_bib17","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1387\/ijdb.041817lv","article-title":"Pain control by ionizing radiation of bone metastasis","volume":"48","author":"Vakaet","year":"2004","journal-title":"Int J Dev Biol"},{"key":"10.1016\/j.spinee.2014.03.043_bib18","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/S1470-2045(11)70008-0","article-title":"Balloon kyphoplasty versus non-surgical fracture management for treatment of painful vertebral body compression fractures in patients with cancer: a multicentre, randomised controlled trial","volume":"12","author":"Berenson","year":"2011","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.spinee.2014.03.043_bib19","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1007\/s11916-012-0271-1","article-title":"The role of radiation therapy in controlling painful bone metastases","volume":"16","author":"Lutz","year":"2012","journal-title":"Curr Pain Headache Rep"},{"key":"10.1016\/j.spinee.2014.03.043_bib20","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/j.ijrobp.2010.06.036","article-title":"Correlation of computed tomography imaging features with pain response in patients with spine metastases after radiation therapy","volume":"81","author":"Mitera","year":"2011","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.spinee.2014.03.043_bib21","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1016\/S0140-6736(07)61602-X","article-title":"The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies","volume":"370","author":"von Elm","year":"2007","journal-title":"Lancet"},{"key":"10.1016\/j.spinee.2014.03.043_bib22","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/S0167-8140(02)00170-6","article-title":"International consensus on palliative radiotherapy endpoints for future clinical trials in bone metastases","volume":"64","author":"Chow","year":"2002","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.spinee.2014.03.043_bib23","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.1016\/j.ijrobp.2011.02.008","article-title":"Update of the international consensus on palliative radiotherapy endpoints for future clinical trials in bone metastases","volume":"82","author":"Chow","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.spinee.2014.03.043_bib24","series-title":"The design and analysis of clinical experiments","author":"Fleiss","year":"1986"},{"key":"10.1016\/j.spinee.2014.03.043_bib25","article-title":"The Spine Instability Neoplastic Score: an independent reliability and reproducibility analysis","author":"Campos","year":"2013","journal-title":"Spine J"},{"key":"10.1016\/j.spinee.2014.03.043_bib26","doi-asserted-by":"crossref","first-page":"213","DOI":"10.6061\/clinics\/2013(02)OA15","article-title":"Interobserver agreement for the spine instability neoplastic score varies according to the experience of the evaluator","volume":"68","author":"Teixeira","year":"2013","journal-title":"Clinics (Sao Paulo)"}],"container-title":["The Spine Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1529943014003519?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1529943014003519?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T19:19:27Z","timestamp":1648754367000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1529943014003519"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12]]},"references-count":26,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["S1529943014003519"],"URL":"https:\/\/doi.org\/10.1016\/j.spinee.2014.03.043","relation":{},"ISSN":["1529-9430"],"issn-type":[{"value":"1529-9430","type":"print"}],"subject":[],"published":{"date-parts":[[2014,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Spinal instability as defined by the spinal instability neoplastic score is associated with radiotherapy failure in metastatic spinal disease","name":"articletitle","label":"Article Title"},{"value":"The Spine Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.spinee.2014.03.043","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}