{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T20:02:40Z","timestamp":1791576160399,"version":"4.3.4"},"reference-count":29,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T00:00:00Z","timestamp":1454284800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,9,25]],"date-time":"2015-09-25T00:00:00Z","timestamp":1443139200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Titan Spine","award":["13040102"],"award-info":[{"award-number":["13040102"]}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","thespinejournalonline.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Spine Journal"],"published-print":{"date-parts":[[2016,2]]},"DOI":"10.1016\/j.spinee.2015.09.038","type":"journal-article","created":{"date-parts":[[2015,9,26]],"date-time":"2015-09-26T03:52:49Z","timestamp":1443239569000},"page":"235-242","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":94,"title":["Does impaction of titanium-coated interbody fusion cages into the disc space cause wear debris or delamination?"],"prefix":"10.1016","volume":"16","author":[{"given":"Annette","family":"Kienle","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Graf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans-Joachim","family":"Wilke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.spinee.2015.09.038_bib0010","doi-asserted-by":"crossref","first-page":"4845","DOI":"10.1016\/j.biomaterials.2007.07.013","article-title":"PEEK biomaterials in trauma, orthopedic, and spinal implants","volume":"28","author":"Kurtz","year":"2007","journal-title":"Biomaterials"},{"key":"10.1016\/j.spinee.2015.09.038_bib0015","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1097\/BRS.0000000000000778","article-title":"Implant materials generate different peri-implant inflammatory factors: poly-ether-ether-ketone promotes fibrosis and microtextured titanium promotes osteogenic factors","volume":"40","author":"Olivares-Navarrete","year":"2015","journal-title":"Spine"},{"key":"10.1016\/j.spinee.2015.09.038_bib0020","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1016\/j.ijom.2013.07.058","article-title":"Coated versus uncoated polyetheretherketone (PEEK) implants: preliminary data of an animal model in sheep","volume":"42","author":"St\u00fcbinger","year":"2013","journal-title":"Int J Oral Maxillofac Surg"},{"key":"10.1016\/j.spinee.2015.09.038_bib0025","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1016\/j.spinee.2014.12.018","article-title":"Plasma-sprayed titanium coating to polyetheretherketone improves the bone-implant interface","volume":"15","author":"Walsh","year":"2014","journal-title":"Spine J"},{"key":"10.1016\/j.spinee.2015.09.038_bib0030","series-title":"Standard Test Method for shear testing of calcium phosphate coatings and metallic coatings","author":"ASTM F1044-05e1","year":"2011"},{"key":"10.1016\/j.spinee.2015.09.038_bib0035","doi-asserted-by":"crossref","first-page":"2239","DOI":"10.1016\/j.biomaterials.2003.09.017","article-title":"Early detachment of titanium particles from various different surfaces of endosseous dental implants","volume":"25","author":"Franchi","year":"2004","journal-title":"Biomaterials"},{"key":"10.1016\/j.spinee.2015.09.038_bib0040","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1016\/S0142-9612(02)00508-2","article-title":"Detachment of titanium and fluorohydroxyapatite particles in unloaded endosseous implants","volume":"24","author":"Martini","year":"2003","journal-title":"Biomaterials"},{"key":"10.1016\/j.spinee.2015.09.038_bib0045","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1002\/(SICI)1097-4636(199807)41:1<41::AID-JBM5>3.0.CO;2-Q","article-title":"Histomorphometrical and mechanical evaluation of titanium plasma-spray-coated implants placed in the cortical bone of goats","volume":"41","author":"Vercaigne","year":"1998","journal-title":"J Biomed Mater Res"},{"key":"10.1016\/j.spinee.2015.09.038_bib0050","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1097\/00007632-200209150-00004","article-title":"The effect of titanium particulate on development and maintenance of a posterolateral spinal arthrodesis: an in vivo rabbit model","volume":"27","author":"Cunningham","year":"2002","journal-title":"Spine"},{"key":"10.1016\/j.spinee.2015.09.038_bib0055","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S1529-9430(02)00443-6","article-title":"The effect of spinal instrumentation particulate wear debris: an in vivo rabbit model and applied clinical study of retrieved instrumentation cases","volume":"3","author":"Cunningham","year":"2003","journal-title":"Spine J"},{"key":"10.1016\/j.spinee.2015.09.038_bib0060","doi-asserted-by":"crossref","first-page":"S125","DOI":"10.1097\/00007632-200310151-00006","article-title":"Spinal implant debris-induced osteolysis","volume":"28","author":"Hallab","year":"2003","journal-title":"Spine"},{"key":"10.1016\/j.spinee.2015.09.038_bib0065","doi-asserted-by":"crossref","first-page":"3363","DOI":"10.1016\/j.actbio.2014.03.037","article-title":"Implant osseointegration and the role of microroughness and nanostructures: lessons for spine implants. Review article","volume":"10","author":"Gittens","year":"2014","journal-title":"Acta Biomater"},{"key":"10.1016\/j.spinee.2015.09.038_bib0070","series-title":"Standard specifications and test methods for components used in the surgical fixation of the spinal skeletal system","author":"ASTM F2193-14","year":"2014"},{"key":"10.1016\/j.spinee.2015.09.038_bib0075","series-title":"34th annual meeting of the International Society for the Study of the Lumbar Spine","article-title":"Contours of vertebral endplates changes with the degree of disc degeneration","author":"Wilke","year":"2007"},{"key":"10.1016\/j.spinee.2015.09.038_bib0080","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1097\/00003086-196600450-00014","article-title":"The load on lumbar disks in different positions of the body","volume":"45","author":"Nachemson","year":"1966","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.spinee.2015.09.038_bib0085","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1097\/00007632-198101000-00020","article-title":"Disc pressure measurements","volume":"6","author":"Nachemson","year":"1981","journal-title":"Spine"},{"key":"10.1016\/j.spinee.2015.09.038_bib0090","doi-asserted-by":"crossref","first-page":"2468","DOI":"10.1097\/00007632-199912010-00008","article-title":"In vivo intradiscal pressure measurement in healthy individuals and in patients with ongoing back problems","author":"Sato","year":"1999","journal-title":"Spine"},{"key":"10.1016\/j.spinee.2015.09.038_bib0095","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1097\/00007632-199904150-00005","article-title":"New in vivo measurements of pressures in the intervertebral disc in daily life","volume":"24","author":"Wilke","year":"1999","journal-title":"Spine"},{"issue":"Suppl. 1","key":"10.1016\/j.spinee.2015.09.038_bib0100","doi-asserted-by":"crossref","first-page":"S111","DOI":"10.1016\/S0268-0033(00)00103-0","article-title":"Intradiscal pressure together with anthropometric data \u2013 a data set for the validation of models","volume":"16","author":"Wilke","year":"2001","journal-title":"Clin Biomech"},{"key":"10.1016\/j.spinee.2015.09.038_bib0105","series-title":"Test methods for intervertebral body fusion devices","author":"ASTM F2077-14","year":"2014"},{"key":"10.1016\/j.spinee.2015.09.038_bib0110","series-title":"Standard practice for characterization of particles","author":"ASTM F1877-05","year":"2010"},{"key":"10.1016\/j.spinee.2015.09.038_bib0115","series-title":"Standard test method for tension testing of calcium phosphate and metallic coatings","author":"ASTM F1147-05 e1","year":"2011"},{"issue":"6 Suppl.","key":"10.1016\/j.spinee.2015.09.038_bib0120","doi-asserted-by":"crossref","first-page":"239S","DOI":"10.1016\/j.spinee.2004.07.014","article-title":"Evaluation of the biological response of wear debris","volume":"4","author":"Chang","year":"2004","journal-title":"Spine J"},{"key":"10.1016\/j.spinee.2015.09.038_bib0125","first-page":"182","article-title":"Biologic effects of implant debris","volume":"67","author":"Hallab","year":"2009","journal-title":"Bull NYU Hosp Jt Dis"},{"key":"10.1016\/j.spinee.2015.09.038_bib0130","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.esas.2009.11.005","article-title":"A review of the biologic effects of spine implant debris: fact from fiction","volume":"3","author":"Hallab","year":"2009","journal-title":"SAS J"},{"key":"10.1016\/j.spinee.2015.09.038_bib0135","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1097\/01.BRS.0000065482.41115.B4","article-title":"Metal concentrations in the serum and hair of patients with titanium alloy spinal implants","volume":"28","author":"Kasai","year":"2003","journal-title":"Spine"},{"key":"10.1016\/j.spinee.2015.09.038_bib0140","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4184\/asj.2007.1.1.1","article-title":"Electron microprobe analysis and tissue reaction around titanium alloy spinal implants","volume":"1","author":"Kim","year":"2007","journal-title":"Asian Spine J"},{"key":"10.1016\/j.spinee.2015.09.038_bib0145","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1097\/00007632-199604010-00020","article-title":"Local tissue of the lumbar spine response to titanium plate \u2013 screw system. Case reports","volume":"21","author":"Xu","year":"1996","journal-title":"Spine"},{"key":"10.1016\/j.spinee.2015.09.038_bib0150","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/S1529-9430(01)00023-7","article-title":"Biocompatibility studies of titanium-based alloy pedicle screw and rod system: histological aspects","volume":"1","author":"Yamaguchi","year":"2001","journal-title":"Spine J"}],"container-title":["The Spine Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1529943015014485?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1529943015014485?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,19]],"date-time":"2018-09-19T05:58:29Z","timestamp":1537336709000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1529943015014485"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2]]},"references-count":29,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,2]]}},"alternative-id":["S1529943015014485"],"URL":"https:\/\/doi.org\/10.1016\/j.spinee.2015.09.038","relation":{},"ISSN":["1529-9430"],"issn-type":[{"value":"1529-9430","type":"print"}],"subject":[],"published":{"date-parts":[[2016,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Does impaction of titanium-coated interbody fusion cages into the disc space cause wear debris or delamination?","name":"articletitle","label":"Article Title"},{"value":"The Spine Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.spinee.2015.09.038","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}