{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,7]],"date-time":"2026-06-07T10:56:57Z","timestamp":1780829817977,"version":"3.54.1"},"reference-count":32,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","thespinejournalonline.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Spine Journal"],"published-print":{"date-parts":[[2016,6]]},"DOI":"10.1016\/j.spinee.2016.02.049","type":"journal-article","created":{"date-parts":[[2016,3,30]],"date-time":"2016-03-30T01:54:18Z","timestamp":1459302858000},"page":"756-763","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"title":["Comparative study of the efficacy of limaprost and pregabalin as single agents and in combination for the treatment of lumbar spinal stenosis: a prospective, double-blind, randomized controlled non-inferiority trial"],"prefix":"10.1016","volume":"16","author":[{"given":"Ho-Joong","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin Hyok","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye Soo","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung-Soo","family":"Suk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Hyup","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moon Soo","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5165-1159","authenticated-orcid":false,"given":"Seong-Hwan","family":"Moon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.spinee.2016.02.049_bib0010","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1056\/NEJMcp0708097","article-title":"Clinical practice. Lumbar spinal stenosis","volume":"358","author":"Katz","year":"2008","journal-title":"N Engl J Med"},{"key":"10.1016\/j.spinee.2016.02.049_bib0015","doi-asserted-by":"crossref","first-page":"2477","DOI":"10.1001\/jama.1968.03150110025004","article-title":"Pseudoclaudication syndrome produced by compression of the cauda equina","volume":"206","author":"Kavanaugh","year":"1968","journal-title":"JAMA"},{"key":"10.1016\/j.spinee.2016.02.049_bib0020","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1097\/00007632-199101000-00012","article-title":"Experimental nerve root compression. A model of acute, graded compression of the porcine cauda equina and an analysis of neural and vascular anatomy","volume":"16","author":"Olmarker","year":"1991","journal-title":"Spine"},{"key":"10.1016\/j.spinee.2016.02.049_bib0025","doi-asserted-by":"crossref","first-page":"35","DOI":"10.5387\/fms.2013-22","article-title":"Therapeutic efficacy of pregabalin in patients with leg symptoms due to lumbar spinal stenosis","volume":"60","author":"Takahashi","year":"2014","journal-title":"Fukushima J Med Sci"},{"key":"10.1016\/j.spinee.2016.02.049_bib0030","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1097\/01.brs.0000261029.29170.e6","article-title":"The efficiency of gabapentin therapy in patients with lumbar spinal stenosis","volume":"32","author":"Yaksi","year":"2007","journal-title":"Spine"},{"key":"10.1016\/j.spinee.2016.02.049_bib0035","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1097\/00007632-200405150-00011","article-title":"Experimental spinal stenosis: relationship between degree of cauda equina compression, neuropathology, and pain","volume":"29","author":"Sekiguchi","year":"2004","journal-title":"Spine"},{"key":"10.1016\/j.spinee.2016.02.049_bib0040","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1213\/00000539-200206000-00030","article-title":"The effects of OP-1206 alpha-CD on walking dysfunction in the rat neuropathic intermittent claudication model","volume":"94","author":"Nakai","year":"2002","journal-title":"Anesth Analg"},{"key":"10.1016\/j.spinee.2016.02.049_bib0045","doi-asserted-by":"crossref","first-page":"109","DOI":"10.2165\/00003495-200767010-00010","article-title":"Limaprost","volume":"67","author":"Swainston Harrison","year":"2007","journal-title":"Drugs"},{"key":"10.1016\/j.spinee.2016.02.049_bib0050","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1097\/BRS.0b013e31818f924d","article-title":"The efficacy of prostaglandin E1 derivative in patients with lumbar spinal stenosis","volume":"34","author":"Matsudaira","year":"2009","journal-title":"Spine"},{"key":"10.1016\/j.spinee.2016.02.049_bib0055","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1097\/BRS.0b013e3181e878a1","article-title":"Limaprost alfadex, a prostaglandin E1 derivative, prevents deterioration of forced exercise capability in rats with chronic compression of the spinal cord","volume":"36","author":"Kurokawa","year":"2011","journal-title":"Spine"},{"key":"10.1016\/j.spinee.2016.02.049_bib0060","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1007\/s00586-012-2551-1","article-title":"Limaprost alfadex and nonsteroidal anti-inflammatory drugs for sciatica due to lumbar spinal stenosis","volume":"22","author":"Onda","year":"2013","journal-title":"Eur Spine J"},{"key":"10.1016\/j.spinee.2016.02.049_bib0065","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1007\/s00776-012-0342-5","article-title":"The effect of a prostaglandin E1 derivative on the symptoms and quality of life of patients with lumbar spinal stenosis","volume":"18","author":"Takahashi","year":"2013","journal-title":"J Orthop Sci"},{"key":"10.1016\/j.spinee.2016.02.049_bib0070","doi-asserted-by":"crossref","first-page":"469","DOI":"10.4184\/asj.2014.8.4.469","article-title":"Comparisons on efficacy of elcatonin and limaprost alfadex in patients with lumbar spinal stenosis and concurrent osteoporosis: a preliminary study using a crossover design","volume":"8","author":"Kanchiku","year":"2014","journal-title":"Asian Spine J"},{"key":"10.1016\/j.spinee.2016.02.049_bib0075","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1177\/2042098613505614","article-title":"Pregabalin: latest safety evidence and clinical implications for the management of neuropathic pain","volume":"5","author":"Toth","year":"2014","journal-title":"Ther Adv Drug Saf"},{"key":"10.1016\/j.spinee.2016.02.049_bib0080","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.pain.2010.04.013","article-title":"The efficacy and safety of pregabalin in the treatment of neuropathic pain associated with chronic lumbosacral radiculopathy","volume":"150","author":"Baron","year":"2010","journal-title":"Pain"},{"key":"10.1016\/j.spinee.2016.02.049_bib0085","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.2176\/nmc.50.1070","article-title":"Efficacy of gabapentin for radiculopathy caused by lumbar spinal stenosis and lumbar disk hernia","volume":"50","author":"Kasimcan","year":"2010","journal-title":"Neurol Med Chir (Tokyo)"},{"key":"10.1016\/j.spinee.2016.02.049_bib0090","doi-asserted-by":"crossref","first-page":"169","DOI":"10.36076\/ppj.2014\/17\/169","article-title":"The effects of gastroretentive gabapentin (Gralise\u00ae) on spinal stenosis patients with radicular pain","volume":"17","author":"Kaye","year":"2014","journal-title":"Pain Physician"},{"key":"10.1016\/j.spinee.2016.02.049_bib0095","doi-asserted-by":"crossref","first-page":"2940","DOI":"10.1097\/00007632-200011150-00017","article-title":"The Oswestry Disability Index","volume":"25","author":"Fairbank","year":"2000","journal-title":"Spine"},{"key":"10.1016\/j.spinee.2016.02.049_bib0100","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/0168-8510(90)90421-9","article-title":"EuroQol\u2014a new facility for the measurement of health-related quality of life","volume":"16","author":"Group","year":"1990","journal-title":"Health Policy (New York)"},{"key":"10.1016\/j.spinee.2016.02.049_bib0105","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/S0741-5214(97)70265-9","article-title":"Efficacy of a new prostaglandin E1 regimen in outpatients with severe intermittent claudication: results of a multicenter placebo-controlled double-blind trial","volume":"25","author":"Diehm","year":"1997","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.spinee.2016.02.049_bib0110","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1179\/016911107X217482","article-title":"Effects of treatment with oral prostaglandin E1 on lumbar spinal canal stenosis","volume":"19","author":"Komori","year":"2007","journal-title":"Pain Clinic"},{"key":"10.1016\/j.spinee.2016.02.049_bib0115","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1007\/s00586-014-3511-8","article-title":"Comparison between walking test and treadmill test for intermittent claudication associated with lumbar spinal canal stenosis","volume":"24","author":"Tanishima","year":"2015","journal-title":"Eur Spine J"},{"key":"10.1016\/j.spinee.2016.02.049_bib0120","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/S0924-980X(97)00055-6","article-title":"Gait analysis during treadmill and overground locomotion in children and adults","volume":"105","author":"Stolze","year":"1997","journal-title":"Electroencephalogr Clin Neurophysiol"},{"key":"10.1016\/j.spinee.2016.02.049_bib0125","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1037\/1082-989X.8.3.322","article-title":"Using the expectation maximization algorithm to estimate coefficient alpha for scales with item-level missing data","volume":"8","author":"Enders","year":"2003","journal-title":"Psychol Methods"},{"key":"10.1016\/j.spinee.2016.02.049_bib0130","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1097\/BRS.0b013e31815e3a10","article-title":"Interpreting change scores for pain and functional status in low back pain: towards international consensus regarding minimal important change","volume":"33","author":"Ostelo","year":"2008","journal-title":"Spine"},{"key":"10.1016\/j.spinee.2016.02.049_bib0135","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1007\/s12630-010-9315-3","article-title":"Lumbar spinal stenosis: a brief review of the nonsurgical management","volume":"57","author":"de Tran","year":"2010","journal-title":"Can J Anaesth"},{"key":"10.1016\/j.spinee.2016.02.049_bib0140","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0304-3959(98)00067-0","article-title":"An experimental model for chronic compression of dorsal root ganglion produced by intervertebral foramen stenosis in the rat","volume":"77","author":"Hu","year":"1998","journal-title":"Pain"},{"key":"10.1016\/j.spinee.2016.02.049_bib0145","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1111\/pme.12229","article-title":"What is the evidence that neuropathic pain is present in chronic low back pain and soft tissue syndromes? An evidence-based structured review","volume":"15","author":"Fishbain","year":"2014","journal-title":"Pain Med"},{"key":"10.1016\/j.spinee.2016.02.049_bib0150","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1111\/j.1526-4637.2010.00825.x","article-title":"Effects of intravenous prostaglandin E1 on pain and body temperature in patients with post-herpetic neuralgia","volume":"11","author":"Kanai","year":"2010","journal-title":"Pain Med"},{"key":"10.1016\/j.spinee.2016.02.049_bib0155","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.pain.2004.01.010","article-title":"Activation of extracellular signal-regulated protein kinase in dorsal horn neurons in the rat neuropathic intermittent claudication model","volume":"109","author":"Liu","year":"2004","journal-title":"Pain"},{"key":"10.1016\/j.spinee.2016.02.049_bib0160","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0304-3959(00)00482-6","article-title":"The LANSS Pain Scale: the Leeds assessment of neuropathic symptoms and signs","volume":"92","author":"Bennett","year":"2001","journal-title":"Pain"},{"key":"10.1016\/j.spinee.2016.02.049_bib0165","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1185\/030079906X132488","article-title":"painDETECT: a new screening questionnaire to identify neuropathic components in patients with back pain","volume":"22","author":"Freynhagen","year":"2006","journal-title":"Curr Med Res Opin"}],"container-title":["The Spine Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1529943016004393?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1529943016004393?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,6,16]],"date-time":"2022-06-16T16:12:58Z","timestamp":1655395978000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1529943016004393"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6]]},"references-count":32,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,6]]}},"alternative-id":["S1529943016004393"],"URL":"https:\/\/doi.org\/10.1016\/j.spinee.2016.02.049","relation":{},"ISSN":["1529-9430"],"issn-type":[{"value":"1529-9430","type":"print"}],"subject":[],"published":{"date-parts":[[2016,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comparative study of the efficacy of limaprost and pregabalin as single agents and in combination for the treatment of lumbar spinal stenosis: a prospective, double-blind, randomized controlled non-inferiority trial","name":"articletitle","label":"Article Title"},{"value":"The Spine Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.spinee.2016.02.049","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}