{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T02:52:39Z","timestamp":1761706359157,"version":"build-2065373602"},"reference-count":30,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,1,16]],"date-time":"2018-01-16T00:00:00Z","timestamp":1516060800000},"content-version":"am","delay-in-days":349,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000185","name":"DARPA","doi-asserted-by":"publisher","award":["64559MSDRP13139"],"award-info":[{"award-number":["64559MSDRP13139"]}],"id":[{"id":"10.13039\/100000185","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007859","name":"University of Kansas","doi-asserted-by":"publisher","award":["QW850028"],"award-info":[{"award-number":["QW850028"]}],"id":[{"id":"10.13039\/100007859","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thespinejournalonline.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Spine Journal"],"published-print":{"date-parts":[[2017,2]]},"DOI":"10.1016\/j.spinee.2016.09.016","type":"journal-article","created":{"date-parts":[[2016,9,21]],"date-time":"2016-09-21T19:30:14Z","timestamp":1474486214000},"page":"252-259","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Quiescent pluripotent stem cells reside within murine peripheral nerves that can be stimulated to proliferate by recombinant human bone morphogenic protein 2 or by nerve trauma"],"prefix":"10.1016","volume":"17","author":[{"given":"Michael H.","family":"Heggeness","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0540-2124","authenticated-orcid":false,"given":"Nora","family":"Strong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul H.","family":"Wooley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8835-5302","authenticated-orcid":false,"given":"Shang-You","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"Suppl. 3","key":"10.1016\/j.spinee.2016.09.016_bib0010","doi-asserted-by":"crossref","first-page":"S43","DOI":"10.1016\/j.injury.2005.07.034","article-title":"Clinical applications of BMPs","volume":"36","author":"De Biase","year":"2005","journal-title":"Injury"},{"key":"10.1016\/j.spinee.2016.09.016_bib0015","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/S0076-6879(87)46031-X","article-title":"Preparation and bioassay of bone morphogenetic protein and polypeptide fragments","volume":"146","author":"Urist","year":"1987","journal-title":"Methods Enzymol"},{"key":"10.1016\/j.spinee.2016.09.016_bib0020","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1126\/science.150.3698.893","article-title":"Bone: formation by autoinduction","volume":"150","author":"Urist","year":"1965","journal-title":"Science"},{"key":"10.1016\/j.spinee.2016.09.016_bib0025","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3310\/hta11300","article-title":"Clinical effectiveness and cost-effectiveness of bone morphogenetic proteins in the non-healing of fractures and spinal fusion: a systematic review","volume":"11","author":"Garrison","year":"2007","journal-title":"Health Technol Assess"},{"key":"10.1016\/j.spinee.2016.09.016_bib0030","doi-asserted-by":"crossref","first-page":"43","DOI":"10.3171\/2012.10.SPINE10231","article-title":"Multilevel anterior cervical discectomy and fusion with and without rhBMP-2: a comparison of dysphagia rates and outcomes in 150 patients","volume":"18","author":"Lu","year":"2013","journal-title":"J Neurosurg Spine"},{"key":"10.1016\/j.spinee.2016.09.016_bib0035","doi-asserted-by":"crossref","first-page":"19","DOI":"10.3171\/spi.2004.1.1.0019","volume":"1","author":"Mummaneni","year":"2004","journal-title":"J Neurosurg Spine"},{"key":"10.1016\/j.spinee.2016.09.016_bib0040","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1097\/00024720-200608000-00008","article-title":"Use of recombinant human bone morphogenetic protein-2 as an adjunct in posterolateral lumbar spine fusion: a prospective CT-scan analysis at one and two years","volume":"19","author":"Singh","year":"2006","journal-title":"J Spinal Disord Tech"},{"key":"10.1016\/j.spinee.2016.09.016_bib0045","doi-asserted-by":"crossref","first-page":"217","DOI":"10.3233\/THC-2010-0584","article-title":"Enhancement of endoprosthesis anchoring using BMP-2","volume":"18","author":"Thorey","year":"2010","journal-title":"Technol Health Care"},{"key":"10.1016\/j.spinee.2016.09.016_bib0050","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1055\/s-0032-1333420","article-title":"A prospective, randomized, controlled trial comparing radiographic and clinical outcomes between stand-alone lateral interbody lumbar fusion with either silicate calcium phosphate or rh-BMP2","volume":"74","author":"Pimenta","year":"2013","journal-title":"J Neurol Surg A Cent Eur Neurosurg"},{"key":"10.1016\/j.spinee.2016.09.016_bib0055","doi-asserted-by":"crossref","first-page":"318","DOI":"10.2106\/JBJS.N.00584","article-title":"Sandwich allografts for long-bone nonunions in patients with osteogenesis imperfecta: a retrospective study","volume":"97","author":"Puvanesarajah","year":"2015","journal-title":"J Bone Joint Surg Am"},{"key":"10.1016\/j.spinee.2016.09.016_bib0060","doi-asserted-by":"crossref","first-page":"E738","DOI":"10.1097\/BRS.0b013e31828fd23c","article-title":"Use of recombinant human bone morphogenetic protein-2 with local bone graft instead of iliac crest bone graft in posterolateral lumbar spine arthrodesis","volume":"38","author":"Park","year":"2013","journal-title":"Spine"},{"key":"10.1016\/j.spinee.2016.09.016_bib0065","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s11010-010-0664-6","article-title":"A synthetic compound that potentiates bone morphogenetic protein-2-induced transdifferentiation of myoblasts into the osteoblastic phenotype","volume":"349","author":"Kato","year":"2011","journal-title":"Mol Cell Biochem"},{"key":"10.1016\/j.spinee.2016.09.016_bib0070","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1097\/00006416-200501000-00014","article-title":"The ABCs of BMPs","volume":"24","author":"Boden","year":"2005","journal-title":"Orthop Nurs"},{"key":"10.1016\/j.spinee.2016.09.016_bib0075","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.spinee.2009.10.003","article-title":"Bone morphogenetic protein-2 used in spinal fusion with spinal cord injury penetrates intrathecally and elicits a functional signaling cascade","volume":"10","author":"Dmitriev","year":"2010","journal-title":"Spine J"},{"key":"10.1016\/j.spinee.2016.09.016_bib0080","doi-asserted-by":"crossref","first-page":"877","DOI":"10.7326\/0003-4819-158-12-201306180-00005","article-title":"Safety and effectiveness of recombinant human bone morphogenetic protein-2 for spinal fusion: a meta-analysis of individual-participant data","volume":"158","author":"Simmonds","year":"2013","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.spinee.2016.09.016_bib0085","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.spinee.2011.04.023","article-title":"A critical review of recombinant human bone morphogenetic protein-2 trials in spinal surgery: emerging safety concerns and lessons learned","volume":"11","author":"Carragee","year":"2011","journal-title":"Spine J"},{"key":"10.1016\/j.spinee.2016.09.016_bib0090","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1016\/j.spinee.2012.09.052","article-title":"Recombinant human bone morphogenetic protein-2: adverse events reported to the Manufacturer and User Facility Device Experience database","volume":"12","author":"Woo","year":"2012","journal-title":"Spine J"},{"key":"10.1016\/j.spinee.2016.09.016_bib0095","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1126\/science.1164270","article-title":"Generation of mouse induced pluripotent stem cells without viral vectors","volume":"322","author":"Okita","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.spinee.2016.09.016_bib0100","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.cell.2006.07.024","article-title":"Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors","volume":"126","author":"Takahashi","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.spinee.2016.09.016_bib0105","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1007\/s10529-009-0064-8","article-title":"Purification of Schwann cells from adult rats by differential detachment","volume":"31","author":"Wu","year":"2009","journal-title":"Biotechnol Lett"},{"key":"10.1016\/j.spinee.2016.09.016_bib0110","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.2106\/00004623-200505000-00022","article-title":"Human periprosthetic tissues implanted in severe combined immunodeficient mice respond to gene transfer of a cytokine inhibitor","volume":"87","author":"Yang","year":"2005","journal-title":"J Bone Joint Surg Am"},{"key":"10.1016\/j.spinee.2016.09.016_bib0115","doi-asserted-by":"crossref","first-page":"e115","DOI":"10.1093\/nar\/gks596","article-title":"Primer3\u2014new capabilities and interfaces","volume":"40","author":"Untergasser","year":"2012","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.spinee.2016.09.016_bib0120","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1093\/bioinformatics\/btm091","article-title":"Enhancements and modifications of primer design program Primer3","volume":"23","author":"Koressaar","year":"2007","journal-title":"Bioinformatics"},{"key":"10.1016\/j.spinee.2016.09.016_bib0125","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1083\/jcb.113.3.681","article-title":"Recombinant human bone morphogenetic protein-2 stimulates osteoblastic maturation and inhibits myogenic differentiation in vitro","volume":"113","author":"Yamaguchi","year":"1991","journal-title":"J Cell Biol"},{"key":"10.1016\/j.spinee.2016.09.016_bib0130","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1002\/(SICI)1097-4652(199710)173:1<93::AID-JCP11>3.0.CO;2-O","article-title":"Dependence of mesenchymal cell responses on duration of exposure to bone morphogenetic protein-2 in vitro","volume":"173","author":"Puleo","year":"1997","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.spinee.2016.09.016_bib0135","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1046\/j.1524-475X.2003.11507.x","article-title":"Bone morphogenetic protein-2 regulates proliferation of human mesenchymal stem cells","volume":"11","author":"Akino","year":"2003","journal-title":"Wound Repair Regen"},{"key":"10.1016\/j.spinee.2016.09.016_bib0140","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1006\/bbrc.2001.5088","article-title":"Cell differentiation under the influence of rh-BMP-2","volume":"284","author":"Wilke","year":"2001","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.spinee.2016.09.016_bib0145","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/gm354","article-title":"Challenges to the clinical application of pluripotent stem cells: towards genomic and functional stability","volume":"4","author":"Fu","year":"2012","journal-title":"Genome Med"},{"key":"10.1016\/j.spinee.2016.09.016_bib0150","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.tibtech.2012.03.003","article-title":"Process engineering of human pluripotent stem cells for clinical application","volume":"30","author":"Serra","year":"2012","journal-title":"Trends Biotechnol"},{"key":"10.1016\/j.spinee.2016.09.016_bib0155","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1002\/stem.1066","article-title":"Concise review: immune recognition of induced pluripotent stem cells","volume":"30","author":"Boyd","year":"2012","journal-title":"Stem Cells"}],"container-title":["The Spine Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1529943016309664?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1529943016309664?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T21:29:16Z","timestamp":1761514156000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1529943016309664"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,2]]}},"alternative-id":["S1529943016309664"],"URL":"https:\/\/doi.org\/10.1016\/j.spinee.2016.09.016","relation":{},"ISSN":["1529-9430"],"issn-type":[{"type":"print","value":"1529-9430"}],"subject":[],"published":{"date-parts":[[2017,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Quiescent pluripotent stem cells reside within murine peripheral nerves that can be stimulated to proliferate by recombinant human bone morphogenic protein 2 or by nerve trauma","name":"articletitle","label":"Article Title"},{"value":"The Spine Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.spinee.2016.09.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}