{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T20:04:42Z","timestamp":1786997082377,"version":"build-2736575974"},"reference-count":39,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thespinejournalonline.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Spine Journal"],"published-print":{"date-parts":[[2019,8]]},"DOI":"10.1016\/j.spinee.2019.04.006","type":"journal-article","created":{"date-parts":[[2019,4,8]],"date-time":"2019-04-08T20:42:02Z","timestamp":1554756122000},"page":"1434-1442","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"title":["Administration of ONO-2506 suppresses neuropathic pain after spinal cord injury by inhibition of astrocytic activation"],"prefix":"10.1016","volume":"19","author":[{"given":"Hiroyuki","family":"Ishiguro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Kaito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunihiko","family":"Hashimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junichi","family":"Kushioka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rintaro","family":"Okada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Tsukazaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joe","family":"Kodama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeynep","family":"Bal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuichiro","family":"Ukon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shota","family":"Takenaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Makino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Sakai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Yoshikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.spinee.2019.04.006_bib0001","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1093\/brain\/awg007","article-title":"Sensory function in spinal cord injury patients with and without central pain","volume":"126","author":"Finnerup","year":"2003","journal-title":"Brain"},{"key":"10.1016\/j.spinee.2019.04.006_bib0002","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1002\/ejp.905","article-title":"Neuropathic pain prevalence following spinal cord injury: a systematic review and meta-analysis","volume":"21","author":"Burke","year":"2017","journal-title":"Eur J Pain"},{"key":"10.1016\/j.spinee.2019.04.006_bib0003","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0304-3959(02)00452-9","article-title":"A longitudinal study of the prevalence and characteristics of pain in the first 5 years following spinal cord injury","volume":"103","author":"Siddall","year":"2003","journal-title":"Pain"},{"key":"10.1016\/j.spinee.2019.04.006_bib0004","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.jns.2017.11.018","article-title":"Neuropathic pain and SCI: identification and treatment strategies in the 21st century","volume":"384","author":"Hatch","year":"2018","journal-title":"J Neurol Sci"},{"key":"10.1016\/j.spinee.2019.04.006_bib0005","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.pain.2008.01.021","article-title":"Propentofylline attenuates allodynia, glial activation and modulates GABAergic tone after spinal cord injury in the rat","volume":"138","author":"Gwak","year":"2008","journal-title":"Pain"},{"key":"10.1016\/j.spinee.2019.04.006_bib0006","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.expneurol.2008.07.016","article-title":"Gliopathy ensures persistent inflammation and chronic pain after spinal cord injury","volume":"214","author":"Hulsebosch","year":"2008","journal-title":"Exp Neurol"},{"key":"10.1016\/j.spinee.2019.04.006_bib0007","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1038\/nm.2231","article-title":"Central mechanisms of pathological pain","volume":"16","author":"Kuner","year":"2010","journal-title":"Nat Med"},{"key":"10.1016\/j.spinee.2019.04.006_bib0008","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1002\/jnr.23881","article-title":"Neuropathic pain following traumatic spinal cord injury: models, measurement, and mechanisms","volume":"95","author":"Kramer","year":"2017","journal-title":"J Neurosci Res"},{"key":"10.1016\/j.spinee.2019.04.006_bib0009","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1254\/jphs.10R04CP","article-title":"Spinal astrocytes as therapeutic targets for pathological pain","volume":"114","author":"Nakagawa","year":"2010","journal-title":"J Pharmacol Sci"},{"key":"10.1016\/j.spinee.2019.04.006_bib0010","doi-asserted-by":"crossref","first-page":"127","DOI":"10.2174\/1568007053544084","article-title":"Arundic acid (ONO-2506) ameliorates delayed ischemic brain damage by preventing astrocytic overproduction of S100B","volume":"4","author":"Asano","year":"2005","journal-title":"Curr Drug Targets CNS Neurol Disord"},{"key":"10.1016\/j.spinee.2019.04.006_bib0011","article-title":"The S100B story: from biomarker to active factor in neural injury","author":"Michetti","year":"2018","journal-title":"J Neurochem"},{"key":"10.1016\/j.spinee.2019.04.006_bib0012","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1097\/00004647-200206000-00011","volume":"22","author":"Tateishi","year":"2002","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1016\/j.spinee.2019.04.006_bib0013","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.jns.2013.12.008","article-title":"Arundic acid (ONO-2506) inhibits secondary injury and improves motor function in rats with spinal cord injury","volume":"337","author":"Hanada","year":"2014","journal-title":"J Neurol Sci"},{"key":"10.1016\/j.spinee.2019.04.006_bib0014","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.brainres.2013.05.002","article-title":"Neuroprotective effect of suppression of astrocytic activation by arundic acid on brain injuries in rats with acute subdural hematomas","volume":"1519","author":"Wajima","year":"2013","journal-title":"Brain Res"},{"key":"10.1016\/j.spinee.2019.04.006_bib0015","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1038\/nn1405","article-title":"Allodynia limits the usefulness of intraspinal neural stem cell grafts; directed differentiation improves outcome","volume":"8","author":"Hofstetter","year":"2005","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.spinee.2019.04.006_bib0016","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.neulet.2012.10.034","article-title":"Serotonin 2C receptor alternative splicing in a spinal cord injury model","volume":"532","author":"Nakae","year":"2013","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.spinee.2019.04.006_bib0017","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.brainres.2006.11.084","article-title":"Expression of S100 protein and protective effect of arundic acid on the rat brain in chronic cerebral hypoperfusion","volume":"1135","author":"Ohtani","year":"2007","journal-title":"Brain Res"},{"key":"10.1016\/j.spinee.2019.04.006_bib0018","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1089\/neu.1995.12.1","article-title":"A sensitive and reliable locomotor rating scale for open field testing in rats","volume":"12","author":"Basso","year":"1995","journal-title":"J Neurotrauma"},{"key":"10.1016\/j.spinee.2019.04.006_bib0019","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0165-0270(94)90144-9","article-title":"Quantitative assessment of tactile allodynia in the rat paw","volume":"53","author":"Chaplan","year":"1994","journal-title":"J Neurosci methods"},{"key":"10.1016\/j.spinee.2019.04.006_bib0020","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/0304-3959(88)90026-7","article-title":"A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia","volume":"32","author":"Hargreaves","year":"1988","journal-title":"Pain"},{"key":"10.1016\/j.spinee.2019.04.006_bib0021","doi-asserted-by":"crossref","first-page":"2294","DOI":"10.1046\/j.1471-4159.1997.69062294.x","article-title":"S100beta induces neuronal cell death through nitric oxide release from astrocytes","volume":"69","author":"Hu","year":"1997","journal-title":"J Neurochem"},{"key":"10.1016\/j.spinee.2019.04.006_bib0022","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1111\/jnc.12790","article-title":"S100B protein activates a RAGE-dependent autocrine loop in astrocytes: implications for its role in the propagation of reactive gliosis","volume":"131","author":"Villarreal","year":"2014","journal-title":"J Neurochem"},{"key":"10.1016\/j.spinee.2019.04.006_bib0023","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1161\/STROKEAHA.107.503821","article-title":"Overexpression of human S100B exacerbates brain damage and periinfarct gliosis after permanent focal ischemia","volume":"39","author":"Mori","year":"2008","journal-title":"Stroke"},{"key":"10.1016\/j.spinee.2019.04.006_bib0024","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1002\/ana.20142","article-title":"Increased susceptibility of S100B transgenic mice to perinatal hypoxia-ischemia","volume":"56","author":"Wainwright","year":"2004","journal-title":"Ann Neurol"},{"key":"10.1016\/j.spinee.2019.04.006_bib0025","doi-asserted-by":"crossref","first-page":"1956","DOI":"10.1161\/01.STR.28.10.1956","article-title":"S-100 protein and neuron-specific enolase concentrations in blood as indicators of infarction volume and prognosis in acute ischemic stroke","volume":"28","author":"Missler","year":"1997","journal-title":"Stroke"},{"key":"10.1016\/j.spinee.2019.04.006_bib0026","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s00701-016-3046-3","article-title":"A review of the clinical utility of serum S100B protein levels in the assessment of traumatic brain injury","volume":"159","author":"Thelin","year":"2017","journal-title":"Acta Neurochir"},{"key":"10.1016\/j.spinee.2019.04.006_bib0027","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.jocn.2007.05.014","article-title":"Elevation of neuron-specific enolase and S-100beta protein level in experimental acute spinal cord injury","volume":"15","author":"Cao","year":"2008","journal-title":"J Clin Neurosci"},{"key":"10.1016\/j.spinee.2019.04.006_bib0028","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1016\/j.neuroscience.2008.01.065","article-title":"Propentofylline-induced astrocyte modulation leads to alterations in glial glutamate promoter activation following spinal nerve transection","volume":"152","author":"Tawfik","year":"2008","journal-title":"Neuroscience"},{"key":"10.1016\/j.spinee.2019.04.006_bib0029","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/508342","article-title":"S100B inhibitor pentamidine attenuates reactive gliosis and reduces neuronal loss in a mouse model of Alzheimer's disease","volume":"2015","author":"Cirillo","year":"2015","journal-title":"Biomed Res Int"},{"key":"10.1016\/j.spinee.2019.04.006_bib0030","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.neuint.2003.06.001","article-title":"Attenuation of a delayed increase in the extracellular glutamate level in the peri-infarct area following focal cerebral ischemia by a novel agent ONO-2506","volume":"45","author":"Mori","year":"2004","journal-title":"Neurochem Int"},{"key":"10.1016\/j.spinee.2019.04.006_bib0031","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.neuropharm.2005.09.014","article-title":"Neuroprotective effect of arundic acid, an astrocyte-modulating agent, in mouse brain against MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) neurotoxicity","volume":"50","author":"Himeda","year":"2006","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.spinee.2019.04.006_bib0032","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.jns.2006.09.001","article-title":"Safety and tolerability of arundic acid in acute ischemic stroke","volume":"251","author":"Pettigrew","year":"2006","journal-title":"J Neurol Sci"},{"key":"10.1016\/j.spinee.2019.04.006_bib0033","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.jns.2014.08.028","article-title":"Evaluation of the effect of tranilast on rats with spinal cord injury","volume":"346","author":"Hanada","year":"2014","journal-title":"J Neurol Sci"},{"key":"10.1016\/j.spinee.2019.04.006_bib0034","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1038\/nrn1956","article-title":"Glial inhibition of CNS axon regeneration","volume":"7","author":"Yiu","year":"2006","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.spinee.2019.04.006_bib0035","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1186\/s12974-015-0327-3","article-title":"Crosstalk between macrophages and astrocytes affects proliferation, reactive phenotype and inflammatory response, suggesting a role during reactive gliosis following spinal cord injury","volume":"12","author":"Haan","year":"2015","journal-title":"J Neuroinflammation"},{"key":"10.1016\/j.spinee.2019.04.006_bib0036","doi-asserted-by":"crossref","first-page":"2409","DOI":"10.1002\/jnr.22411","article-title":"Endogenous expression of interleukin-4 regulates macrophage activation and confines cavity formation after traumatic spinal cord injury","volume":"88","author":"Lee","year":"2010","journal-title":"J Neurosci Res"},{"key":"10.1016\/j.spinee.2019.04.006_bib0037","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.expneurol.2011.10.010","article-title":"Spatial and temporal activation of spinal glial cells: role of gliopathy in central neuropathic pain following spinal cord injury in rats","volume":"234","author":"Gwak","year":"2012","journal-title":"Exp Neurol"},{"key":"10.1016\/j.spinee.2019.04.006_bib0038","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.expneurol.2010.03.002","article-title":"Intrathecal injection of carbenoxolone, a gap junction decoupler, attenuates the induction of below-level neuropathic pain after spinal cord injury in rats","volume":"224","author":"Roh","year":"2010","journal-title":"Exp Neurol"},{"key":"10.1016\/j.spinee.2019.04.006_bib0039","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1016\/j.mehy.2006.05.006","article-title":"Could treatment with arundic acid (ONO-2506) increase vulnerability for depression?","volume":"67","author":"Manev","year":"2006","journal-title":"Med Hypotheses"}],"container-title":["The Spine Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1529943019301251?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1529943019301251?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T21:30:03Z","timestamp":1761514203000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1529943019301251"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8]]},"references-count":39,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["S1529943019301251"],"URL":"https:\/\/doi.org\/10.1016\/j.spinee.2019.04.006","relation":{},"ISSN":["1529-9430"],"issn-type":[{"value":"1529-9430","type":"print"}],"subject":[],"published":{"date-parts":[[2019,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Administration of ONO-2506 suppresses neuropathic pain after spinal cord injury by inhibition of astrocytic activation","name":"articletitle","label":"Article Title"},{"value":"The Spine Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.spinee.2019.04.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}