{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T15:14:11Z","timestamp":1772032451226,"version":"3.50.1"},"reference-count":48,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thespinejournalonline.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Spine Journal"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1016\/j.spinee.2019.06.014","type":"journal-article","created":{"date-parts":[[2019,6,13]],"date-time":"2019-06-13T23:06:23Z","timestamp":1560467183000},"page":"1911-1916","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"title":["Paraspinal muscle ladybird homeobox 1 (LBX1) in adolescent idiopathic scoliosis: a cross-sectional study"],"prefix":"10.1016","volume":"19","author":[{"given":"William","family":"Jennings","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maggie","family":"Hou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Devin","family":"Perterson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Missiuna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lehana","family":"Thabane","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Tarnopolsky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Constantine","family":"Samaan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.spinee.2019.06.014_bib0001","doi-asserted-by":"crossref","first-page":"15030","DOI":"10.1038\/nrdp.2015.30","article-title":"Adolescent idiopathic scoliosis","volume":"1","author":"Cheng","year":"2015","journal-title":"Nat Rev Dis Primers"},{"key":"10.1016\/j.spinee.2019.06.014_bib0002","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s11832-012-0457-4","article-title":"Epidemiology of adolescent idiopathic scoliosis","volume":"7","author":"Konieczny","year":"2013","journal-title":"J Childrens Orthop"},{"key":"10.1016\/j.spinee.2019.06.014_bib0003","first-page":"f2508","article-title":"Adolescent idiopathic scoliosis","volume":"346","author":"Altaf","year":"2013","journal-title":"BMJ (Clinical research ed)"},{"key":"10.1016\/j.spinee.2019.06.014_bib0004","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1016\/S0140-6736(08)60658-3","article-title":"Adolescent idiopathic scoliosis","volume":"371","author":"Weinstein","year":"2008","journal-title":"Lancet"},{"key":"10.1016\/j.spinee.2019.06.014_bib0005","doi-asserted-by":"crossref","first-page":"S44","DOI":"10.1097\/BPO.0000000000001350","article-title":"The Natural History of Adolescent Idiopathic Scoliosis","volume":"39(6, Supplement 1)","author":"Weinstein","year":"2019","journal-title":"J Pediatr Orthop"},{"key":"10.1016\/j.spinee.2019.06.014_bib0006","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.jpeds.2017.12.031","article-title":"Variation in adolescent idiopathic scoliosis surgery: implications for improving healthcare value","volume":"195","author":"Workman","year":"2018","journal-title":"J Pediatr"},{"key":"10.1016\/j.spinee.2019.06.014_bib0007","doi-asserted-by":"crossref","first-page":"2427","DOI":"10.2106\/00004623-200711000-00013","article-title":"Non-neurologic complications following surgery for adolescent idiopathic scoliosis","volume":"89","author":"Carreon","year":"2007","journal-title":"J Bone Joint Surg Am"},{"key":"10.1016\/j.spinee.2019.06.014_bib0008","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1097\/BRS.0b013e3181f3a326","article-title":"Complications in the surgical treatment of 19,360 cases of pediatric scoliosis: a review of the Scoliosis Research Society Morbidity and Mortality database","volume":"36","author":"Reames","year":"2011","journal-title":"Spine"},{"key":"10.1016\/j.spinee.2019.06.014_bib0009","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1097\/01.brs.0000259865.08984.00","article-title":"Adolescent idiopathic scoliosis in twins: a population-based survey","volume":"32","author":"Andersen","year":"2007","journal-title":"Spine (Phila Pa 1976)"},{"key":"10.1016\/j.spinee.2019.06.014_bib0010","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1002\/ajmg.a.33145","article-title":"Polygenic inheritance of adolescent idiopathic scoliosis: a study of extended families in Utah","volume":"152A","author":"Ward","year":"2010","journal-title":"Am J Med Genet A"},{"key":"10.1016\/j.spinee.2019.06.014_bib0011","doi-asserted-by":"crossref","first-page":"E1098","DOI":"10.1097\/BRS.0000000000002123","article-title":"Genetic variant of GPR126 gene is functionally associated with adolescent idiopathic scoliosis in Chinese population","volume":"42","author":"Qin","year":"2017","journal-title":"Spine (Phila Pa 1976)"},{"key":"10.1016\/j.spinee.2019.06.014_bib0012","doi-asserted-by":"crossref","first-page":"1964","DOI":"10.1111\/jcmm.13486","article-title":"Genetic polymorphisms of GPR126 are functionally associated with PUMC classifications of adolescent idiopathic scoliosis in a Northern Han population","volume":"22","author":"Liu","year":"2018","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.spinee.2019.06.014_bib0013","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1097\/BRS.0000000000002111","article-title":"Genetic polymorphism of LBX1 is associated with adolescent idiopathic scoliosis in Northern Chinese Han Population","volume":"42","author":"Liu","year":"2017","journal-title":"Spine (Phila Pa 1976)"},{"key":"10.1016\/j.spinee.2019.06.014_bib0014","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1097\/BRS.0000000000000303","article-title":"Association between rs11190870 polymorphism near lbx1 and susceptibility to adolescent idiopathic scoliosis in East Asian population: a genetic meta-analysis","volume":"39","author":"Liang","year":"2014","journal-title":"Spine"},{"key":"10.1016\/j.spinee.2019.06.014_bib0015","first-page":"578","article-title":"[The current review and prospects of the genetic study and clinical treatment of adolescent idiopathic scoliosis]","volume":"56","author":"Qiu","year":"2018","journal-title":"Zhonghua Wai Ke Za Zhi"},{"key":"10.1016\/j.spinee.2019.06.014_bib0016","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1097\/BLO.0b013e3180d09dcc","article-title":"Genetic association of complex traits: using idiopathic scoliosis as an example","volume":"462","author":"Cheng","year":"2007","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.spinee.2019.06.014_bib0017","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1097\/BLO.0b013e318126c062","article-title":"Genetics of familial idiopathic scoliosis","volume":"462","author":"Miller","year":"2007","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.spinee.2019.06.014_bib0018","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1007\/s00586-012-2389-6","article-title":"The genetic epidemiology of idiopathic scoliosis","volume":"21","author":"Gorman","year":"2012","journal-title":"Eur Spine J"},{"key":"10.1016\/j.spinee.2019.06.014_bib0019","article-title":"Genetic aspects of congenital and idiopathic scoliosis","volume":"2012","author":"Giampietro","year":"2012","journal-title":"Scientifica (Cairo)"},{"key":"10.1016\/j.spinee.2019.06.014_bib0020","doi-asserted-by":"crossref","first-page":"2239","DOI":"10.1016\/j.spinee.2015.05.013","article-title":"Candidate gene analysis and exome sequencing confirm LBX1 as a susceptibility gene for idiopathic scoliosis","volume":"15","author":"Grauers","year":"2015","journal-title":"Spine J"},{"key":"10.1016\/j.spinee.2019.06.014_bib0021","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1186\/s12891-016-1139-z","article-title":"Associations of LBX1 gene and adolescent idiopathic scoliosis susceptibility: a meta-analysis based on 34,626 subjects","volume":"17","author":"Cao","year":"2016","journal-title":"BMC Musculoskelet Disord"},{"key":"10.1016\/j.spinee.2019.06.014_bib0022","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1038\/ng.974","article-title":"A genome-wide association study identifies common variants near LBX1 associated with adolescent idiopathic scoliosis","volume":"43","author":"Takahashi","year":"2011","journal-title":"Nat Genet"},{"key":"10.1016\/j.spinee.2019.06.014_bib0023","doi-asserted-by":"crossref","first-page":"2968","DOI":"10.1016\/j.spinee.2014.05.019","article-title":"Association of rs11190870 near LBX1 with adolescent idiopathic scoliosis in East Asians: a systematic review and meta-analysis","volume":"14","author":"Chen","year":"2014","journal-title":"Spine J"},{"key":"10.1016\/j.spinee.2019.06.014_bib0024","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1038\/jhg.2012.11","article-title":"SNP rs11190870 near LBX1 is associated with adolescent idiopathic scoliosis in southern Chinese","volume":"57","author":"Fan","year":"2012","journal-title":"J Hum Genet"},{"key":"10.1016\/j.spinee.2019.06.014_bib0025","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1007\/s00586-012-2532-4","article-title":"Association of rs11190870 near LBX1 with adolescent idiopathic scoliosis susceptibility in a Han Chinese population","volume":"22","author":"Jiang","year":"2013","journal-title":"Eur Spine J"},{"key":"10.1016\/j.spinee.2019.06.014_bib0026","doi-asserted-by":"crossref","first-page":"e53234","DOI":"10.1371\/journal.pone.0053234","article-title":"Association between common variants near LBX1 and adolescent idiopathic scoliosis replicated in the Chinese Han population","volume":"8","author":"Gao","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.spinee.2019.06.014_bib0027","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1136\/jmedgenet-2013-102067","article-title":"A meta-analysis identifies adolescent idiopathic scoliosis association with LBX1 locus in multiple ethnic groups","volume":"51","author":"Londono","year":"2014","journal-title":"J Med Genet"},{"key":"10.1016\/j.spinee.2019.06.014_bib0028","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1093\/hmg\/ddq571","article-title":"Genome-wide association studies of adolescent idiopathic scoliosis suggest candidate susceptibility genes","volume":"20","author":"Sharma","year":"2011","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.spinee.2019.06.014_bib0029","doi-asserted-by":"crossref","first-page":"2074","DOI":"10.1002\/ajmg.a.36589","article-title":"Microduplication 10q24.31 in a Spanish girl with scoliosis and myopathy: the critical role of LBX","volume":"164A","author":"Fernandez-Jaen","year":"2014","journal-title":"Am J Med Genet A"},{"key":"10.1016\/j.spinee.2019.06.014_bib0030","doi-asserted-by":"crossref","first-page":"4902","DOI":"10.1523\/JNEUROSCI.0717-07.2007","article-title":"Lbx1 acts as a selector gene in the fate determination of somatosensory and viscerosensory relay neurons in the hindbrain","volume":"27","author":"Sieber","year":"2007","journal-title":"J Neurosci"},{"key":"10.1016\/j.spinee.2019.06.014_bib0031","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0925-4773(00)00537-2","article-title":"Lbx1 marks a subset of interneurons in chick hindbrain and spinal cord","volume":"101","author":"Schubert","year":"2001","journal-title":"Mech Dev"},{"key":"10.1016\/j.spinee.2019.06.014_bib0032","doi-asserted-by":"crossref","first-page":"7174","DOI":"10.1093\/emboj\/20.24.7174","article-title":"Activation of myogenesis by the homeobox gene Lbx1 requires cell proliferation","volume":"20","author":"Mennerich","year":"2001","journal-title":"Embo j"},{"key":"10.1016\/j.spinee.2019.06.014_bib0033","doi-asserted-by":"crossref","first-page":"e122","DOI":"10.1371\/journal.pone.0000122","article-title":"Shaping leg muscles in Drosophila: role of ladybird, a conserved regulator of appendicular myogenesis","volume":"1","author":"Maqbool","year":"2006","journal-title":"PLoS One"},{"key":"10.1016\/j.spinee.2019.06.014_bib0034","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.ydbio.2017.08.025","article-title":"Phosphorylation of Lbx1 controls lateral myoblast migration into the limb","volume":"430","author":"Masselink","year":"2017","journal-title":"Dev Biol"},{"key":"10.1016\/j.spinee.2019.06.014_bib0035","doi-asserted-by":"crossref","DOI":"10.4061\/2011\/130970","article-title":"Transcription factor lbx1 expression in mouse embryonic stem cell-derived phenotypes","volume":"2011","author":"Schmitteckert","year":"2011","journal-title":"Stem Cells Int"},{"key":"10.1016\/j.spinee.2019.06.014_bib0036","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1242\/dev.02183","article-title":"A novel role for lbx1 in Xenopus hypaxial myogenesis","volume":"133","author":"Martin","year":"2006","journal-title":"Development"},{"key":"10.1016\/j.spinee.2019.06.014_bib0037","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2016-011812","article-title":"Understanding the role of the immune system in adolescent idiopathic scoliosis: tmmunometabolic CONnections to Scoliosis (ICONS) study protocol","volume":"6","author":"Samaan","year":"2016","journal-title":"BMJ open"},{"key":"10.1016\/j.spinee.2019.06.014_bib0038","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/s40814-017-0193-0","article-title":"Understanding muscle-immune interactions in adolescent idiopathic scoliosis: a feasibility study","volume":"3","author":"Rudrapatna","year":"2017","journal-title":"Pilot Feasibility Stud"},{"key":"10.1016\/j.spinee.2019.06.014_bib0039","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.ijsu.2018.01.051","article-title":"The association of rs11190870 near LBX1 with the susceptibility and severity of AIS, a meta-analysis","volume":"54","author":"Li","year":"2018","journal-title":"Int J Surg"},{"key":"10.1016\/j.spinee.2019.06.014_bib0040","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/0925-4773(95)00450-5","article-title":"Mouse Lbx1 and human LBX1 define a novel mammalian homeobox gene family related to the Drosophila lady bird genes","volume":"53","author":"Jagla","year":"1995","journal-title":"Mech Dev"},{"key":"10.1016\/j.spinee.2019.06.014_bib0041","doi-asserted-by":"crossref","first-page":"4178","DOI":"10.1242\/jcs.011668","article-title":"Functional analysis of homeodomain-containing transcription factor Lbx1 in satellite cells of mouse skeletal muscle","volume":"120","author":"Watanabe","year":"2007","journal-title":"J Cell Sci"},{"key":"10.1016\/j.spinee.2019.06.014_bib0042","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1007\/s00427-009-0314-8","article-title":"Lbx1 expression and frog limb development","volume":"219","author":"Sabo","year":"2009","journal-title":"Dev Genes Evol"},{"key":"10.1016\/j.spinee.2019.06.014_bib0043","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1002\/(SICI)1097-010X(20000215)286:3<270::AID-JEZ6>3.0.CO;2-P","article-title":"Expression of lbx1 involved in the hypaxial musculature formation of the mouse embryo","volume":"286","author":"Uchiyama","year":"2000","journal-title":"J Exp Zool"},{"key":"10.1016\/j.spinee.2019.06.014_bib0044","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1242\/dev.127.2.413","article-title":"Lbx1 is required for muscle precursor migration along a lateral pathway into the limb","volume":"127","author":"Gross","year":"2000","journal-title":"Development"},{"key":"10.1016\/j.spinee.2019.06.014_bib0045","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1242\/dev.127.2.437","article-title":"The role of Lbx1 in migration of muscle precursor cells","volume":"127","author":"Brohmann","year":"2000","journal-title":"Development"},{"key":"10.1016\/j.spinee.2019.06.014_bib0046","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1093\/hmg\/ddg212","article-title":"A genomic rearrangement resulting in a tandem duplication is associated with split hand-split foot malformation 3 (SHFM3) at 10q24","volume":"12","author":"de Mollerat","year":"2003","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.spinee.2019.06.014_bib0047","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1002\/ajmg.a.31247","article-title":"Split-hand\/split-foot malformation 3 (SHFM3) at 10q24, development of rapid diagnostic methods and gene expression from the region","volume":"140","author":"Lyle","year":"2006","journal-title":"Am J Med Genet A"},{"key":"10.1016\/j.spinee.2019.06.014_bib0048","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1002\/(SICI)1096-8628(19960424)62:4<427::AID-AJMG16>3.0.CO;2-Q","article-title":"A split hand-split foot (SHFM3) gene is located at 10q24\u2013>25","volume":"62","author":"Gurrieri","year":"1996","journal-title":"Am J Med Genet"}],"container-title":["The Spine Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1529943019308095?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1529943019308095?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T21:31:26Z","timestamp":1761514286000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1529943019308095"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12]]},"references-count":48,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["S1529943019308095"],"URL":"https:\/\/doi.org\/10.1016\/j.spinee.2019.06.014","relation":{},"ISSN":["1529-9430"],"issn-type":[{"value":"1529-9430","type":"print"}],"subject":[],"published":{"date-parts":[[2019,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Paraspinal muscle ladybird homeobox 1 (LBX1) in adolescent idiopathic scoliosis: a cross-sectional study","name":"articletitle","label":"Article Title"},{"value":"The Spine Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.spinee.2019.06.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}