{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T21:38:46Z","timestamp":1761514726714,"version":"build-2065373602"},"reference-count":33,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100008127","name":"DePuy Synthes Spine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008127","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thespinejournalonline.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Spine Journal"],"published-print":{"date-parts":[[2020,8]]},"DOI":"10.1016\/j.spinee.2020.04.010","type":"journal-article","created":{"date-parts":[[2020,4,20]],"date-time":"2020-04-20T02:19:48Z","timestamp":1587349188000},"page":"1276-1285","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["Probability of severe frailty development among operative and nonoperative adult spinal deformity patients: an actuarial survivorship analysis over a 3-year period"],"prefix":"10.1016","volume":"20","author":[{"given":"Peter G.","family":"Passias","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank A.","family":"Segreto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cole A.","family":"Bortz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samantha R.","family":"Horn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katherine E.","family":"Pierce","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Naessig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Avery E.","family":"Brown","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brendan","family":"Jackson-Fowl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Waleed","family":"Ahmad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheongeun","family":"Oh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virginie","family":"Lafage","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renaud","family":"Lafage","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justin S.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan H.","family":"Daniels","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Breton G.","family":"Line","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han Jo","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan S.","family":"Uribe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert K.","family":"Eastlack","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. Kojo","family":"Hamilton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric O.","family":"Klineberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas C.","family":"Burton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert A.A.","family":"Hart","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank J.","family":"Schwab","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher I.","family":"Shaffrey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher P.","family":"Ames","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shay","family":"Bess","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.spinee.2020.04.010_bib0001","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/1471-2318-8-24","article-title":"A standard procedure for creating a frailty index","volume":"8","author":"Searle","year":"2008","journal-title":"BMC Geriatr"},{"key":"10.1016\/j.spinee.2020.04.010_bib0002","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1100\/tsw.2001.58","article-title":"Accumulation of deficits as a proxy measure of Aging","volume":"1","author":"Mitnitski","year":"2001","journal-title":"Sci World J"},{"issue":"3","key":"10.1016\/j.spinee.2020.04.010_bib0003","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.mad.2006.12.004","article-title":"Cumulative index of health disorders as an indicator of aging-associated processes in the elderly: Results from analyses of the National Long Term Care Survey","volume":"128","author":"Kulminski","year":"2007","journal-title":"Mech Ageing Dev"},{"key":"10.1016\/j.spinee.2020.04.010_bib0004","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/srep43068","article-title":"A frailty index based on deficit accumulation quantifies mortality risk in humans and in mice","volume":"7","author":"Rockwood","year":"2017","journal-title":"Sci Rep"},{"issue":"May","key":"10.1016\/j.spinee.2020.04.010_bib0005","first-page":"1","article-title":"Evaluating frailty scores to predict mortality in older adults using data from population based electronic health records: case control study","author":"Stow","year":"2018","journal-title":"Age Ageing"},{"issue":"11","key":"10.1016\/j.spinee.2020.04.010_bib0006","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0187825","article-title":"Predicting mortality and hospitalization of older adults by the multimorbidity frailty index","volume":"12","author":"Wen","year":"2017","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.spinee.2020.04.010_bib0007","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.surg.2016.04.030","article-title":"Impact of frailty on surgical outcomes: the right patient for the right procedure","volume":"160","author":"Mosquera","year":"2016","journal-title":"Surgery"},{"issue":"5","key":"10.1016\/j.spinee.2020.04.010_bib0008","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1097\/BRS.0000000000001755","article-title":"Frailty index as a predictor of adverse postoperative outcomes in patients undergoing cervical spinal fusion","volume":"42","author":"Shin","year":"2017","journal-title":"Spine (Phila Pa 1976)"},{"issue":"6","key":"10.1016\/j.spinee.2020.04.010_bib0009","doi-asserted-by":"crossref","first-page":"E3","DOI":"10.3171\/2017.10.FOCUS17472","article-title":"An assessment of frailty as a tool for risk stratification in adult spinal deformity surgery","volume":"43","author":"Miller","year":"2017","journal-title":"Neurosurg Focus"},{"issue":"5","key":"10.1016\/j.spinee.2020.04.010_bib0010","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1093\/ageing\/afx081","article-title":"Frailty status at admission to hospital predicts multiple adverse outcomes","volume":"46","author":"Hubbard","year":"2017","journal-title":"Age Ageing"},{"issue":"1","key":"10.1016\/j.spinee.2020.04.010_bib0011","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1186\/s12877-016-0329-8","article-title":"Frailty and post-operative outcomes in older surgical patients: a systematic review","volume":"16","author":"Lin","year":"2016","journal-title":"BMC Geriatr"},{"issue":"13","key":"10.1016\/j.spinee.2020.04.010_bib0012","doi-asserted-by":"crossref","first-page":"3825","DOI":"10.1245\/s10434-017-6111-0","article-title":"Frailty correlates with postoperative mortality and major morbidity after cytoreductive surgery with hyperthermic intraperitoneal chemotherapy","volume":"24","author":"Konstantinidis","year":"2017","journal-title":"Ann Surg Oncol"},{"issue":"6","key":"10.1016\/j.spinee.2020.04.010_bib0013","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1007\/s00586-005-0927-1","article-title":"Validation of new clinical quantitative analysis software applicable in spine orthopaedic studies","volume":"15","author":"Champain","year":"2006","journal-title":"Eur Spine J"},{"unstructured":"O'Brien MF, Kuklo TRTR, Blanke KM, Lenke LG. Spinal Deformity Study Group Radiographic Measurement Manual. 2005. http:\/\/www.oref.org\/docs\/default-source\/default-document-library\/sdsg-radiographic-measuremnt-manual.pdf?sfvrsn=2.","key":"10.1016\/j.spinee.2020.04.010_bib0014"},{"issue":"6","key":"10.1016\/j.spinee.2020.04.010_bib0015","first-page":"1","article-title":"External validation of the adult spinal deformity (ASD) frailty index (ASD-FI)","volume":"43","author":"Miller","year":"2018","journal-title":"Eur Spine J"},{"issue":"1968","key":"10.1016\/j.spinee.2020.04.010_bib0016","first-page":"61","article-title":"External Validation of the Adult Spinal Deformity (ASD) Frailty Index (ASD-FI) in the Scoli-RISK-1 patient database","volume":"875","author":"Miller","year":"2018","journal-title":"Spine (Phila Pa 1976)"},{"key":"10.1016\/j.spinee.2020.04.010_bib0017","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1146\/annurev.publhealth.21.1.121","article-title":"Causal effects in clinical and epidemiological studies via potential outcomes: concepts and analytical approaches","volume":"21","author":"Little","year":"2000","journal-title":"Annu Rev Public Health"},{"key":"10.1016\/j.spinee.2020.04.010_bib0018","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1097\/BRS.0b013e31823e15e2","article-title":"SRS-Schwab adult spinal deformity classification: a validation study","volume":"37","author":"Dewald","year":"2012","journal-title":"Spine (Phila Pa 1976)"},{"issue":"1","key":"10.1016\/j.spinee.2020.04.010_bib0019","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1097\/BRS.0b013e31820cccfb","article-title":"Spinal fusion in the United States: analysis of trends from 1998 to 2008","volume":"37","author":"Rajaee","year":"2012","journal-title":"Spine (Phila Pa 1976)"},{"issue":"17","key":"10.1016\/j.spinee.2020.04.010_bib0020","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.2106\/JBJS.N.01141","article-title":"Prevalence of total hip and knee replacement in the United States","volume":"97","author":"Maradit Kremers","year":"2015","journal-title":"J Bone Jt Surg"},{"key":"10.1016\/j.spinee.2020.04.010_bib0021","doi-asserted-by":"crossref","first-page":"e548","DOI":"10.1016\/j.wneu.2018.01.079","article-title":"Frailty and health-related quality of life improvement following adult spinal deformity surgery","volume":"112","author":"Reid","year":"2018","journal-title":"World Neurosurg"},{"key":"10.1016\/j.spinee.2020.04.010_bib0022","first-page":"1","article-title":"Impact of frailty and comorbidities on surgical outcomes and complications in adult spinal disorders","author":"Yagi","year":"2018","journal-title":"Spine (Phila Pa 1976)"},{"issue":"1","key":"10.1016\/j.spinee.2020.04.010_bib0023","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s12891-018-1935-8","article-title":"Frailty as a predictor of hospital length of stay after elective total joint replacements in elderly patients","volume":"19","author":"Wang","year":"2018","journal-title":"BMC Musculoskelet Disord"},{"issue":"7","key":"10.1016\/j.spinee.2020.04.010_bib0024","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1093\/gerona\/62.7.731","article-title":"Frailty: An emerging research and clinical paradigm - issues and controversies","volume":"62","author":"Bergman","year":"2007","journal-title":"J Gerontol Ser A Biol Sci Med Sci"},{"issue":"7","key":"10.1016\/j.spinee.2020.04.010_bib0025","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1038\/nrn3516","article-title":"Cognitive and emotional control of pain and its disruption in chronic pain","volume":"14","author":"Bushnell","year":"2013","journal-title":"Nat Rev Neurosci"},{"issue":"2","key":"10.1016\/j.spinee.2020.04.010_bib0026","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1097\/SPC.0000000000000054","article-title":"Cognition and pain","volume":"8","author":"Moriarty","year":"2014","journal-title":"Curr Opin Support Palliat Care"},{"issue":"Suppl 2","key":"10.1016\/j.spinee.2020.04.010_bib0027","first-page":"S69","article-title":"The complex relationship between depression and dementia","volume":"13","author":"Muliyala","year":"2010","journal-title":"Ann Indian Acad Neurol"},{"issue":"8","key":"10.1016\/j.spinee.2020.04.010_bib0028","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1093\/gerona\/60.8.1017","article-title":"Serum C-reactive protein and cognitive function in healthy elderly Italian community dwellers","volume":"60","author":"Ravaglia","year":"2005","journal-title":"J Gerontol A Biol Sci Med Sci"},{"issue":"5","key":"10.1016\/j.spinee.2020.04.010_bib0029","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1001\/archneur.61.5.668","article-title":"Inflammatory proteins in plasma and the risk of dementia: the rotterdam study","volume":"61","author":"Engelhart","year":"2004","journal-title":"Arch Neurol"},{"issue":"12","key":"10.1016\/j.spinee.2020.04.010_bib0030","doi-asserted-by":"crossref","first-page":"2041","DOI":"10.1046\/j.1532-5415.2002.50619.x","article-title":"Cytokines and cognition\u2013the case for a head-to-toe inflammatory paradigm","volume":"50","author":"Wilson","year":"2002","journal-title":"J Am Geriatr Soc"},{"issue":"6","key":"10.1016\/j.spinee.2020.04.010_bib0031","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1002\/hup.609","article-title":"Cytokines: abnormalities in major depression and implications for pharmacological treatment","volume":"19","author":"O'Brien","year":"2004","journal-title":"Hum Psychopharmacol"},{"issue":"20","key":"10.1016\/j.spinee.2020.04.010_bib0032","doi-asserted-by":"crossref","first-page":"2333","DOI":"10.1001\/archinte.162.20.2333","article-title":"Frailty and activation of the inflammation and coagulation systems with and without clinical comorbidities: results from the Cardiovascular Health Study","volume":"162","author":"Walston","year":"2002","journal-title":"Arch Intern Med"},{"issue":"7","key":"10.1016\/j.spinee.2020.04.010_bib0033","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1046\/j.1532-5415.2002.50315.x","article-title":"Serum interleukin-6 and hemoglobin as physiological correlates in the geriatric syndrome of frailty: a pilot study","volume":"50","author":"Leng","year":"2002","journal-title":"J Am Geriatr Soc"}],"container-title":["The Spine Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1529943020301455?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1529943020301455?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T21:33:12Z","timestamp":1761514392000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1529943020301455"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8]]},"references-count":33,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2020,8]]}},"alternative-id":["S1529943020301455"],"URL":"https:\/\/doi.org\/10.1016\/j.spinee.2020.04.010","relation":{},"ISSN":["1529-9430"],"issn-type":[{"type":"print","value":"1529-9430"}],"subject":[],"published":{"date-parts":[[2020,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Probability of severe frailty development among operative and nonoperative adult spinal deformity patients: an actuarial survivorship analysis over a 3-year period","name":"articletitle","label":"Article Title"},{"value":"The Spine Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.spinee.2020.04.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}