{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:15:16Z","timestamp":1790813716719,"version":"4.1.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","thespinejournalonline.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Spine Journal"],"published-print":{"date-parts":[[2024,4]]},"DOI":"10.1016\/j.spinee.2023.10.005","type":"journal-article","created":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T05:24:34Z","timestamp":1697952274000},"page":"721-729","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["An investigational time course study of titanium plasma spray on osseointegration of PEEK and titanium implants: an in vivo ovine model"],"prefix":"10.1016","volume":"24","author":[{"given":"Bryan W.","family":"Cunningham","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daina M.","family":"Brooks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5913-6522","authenticated-orcid":false,"given":"Nicholas P.","family":"Rolle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0258-6223","authenticated-orcid":false,"given":"David A.","family":"Weiner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhai","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.spinee.2023.10.005_bib0001","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/1471-2474-13-32","article-title":"Osseointegration and biocompatibility of different metal implants\u2013a comparative experimental investigation in sheep","volume":"13","author":"Plecko","year":"2012","journal-title":"BMC Musculoskelet Disord"},{"issue":"6","key":"10.1016\/j.spinee.2023.10.005_bib0002","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1002\/jbm.b.33471","article-title":"Titanium and hydroxyapatite coating of polyetheretherketone and carbon fiber-reinforced polyetheretherketone: a pilot study in sheep","volume":"104","author":"Stubinger","year":"2016","journal-title":"J Biomed Mater Res B Appl Biomater"},{"issue":"10","key":"10.1016\/j.spinee.2023.10.005_bib0003","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1016\/j.spinee.2016.05.017","article-title":"Optimizing surface characteristics for cell adhesion and proliferation on titanium plasma spray coatings on polyetheretherketone","volume":"16","author":"Yoon","year":"2016","journal-title":"Spine J"},{"issue":"32","key":"10.1016\/j.spinee.2023.10.005_bib0004","doi-asserted-by":"crossref","first-page":"4845","DOI":"10.1016\/j.biomaterials.2007.07.013","article-title":"PEEK biomaterials in trauma, orthopedic, and spinal implants","volume":"28","author":"Kurtz","year":"2007","journal-title":"Biomaterials"},{"issue":"6","key":"10.1016\/j.spinee.2023.10.005_bib0005","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1097\/BRS.0000000000000778","article-title":"Implant materials generate different peri-implant inflammatory factors: poly-ether-ether-ketone promotes fibrosis and microtextured titanium promotes osteogenic factors","volume":"40","author":"Olivares-Navarrete","year":"2015","journal-title":"Spine (Phila Pa 1976)"},{"key":"10.1016\/j.spinee.2023.10.005_bib0006","doi-asserted-by":"crossref","first-page":"35","DOI":"10.14444\/2035","article-title":"Fine grained osseointegrative coating improves biocompatibility of PEEK in heterotopic sheep model","volume":"9","author":"Meers","year":"2015","journal-title":"Int J Spine Surg"},{"key":"10.1016\/j.spinee.2023.10.005_bib0007","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/1749-799X-6-56","article-title":"Osseointegration of porous titanium implants with and without electrochemically deposited DCPD coating in an ovine model","volume":"6","author":"Chen","year":"2011","journal-title":"J Orthop Surg Res"},{"issue":"3","key":"10.1016\/j.spinee.2023.10.005_bib0008","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1002\/jbm.a.32000","article-title":"Effect of surface roughness, porosity, and a resorbable calcium phosphate coating on osseointegration of titanium in a minipig model","volume":"89","author":"Schwarz","year":"2009","journal-title":"J Biomed Mater Res A"},{"issue":"1","key":"10.1016\/j.spinee.2023.10.005_bib0009","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1002\/(SICI)1097-4636(200007)51:1<15::AID-JBM3>3.0.CO;2-9","article-title":"Morphometric and mechanical evaluation of titanium implant integration: comparison of five surface structures","volume":"51","author":"Svehla","year":"2000","journal-title":"J Biomed Mater Res"},{"issue":"3","key":"10.1016\/j.spinee.2023.10.005_bib0010","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.arth.2013.10.003","article-title":"Osseointegration of multiphase anodic spark deposition treated porous titanium implants in an ovine model","volume":"30","author":"Bertollo","year":"2015","journal-title":"J Arthroplasty"},{"issue":"1","key":"10.1016\/j.spinee.2023.10.005_bib0011","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1034\/j.1600-0501.1995.060103.x","article-title":"A histomorphometric and removal torque study of screw-shaped titanium implants with three different surface topographies","volume":"6","author":"Wennerberg","year":"1995","journal-title":"Clin. Oral Implants Res."},{"key":"10.1016\/j.spinee.2023.10.005_bib0012","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.colsurfb.2018.12.037","article-title":"Improved response of osteoprogenitor cells to titanium plasma-sprayed PEEK surfaces","volume":"175","author":"Hickey","year":"2019","journal-title":"Colloids Surf B Biointerfaces"},{"issue":"7\u20138","key":"10.1016\/j.spinee.2023.10.005_bib0013","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/j.micron.2005.05.010","article-title":"Biological fixation of endosseous implants","volume":"36","author":"Franchi","year":"2005","journal-title":"Micron"},{"key":"10.1016\/j.spinee.2023.10.005_bib0014","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1100\/tsw.2004.211","article-title":"Osteogenesis and morphology of the peri-implant bone facing dental implants","volume":"4","author":"Franchi","year":"2004","journal-title":"ScientificWorldJournal"},{"issue":"15","key":"10.1016\/j.spinee.2023.10.005_bib0015","doi-asserted-by":"crossref","first-page":"3235","DOI":"10.1016\/S0142-9612(02)00078-9","article-title":"In vitro investigation of titanium and hydroxyapatite dental implant surfaces using a rat bone marrow stromal cell culture system","volume":"23","author":"Knabe","year":"2002","journal-title":"Biomaterials"},{"issue":"11","key":"10.1016\/j.spinee.2023.10.005_bib0016","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1016\/j.spinee.2013.03.047","article-title":"Rough titanium alloys regulate osteoblast production of angiogenic factors","volume":"13","author":"Olivares-Navarrete","year":"2013","journal-title":"Spine J"},{"issue":"5","key":"10.1016\/j.spinee.2023.10.005_bib0017","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1016\/j.spinee.2014.12.018","article-title":"Plasma-sprayed titanium coating to polyetheretherketone improves the bone-implant interface","volume":"15","author":"Walsh","year":"2015","journal-title":"Spine J"},{"issue":"13","key":"10.1016\/j.spinee.2023.10.005_bib0018","doi-asserted-by":"crossref","first-page":"3465","DOI":"10.1016\/j.biomaterials.2009.12.030","article-title":"The electron beam deposition of titanium on polyetheretherketone (PEEK) and the resulting enhanced biological properties","volume":"31","author":"Han","year":"2010","journal-title":"Biomaterials"},{"issue":"1","key":"10.1016\/j.spinee.2023.10.005_bib0019","doi-asserted-by":"crossref","first-page":"16270","DOI":"10.1038\/s41598-017-16465-4","article-title":"A comparison of micro-CT and histomorphometry for evaluation of osseointegration of PEO-coated titanium implants in a rat model","volume":"7","author":"He","year":"2017","journal-title":"Sci Rep"},{"issue":"7","key":"10.1016\/j.spinee.2023.10.005_bib0020","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1002\/jbm.b.32938","article-title":"Utilizing micro-computed tomography to evaluate bone structure surrounding dental implants: a comparison with histomorphometry","volume":"101","author":"Vandeweghe","year":"2013","journal-title":"J Biomed Mater Res Part B: Appl Biomater"},{"issue":"10","key":"10.1016\/j.spinee.2023.10.005_bib0021","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0276269","article-title":"Comparison of three-dimensional digital analyses and two-dimensional histomorphometric analyses of the bone-implant interface","volume":"17","author":"Hong","year":"2022","journal-title":"PLoS One"},{"issue":"27","key":"10.1016\/j.spinee.2023.10.005_bib0022","doi-asserted-by":"crossref","first-page":"4539","DOI":"10.1016\/j.biomaterials.2009.05.017","article-title":"The quantitative assessment of peri-implant bone responses using histomorphometry and micro-computed tomography","volume":"30","author":"Schouten","year":"2009","journal-title":"Biomaterials"},{"issue":"18","key":"10.1016\/j.spinee.2023.10.005_bib0023","doi-asserted-by":"crossref","first-page":"4909","DOI":"10.1016\/j.biomaterials.2010.02.071","article-title":"Regulation of angiogenesis during osseointegration by titanium surface microstructure and energy","volume":"31","author":"Raines","year":"2010","journal-title":"Biomaterials"},{"issue":"2","key":"10.1016\/j.spinee.2023.10.005_bib0024","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.biomaterials.2004.02.021","article-title":"Integrins as linker proteins between osteoblasts and bone replacing materials. a critical review","volume":"26","author":"Siebers","year":"2005","journal-title":"Biomaterials"},{"key":"10.1016\/j.spinee.2023.10.005_bib0025","series-title":"Titanium and titanium alloys as biomaterials","author":"De Viteri","year":"2013"},{"issue":"12","key":"10.1016\/j.spinee.2023.10.005_bib0026","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.1016\/S1359-6454(01)00136-7","article-title":"Deposition of calcium ions on rutile (110): a first-principles investigation","volume":"49","author":"Svetina","year":"2001","journal-title":"Acta Mater"},{"key":"10.1016\/j.spinee.2023.10.005_bib0027","doi-asserted-by":"crossref","first-page":"328943","DOI":"10.1155\/2015\/328943","article-title":"In vivo osseointegration performance of titanium dioxide coating modified polyetheretherketone using arc ion plating for spinal implant application","volume":"2015","author":"Tsou","year":"2015","journal-title":"Biomed Res Int"},{"issue":"6","key":"10.1016\/j.spinee.2023.10.005_bib0028","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/0142-9612(91)90057-H","article-title":"A study on the mechanism of protein adsorption to TiO2","volume":"12","author":"Ellingsen","year":"1991","journal-title":"Biomaterials"},{"issue":"5","key":"10.1016\/j.spinee.2023.10.005_bib0029","doi-asserted-by":"crossref","DOI":"10.1088\/1748-6041\/4\/5\/055003","article-title":"Superior biocompatibility and osteogenic efficacy of micro-arc oxidation-treated titanium implants in the canine mandible","volume":"4","author":"Ran","year":"2009","journal-title":"Biomed Mater"},{"issue":"2","key":"10.1016\/j.spinee.2023.10.005_bib0030","first-page":"61","article-title":"Biology of implant osseointegration","volume":"9","author":"Mavrogenis","year":"2009","journal-title":"J Musculoskelet Neuronal Interact"}],"container-title":["The Spine Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1529943023034630?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1529943023034630?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,3,26]],"date-time":"2024-03-26T13:55:36Z","timestamp":1711461336000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1529943023034630"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":30,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["S1529943023034630"],"URL":"https:\/\/doi.org\/10.1016\/j.spinee.2023.10.005","relation":{},"ISSN":["1529-9430"],"issn-type":[{"value":"1529-9430","type":"print"}],"subject":[],"published":{"date-parts":[[2024,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"An investigational time course study of titanium plasma spray on osseointegration of PEEK and titanium implants: an in vivo ovine model","name":"articletitle","label":"Article Title"},{"value":"The Spine Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.spinee.2023.10.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}