{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T16:12:35Z","timestamp":1790957555389,"version":"4.1.0"},"reference-count":77,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,29]],"date-time":"2024-11-29T00:00:00Z","timestamp":1732838400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003554","name":"Lundbeck Foundation","doi-asserted-by":"publisher","award":["R344-2020-952"],"award-info":[{"award-number":["R344-2020-952"]}],"id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003554","name":"Lundbeck Foundation","doi-asserted-by":"publisher","award":["R412-2022-449"],"award-info":[{"award-number":["R412-2022-449"]}],"id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","thespinejournalonline.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Spine Journal"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.spinee.2024.11.010","type":"journal-article","created":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T03:48:28Z","timestamp":1732679308000},"page":"609-619","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Spinal cord blood flow elevation with systemic vasopressor noradrenaline is partly mediated by vasodilation of spinal arteries due to reduced expression of alpha adrenoreceptors"],"prefix":"10.1016","volume":"25","author":[{"given":"Seyar","family":"Entezari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathias M\u00f8ller","family":"Thygesen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5431-4409","authenticated-orcid":false,"given":"Christian","family":"Staehr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizaveta","family":"Melnikova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-4711-4729","authenticated-orcid":false,"given":"Mathias","family":"Skov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajkumar","family":"Rajanathan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mads","family":"Rasmussen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikkel Mylius","family":"Rasmussen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3303-1095","authenticated-orcid":false,"given":"Vladimir V.","family":"Matchkov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.spinee.2024.11.010_bib0001","doi-asserted-by":"crossref","DOI":"10.1016\/j.jcot.2022.102024","article-title":"Significance of spinal cord perfusion pressure following spinal cord injury: a systematic scoping review","volume":"34","author":"Gee","year":"2022","journal-title":"J Clin Orthop Trauma"},{"key":"10.1016\/j.spinee.2024.11.010_bib0002","doi-asserted-by":"crossref","first-page":"353","DOI":"10.3171\/jns.1979.50.3.0353","article-title":"Spinal cord blood flow and conduction during experimental cord compression in normotensive and hypotensive dogs","volume":"50","author":"Griffiths","year":"1979","journal-title":"J. Neurosurg."},{"key":"10.1016\/j.spinee.2024.11.010_bib0003","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.1089\/neu.2013.2993","article-title":"Substance P as a mediator of neurogenic inflammation after balloon compression induced spinal cord injury","volume":"30","author":"Leonard","year":"2013","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.spinee.2024.11.010_bib0004","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.expneurol.2014.04.023","article-title":"The paradox of chronic neuroinflammation, systemic immune suppression, autoimmunity after traumatic chronic spinal cord injury","volume":"258","author":"Schwab","year":"2014","journal-title":"Exp Neurol"},{"key":"10.1016\/j.spinee.2024.11.010_bib0005","doi-asserted-by":"crossref","first-page":"3336","DOI":"10.1089\/neu.2017.5034","article-title":"Changes in pressure, hemodynamics, and metabolism within the spinal cord during the first 7 days after injury using a porcine model","volume":"34","author":"Streijger","year":"2017","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.spinee.2024.11.010_bib0006","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1097\/CCM.0000000000000028","article-title":"Monitoring of spinal cord perfusion pressure in acute spinal cord injury: initial findings of the injured spinal cord pressure evaluation study*","volume":"42","author":"Werndle","year":"2014","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.spinee.2024.11.010_bib0007","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1006\/exnr.1999.7118","article-title":"Depletion of hematogenous macrophages promotes partial hindlimb recovery and neuroanatomical repair after experimental spinal cord injury","volume":"158","author":"Popovich","year":"1999","journal-title":"Exp Neurol"},{"key":"10.1016\/j.spinee.2024.11.010_bib0008","doi-asserted-by":"crossref","first-page":"13435","DOI":"10.1523\/JNEUROSCI.3257-09.2009","article-title":"Identification of two distinct macrophage subsets with divergent effects causing either neurotoxicity or regeneration in the injured mouse spinal cord","volume":"29","author":"Kigerl","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.spinee.2024.11.010_bib0009","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1136\/jnnp-2016-314600","article-title":"Intraspinal pressure and spinal cord perfusion pressure predict neurological outcome after traumatic spinal cord injury","volume":"88","author":"Saadoun","year":"2017","journal-title":"J Neurol, Neurosurg, Psychiatr"},{"key":"10.1016\/j.spinee.2024.11.010_bib0010","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1227\/01.neu.0000430319.32247.7f","article-title":"Guidelines for the management of acute cervical spine and spinal cord injuries: 2013 update","volume":"60","author":"Walters","year":"2013","journal-title":"Neurosurgery"},{"key":"10.1016\/j.spinee.2024.11.010_bib0011","doi-asserted-by":"crossref","first-page":"239","DOI":"10.3171\/jns.1997.87.2.0239","article-title":"Combined medical and surgical treatment after acute spinal cord injury: results of a prospective pilot study to assess the merits of aggressive medical resuscitation and blood pressure management","volume":"87","author":"Vale","year":"1997","journal-title":"J Neurosurg"},{"issue":"Suppl 2","key":"10.1016\/j.spinee.2024.11.010_bib0012","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1227\/NEU.0b013e318276ee16","article-title":"The acute cardiopulmonary management of patients with cervical spinal cord injuries","volume":"72","author":"Ryken","year":"2013","journal-title":"Neurosurgery"},{"key":"10.1016\/j.spinee.2024.11.010_bib0013","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1227\/01.neu.0000430319.32247.7f","article-title":"American Association of Neurological S, and Congress of Neurological S. Guidelines for the management of acute cervical spine and spinal cord injuries: 2013 update","volume":"60","author":"Walters","year":"2013","journal-title":"Neurosurgery"},{"key":"10.1016\/j.spinee.2024.11.010_bib0014","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1038\/sc.2009.150","article-title":"A systematic review of the evidence supporting a role for vasopressor support in acute SCI","volume":"48","author":"Ploumis","year":"2010","journal-title":"Spinal Cord"},{"key":"10.1016\/j.spinee.2024.11.010_bib0015","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1007\/s12028-009-9214-z","article-title":"Role of vasopressor administration in patients with acute neurologic injury","volume":"11","author":"Muzevich","year":"2009","journal-title":"Neurocrit Care"},{"key":"10.1016\/j.spinee.2024.11.010_bib0016","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1080\/10790268.2019.1660840","article-title":"Current practices and goals for mean arterial pressure and spinal cord perfusion pressure in acute traumatic spinal cord injury: defining the gaps in knowledge","volume":"44","author":"Menacho","year":"2021","journal-title":"J. Spinal Cord Med."},{"key":"10.1016\/j.spinee.2024.11.010_bib0017","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1152\/physrev.1990.70.4.921","article-title":"Structure and function of small arteries","volume":"70","author":"Mulvany","year":"1990","journal-title":"Physiol. Rev."},{"issue":"7","key":"10.1016\/j.spinee.2024.11.010_bib0018","doi-asserted-by":"crossref","first-page":"936","DOI":"10.3390\/biom11070936","article-title":"Ligands of adrenergic receptors: a structural point of view","volume":"11","author":"Wu","year":"2021","journal-title":"Biomolecules"},{"key":"10.1016\/j.spinee.2024.11.010_bib0019","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.ando.2020.03.012","article-title":"Adrenergic receptors and cardiovascular effects of catecholamines","volume":"82","author":"Motiejunaite","year":"2021","journal-title":"Ann Endocrinol (Paris)"},{"key":"10.1016\/j.spinee.2024.11.010_bib0020","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.1172\/JCI116427","article-title":"Characterization and distribution of alpha 2-adrenergic receptors in the human intestinal mucosa","volume":"91","author":"Valet","year":"1993","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.spinee.2024.11.010_bib0021","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/S0026-895X(24)12504-7","article-title":"Differential distribution of beta-adrenergic receptor subtypes in blood vessels of knockout mice lacking beta(1)- or beta(2)-adrenergic receptors","volume":"60","author":"Chruscinski","year":"2001","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.spinee.2024.11.010_bib0022","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S0031-6997(24)01495-9","article-title":"Vascular adrenoceptors: an update","volume":"53","author":"Guimaraes","year":"2001","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.spinee.2024.11.010_bib0023","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S1054-3589(10)59005-7","article-title":"Beta3-adrenergic receptors in cardiac and vascular tissues emerging concepts and therapeutic perspectives","volume":"59","author":"Dessy","year":"2010","journal-title":"Adv. Pharmacol."},{"issue":"4","key":"10.1016\/j.spinee.2024.11.010_bib0024","doi-asserted-by":"crossref","first-page":"357","DOI":"10.3390\/cells8040357","article-title":"Everything you always wanted to know about beta(3)-AR * (* But Were Afraid to Ask)","volume":"8","author":"Schena","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.spinee.2024.11.010_bib0025","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2020.581098","article-title":"alpha(1)-adrenergic receptors in neurotransmission, synaptic plasticity, and cognition","volume":"11","author":"Perez","year":"2020","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.spinee.2024.11.010_bib0026","doi-asserted-by":"crossref","first-page":"e1205","DOI":"10.1212\/WNL.0000000000008125","article-title":"Empirical targets for acute hemodynamic management of individuals with spinal cord injury","volume":"93","author":"Squair","year":"2019","journal-title":"Neurology"},{"key":"10.1016\/j.spinee.2024.11.010_bib0027","doi-asserted-by":"crossref","first-page":"3028","DOI":"10.1007\/s00586-021-06905-1","article-title":"A review of spinal cord perfusion pressure guided interventions in traumatic spinal cord injury","volume":"30","author":"Thygesen","year":"2021","journal-title":"Eur Spine J: Offic Pub Eur Spine Soc, Eur Spinal Deformity Soc, and Eur Section Cervical Spine Res Soc"},{"key":"10.1016\/j.spinee.2024.11.010_bib0028","doi-asserted-by":"crossref","first-page":"2941","DOI":"10.1089\/neu.2017.4982","article-title":"Continuous monitoring and visualization of optimum spinal cord perfusion pressure in patients with acute cord injury","volume":"34","author":"Chen","year":"2017","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.spinee.2024.11.010_bib0029","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1089\/neu.2018.5961","article-title":"Spinal cord blood flow in patients with acute Spinal cord injuries","volume":"36","author":"Gallagher","year":"2019","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.spinee.2024.11.010_bib0030","doi-asserted-by":"crossref","first-page":"15","DOI":"10.3171\/jns.1991.75.1.0015","article-title":"Review of the secondary injury theory of acute spinal cord trauma with emphasis on vascular mechanisms","volume":"75","author":"Tator","year":"1991","journal-title":"J Neurosurg"},{"key":"10.1016\/j.spinee.2024.11.010_bib0031","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1007\/s13311-019-00820-6","article-title":"Targeted perfusion therapy in spinal cord trauma","volume":"17","author":"Saadoun","year":"2020","journal-title":"Neurotherapeutics"},{"issue":"2","key":"10.1016\/j.spinee.2024.11.010_bib0032","doi-asserted-by":"crossref","first-page":"256","DOI":"10.3171\/2020.1.SPINE191005","article-title":"Initial blood pressure is important for long-term outcome after traumatic spinal cord injury","volume":"33","author":"Haldrup","year":"2020","journal-title":"J Neurosurg Spine"},{"key":"10.1016\/j.spinee.2024.11.010_bib0033","first-page":"42","article-title":"[Adrenergic innervation of the extramedullary arteries of the spinal cord of cats]","volume":"69","author":"Palashchenko","year":"1975","journal-title":"Arkh. Anat. Gistol. Embriol."},{"key":"10.1016\/j.spinee.2024.11.010_bib0034","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1097\/00000542-199908000-00023","article-title":"Direct effects of alpha1- and alpha2-adrenergic agonists on spinal and cerebral pial vessels in dogs","volume":"91","author":"Iida","year":"1999","journal-title":"Anesthesiology"},{"key":"10.1016\/j.spinee.2024.11.010_bib0035","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1097\/00000542-198409000-00002","article-title":"The effects of subarachnoid lidocaine and phenylephrine on spinal cord and cerebral blood flow in dogs","volume":"61","author":"Dohi","year":"1984","journal-title":"Anesthesiology"},{"key":"10.1016\/j.spinee.2024.11.010_bib0036","doi-asserted-by":"crossref","first-page":"115","DOI":"10.14740\/cr1478","article-title":"Mechanism of increased spinal cord blood flow due to noradrenaline administration using vascular resistance: an experimental study using a canine model","volume":"14","author":"Kise","year":"2023","journal-title":"Cardiol Res"},{"key":"10.1016\/j.spinee.2024.11.010_bib0037","first-page":"687","article-title":"Alpha receptor stimulation by Norepinephrine and blockade by Benoxathian in spinal pial arteries of rabbit","volume":"25","author":"Kim","year":"1996","journal-title":"J Korean Neurosurg Soc"},{"key":"10.1016\/j.spinee.2024.11.010_bib0038","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1213\/00000539-198707000-00003","article-title":"Spinal cord blood flow during spinal anesthesia in dogs: the effects of tetracaine, epinephrine, acute blood loss, and hypercapnia","volume":"66","author":"Dohi","year":"1987","journal-title":"Anesth. Analg."},{"key":"10.1016\/j.spinee.2024.11.010_bib0039","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1007\/BF03009534","article-title":"The effect of subarachnoid epinephrine and phenylephrine on spinal cord blood flow","volume":"31","author":"Kozody","year":"1984","journal-title":"Can. Anaesth. Soc. J."},{"key":"10.1016\/j.spinee.2024.11.010_bib0040","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1213\/00000539-198612000-00011","article-title":"Effect of epidural clonidine on spinal cord blood flow and regional and central hemodynamics in pigs","volume":"65","author":"Gordh","year":"1986","journal-title":"Anesth. Analg."},{"key":"10.1016\/j.spinee.2024.11.010_bib0041","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1227\/NEU.0000000000000638","article-title":"Cerebrospinal fluid drainage and induced hypertension improve spinal cord perfusion after acute spinal cord injury in pigs","volume":"76","author":"Martirosyan","year":"2015","journal-title":"Neurosurgery"},{"key":"10.1016\/j.spinee.2024.11.010_bib0042","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1161\/01.STR.20.3.372","article-title":"Spinal cord blood flow and systemic blood pressure after experimental spinal cord injury in rats","volume":"20","author":"Guha","year":"1989","journal-title":"Stroke"},{"key":"10.1016\/j.spinee.2024.11.010_bib0043","doi-asserted-by":"crossref","first-page":"12","DOI":"10.3171\/jns.1976.44.1.0012","article-title":"Spinal cord blood flow as affected by changes in systemic arterial blood pressure","volume":"44","author":"Kobrine","year":"1976","journal-title":"J Neurosurg"},{"key":"10.1016\/j.spinee.2024.11.010_bib0044","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1161\/01.STR.17.6.1183","article-title":"Autoregulation of spinal cord blood flow: is the cord a microcosm of the brain?","volume":"17","author":"Hickey","year":"1986","journal-title":"Stroke"},{"key":"10.1016\/j.spinee.2024.11.010_bib0045","doi-asserted-by":"crossref","first-page":"7","DOI":"10.14245\/ns.2040144.072","article-title":"Hemodynamic management of acute spinal cord injury: a literature review","volume":"18","author":"Lee","year":"2021","journal-title":"Neurospine"},{"key":"10.1016\/j.spinee.2024.11.010_bib0046","article-title":"Reporting animal research: explanation and elaboration for the ARRIVE guidelines 2.0","volume":"18","author":"Percie du Sert","year":"2020","journal-title":"PLoS Biol"},{"key":"10.1016\/j.spinee.2024.11.010_bib0047","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1007\/BF02518878","article-title":"Multichannel laser-doppler probe for blood perfusion measurements with depth discrimination","volume":"36","author":"Liebert","year":"1998","journal-title":"Med. Biol. Eng. Comput."},{"key":"10.1016\/j.spinee.2024.11.010_bib0048","unstructured":"Fredriksson I, Fors C and Johansson J. Laser Doppler Flowmetry - a Theoretical Framework. Department of Biomedical Engineering, Link\u00f6ping University (2007), www.imt.liu.se\/bit\/ldf\/ldfmain.html."},{"key":"10.1016\/j.spinee.2024.11.010_bib0049","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/3-211-32318-X_10","article-title":"ICM+: software for on-line analysis of bedside monitoring data after severe head trauma","volume":"95","author":"Smielewski","year":"2005","journal-title":"Acta neurochirurgica Supplement"},{"key":"10.1016\/j.spinee.2024.11.010_bib0050","doi-asserted-by":"crossref","first-page":"e13059","DOI":"10.1111\/apha.13059","article-title":"The alpha2 isoform Na,K-ATPase modulates contraction of rat mesenteric small artery via cSrc-dependent Ca(2+) sensitization","volume":"224","author":"Bouzinova","year":"2018","journal-title":"Acta Physiol (Oxf)"},{"key":"10.1016\/j.spinee.2024.11.010_bib0051","doi-asserted-by":"crossref","first-page":"5037","DOI":"10.1113\/JP274604","article-title":"Intravital investigation of rat mesenteric small artery tone and blood flow","volume":"595","author":"Nyvad","year":"2017","journal-title":"J. Physiol."},{"key":"10.1016\/j.spinee.2024.11.010_bib0052","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1038\/260617a0","article-title":"Mechanical properties of vascular smooth muscle cells in situ","volume":"260","author":"Mulvany","year":"1976","journal-title":"Nature"},{"key":"10.1016\/j.spinee.2024.11.010_bib0053","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1177\/0271678X18761712","article-title":"Smooth muscle Ca(2+) sensitization causes hypercontractility of middle cerebral arteries in mice bearing the familial hemiplegic migraine type 2 associated mutation","volume":"39","author":"Staehr","year":"2018","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.spinee.2024.11.010_bib0054","doi-asserted-by":"crossref","first-page":"12","DOI":"10.3171\/jns.1976.44.1.0012","article-title":"Spinal cord blood flow as affected by changes in systemic arterial blood pressure","volume":"44","author":"Kobrine","year":"1976","journal-title":"J Neurosurg"},{"key":"10.1016\/j.spinee.2024.11.010_bib0055","series-title":"Generalized, linear, and mixed models","author":"McCulloch","year":"2001"},{"key":"10.1016\/j.spinee.2024.11.010_bib0056","series-title":"Stata 18 multilevel mixed-effects reference manual","year":"2023"},{"issue":"Pt 2","key":"10.1016\/j.spinee.2024.11.010_bib0057","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1111\/j.1469-7793.1998.577bk.x","article-title":"Mechanisms of Ca2+ sensitization of force production by noradrenaline in rat mesenteric small arteries","volume":"510","author":"Buus","year":"1998","journal-title":"J. Physiol."},{"key":"10.1016\/j.spinee.2024.11.010_bib0058","doi-asserted-by":"crossref","DOI":"10.1016\/j.vph.2023.107231","article-title":"Heterogeneous vasomotor responses in segments from Gottingen Minipigs coronary, cerebral, and mesenteric artery: A comparative study","volume":"153","author":"Sams","year":"2023","journal-title":"Vascul Pharmacol"},{"key":"10.1016\/j.spinee.2024.11.010_bib0059","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.jtcvs.2014.09.121","article-title":"Directly measuring spinal cord blood flow and spinal cord perfusion pressure via the collateral network: correlations with changes in systemic blood pressure","volume":"149","author":"Kise","year":"2015","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"10.1016\/j.spinee.2024.11.010_bib0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.mvr.2023.104494","article-title":"The pig is a better model than the rabbit or rat for studying the pathophysiology of human mesenteric arteries","volume":"147","author":"Cupitra","year":"2023","journal-title":"Microvasc. Res."},{"key":"10.1016\/j.spinee.2024.11.010_bib0061","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1152\/ajplegacy.1972.223.4.878","article-title":"Beta-adrenergic receptors in coronary and skeletal muscle arteries","volume":"223","author":"Baron","year":"1972","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.spinee.2024.11.010_bib0062","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1111\/j.1476-5381.1970.tb12893.x","article-title":"The effect of \"selective\" beta-adrenoceptor blocking drugs on the myocardial circulation","volume":"39","author":"Parratt","year":"1970","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.spinee.2024.11.010_bib0063","first-page":"368","article-title":"Effect of norepinephrine on isolated coronary artery of normal and myocardial infarcted pigs","volume":"10","author":"Agarwal","year":"1982","journal-title":"Artery"},{"key":"10.1016\/j.spinee.2024.11.010_bib0064","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1161\/01.CIR.0000023896.70583.9F","article-title":"Norepinephrine elicits beta2-receptor-mediated dilation of isolated human coronary arterioles","volume":"106","author":"Sun","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.spinee.2024.11.010_bib0065","doi-asserted-by":"crossref","first-page":"174","DOI":"10.3181\/00379727-191-42905","article-title":"Influence of intraarterial norepinephrine on cerebral hemodynamics of newborn pigs","volume":"191","author":"Rogers","year":"1989","journal-title":"Proc. Soc. Exp. Biol. Med."},{"key":"10.1016\/j.spinee.2024.11.010_bib0066","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1161\/01.RES.51.6.769","article-title":"Relaxation to transmural nerve stimulation and exogenously added norepinephrine in porcine cerebral vessels. A study utilizing cerebrovascular intrinsic tone","volume":"51","author":"Winquist","year":"1982","journal-title":"Circ. Res."},{"key":"10.1016\/j.spinee.2024.11.010_bib0067","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1161\/01.RES.35.6.835","article-title":"Pharmacological characterization of adrenergic alpha and beta receptors mediating the vasomotor responses of cerebral arteries in vitro","volume":"35","author":"Edvinsson","year":"1974","journal-title":"Circ. Res."},{"key":"10.1016\/j.spinee.2024.11.010_bib0068","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/0006-8993(76)90356-5","article-title":"Autonomic nerves, mast cells, and amine receptors in human brain vessels. A histochemical and pharmacological study","volume":"115","author":"Edvinsson","year":"1976","journal-title":"Brain Res."},{"key":"10.1016\/j.spinee.2024.11.010_bib0069","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1089\/neu.2019.6844","article-title":"Interventions to optimize spinal cord perfusion in patients with acute traumatic spinal cord injuries: a systematic review","volume":"37","author":"Evaniew","year":"2020","journal-title":"J Neurotrauma"},{"key":"10.1016\/j.spinee.2024.11.010_bib0070","doi-asserted-by":"crossref","first-page":"e477","DOI":"10.1097\/CCM.0000000000005433","article-title":"Monitoring spinal cord tissue oxygen in patients with acute, severe traumatic spinal cord injuries","volume":"50","author":"Visagan","year":"2022","journal-title":"Crit Care Med"},{"key":"10.1016\/j.spinee.2024.11.010_bib0071","doi-asserted-by":"crossref","first-page":"2937","DOI":"10.1089\/neu.2021.0084","article-title":"Duraplasty in traumatic thoracic spinal cord injury: impact on spinal cord hemodynamics, tissue metabolism, histology, and behavioral recovery using a porcine model","volume":"38","author":"Streijger","year":"2021","journal-title":"J Neurotrauma"},{"key":"10.1016\/j.spinee.2024.11.010_bib0072","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1089\/neu.2017.5285","article-title":"A direct comparison between norepinephrine and phenylephrine for augmenting spinal cord perfusion in a porcine model of spinal cord injury","volume":"35","author":"Streijger","year":"2018","journal-title":"J Neurotrauma"},{"key":"10.1016\/j.spinee.2024.11.010_bib0073","first-page":"A10","article-title":"Pathological patterns of spinal cord blood flow after injury visualised with laser speckle contrast imaging","volume":"35","author":"Gallagher","year":"2018","journal-title":"J neurotrauma"},{"key":"10.1016\/j.spinee.2024.11.010_bib0074","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1227\/NEU.0b013e318260feb1","article-title":"The relationship between cerebral blood flow autoregulation and cerebrovascular pressure reactivity after traumatic brain injury","volume":"71","author":"Budohoski","year":"2012","journal-title":"Neurosurgery"},{"key":"10.1016\/j.spinee.2024.11.010_bib0075","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1007\/s00701-017-3310-1","article-title":"Pressure reactivity index: journey through the past 20 years","volume":"159","author":"Czosnyka","year":"2017","journal-title":"Acta Neurochirurgica"},{"key":"10.1016\/j.spinee.2024.11.010_bib0076","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1097\/ANA.0000000000000596","article-title":"Effects of vasopressors on cerebral circulation and oxygenation: a narrative review of pharmacodynamics in health and traumatic brain injury","volume":"32","author":"Thorup","year":"2020","journal-title":"J Neurosurg Anesthesiol"},{"key":"10.1016\/j.spinee.2024.11.010_bib0077","doi-asserted-by":"crossref","first-page":"e00655","DOI":"10.1002\/prp2.655","article-title":"The cerebrovascular response to norepinephrine: a scoping systematic review of the animal and human literature","volume":"8","author":"Froese","year":"2020","journal-title":"Pharmacol Res Perspect"}],"container-title":["The Spine Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1529943024011513?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1529943024011513?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T10:07:03Z","timestamp":1739441223000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1529943024011513"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":77,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["S1529943024011513"],"URL":"https:\/\/doi.org\/10.1016\/j.spinee.2024.11.010","relation":{},"ISSN":["1529-9430"],"issn-type":[{"value":"1529-9430","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Spinal cord blood flow elevation with systemic vasopressor noradrenaline is partly mediated by vasodilation of spinal arteries due to reduced expression of alpha adrenoreceptors","name":"articletitle","label":"Article Title"},{"value":"The Spine Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.spinee.2024.11.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}