{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T12:04:28Z","timestamp":1792843468277,"version":"4.5.0"},"reference-count":24,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004844","name":"National Cheng Kung University Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004844","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020595","name":"NSTC","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thespinejournalonline.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Spine Journal"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.spinee.2025.05.002","type":"journal-article","created":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T19:43:26Z","timestamp":1746474206000},"page":"1857-1865","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Does intraoperative antiseptic solution soaking reduce microbial contamination in spine surgery? A randomized controlled trial"],"prefix":"10.1016","volume":"25","author":[{"given":"Yuan-Fu","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Chia","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Po-Lin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao-Jun","family":"Chuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting-Yuan","family":"Tu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao-Jui","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Meng","family":"Hsiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7315-7709","authenticated-orcid":false,"given":"Cheng-Li","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4 Suppl","key":"10.1016\/j.spinee.2025.05.002_bib0001","doi-asserted-by":"crossref","first-page":"5S","DOI":"10.1177\/2192568218799056","article-title":"Surgical site infection in spine surgery: who is at risk?","volume":"8","author":"Yao","year":"2018","journal-title":"Global Spine J"},{"issue":"13","key":"10.1016\/j.spinee.2025.05.002_bib0002","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1097\/01.BRS.0000067109.23914.0A","article-title":"Risk factors for surgical site infection in the patient with spinal injury","volume":"28","author":"Blam","year":"2003","journal-title":"Spine (Phila Pa 1976)"},{"issue":"12","key":"10.1016\/j.spinee.2025.05.002_bib0003","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1097\/BRS.0b013e3181c212d1","article-title":"Infection after spinal fusion for pediatric spinal deformity: thirty years of experience at a single institution","volume":"35","author":"Cahill","year":"2010","journal-title":"Spine (Phila Pa 1976)"},{"issue":"6","key":"10.1016\/j.spinee.2025.05.002_bib0004","doi-asserted-by":"crossref","first-page":"330","DOI":"10.5435\/00124635-200806000-00005","article-title":"Postoperative spinal wound infections","volume":"16","author":"Sasso","year":"2008","journal-title":"J Am Acad Orthop Surg"},{"key":"10.1016\/j.spinee.2025.05.002_bib0005","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.jhin.2023.07.014","article-title":"Bacterial reservoir in deeper skin is a potential source for surgical site and biomaterial-associated infections","volume":"140","author":"Guarch-Perez","year":"2023","journal-title":"J Hosp Infect"},{"issue":"9","key":"10.1016\/j.spinee.2025.05.002_bib0006","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1016\/j.spinee.2024.04.018","article-title":"Cutibacterium acnes in spine surgery: pathophysiology, diagnosis, and treatment","volume":"24","author":"Baroudi","year":"2024","journal-title":"Spine J"},{"issue":"4","key":"10.1016\/j.spinee.2025.05.002_bib0007","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.spinee.2022.10.016","article-title":"Unexpected intraoperative positive culture (UIPC) in presumed aseptic revision spine surgery: a systematic review and meta-analysis","volume":"23","author":"Aldahamsheh","year":"2023","journal-title":"Spine J"},{"issue":"24","key":"10.1016\/j.spinee.2025.05.002_bib0008","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.1097\/BRS.0000000000001909","article-title":"Propionibacterium acnes, coagulase-negative Staphylococcus, and the \"biofilm-like\" intervertebral disc","volume":"41","author":"Coscia","year":"2016","journal-title":"Spine (Phila Pa 1976)"},{"issue":"5","key":"10.1016\/j.spinee.2025.05.002_bib0009","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1007\/s00586-017-4972-3","article-title":"ISSLS PRIZE IN CLINICAL SCIENCE 2017: is infection the possible initiator of disc disease? An insight from proteomic analysis","volume":"26","author":"Rajasekaran","year":"2017","journal-title":"Eur. Spine J."},{"issue":"2","key":"10.1016\/j.spinee.2025.05.002_bib0010","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1177\/2192568218819817","article-title":"Current strategies in prevention of postoperative infections in spine surgery","volume":"10","author":"Atesok","year":"2020","journal-title":"Global Spine J"},{"issue":"1","key":"10.1016\/j.spinee.2025.05.002_bib0011","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1186\/s12891-022-05763-2","article-title":"Irrigation techniques used in spine surgery for surgical site infection prophylaxis: a systematic review and meta-analysis","volume":"23","author":"Torres","year":"2022","journal-title":"BMC Musculoskelet Disord"},{"issue":"8","key":"10.1016\/j.spinee.2025.05.002_bib0012","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1089\/sur.2018.156","article-title":"Antiseptic irrigation as an effective interventional strategy for reducing the risk of surgical site infections","volume":"19","author":"Edmiston","year":"2018","journal-title":"Surg Infect (Larchmt)"},{"issue":"15","key":"10.1016\/j.spinee.2025.05.002_bib0013","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1097\/01.brs.0000171907.60775.85","article-title":"Efficacy of dilute betadine solution irrigation in the prevention of postoperative infection of spinal surgery","volume":"30","author":"Cheng","year":"2005","journal-title":"Spine (Phila Pa 1976)"},{"issue":"6","key":"10.1016\/j.spinee.2025.05.002_bib0014","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1007\/s00586-005-0975-6","article-title":"Can povidone-iodine solution be used safely in a spinal surgery?","volume":"15","author":"Chang","year":"2006","journal-title":"Eur Spine J"},{"issue":"4","key":"10.1016\/j.spinee.2025.05.002_bib0015","doi-asserted-by":"crossref","first-page":"222","DOI":"10.5662\/wjm.v11.i4.222","article-title":"Wound irrigation for preventing surgical site infections","volume":"11","author":"Papadakis","year":"2021","journal-title":"World J Methodol"},{"issue":"5 Suppl","key":"10.1016\/j.spinee.2025.05.002_bib0016","doi-asserted-by":"crossref","first-page":"S49","DOI":"10.1016\/j.ajic.2012.10.030","article-title":"Reducing the risk of surgical site infections: does chlorhexidine gluconate provide a risk reduction benefit?","volume":"41","author":"Edmiston","year":"2013","journal-title":"Am J Infect Control"},{"issue":"2","key":"10.1016\/j.spinee.2025.05.002_bib0017","doi-asserted-by":"crossref","DOI":"10.1111\/iwj.14463","article-title":"Comparing the efficacy of chlorhexidine and povidone-iodine in preventing surgical site infections: a systematic review and meta-analysis","volume":"21","author":"Bai","year":"2023","journal-title":"Int Wound J"},{"issue":"4","key":"10.1016\/j.spinee.2025.05.002_bib0018","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.artd.2017.03.005","article-title":"Intraoperative chlorhexidine irrigation to prevent infection in total hip and knee arthroplasty","volume":"3","author":"Frisch","year":"2017","journal-title":"Arthroplast Today"},{"issue":"2","key":"10.1016\/j.spinee.2025.05.002_bib0019","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s00423-015-1279-x","article-title":"Intra-operative wound irrigation to reduce surgical site infections after abdominal surgery: a systematic review and meta-analysis","volume":"400","author":"Mueller","year":"2015","journal-title":"Langenbecks Arch Surg"},{"issue":"1\u20132","key":"10.1016\/j.spinee.2025.05.002_bib0020","first-page":"24","article-title":"Standardising intraoperative irrigation with 0.05% chlorhexidine gluconate in caesarean delivery to reduce surgical site infections: a single institution experience","volume":"30","author":"Mangold","year":"2020","journal-title":"J Perioper Pract"},{"issue":"4","key":"10.1016\/j.spinee.2025.05.002_bib0021","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1097\/BRS.0b013e318278ec06","article-title":"Does surgical technique affect the incidence of spondylodiscitis post-lumbar microdiscectomy? A retrospective analysis of 3063 patients","volume":"38","author":"Kaliaperumal","year":"2013","journal-title":"Spine (Phila Pa 1976)"},{"issue":"2","key":"10.1016\/j.spinee.2025.05.002_bib0022","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1097\/AAP.0b013e318244179a","article-title":"Neurologic complications after chlorhexidine antisepsis for spinal anesthesia","volume":"37","author":"Sviggum","year":"2012","journal-title":"Reg Anesth Pain Med"},{"issue":"3","key":"10.1016\/j.spinee.2025.05.002_bib0023","first-page":"5900","article-title":"Postoperative spine infections","volume":"7","author":"Parchi","year":"2015","journal-title":"Orthop Rev (Pavia)"},{"issue":"4","key":"10.1016\/j.spinee.2025.05.002_bib0024","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/j.jse.2022.10.033","article-title":"Extended skin cleaning on the shoulder with chlorhexidine reduces the cutaneous bacterial load but fails to decrease suture contamination in patients undergoing arthroscopy rotator cuff repair","volume":"32","author":"Hong","year":"2023","journal-title":"J Shoulder Elbow Surg"}],"container-title":["The Spine Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S152994302500230X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S152994302500230X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T20:59:02Z","timestamp":1762549142000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S152994302500230X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":24,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["S152994302500230X"],"URL":"https:\/\/doi.org\/10.1016\/j.spinee.2025.05.002","relation":{},"ISSN":["1529-9430"],"issn-type":[{"value":"1529-9430","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Does intraoperative antiseptic solution soaking reduce microbial contamination in spine surgery? A randomized controlled trial","name":"articletitle","label":"Article Title"},{"value":"The Spine Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.spinee.2025.05.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}