{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T01:13:33Z","timestamp":1780362813582,"version":"3.54.1"},"reference-count":41,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100010816","name":"Anhui Science and Technology Department","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010816","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016039","name":"The University of Texas Southwestern Medical School Center for Depression Research and Clinical Care","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016039","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017413","name":"Innovation Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017413","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002947","name":"Anhui Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002947","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009558","name":"University Natural Science Research Project of Anhui Province","doi-asserted-by":"publisher","award":["2024AH050760"],"award-info":[{"award-number":["2024AH050760"]}],"id":[{"id":"10.13039\/501100009558","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007924","name":"Bengbu Medical College","doi-asserted-by":"publisher","award":["AHTT2022B003"],"award-info":[{"award-number":["AHTT2022B003"]}],"id":[{"id":"10.13039\/501100007924","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007924","name":"Bengbu Medical College","doi-asserted-by":"publisher","award":["AHIAI2022R03"],"award-info":[{"award-number":["AHIAI2022R03"]}],"id":[{"id":"10.13039\/501100007924","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007924","name":"Bengbu Medical College","doi-asserted-by":"publisher","award":["AHTT2022A004"],"award-info":[{"award-number":["AHTT2022A004"]}],"id":[{"id":"10.13039\/501100007924","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thespinejournalonline.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Spine Journal"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.spinee.2025.05.018","type":"journal-article","created":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T19:37:46Z","timestamp":1747251466000},"page":"2569-2584","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["TBRG4 regulates ubiquitination of Beclin1 and participates in autophagy pathway to inhibit intervertebral disc degeneration"],"prefix":"10.1016","volume":"25","author":[{"given":"Xilong","family":"Cui","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2624-0796","authenticated-orcid":false,"given":"Haiyang","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.spinee.2025.05.018_bib0001","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2021.101394","article-title":"The potential role of melatonin in retarding intervertebral disc ageing and degeneration: a systematic review","volume":"70","author":"Cheng","year":"2021","journal-title":"Ageing Res Rev"},{"issue":"4","key":"10.1016\/j.spinee.2025.05.018_bib0002","doi-asserted-by":"crossref","first-page":"e343","DOI":"10.1002\/wdev.343","article-title":"Defects in intervertebral disc and spine during development, degeneration, and pain: new research directions for disc regeneration and therapy","volume":"8","author":"Mohanty","year":"2019","journal-title":"Wiley Interdiscip Rev Dev Biol"},{"issue":"5","key":"10.1016\/j.spinee.2025.05.018_bib0003","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1016\/j.ejrad.2015.01.018","article-title":"Spinal pain","volume":"84","author":"Izzo","year":"2015","journal-title":"Eur. J. Radiol."},{"issue":"1","key":"10.1016\/j.spinee.2025.05.018_bib0004","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1186\/s12891-023-06907-8","article-title":"Serum antioxidant enzymes in spinal stenosis patients with lumbar disc herniation: correlation with degeneration severity and spinal fusion rate","volume":"24","author":"Guo","year":"2023","journal-title":"BMC Musculoskelet Disord"},{"issue":"2","key":"10.1016\/j.spinee.2025.05.018_bib0005","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph14020183","article-title":"Associations between obesity and spinal diseases: a medical expenditure panel study analysis","volume":"14","author":"Sheng","year":"2017","journal-title":"Int J Environ Res Public Health"},{"key":"10.1016\/j.spinee.2025.05.018_bib0006","first-page":"30","article-title":"Nutrient supply and intervertebral disc metabolism","volume":"88","author":"Grunhagen","year":"2006","journal-title":"J Bone Joint Surg Am."},{"key":"10.1016\/j.spinee.2025.05.018_bib0007","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.redox.2018.09.006","article-title":"Sirtuin 3-dependent mitochondrial redox homeostasis protects against AGEs-induced intervertebral disc degeneration","volume":"19","author":"Song","year":"2018","journal-title":"Redox Biol"},{"key":"10.1016\/j.spinee.2025.05.018_bib0008","doi-asserted-by":"crossref","first-page":"171","DOI":"10.22203\/eCM.v036a13","article-title":"Age-dependent changes in intervertebral disc cell mitochondria and bioenergetics","volume":"36","author":"Hartman","year":"2018","journal-title":"Eur Cell Mater"},{"issue":"8","key":"10.1016\/j.spinee.2025.05.018_bib0009","doi-asserted-by":"crossref","first-page":"2252","DOI":"10.7150\/thno.30658","article-title":"Progerin accumulation in nucleus pulposus cells impairs mitochondrial function and induces intervertebral disc degeneration and therapeutic effects of sulforaphane","volume":"9","author":"Xu","year":"2019","journal-title":"Theranostics"},{"issue":"19","key":"10.1016\/j.spinee.2025.05.018_bib0010","doi-asserted-by":"crossref","first-page":"10941","DOI":"10.1093\/nar\/gkx772","article-title":"The FASTK family of proteins: emerging regulators of mitochondrial RNA biology","volume":"45","author":"Jourdain","year":"2017","journal-title":"Nucleic Acids Res"},{"issue":"3","key":"10.1016\/j.spinee.2025.05.018_bib0011","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1016\/j.celrep.2014.03.035","article-title":"Functional genomic analysis of human mitochondrial RNA processing","volume":"7","author":"Wolf","year":"2014","journal-title":"Cell Rep"},{"issue":"2","key":"10.1016\/j.spinee.2025.05.018_bib0012","doi-asserted-by":"crossref","first-page":"157","DOI":"10.14715\/cmb\/2020.66.2.26","article-title":"TBRG4 silencing promotes progression of squamous cell carcinoma via regulation of CAV-1 expression and ROS formation","volume":"66","author":"Wang","year":"2020","journal-title":"Cell Mol Biol (Noisy-le-grand)"},{"key":"10.1016\/j.spinee.2025.05.018_bib0013","doi-asserted-by":"crossref","first-page":"7271","DOI":"10.2147\/OTT.S249477","article-title":"TBRG4 Knockdown suppresses proliferation and growth of Human osteosarcoma cell lines MG63 through PI3K\/Akt pathway","volume":"13","author":"Huang","year":"2020","journal-title":"Onco Targets Ther"},{"issue":"1","key":"10.1016\/j.spinee.2025.05.018_bib0014","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1186\/s12885-024-11943-1","article-title":"High expression of TBRG4 in relation to unfavorable outcome and cell ferroptosis in hepatocellular carcinoma","volume":"24","author":"Tao","year":"2024","journal-title":"BMC Cancer"},{"key":"10.1016\/j.spinee.2025.05.018_bib0015","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/978-94-007-2869-1_7","article-title":"The mitochondrial pathways of apoptosis","volume":"942","author":"Estaquier","year":"2012","journal-title":"Adv Exp Med Biol"},{"issue":"1","key":"10.1016\/j.spinee.2025.05.018_bib0016","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1038\/s42003-024-06248-9","article-title":"Palmitic acid induces lipid droplet accumulation and senescence in nucleus pulposus cells via ER-stress pathway","volume":"7","author":"Chen","year":"2024","journal-title":"Commun Biol"},{"issue":"13","key":"10.1016\/j.spinee.2025.05.018_bib0017","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.252197","article-title":"Super-resolution microscopy reveals the arrangement of inner membrane protein complexes in mammalian mitochondria","volume":"134","author":"Palmer","year":"2021","journal-title":"J Cell Sci"},{"issue":"11","key":"10.1016\/j.spinee.2025.05.018_bib0018","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1515\/hsz-2012-0239","article-title":"Mitofilin complexes: conserved organizers of mitochondrial membrane architecture","volume":"393","author":"Zerbes","year":"2012","journal-title":"Biol chem"},{"issue":"5","key":"10.1016\/j.spinee.2025.05.018_bib0019","doi-asserted-by":"crossref","first-page":"7035","DOI":"10.18632\/aging.202558","article-title":"ENAM gene associated with T classification and inhibits proliferation in renal clear cell carcinoma","volume":"13","author":"Ren","year":"2021","journal-title":"Aging"},{"key":"10.1016\/j.spinee.2025.05.018_bib0020","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.ijbiomac.2022.02.005","article-title":"Beclin1-mediated interplay between autophagy and apoptosis: new understanding","volume":"204","author":"Prerna","year":"2022","journal-title":"Int J Biol Macromol."},{"issue":"10258","key":"10.1016\/j.spinee.2025.05.018_bib0021","first-page":"1204","article-title":"Global burden of 369 diseases and injuries in 204 countries and territories, 1990-2019: a systematic analysis for the Global Burden of Disease Study","volume":"396","year":"2019","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.spinee.2025.05.018_bib0022","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/s41584-021-00713-z","article-title":"A new immunometabolic perspective of intervertebral disc degeneration","volume":"18","author":"Francisco","year":"2022","journal-title":"Nat Rev Rheumatol"},{"issue":"3","key":"10.1016\/j.spinee.2025.05.018_bib0023","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.12779","article-title":"The mitochondria-targeted anti-oxidant MitoQ protects against intervertebral disc degeneration by ameliorating mitochondrial dysfunction and redox imbalance","volume":"53","author":"Kang","year":"2020","journal-title":"Cell Prolif"},{"issue":"7","key":"10.1016\/j.spinee.2025.05.018_bib0024","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1038\/s12276-021-00650-7","article-title":"Mitochondrial quality control in intervertebral disc degeneration","volume":"53","author":"Song","year":"2021","journal-title":"Exp Mol Med"},{"issue":"11","key":"10.1016\/j.spinee.2025.05.018_bib0026","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1010990","article-title":"Mitochondrial protein, TBRG4, modulates KSHV and EBV reactivation from latency","volume":"18","author":"Zhang","year":"2022","journal-title":"PLoS Pathog"},{"issue":"2","key":"10.1016\/j.spinee.2025.05.018_bib0027","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1002\/ijc.33547","article-title":"Expression quantitative trait loci of genes predicting outcome are associated with survival of multiple myeloma patients","volume":"149","author":"Macauda","year":"2021","journal-title":"Int J Cancer"},{"issue":"3","key":"10.1016\/j.spinee.2025.05.018_bib0028","doi-asserted-by":"crossref","first-page":"429","DOI":"10.15171\/apb.2018.050","article-title":"Effect of Ghrelin on caspase 3 and Bcl2 gene expression in H2O2 treated rat\u2019s bone marrow stromal cells","volume":"8","author":"Abdanipour","year":"2018","journal-title":"Adv Pharm Bull"},{"issue":"8","key":"10.1016\/j.spinee.2025.05.018_bib0029","first-page":"13007","article-title":"Short interfering RNA directed against the GOLPH3 gene enhances the effect of chemotherapy against oral squamous cell carcinoma by regulating Caspase3, Bcl2 and cytochrome-c expression","volume":"8","author":"Cui","year":"2015","journal-title":"Int J Clin Exp Med"},{"issue":"34","key":"10.1016\/j.spinee.2025.05.018_bib0030","doi-asserted-by":"crossref","first-page":"57870","DOI":"10.18632\/oncotarget.18628","article-title":"The PI3K\/Akt pathway: a critical player in intervertebral disc degeneration","volume":"8","author":"Ouyang","year":"2017","journal-title":"Oncotarget"},{"issue":"5","key":"10.1016\/j.spinee.2025.05.018_bib0031","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1159\/000446447","article-title":"Klotho deficiency aggravates tacrolimus-induced renal injury via the phosphatidylinositol 3-kinase-Akt-forkhead box protein O pathway","volume":"43","author":"Jin","year":"2016","journal-title":"Am J Nephrol"},{"issue":"10","key":"10.1016\/j.spinee.2025.05.018_bib0032","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1038\/s41419-018-1024-9","article-title":"Parkin-mediated mitophagy as a potential therapeutic target for intervertebral disc degeneration","volume":"9","author":"Zhang","year":"2018","journal-title":"Cell Death Dis"},{"issue":"9","key":"10.1016\/j.spinee.2025.05.018_bib0033","first-page":"6221","article-title":"Moxibustion alleviates intervertebral disc degeneration via activation of the HIF-1\u03b1\/VEGF pathway in a rat model","volume":"11","author":"Zhang","year":"2019","journal-title":"Am J Transl Res"},{"issue":"1","key":"10.1016\/j.spinee.2025.05.018_bib0034","article-title":"MARCHF8-mediated ubiquitination via TGFBI regulates NF-\u03bab dependent inflammatory responses and ECM degradation in intervertebral disc degeneration","volume":"20","author":"Zhang","year":"2025","journal-title":"PloS one"},{"key":"10.1016\/j.spinee.2025.05.018_bib0036","doi-asserted-by":"crossref","first-page":"5601734","DOI":"10.1155\/2019\/5601734","article-title":"Ligustrazine prevents intervertebral disc degeneration via suppression of aberrant tgf\u03b2 activation in nucleus pulposus cells","volume":"2019","author":"Liu","year":"2019","journal-title":"BioMed Res Int"},{"key":"10.1016\/j.spinee.2025.05.018_bib0037","doi-asserted-by":"crossref","first-page":"101593","DOI":"10.1016\/j.redox.2020.101593","article-title":"TGF-\u03b21 attenuates mitochondrial bioenergetics in pulmonary arterial endothelial cells via the disruption of carnitine homeostasis","volume":"36","author":"Sun","year":"2020","journal-title":"Redox biology"},{"issue":"5","key":"10.1016\/j.spinee.2025.05.018_bib0038","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.13579","article-title":"TGF-\u03b23 mediates mitochondrial dynamics through the p-Smad3\/AMPK pathway","volume":"57","author":"Du","year":"2024","journal-title":"Cell proliferation"},{"issue":"1","key":"10.1016\/j.spinee.2025.05.018_bib0039","doi-asserted-by":"crossref","DOI":"10.1002\/jsp2.1238","article-title":"Harmonization and standardization of nucleus pulposus cell extraction and culture methods","volume":"6","author":"Basatvat","year":"2023","journal-title":"JOR spine"},{"issue":"11","key":"10.1016\/j.spinee.2025.05.018_bib0040","doi-asserted-by":"crossref","first-page":"3338","DOI":"10.1080\/15548627.2021.1872227","article-title":"HIF1A Alleviates compression-induced apoptosis of nucleus pulposus derived stem cells via upregulating autophagy","volume":"17","author":"He","year":"2021","journal-title":"Autophagy"},{"issue":"6","key":"10.1016\/j.spinee.2025.05.018_bib0041","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1080\/15548627.2022.2162245","article-title":"The mitophagy receptor BNIP3 is critical for the regulation of metabolic homeostasis and mitochondrial function in the nucleus pulposus cells of the intervertebral disc","volume":"19","author":"Madhu","year":"2023","journal-title":"Autophagy"},{"key":"10.1016\/j.spinee.2025.05.018_fur1","doi-asserted-by":"crossref","first-page":"5601593","DOI":"10.1155\/2017\/5601593","article-title":"ROS: crucial intermediators in the pathogenesis of intervertebral disc degeneration","volume":"2017","author":"Feng","year":"2017","journal-title":"Oxid Med Cell Longev"},{"issue":"3","key":"10.1016\/j.spinee.2025.05.018_fur2","first-page":"282","article-title":"Tissue engineering material KLD-12 polypeptide \/TGF-\u03b21 the protective effect and mechanism of nanofiber gel on early intervertebral disc degeneration. Cell mol biol (Noisy-le-Grand","volume":"68","author":"Zhao","year":"2022","journal-title":"France)"}],"container-title":["The Spine Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1529943025002414?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1529943025002414?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T04:19:11Z","timestamp":1761193151000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1529943025002414"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":41,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["S1529943025002414"],"URL":"https:\/\/doi.org\/10.1016\/j.spinee.2025.05.018","relation":{},"ISSN":["1529-9430"],"issn-type":[{"value":"1529-9430","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"TBRG4 regulates ubiquitination of Beclin1 and participates in autophagy pathway to inhibit intervertebral disc degeneration","name":"articletitle","label":"Article Title"},{"value":"The Spine Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.spinee.2025.05.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}