{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T23:45:53Z","timestamp":1791071153659,"version":"4.1.0"},"reference-count":61,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,7,5]],"date-time":"2014-07-05T00:00:00Z","timestamp":1404518400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Stem Cell"],"published-print":{"date-parts":[[2014,8]]},"DOI":"10.1016\/j.stem.2014.06.019","type":"journal-article","created":{"date-parts":[[2014,8,7]],"date-time":"2014-08-07T11:46:57Z","timestamp":1407412017000},"page":"139-153","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":131,"title":["Loss of Fbw7 Reprograms Adult Pancreatic Ductal Cells into \u03b1, \u03b4, and \u03b2 Cells"],"prefix":"10.1016","volume":"15","author":[{"given":"Rocio","family":"Sancho","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph","family":"Gruber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoqiang","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel","family":"Behrens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.stem.2014.06.019_bib1","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.devcel.2013.05.018","article-title":"Adult duct-lining cells can reprogram into \u03b2-like cells able to counter repeated cycles of toxin-induced diabetes","volume":"26","author":"Al-Hasani","year":"2013","journal-title":"Dev. Cell"},{"key":"10.1016\/j.stem.2014.06.019_bib2","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1038\/23716","article-title":"Notch signalling controls pancreatic cell differentiation","volume":"400","author":"Apelqvist","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.stem.2014.06.019_bib3","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.2337\/db10-1797","article-title":"How does type 1 diabetes develop?: the notion of homicide or \u03b2-cell suicide revisited","volume":"60","author":"Atkinson","year":"2011","journal-title":"Diabetes"},{"key":"10.1016\/j.stem.2014.06.019_bib4","doi-asserted-by":"crossref","first-page":"1892","DOI":"10.1038\/sj.cdd.4401883","article-title":"Ngn3 expression during postnatal in\u00a0vitro beta cell neogenesis induced by the JAK\/STAT pathway","volume":"13","author":"Baeyens","year":"2006","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.stem.2014.06.019_bib5","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1038\/nbt.2747","article-title":"Transient cytokine treatment induces acinar cell reprogramming and regenerates functional beta cell mass in diabetic mice","volume":"32","author":"Baeyens","year":"2014","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.stem.2014.06.019_bib6","doi-asserted-by":"crossref","first-page":"15336","DOI":"10.1073\/pnas.1201701109","article-title":"In\u00a0vivo reprogramming of Sox9+ cells in the liver to insulin-secreting ducts","volume":"109","author":"Banga","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"Suppl 2","key":"10.1016\/j.stem.2014.06.019_bib7","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1111\/j.1399-543X.2004.00075.x","article-title":"The pancreatic ductal epithelium serves as a potential pool of progenitor cells","volume":"5","author":"Bonner-Weir","year":"2004","journal-title":"Pediatr. Diabetes"},{"key":"10.1016\/j.stem.2014.06.019_bib8","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1042\/BST0360353","article-title":"Transdifferentiation of pancreatic ductal cells to endocrine beta-cells","volume":"36","author":"Bonner-Weir","year":"2008","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.stem.2014.06.019_bib9","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.cell.2009.05.035","article-title":"The ectopic expression of Pax4 in the mouse pancreas converts progenitor cells into alpha and subsequently beta cells","volume":"138","author":"Collombat","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.stem.2014.06.019_bib10","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1053\/j.gastro.2011.07.003","article-title":"Duct cells contribute to regeneration of endocrine and acinar cells following pancreatic damage in adult mice","volume":"141","author":"Criscimanna","year":"2011","journal-title":"Gastroenterology"},{"key":"10.1016\/j.stem.2014.06.019_bib11","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1038\/ncb2098","article-title":"Identification of a co-activator that links growth factor signalling to c-Jun\/AP-1 activation","volume":"12","author":"Davies","year":"2010","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.stem.2014.06.019_bib12","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/0012-1606(92)90121-V","article-title":"The midgestational human fetal pancreas contains cells coexpressing islet hormones","volume":"153","author":"De Krijger","year":"1992","journal-title":"Dev. Biol."},{"key":"10.1016\/j.stem.2014.06.019_bib13","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/nature02520","article-title":"Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation","volume":"429","author":"Dor","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.stem.2014.06.019_bib14","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1038\/nrg841","article-title":"Pancreatic organogenesis\u2014developmental mechanisms and implications for therapy","volume":"3","author":"Edlund","year":"2002","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.stem.2014.06.019_bib15","doi-asserted-by":"crossref","first-page":"11705","DOI":"10.1074\/jbc.M112.388173","article-title":"Neurogenin3 cooperates with Foxa2 to autoactivate its own expression","volume":"288","author":"Ejarque","year":"2013","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.stem.2014.06.019_bib16","doi-asserted-by":"crossref","first-page":"4213","DOI":"10.1242\/dev.01280","article-title":"Notch inhibits Ptf1 function and acinar cell differentiation in developing mouse and zebrafish pancreas","volume":"131","author":"Esni","year":"2004","journal-title":"Development"},{"key":"10.1016\/j.stem.2014.06.019_bib17","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.cmet.2005.12.005","article-title":"Notch\/Rbp-j signaling prevents premature endocrine and ductal cell differentiation in the pancreas","volume":"3","author":"Fujikura","year":"2006","journal-title":"Cell Metab."},{"key":"10.1016\/j.stem.2014.06.019_bib18","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1073\/pnas.97.4.1607","article-title":"neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas","volume":"97","author":"Gradwohl","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.stem.2014.06.019_bib19","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1083\/jcb.200802076","article-title":"Isoform- and cell cycle-dependent substrate degradation by the Fbw7 ubiquitin ligase","volume":"181","author":"Grim","year":"2008","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.stem.2014.06.019_bib20","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1210\/en.2004-1576","article-title":"Minireview: transcriptional regulation in pancreatic development","volume":"146","author":"Habener","year":"2005","journal-title":"Endocrinology"},{"key":"10.1016\/j.stem.2014.06.019_bib21","doi-asserted-by":"crossref","first-page":"E177","DOI":"10.1152\/ajpendo.00321.2002","article-title":"Transgenic mice with green fluorescent protein-labeled pancreatic beta -cells","volume":"284","author":"Hara","year":"2003","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.stem.2014.06.019_bib22","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1083\/jcb.200203074","article-title":"Recapitulation of embryonic neuroendocrine differentiation in adult human pancreatic duct cells expressing neurogenin 3","volume":"159","author":"Heremans","year":"2002","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.stem.2014.06.019_bib23","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/S1535-6108(03)00309-X","article-title":"Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse","volume":"4","author":"Hingorani","year":"2003","journal-title":"Cancer Cell"},{"key":"10.1016\/j.stem.2014.06.019_bib24","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1038\/nn.2644","article-title":"Fbw7 controls neural stem cell differentiation and progenitor apoptosis via Notch and c-Jun","volume":"13","author":"Hoeck","year":"2010","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.stem.2014.06.019_bib25","doi-asserted-by":"crossref","first-page":"19915","DOI":"10.1073\/pnas.0805803105","article-title":"Carbonic anhydrase II-positive pancreatic cells are progenitors for both endocrine and exocrine pancreas after birth","volume":"105","author":"Inada","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.stem.2014.06.019_bib26","doi-asserted-by":"crossref","first-page":"2373","DOI":"10.1182\/blood-2010-07-294801","article-title":"Ex\u00a0vivo maintenance of hematopoietic stem cells by quiescence induction through Fbxw7 overexpression","volume":"117","author":"Iriuchishima","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.stem.2014.06.019_bib27","doi-asserted-by":"crossref","first-page":"6164","DOI":"10.1038\/onc.2008.216","article-title":"Notch-dependent cell cycle arrest and apoptosis in mouse embryonic fibroblasts lacking Fbxw7","volume":"27","author":"Ishikawa","year":"2008","journal-title":"Oncogene"},{"key":"10.1016\/j.stem.2014.06.019_bib28","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.ydbio.2011.07.030","article-title":"The F-box protein Fbw7 is required for cerebellar development","volume":"358","author":"Jandke","year":"2011","journal-title":"Dev. Biol."},{"key":"10.1016\/j.stem.2014.06.019_bib29","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1038\/71657","article-title":"Control of endodermal endocrine development by Hes-1","volume":"24","author":"Jensen","year":"2000","journal-title":"Nat. Genet."},{"key":"10.1016\/j.stem.2014.06.019_bib30","doi-asserted-by":"crossref","first-page":"150","DOI":"10.5966\/sctm.2011-0025","article-title":"Concise review: pancreas regeneration: recent advances and perspectives","volume":"1","author":"Lysy","year":"2012","journal-title":"Stem Cells Transl. Med."},{"key":"10.1016\/j.stem.2014.06.019_bib31","doi-asserted-by":"crossref","first-page":"13754","DOI":"10.1074\/jbc.M110.194936","article-title":"Fbxw7-dependent degradation of Notch is required for control of \u201cstemness\u201d and neuronal-glial differentiation in neural stem cells","volume":"286","author":"Matsumoto","year":"2011","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.stem.2014.06.019_bib32","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1002\/dvg.20397","article-title":"A CK19(CreERT) knockin mouse line allows for conditional DNA recombination in epithelial cells in multiple endodermal organs","volume":"46","author":"Means","year":"2008","journal-title":"Genesis"},{"key":"10.1016\/j.stem.2014.06.019_bib33","doi-asserted-by":"crossref","first-page":"14920","DOI":"10.1073\/pnas.2436557100","article-title":"Notch signaling controls multiple steps of pancreatic differentiation","volume":"100","author":"Murtaugh","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.stem.2014.06.019_bib34","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/nrc1881","article-title":"Ubiquitin ligases: cell-cycle control and cancer","volume":"6","author":"Nakayama","year":"2006","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.stem.2014.06.019_bib35","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1038\/nature03914","article-title":"Interaction of phosphorylated c-Jun with TCF4 regulates intestinal cancer development","volume":"437","author":"Nateri","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.stem.2014.06.019_bib36","doi-asserted-by":"crossref","first-page":"e55","DOI":"10.1093\/nar\/gkp112","article-title":"Efficient mouse transgenesis using Gateway-compatible ROSA26 locus targeting vectors and F1 hybrid ES cells","volume":"37","author":"Nyabi","year":"2009","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.stem.2014.06.019_bib37","doi-asserted-by":"crossref","first-page":"3291","DOI":"10.1242\/dev.121.10.3291","article-title":"Disruption of the mouse RBP-J kappa gene results in early embryonic death","volume":"121","author":"Oka","year":"1995","journal-title":"Development"},{"key":"10.1016\/j.stem.2014.06.019_bib38","doi-asserted-by":"crossref","first-page":"1998","DOI":"10.1101\/gad.1670808","article-title":"On the origin of the beta cell","volume":"22","author":"Oliver-Krasinski","year":"2008","journal-title":"Genes Dev."},{"key":"10.1016\/j.stem.2014.06.019_bib39","doi-asserted-by":"crossref","first-page":"2875","DOI":"10.1084\/jem.20062299","article-title":"Conditional inactivation of Fbxw7 impairs cell-cycle exit during T\u00a0cell differentiation and results in lymphomatogenesis","volume":"204","author":"Onoyama","year":"2007","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.stem.2014.06.019_bib40","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1172\/JCI40725","article-title":"Fbxw7 regulates lipid metabolism and cell fate decisions in the mouse liver","volume":"121","author":"Onoyama","year":"2011","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.stem.2014.06.019_bib41","doi-asserted-by":"crossref","first-page":"2472","DOI":"10.1242\/dev.093187","article-title":"How to make a functional \u03b2-cell","volume":"140","author":"Pagliuca","year":"2013","journal-title":"Development"},{"key":"10.1016\/j.stem.2014.06.019_bib42","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1677\/joe.0.1810011","article-title":"Beta cell differentiation during early human pancreas development","volume":"181","author":"Piper","year":"2004","journal-title":"J.\u00a0Endocrinol."},{"key":"10.1016\/j.stem.2014.06.019_bib43","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1038\/ncb1601","article-title":"The ubiquitin-specific protease USP28 is required for MYC stability","volume":"9","author":"Popov","year":"2007","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.stem.2014.06.019_bib44","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1242\/bio.20121750","article-title":"Complex regulation controls Neurogenin3 proteolysis","volume":"1","author":"Roark","year":"2012","journal-title":"Biol. Open"},{"key":"10.1016\/j.stem.2014.06.019_bib45","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1053\/j.gastro.2010.05.078","article-title":"F-box and WD repeat domain-containing 7 regulates intestinal cell lineage commitment and is a haploinsufficient tumor suppressor","volume":"139","author":"Sancho","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1016\/j.stem.2014.06.019_bib46","doi-asserted-by":"crossref","first-page":"e1001586","DOI":"10.1371\/journal.pbio.1001586","article-title":"Fbw7 repression by hes5 creates a feedback loop that modulates Notch-mediated intestinal and neural stem cell fate decisions","volume":"11","author":"Sancho","year":"2013","journal-title":"PLoS Biol."},{"key":"10.1016\/j.stem.2014.06.019_bib47","doi-asserted-by":"crossref","first-page":"3533","DOI":"10.1242\/dev.127.16.3533","article-title":"Expression of neurogenin3 reveals an islet cell precursor population in the pancreas","volume":"127","author":"Schwitzgebel","year":"2000","journal-title":"Development"},{"key":"10.1016\/j.stem.2014.06.019_bib48","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1471-213X-1-4","article-title":"Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus","volume":"1","author":"Srinivas","year":"2001","journal-title":"BMC Dev. Biol."},{"key":"10.1016\/j.stem.2014.06.019_bib49","doi-asserted-by":"crossref","first-page":"e37055","DOI":"10.1371\/journal.pone.0037055","article-title":"Plasticity of adult human pancreatic duct cells by neurogenin3-mediated reprogramming","volume":"7","author":"Swales","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.stem.2014.06.019_bib50","doi-asserted-by":"crossref","first-page":"2557","DOI":"10.2337\/diabetes.54.9.2557","article-title":"Very slow turnover of beta-cells in aged adult mice","volume":"54","author":"Teta","year":"2005","journal-title":"Diabetes"},{"key":"10.1016\/j.stem.2014.06.019_bib51","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1084\/jem.20080277","article-title":"Control of hematopoietic stem cell quiescence by the E3 ubiquitin ligase Fbw7","volume":"205","author":"Thompson","year":"2008","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.stem.2014.06.019_bib52","doi-asserted-by":"crossref","first-page":"e523","DOI":"10.1038\/cddis.2013.52","article-title":"Neurogenin 3+ cells contribute to \u03b2-cell neogenesis and proliferation in injured adult mouse pancreas","volume":"4","author":"Van de Casteele","year":"2013","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.stem.2014.06.019_bib53","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/nature05541","article-title":"Restoration of p53 function leads to tumour regression in\u00a0vivo","volume":"445","author":"Ventura","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.stem.2014.06.019_bib54","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.ydbio.2008.02.052","article-title":"Myt1 and Ngn3 form a feed-forward expression loop to promote endocrine islet cell differentiation","volume":"317","author":"Wang","year":"2008","journal-title":"Dev. Biol."},{"key":"10.1016\/j.stem.2014.06.019_bib55","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1038\/embor.2011.231","article-title":"Emerging roles of the FBW7 tumour suppressor in stem cell differentiation","volume":"13","author":"Wang","year":"2012","journal-title":"EMBO Rep."},{"key":"10.1016\/j.stem.2014.06.019_bib56","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/nrc2290","article-title":"FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation","volume":"8","author":"Welcker","year":"2008","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.stem.2014.06.019_bib57","doi-asserted-by":"crossref","first-page":"9085","DOI":"10.1073\/pnas.0402770101","article-title":"The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation","volume":"101","author":"Welcker","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.stem.2014.06.019_bib58","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.cell.2007.12.015","article-title":"Beta cells can be generated from endogenous progenitors in injured adult mouse pancreas","volume":"132","author":"Xu","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.stem.2014.06.019_bib59","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/j.cell.2013.04.008","article-title":"Betatrophin: a hormone that controls pancreatic \u03b2 cell proliferation","volume":"153","author":"Yi","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.stem.2014.06.019_bib60","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/nrg2318","article-title":"Genetic programming of liver and pancreas progenitors: lessons for stem-cell differentiation","volume":"9","author":"Zaret","year":"2008","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.stem.2014.06.019_bib61","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1038\/nature07314","article-title":"In\u00a0vivo reprogramming of adult pancreatic exocrine cells to beta-cells","volume":"455","author":"Zhou","year":"2008","journal-title":"Nature"}],"container-title":["Cell Stem Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1934590914002951?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1934590914002951?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T18:07:55Z","timestamp":1649873275000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1934590914002951"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8]]},"references-count":61,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,8]]}},"alternative-id":["S1934590914002951"],"URL":"https:\/\/doi.org\/10.1016\/j.stem.2014.06.019","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.718524572.793498253","asserted-by":"object"}]},"ISSN":["1934-5909"],"issn-type":[{"value":"1934-5909","type":"print"}],"subject":[],"published":{"date-parts":[[2014,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Loss of Fbw7 Reprograms Adult Pancreatic Ductal Cells into \u03b1, \u03b4, and \u03b2 Cells","name":"articletitle","label":"Article Title"},{"value":"Cell Stem Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.stem.2014.06.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.stem.2014.07.006","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}