{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T22:35:42Z","timestamp":1791326142406,"version":"4.3.1"},"reference-count":37,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2016,2,11]],"date-time":"2016-02-11T00:00:00Z","timestamp":1455148800000},"content-version":"vor","delay-in-days":498,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100002338","name":"Ministry of Education of the People&apos;s Republic of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002338","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003711","name":"Ministry of Science and Technology","doi-asserted-by":"publisher","award":["2013DFG30680"],"award-info":[{"award-number":["2013DFG30680"]}],"id":[{"id":"10.13039\/501100003711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2012CB966401"],"award-info":[{"award-number":["2012CB966401"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013076","name":"National Major Science and Technology Projects of China","doi-asserted-by":"publisher","award":["2013ZX10001003"],"award-info":[{"award-number":["2013ZX10001003"]}],"id":[{"id":"10.13039\/501100013076","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["91310305"],"award-info":[{"award-number":["91310305"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Stem Cell"],"published-print":{"date-parts":[[2014,10]]},"DOI":"10.1016\/j.stem.2014.09.004","type":"journal-article","created":{"date-parts":[[2014,10,2]],"date-time":"2014-10-02T12:18:56Z","timestamp":1412252336000},"page":"488-497","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":123,"title":["Generation of Naive Induced Pluripotent Stem Cells from Rhesus Monkey Fibroblasts"],"prefix":"10.1016","volume":"15","author":[{"given":"Riguo","family":"Fang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haibo","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dicong","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengang","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haisong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenchuan","family":"Miao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weifeng","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongkui","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.stem.2014.09.004_bib1","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/309255a0","article-title":"Formation of germ-line chimaeras from embryo-derived teratocarcinoma cell lines","volume":"309","author":"Bradley","year":"1984","journal-title":"Nature"},{"key":"10.1016\/j.stem.2014.09.004_bib2","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/nature05950","article-title":"Derivation of pluripotent epiblast stem cells from mammalian embryos","volume":"448","author":"Brons","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.stem.2014.09.004_bib3","doi-asserted-by":"crossref","first-page":"5709","DOI":"10.1073\/pnas.94.11.5709","article-title":"The origin and efficient derivation of embryonic stem cells in the mouse","volume":"94","author":"Brook","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.stem.2014.09.004_bib4","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.stem.2010.05.003","article-title":"A murine ESC-like state facilitates transgenesis and homologous recombination in human pluripotent stem cells","volume":"6","author":"Buecker","year":"2010","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.stem.2014.09.004_bib5","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.stem.2013.11.015","article-title":"Induction of a human pluripotent state with distinct regulatory circuitry that resembles preimplantation epiblast","volume":"13","author":"Chan","year":"2013","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.stem.2014.09.004_bib6","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1126\/science.1248882","article-title":"Defining an essential transcription factor program for na\u00efve pluripotency","volume":"344","author":"Dunn","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.stem.2014.09.004_bib7","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1038\/292154a0","article-title":"Establishment in culture of pluripotential cells from mouse embryos","volume":"292","author":"Evans","year":"1981","journal-title":"Nature"},{"key":"10.1016\/j.stem.2014.09.004_bib8","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1038\/nature12745","article-title":"Derivation of novel human ground state naive pluripotent stem cells","volume":"504","author":"Gafni","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.stem.2014.09.004_bib9","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1038\/embor.2013.67","article-title":"Prdm14 promotes germline fate and naive pluripotency by repressing FGF signalling and DNA methylation","volume":"14","author":"Grabole","year":"2013","journal-title":"EMBO Rep."},{"key":"10.1016\/j.stem.2014.09.004_bib10","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.stem.2010.01.003","article-title":"Conserved and divergent roles of FGF signaling in mouse epiblast stem cells and human embryonic stem cells","volume":"6","author":"Greber","year":"2010","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.stem.2014.09.004_bib11","doi-asserted-by":"crossref","first-page":"9222","DOI":"10.1073\/pnas.1004584107","article-title":"Human embryonic stem cells with biological and epigenetic characteristics similar to those of mouse ESCs","volume":"107","author":"Hanna","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.stem.2014.09.004_bib12","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1007\/s12015-011-9306-y","article-title":"Simultaneous suppression of TGF-\u03b2 and ERK signaling contributes to the highly efficient and reproducible generation of mouse embryonic stem cells from previously considered refractory and non-permissive strains","volume":"8","author":"Hassani","year":"2012","journal-title":"Stem Cell Rev."},{"key":"10.1016\/j.stem.2014.09.004_bib13","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1007\/s12015-013-9473-0","article-title":"Inhibition of TGF\u03b2 signaling promotes ground state pluripotency","volume":"10","author":"Hassani","year":"2014","journal-title":"Stem Cell Rev."},{"key":"10.1016\/j.stem.2014.09.004_bib14","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1038\/sj.emboj.7600038","article-title":"Hematopoietic, angiogenic and eye defects in Meis1 mutant animals","volume":"23","author":"Hisa","year":"2004","journal-title":"EMBO J."},{"key":"10.1016\/j.stem.2014.09.004_bib15","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1101\/gad.11.8.1048","article-title":"GATA4 transcription factor is required for ventral morphogenesis and heart tube formation","volume":"11","author":"Kuo","year":"1997","journal-title":"Genes Dev."},{"key":"10.1016\/j.stem.2014.09.004_bib16","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.stem.2008.11.014","article-title":"Generation of rat and human induced pluripotent stem cells by combining genetic reprogramming and chemical inhibitors","volume":"4","author":"Li","year":"2009","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.stem.2014.09.004_bib17","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1038\/cr.2010.142","article-title":"Generation of iPSCs from mouse fibroblasts with a single gene, Oct4, and small molecules","volume":"21","author":"Li","year":"2011","journal-title":"Cell Res."},{"key":"10.1016\/j.stem.2014.09.004_bib18","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.stem.2008.10.014","article-title":"Generation of induced pluripotent stem cells from adult rhesus monkey fibroblasts","volume":"3","author":"Liu","year":"2008","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.stem.2014.09.004_bib19","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.stem.2009.05.015","article-title":"Naive and primed pluripotent states","volume":"4","author":"Nichols","year":"2009","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.stem.2014.09.004_bib20","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1038\/nature08113","article-title":"A parallel circuit of LIF signalling pathways maintains pluripotency of mouse ES cells","volume":"460","author":"Niwa","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.stem.2014.09.004_bib21","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1038\/nmeth.1591","article-title":"A more efficient method to generate integration-free human iPS cells","volume":"8","author":"Okita","year":"2011","journal-title":"Nat. Methods"},{"key":"10.1016\/j.stem.2014.09.004_bib22","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1016\/j.cell.2009.07.039","article-title":"Nanog is the gateway to the pluripotent ground state","volume":"138","author":"Silva","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.stem.2014.09.004_bib23","doi-asserted-by":"crossref","first-page":"e58601","DOI":"10.1371\/journal.pone.0058601","article-title":"MUC1\u2217 ligand, NM23-H1, is a novel growth factor that maintains human stem cells in a more na\u00efve state","volume":"8","author":"Smagghe","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1016\/j.stem.2014.09.004_bib24","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.cell.2007.11.019","article-title":"Induction of pluripotent stem cells from adult human fibroblasts by defined factors","volume":"131","author":"Takahashi","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.stem.2014.09.004_bib25","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1038\/nature05972","article-title":"New cell lines from mouse epiblast share defining features with human embryonic stem cells","volume":"448","author":"Tesar","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.stem.2014.09.004_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.stem.2014.07.002","article-title":"Systematic Identification of Culture Conditions for Induction and Maintenance of Naive Human Pluripotency","author":"Theunissen","year":"2014","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.stem.2014.09.004_bib27","doi-asserted-by":"crossref","first-page":"7844","DOI":"10.1073\/pnas.92.17.7844","article-title":"Isolation of a primate embryonic stem cell line","volume":"92","author":"Thomson","year":"1995","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.stem.2014.09.004_bib28","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1126\/science.282.5391.1145","article-title":"Embryonic stem cell lines derived from human blastocysts","volume":"282","author":"Thomson","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.stem.2014.09.004_bib29","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1242\/dev.033951","article-title":"Activin\/Nodal signalling maintains pluripotency by controlling Nanog expression","volume":"136","author":"Vallier","year":"2009","journal-title":"Development"},{"key":"10.1016\/j.stem.2014.09.004_bib30","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1038\/ncb2581","article-title":"Dll1+ secretory progenitor cells revert to stem cells upon crypt damage","volume":"14","author":"van Es","year":"2012","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.stem.2014.09.004_bib31","doi-asserted-by":"crossref","first-page":"18283","DOI":"10.1073\/pnas.1100893108","article-title":"Rapid and efficient reprogramming of somatic cells to induced pluripotent stem cells by retinoic acid receptor gamma and liver receptor homolog 1","volume":"108","author":"Wang","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.stem.2014.09.004_bib32","doi-asserted-by":"crossref","first-page":"4484","DOI":"10.1073\/pnas.1319738111","article-title":"Derivation of naive human embryonic stem cells","volume":"111","author":"Ware","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.stem.2014.09.004_bib33","doi-asserted-by":"crossref","first-page":"8129","DOI":"10.1073\/pnas.1002024107","article-title":"Revealing a core signaling regulatory mechanism for pluripotent stem cell survival and self-renewal by small molecules","volume":"107","author":"Xu","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.stem.2014.09.004_bib34","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.stem.2012.12.012","article-title":"PRDM14 ensures naive pluripotency through dual regulation of signaling and epigenetic pathways in mouse embryonic stem cells","volume":"12","author":"Yamaji","year":"2013","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.stem.2014.09.004_bib35","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/nature06968","article-title":"The ground state of embryonic stem cell self-renewal","volume":"453","author":"Ying","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.stem.2014.09.004_bib36","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1126\/science.1151526","article-title":"Induced pluripotent stem cell lines derived from human somatic cells","volume":"318","author":"Yu","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.stem.2014.09.004_bib37","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/sj.cr.7290105","article-title":"MAPK signal pathways in the regulation of cell proliferation in mammalian cells","volume":"12","author":"Zhang","year":"2002","journal-title":"Cell Res."}],"updated-by":[{"DOI":"10.1016\/j.stem.2015.01.001","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2015,2,5]],"date-time":"2015-02-05T00:00:00Z","timestamp":1423094400000}}],"container-title":["Cell Stem Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1934590914003956?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1934590914003956?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T13:44:51Z","timestamp":1761831891000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1934590914003956"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10]]},"references-count":37,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["S1934590914003956"],"URL":"https:\/\/doi.org\/10.1016\/j.stem.2014.09.004","relation":{},"ISSN":["1934-5909"],"issn-type":[{"value":"1934-5909","type":"print"}],"subject":[],"published":{"date-parts":[[2014,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Generation of Naive Induced Pluripotent Stem Cells from Rhesus Monkey Fibroblasts","name":"articletitle","label":"Article Title"},{"value":"Cell Stem Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.stem.2014.09.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}