{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T22:57:55Z","timestamp":1791413875290,"version":"4.3.3"},"reference-count":35,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,7,7]],"date-time":"2017-07-07T00:00:00Z","timestamp":1499385600000},"content-version":"vor","delay-in-days":371,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Stem Cell"],"published-print":{"date-parts":[[2016,7]]},"DOI":"10.1016\/j.stem.2016.03.013","type":"journal-article","created":{"date-parts":[[2016,4,14]],"date-time":"2016-04-14T23:58:33Z","timestamp":1460678313000},"page":"81-94","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":103,"title":["Activation of Endogenous Retroviruses in Dnmt1 \u2212\/\u2212 ESCs Involves Disruption of SETDB1-Mediated Repression by NP95 Binding to Hemimethylated DNA"],"prefix":"10.1016","volume":"19","author":[{"given":"Jafar","family":"Sharif","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takaho\u00a0A.","family":"Endo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manabu","family":"Nakayama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad\u00a0M.","family":"Karimi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Midori","family":"Shimada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kayoko","family":"Katsuyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Preeti","family":"Goyal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Brind\u2019Amour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-An","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhixiong","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoyuki","family":"Ishikura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoko","family":"Mizutani-Koseki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osamu","family":"Ohara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoichi","family":"Shinkai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Nakanishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hehuang","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew\u00a0C.","family":"Lorincz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruhiko","family":"Koseki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.stem.2016.03.013_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1756-8935-8-1","article-title":"Selective impairment of methylation maintenance is the major cause of DNA methylation reprogramming in the early embryo","volume":"8","author":"Arand","year":"2015","journal-title":"Epigenetics Chromatin"},{"key":"10.1016\/j.stem.2016.03.013_bib2","doi-asserted-by":"crossref","first-page":"12950","DOI":"10.1073\/pnas.1203701109","article-title":"Recognition of modification status on a histone H3 tail by linked histone reader modules of the epigenetic regulator UHRF1","volume":"109","author":"Arita","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.stem.2016.03.013_bib3","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1126\/science.1147939","article-title":"UHRF1 plays a role in maintaining DNA methylation in mammalian cells","volume":"317","author":"Bostick","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.stem.2016.03.013_bib4","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1038\/nature02886","article-title":"Meiotic catastrophe and retrotransposon reactivation in male germ cells lacking Dnmt3L","volume":"431","author":"Bourc\u2019his","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.stem.2016.03.013_bib5","first-page":"1964","article-title":"Derivation of mouse trophoblast stem cells from blastocysts","volume":"40","author":"Chiu","year":"2010","journal-title":"J.\u00a0Vis. Exp."},{"key":"10.1016\/j.stem.2016.03.013_bib6","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.stem.2007.12.011","article-title":"Promoter CpG methylation contributes to ES cell gene regulation in parallel with Oct4\/Nanog, PcG complex, and histone H3 K4\/K27 trimethylation","volume":"2","author":"Fouse","year":"2008","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.stem.2016.03.013_bib7","doi-asserted-by":"crossref","first-page":"e0137509","DOI":"10.1371\/journal.pone.0137509","article-title":"Dual functions of the RFTS domain of Dnmt1 in replication-coupled DNA methylation and in protection of the genome from aberrant methylation","volume":"10","author":"Garvilles","year":"2015","journal-title":"PLoS ONE"},{"key":"10.1016\/j.stem.2016.03.013_bib8","doi-asserted-by":"crossref","first-page":"21082","DOI":"10.1074\/jbc.M110.125674","article-title":"Repression of retrotransposal elements in mouse embryonic stem cells is primarily mediated by a DNA methylation-independent mechanism","volume":"285","author":"Hutnick","year":"2010","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.stem.2016.03.013_bib9","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/83730","article-title":"Loss of genomic methylation causes p53-dependent apoptosis and epigenetic deregulation","volume":"27","author":"Jackson-Grusby","year":"2001","journal-title":"Nat. Genet."},{"key":"10.1016\/j.stem.2016.03.013_bib10","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1038\/emboj.2012.331","article-title":"Replication-coupled passive DNA demethylation for the erasure of genome imprints in mice","volume":"32","author":"Kagiwada","year":"2013","journal-title":"EMBO J."},{"key":"10.1016\/j.stem.2016.03.013_bib11","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/j.stem.2011.04.004","article-title":"DNA methylation and SETDB1\/H3K9me3 regulate predominantly distinct sets of genes, retroelements, and chimeric transcripts in mESCs","volume":"8","author":"Karimi","year":"2011","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.stem.2016.03.013_bib12","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1101\/gr.148023.112","article-title":"High-resolution DNA methylome analysis of primordial germ cells identifies gender-specific reprogramming in mice","volume":"23","author":"Kobayashi","year":"2013","journal-title":"Genome Res."},{"key":"10.1016\/j.stem.2016.03.013_bib13","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1101\/gad.1640708","article-title":"DNA methylation of retrotransposon genes is regulated by Piwi family members MILI and MIWI2 in murine fetal testes","volume":"22","author":"Kuramochi-Miyagawa","year":"2008","journal-title":"Genes Dev."},{"key":"10.1016\/j.stem.2016.03.013_bib14","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1016\/j.stem.2014.05.008","article-title":"Reprogramming the methylome: erasing memory and creating diversity","volume":"14","author":"Lee","year":"2014","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.stem.2016.03.013_bib15","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.tibs.2011.11.006","article-title":"Silencing of endogenous retroviruses: when and why do histone marks predominate?","volume":"37","author":"Leung","year":"2012","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.stem.2016.03.013_bib16","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/0092-8674(92)90611-F","article-title":"Targeted mutation of the DNA methyltransferase gene results in embryonic lethality","volume":"69","author":"Li","year":"1992","journal-title":"Cell"},{"key":"10.1016\/j.stem.2016.03.013_bib17","doi-asserted-by":"crossref","first-page":"2041","DOI":"10.1101\/gad.244848.114","article-title":"Setdb1 is required for germline development and silencing of H3K9me3-marked endogenous retroviruses in primordial germ cells","volume":"28","author":"Liu","year":"2014","journal-title":"Genes Dev."},{"key":"10.1016\/j.stem.2016.03.013_bib18","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1038\/nature08858","article-title":"Proviral silencing in embryonic stem cells requires the histone methyltransferase ESET","volume":"464","author":"Matsui","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.stem.2016.03.013_bib19","doi-asserted-by":"crossref","first-page":"5868","DOI":"10.1093\/nar\/gki901","article-title":"Reduced representation bisulfite sequencing for comparative high-resolution DNA methylation analysis","volume":"33","author":"Meissner","year":"2005","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.stem.2016.03.013_bib20","doi-asserted-by":"crossref","first-page":"e68846","DOI":"10.1371\/journal.pone.0068846","article-title":"Regulation of lineage specific DNA hypomethylation in mouse trophectoderm","volume":"8","author":"Oda","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1016\/j.stem.2016.03.013_bib21","doi-asserted-by":"crossref","first-page":"R174","DOI":"10.1016\/j.cub.2007.12.045","article-title":"Cytosine methylation: remaining faithful","volume":"18","author":"Ooi","year":"2008","journal-title":"Curr. Biol."},{"key":"10.1016\/j.stem.2016.03.013_bib22","doi-asserted-by":"crossref","first-page":"5795","DOI":"10.1038\/ncomms6795","article-title":"MORC1 represses transposable elements in the mouse male germline","volume":"5","author":"Pastor","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.stem.2016.03.013_bib23","doi-asserted-by":"crossref","first-page":"34490","DOI":"10.1074\/jbc.C800169200","article-title":"Structure and hemimethylated CpG binding of the SRA domain from human UHRF1","volume":"283","author":"Qian","year":"2008","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.stem.2016.03.013_bib24","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1038\/nsmb.2391","article-title":"Association of UHRF1 with methylated H3K9 directs the maintenance of DNA methylation","volume":"19","author":"Rothbart","year":"2012","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.stem.2016.03.013_bib25","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.virol.2010.12.007","article-title":"Dynamic control of endogenous retroviruses during development","volume":"411","author":"Rowe","year":"2011","journal-title":"Virology"},{"key":"10.1016\/j.stem.2016.03.013_bib26","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/nature08674","article-title":"KAP1 controls endogenous retroviruses in embryonic stem cells","volume":"463","author":"Rowe","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.stem.2016.03.013_bib27","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/j.molcel.2012.11.001","article-title":"The dynamics of genome-wide DNA methylation reprogramming in mouse primordial germ cells","volume":"48","author":"Seisenberger","year":"2012","journal-title":"Mol. Cell"},{"key":"10.1016\/j.stem.2016.03.013_bib28","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1038\/nature06397","article-title":"The SRA protein Np95 mediates epigenetic inheritance by recruiting Dnmt1 to methylated DNA","volume":"450","author":"Sharif","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.stem.2016.03.013_bib29","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.stem.2014.09.002","article-title":"Tet3 and DNA replication mediate demethylation of both the maternal and paternal genomes in mouse zygotes","volume":"15","author":"Shen","year":"2014","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.stem.2016.03.013_bib30","doi-asserted-by":"crossref","first-page":"e253","DOI":"10.1371\/journal.pbio.0060253","article-title":"Promotion of reprogramming to ground state pluripotency by signal inhibition","volume":"6","author":"Silva","year":"2008","journal-title":"PLoS Biol."},{"key":"10.1016\/j.stem.2016.03.013_bib31","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1038\/2413","article-title":"Transcription of IAP endogenous retroviruses is constrained by cytosine methylation","volume":"20","author":"Walsh","year":"1998","journal-title":"Nat. Genet."},{"key":"10.1016\/j.stem.2016.03.013_bib32","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.devcel.2011.01.005","article-title":"MITOPLD is a mitochondrial protein essential for nuage formation and piRNA biogenesis in the mouse germline","volume":"20","author":"Watanabe","year":"2011","journal-title":"Dev. Cell"},{"key":"10.1016\/j.stem.2016.03.013_bib33","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1016\/j.molcel.2012.07.019","article-title":"A role for Fkbp6 and the chaperone machinery in piRNA amplification and transposon silencing","volume":"47","author":"Xiol","year":"2012","journal-title":"Mol. Cell"},{"key":"10.1016\/j.stem.2016.03.013_bib34","doi-asserted-by":"crossref","first-page":"2507","DOI":"10.1101\/gad.1831909","article-title":"Eset partners with Oct4 to restrict extraembryonic trophoblast lineage potential in embryonic stem cells","volume":"23","author":"Yuan","year":"2009","journal-title":"Genes Dev."},{"key":"10.1016\/j.stem.2016.03.013_bib35","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1101\/gr.163147.113","article-title":"The dynamics of DNA methylation fidelity during mouse embryonic stem cell self-renewal and differentiation","volume":"24","author":"Zhao","year":"2014","journal-title":"Genome Res."}],"container-title":["Cell Stem Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1934590916001193?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1934590916001193?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,13]],"date-time":"2018-09-13T09:56:10Z","timestamp":1536832570000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1934590916001193"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,7]]}},"alternative-id":["S1934590916001193"],"URL":"https:\/\/doi.org\/10.1016\/j.stem.2016.03.013","relation":{},"ISSN":["1934-5909"],"issn-type":[{"value":"1934-5909","type":"print"}],"subject":[],"published":{"date-parts":[[2016,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Activation of Endogenous Retroviruses in Dnmt1\u2212\/\u2212 ESCs Involves Disruption of SETDB1-Mediated Repression by NP95 Binding to Hemimethylated DNA","name":"articletitle","label":"Article Title"},{"value":"Cell Stem Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.stem.2016.03.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}