{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T09:06:32Z","timestamp":1792659992943,"version":"4.5.0"},"reference-count":69,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,1,4]],"date-time":"2019-01-04T00:00:00Z","timestamp":1546560000000},"content-version":"vor","delay-in-days":368,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100010559","name":"Children's Hospital of Pittsburgh","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010559","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007177","name":"CRC Health Group","doi-asserted-by":"publisher","award":["UL1TR000430"],"award-info":[{"award-number":["UL1TR000430"]}],"id":[{"id":"10.13039\/100007177","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000901","name":"Juvenile Diabetes Research Foundation International","doi-asserted-by":"publisher","award":["1-INO-2014-167-A-V"],"award-info":[{"award-number":["1-INO-2014-167-A-V"]}],"id":[{"id":"10.13039\/100000901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01DK111460"],"award-info":[{"award-number":["R01DK111460"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01DK112836"],"award-info":[{"award-number":["R01DK112836"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01DK098196"],"award-info":[{"award-number":["R01DK098196"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Stem Cell"],"published-print":{"date-parts":[[2018,1]]},"DOI":"10.1016\/j.stem.2017.11.020","type":"journal-article","created":{"date-parts":[[2018,1,4]],"date-time":"2018-01-04T11:47:24Z","timestamp":1515066444000},"page":"78-90.e4","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":183,"title":["Endogenous Reprogramming of Alpha Cells into Beta Cells, Induced by Viral Gene Therapy, Reverses Autoimmune Diabetes"],"prefix":"10.1016","volume":"22","author":[{"given":"Xiangwei","family":"Xiao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiyo","family":"Shiota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gina M.","family":"Coudriet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shane","family":"Fischbach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krishna","family":"Prasadan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Fusco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabarinathan","family":"Ramachandran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr","family":"Witkowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon D.","family":"Piganelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George K.","family":"Gittes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.stem.2017.11.020_bib1","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1677\/JME-06-0053","article-title":"Molecular regulation of pancreatic beta-cell mass development, maintenance, and expansion","volume":"38","author":"Ackermann","year":"2007","journal-title":"J.\u00a0Mol. Endocrinol."},{"key":"10.1016\/j.stem.2017.11.020_bib2","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.molmet.2016.01.002","article-title":"Integration of ATAC-seq and RNA-seq identifies human alpha cell and beta cell signature genes","volume":"5","author":"Ackermann","year":"2016","journal-title":"Mol. Metab."},{"key":"10.1016\/j.stem.2017.11.020_bib3","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1042\/BJ20111678","article-title":"Reprogramming of pancreatic exocrine cells towards a beta (\u03b2) cell character using Pdx1, Ngn3 and MafA","volume":"442","author":"Akinci","year":"2012","journal-title":"Biochem. J."},{"key":"10.1016\/j.stem.2017.11.020_bib4","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1038\/9442","article-title":"The NOD mouse model of type 1 diabetes: As good as it gets?","volume":"5","author":"Atkinson","year":"1999","journal-title":"Nat. Med."},{"key":"10.1016\/j.stem.2017.11.020_bib5","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1038\/nbt.2747","article-title":"Transient cytokine treatment induces acinar cell reprogramming and regenerates functional beta cell mass in diabetic mice","volume":"32","author":"Baeyens","year":"2014","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.stem.2017.11.020_bib6","doi-asserted-by":"crossref","first-page":"15336","DOI":"10.1073\/pnas.1201701109","article-title":"In\u00a0vivo reprogramming of Sox9+ cells in the liver to insulin-secreting ducts","volume":"109","author":"Banga","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"Suppl 1","key":"10.1016\/j.stem.2017.11.020_bib7","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/j.1463-1326.2011.01440.x","article-title":"Transcriptional regulation of \u03b1-cell differentiation","volume":"13","author":"Bramswig","year":"2011","journal-title":"Diabetes Obes. Metab."},{"key":"10.1016\/j.stem.2017.11.020_bib8","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1172\/JCI66514","article-title":"Epigenomic plasticity enables human pancreatic \u03b1 to \u03b2 cell reprogramming","volume":"123","author":"Bramswig","year":"2013","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.stem.2017.11.020_bib9","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/j.cmet.2014.11.004","article-title":"Impaired islet function in commonly used transgenic mouse lines due to human growth hormone minigene expression","volume":"20","author":"Brouwers","year":"2014","journal-title":"Cell Metab."},{"key":"10.1016\/j.stem.2017.11.020_bib10","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1111\/j.1600-6143.2007.01777.x","article-title":"Pretransplant HLA antibodies are associated with reduced graft survival after clinical islet transplantation","volume":"7","author":"Campbell","year":"2007","journal-title":"Am. J. Transplant."},{"key":"10.1016\/j.stem.2017.11.020_bib11","doi-asserted-by":"crossref","DOI":"10.14814\/phy2.12863","article-title":"Unexpected effects of the MIP-CreER transgene and tamoxifen on \u03b2-cell growth in C57Bl6\/J male mice","volume":"4","author":"Carboneau","year":"2016","journal-title":"Physiol. Rep."},{"key":"10.1016\/j.stem.2017.11.020_bib12","doi-asserted-by":"crossref","first-page":"4493","DOI":"10.1210\/en.2013-1463","article-title":"Pancreatic duct ligation after almost complete \u03b2-cell loss: Exocrine regeneration but no evidence of \u03b2-cell regeneration","volume":"154","author":"Cavelti-Weder","year":"2013","journal-title":"Endocrinology"},{"key":"10.1016\/j.stem.2017.11.020_bib13","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/j.cmet.2017.01.009","article-title":"Converting adult pancreatic islet \u03b1 cells into \u03b2 cells by targeting both Dnmt1 and Arx","volume":"25","author":"Chakravarthy","year":"2017","journal-title":"Cell Metab."},{"key":"10.1016\/j.stem.2017.11.020_bib14","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/nature13633","article-title":"Diabetes recovery by age-dependent conversion of pancreatic \u03b4-cells into insulin producers","volume":"514","author":"Chera","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.stem.2017.11.020_bib15","doi-asserted-by":"crossref","first-page":"e43959","DOI":"10.1371\/journal.pone.0043959","article-title":"Beta cell count instead of beta cell mass to assess and localize growth in beta cell population following pancreatic duct ligation in mice","volume":"7","author":"Chintinne","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.stem.2017.11.020_bib16","doi-asserted-by":"crossref","first-page":"44","DOI":"10.2337\/diab.42.1.44","article-title":"Adoptive transfer of diabetes into immunodeficient NOD-scid\/scid mice. Relative contributions of CD4+ and CD8+ T-cells from diabetic versus prediabetic NOD.NON-Thy-1a donors","volume":"42","author":"Christianson","year":"1993","journal-title":"Diabetes"},{"key":"10.1016\/j.stem.2017.11.020_bib17","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.cell.2009.05.035","article-title":"The ectopic expression of Pax4 in the mouse pancreas converts progenitor cells into alpha and subsequently beta cells","volume":"138","author":"Collombat","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.stem.2017.11.020_bib18","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.2337\/db11-1591","article-title":"Modulation of redox balance leaves murine diabetogenic TH1 T\u00a0cells \u201cLAG-3-ing\u201d behind","volume":"61","author":"Delmastro","year":"2012","journal-title":"Diabetes"},{"key":"10.1016\/j.stem.2017.11.020_bib19","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1172\/JCI29988","article-title":"Preexisting pancreatic acinar cells contribute to acinar cell, but not islet beta cell, regeneration","volume":"117","author":"Desai","year":"2007","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.stem.2017.11.020_bib20","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/nature02520","article-title":"Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation","volume":"429","author":"Dor","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.stem.2017.11.020_bib21","doi-asserted-by":"crossref","first-page":"9253","DOI":"10.1073\/pnas.91.20.9253","article-title":"Major species differences between humans and rodents in the susceptibility to pancreatic beta-cell injury","volume":"91","author":"Eizirik","year":"1994","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.stem.2017.11.020_bib22","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1006\/dbio.2001.0359","article-title":"Regulatory regions driving developmental and tissue-specific expression of the essential pancreatic gene pdx1","volume":"238","author":"Gannon","year":"2001","journal-title":"Dev. Biol."},{"key":"10.1016\/j.stem.2017.11.020_bib23","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1172\/JCI22098","article-title":"Beta cell replication is the primary mechanism for maintaining postnatal beta cell mass","volume":"114","author":"Georgia","year":"2004","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.stem.2017.11.020_bib24","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.jviromet.2012.04.004","article-title":"Rapid and simplified purification of recombinant adeno-associated virus","volume":"183","author":"Guo","year":"2012","journal-title":"J.\u00a0Virol. Methods"},{"key":"10.1016\/j.stem.2017.11.020_bib25","doi-asserted-by":"crossref","first-page":"103","DOI":"10.4161\/bioe.22293","article-title":"A simplified purification method for AAV variant by Polyethylene Glycol aqueous two-phase partitioning","volume":"4","author":"Guo","year":"2012","journal-title":"Bioengineered"},{"key":"10.1016\/j.stem.2017.11.020_bib26","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.tem.2011.05.003","article-title":"MafA and MafB activity in pancreatic \u03b2 cells","volume":"22","author":"Hang","year":"2011","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.stem.2017.11.020_bib27","doi-asserted-by":"crossref","first-page":"2317","DOI":"10.1242\/dev.127.11.2317","article-title":"Adult insulin- and glucagon-producing cells differentiate from two independent cell lineages","volume":"127","author":"Herrera","year":"2000","journal-title":"Development"},{"key":"10.1016\/j.stem.2017.11.020_bib28","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1002\/dvg.20411","article-title":"Robust acinar cell transgene expression of CreErT via BAC recombineering","volume":"46","author":"Ji","year":"2008","journal-title":"Genesis"},{"key":"10.1016\/j.stem.2017.11.020_bib29","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1007\/s00125-011-2070-3","article-title":"In\u00a0vivo genetic engineering of murine pancreatic beta cells mediated by single-stranded adeno-associated viral vectors of serotypes 6, 8 and 9","volume":"54","author":"Jimenez","year":"2011","journal-title":"Diabetologia"},{"key":"10.1016\/j.stem.2017.11.020_bib30","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1242\/dev.053843","article-title":"Lineage tracing reveals the dynamic contribution of Hes1+ cells to the developing and adult pancreas","volume":"138","author":"Kopinke","year":"2011","journal-title":"Development"},{"key":"10.1016\/j.stem.2017.11.020_bib31","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.4161\/cc.10.12.16010","article-title":"Progenitor cell domains in the developing and adult pancreas","volume":"10","author":"Kopp","year":"2011","journal-title":"Cell Cycle"},{"key":"10.1016\/j.stem.2017.11.020_bib32","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1242\/dev.056499","article-title":"Sox9+ ductal cells are multipotent progenitors throughout development but do not produce new endocrine cells in the normal or injured adult pancreas","volume":"138","author":"Kopp","year":"2011","journal-title":"Development"},{"key":"10.1016\/j.stem.2017.11.020_bib33","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.cmet.2009.12.005","article-title":"Ductal origin hypothesis of pancreatic regeneration under attack","volume":"11","author":"Kushner","year":"2010","journal-title":"Cell Metab."},{"key":"10.1016\/j.stem.2017.11.020_bib34","doi-asserted-by":"crossref","first-page":"e00940","DOI":"10.7554\/eLife.00940","article-title":"Expansion and conversion of human pancreatic ductal cells into insulin-secreting endocrine cells","volume":"2","author":"Lee","year":"2013","journal-title":"eLife"},{"key":"10.1016\/j.stem.2017.11.020_bib35","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1038\/nbt.3082","article-title":"Long-term persistence and development of induced pancreatic beta cells generated by lineage conversion of acinar cells","volume":"32","author":"Li","year":"2014","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.stem.2017.11.020_bib36","doi-asserted-by":"crossref","first-page":"2292","DOI":"10.2337\/db09-0257","article-title":"Importance of extranuclear estrogen receptor-alpha and membrane G protein-coupled estrogen receptor in pancreatic islet survival","volume":"58","author":"Liu","year":"2009","journal-title":"Diabetes"},{"key":"10.1016\/j.stem.2017.11.020_bib37","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.1053\/j.gastro.2010.01.046","article-title":"Alpha cell-specific Men1 ablation triggers the transdifferentiation of glucagon-expressing cells and insulinoma development","volume":"138","author":"Lu","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1016\/j.stem.2017.11.020_bib38","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.2337\/db07-1369","article-title":"Beta-cell replication is the primary mechanism subserving the postnatal expansion of beta-cell mass in humans","volume":"57","author":"Meier","year":"2008","journal-title":"Diabetes"},{"key":"10.1016\/j.stem.2017.11.020_bib39","doi-asserted-by":"crossref","first-page":"3798","DOI":"10.2337\/db15-0272","article-title":"Phenotypic characterization of MIP-CreERT1Lphi mice with transgene-driven islet expression of human growth hormone","volume":"64","author":"Oropeza","year":"2015","journal-title":"Diabetes"},{"key":"10.1016\/j.stem.2017.11.020_bib40","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1242\/dev.090159","article-title":"Spatiotemporal patterns of multipotentiality in Ptf1a-expressing cells during pancreas organogenesis and injury-induced facultative restoration","volume":"140","author":"Pan","year":"2013","journal-title":"Development"},{"key":"10.1016\/j.stem.2017.11.020_bib41","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1002\/dmr.5610080303","article-title":"Pancreatic beta cells in insulin-dependent diabetes","volume":"8","author":"Pipeleers","year":"1992","journal-title":"Diabetes Metab. Rev."},{"key":"10.1016\/j.stem.2017.11.020_bib42","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1111\/j.1749-6632.2002.tb02948.x","article-title":"A view on beta cell transplantation in diabetes","volume":"958","author":"Pipeleers","year":"2002","journal-title":"Ann. N Y Acad. Sci."},{"issue":"Suppl 4","key":"10.1016\/j.stem.2017.11.020_bib43","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1111\/j.1463-1326.2008.00941.x","article-title":"Restoring a functional beta-cell mass in diabetes","volume":"10","author":"Pipeleers","year":"2008","journal-title":"Diabetes Obes. Metab."},{"key":"10.1016\/j.stem.2017.11.020_bib44","first-page":"2166","article-title":"Prevention of both rejection and recurrence of autoimmune disease in the NOD\/Lt mouse following segmental pancreas transplantation","volume":"27","author":"Purcell","year":"1995","journal-title":"Transplant. Proc."},{"key":"10.1016\/j.stem.2017.11.020_bib45","doi-asserted-by":"crossref","first-page":"294","DOI":"10.2174\/15733998113099990063","article-title":"Pancreatic islet transplantation in type 1 diabetes mellitus: An update on recent developments","volume":"9","author":"Ramesh","year":"2013","journal-title":"Curr. Diabetes Rev."},{"key":"10.1016\/j.stem.2017.11.020_bib46","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.2337\/db12-0848","article-title":"\u03b2-Cells are not generated in pancreatic duct ligation-induced injury in adult mice","volume":"62","author":"Rankin","year":"2013","journal-title":"Diabetes"},{"key":"10.1016\/j.stem.2017.11.020_bib47","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1210\/mend.16.3.0794","article-title":"A nonclassical estrogen membrane receptor triggers rapid differential actions in the endocrine pancreas","volume":"16","author":"Ropero","year":"2002","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.stem.2017.11.020_bib48","doi-asserted-by":"crossref","first-page":"E1030","DOI":"10.1152\/ajpendo.00022.2013","article-title":"\u03b1-Cells are dispensable in postnatal morphogenesis and maturation of mouse pancreatic islets","volume":"305","author":"Shiota","year":"2013","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.stem.2017.11.020_bib49","doi-asserted-by":"crossref","first-page":"2399","DOI":"10.1007\/s00125-017-4425-x","article-title":"Gcg CreERT2 knockin mice as a tool for genetic manipulation in pancreatic alpha cells","volume":"60","author":"Shiota","year":"2017","journal-title":"Diabetologia"},{"key":"10.1016\/j.stem.2017.11.020_bib50","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/j.devcel.2009.11.003","article-title":"Pancreatic exocrine duct cells give rise to insulin-producing beta cells during embryogenesis but not after birth","volume":"17","author":"Solar","year":"2009","journal-title":"Dev. Cell"},{"key":"10.1016\/j.stem.2017.11.020_bib51","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/j.devcel.2007.04.011","article-title":"Growth and regeneration of adult beta cells does not involve specialized progenitors","volume":"12","author":"Teta","year":"2007","journal-title":"Dev. Cell"},{"key":"10.1016\/j.stem.2017.11.020_bib52","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1038\/nature08894","article-title":"Conversion of adult pancreatic alpha-cells to beta-cells after extreme beta-cell loss","volume":"464","author":"Thorel","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.stem.2017.11.020_bib53","doi-asserted-by":"crossref","first-page":"2872","DOI":"10.2337\/db11-0876","article-title":"Normal glucagon signaling and \u03b2-cell function after near-total \u03b1-cell ablation in adult mice","volume":"60","author":"Thorel","year":"2011","journal-title":"Diabetes"},{"key":"10.1016\/j.stem.2017.11.020_bib54","doi-asserted-by":"crossref","first-page":"3331","DOI":"10.1172\/JCI44564","article-title":"Estrogen receptor activation reduces lipid synthesis in pancreatic islets and prevents \u03b2 cell failure in rodent models of type 2 diabetes","volume":"121","author":"Tiano","year":"2011","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.stem.2017.11.020_bib55","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1007\/s00125-014-3416-4","article-title":"Beta cell regeneration after single-round immunological destruction in a mouse model","volume":"58","author":"Tonne","year":"2014","journal-title":"Diabetologia"},{"key":"10.1016\/j.stem.2017.11.020_bib56","doi-asserted-by":"crossref","first-page":"947","DOI":"10.2337\/db09-0498","article-title":"Recurrence of type 1 diabetes after simultaneous pancreas-kidney transplantation, despite immunosuppression, is associated with autoantibodies and pathogenic autoreactive CD4 T-cells","volume":"59","author":"Vendrame","year":"2010","journal-title":"Diabetes"},{"key":"10.1016\/j.stem.2017.11.020_bib57","first-page":"727","article-title":"Islet transplantation as a treatment for diabetes","volume":"69","author":"Weir","year":"1998","journal-title":"J.\u00a0Am. Optom. Assoc."},{"key":"10.1016\/j.stem.2017.11.020_bib58","doi-asserted-by":"crossref","first-page":"2207","DOI":"10.1172\/JCI66323","article-title":"No evidence for \u03b2 cell neogenesis in murine adult pancreas","volume":"123","author":"Xiao","year":"2013","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.stem.2017.11.020_bib59","doi-asserted-by":"crossref","first-page":"8636","DOI":"10.1074\/jbc.M112.422949","article-title":"Hypoglycemia reduces vascular endothelial growth factor A production by pancreatic beta cells as a regulator of beta cell mass","volume":"288","author":"Xiao","year":"2013","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.stem.2017.11.020_bib60","doi-asserted-by":"crossref","first-page":"25297","DOI":"10.1074\/jbc.M113.484022","article-title":"Neurogenin3 activation is not sufficient to direct duct-to-beta cell transdifferentiation in the adult pancreas","volume":"288","author":"Xiao","year":"2013","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.stem.2017.11.020_bib61","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.2337\/db12-1428","article-title":"TGF\u03b2 receptor signaling is essential for inflammation-induced but not \u03b2-cell workload-induced \u03b2-cell proliferation","volume":"62","author":"Xiao","year":"2013","journal-title":"Diabetes"},{"key":"10.1016\/j.stem.2017.11.020_bib62","doi-asserted-by":"crossref","first-page":"E1211","DOI":"10.1073\/pnas.1321347111","article-title":"M2 macrophages promote beta-cell proliferation by up-regulation of SMAD7","volume":"111","author":"Xiao","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.stem.2017.11.020_bib63","doi-asserted-by":"crossref","first-page":"2719","DOI":"10.1038\/nprot.2014.183","article-title":"Pancreatic cell tracing, lineage tagging and targeted genetic manipulations in multiple cell types using pancreatic ductal infusion of adeno-associated viral vectors and\/or cell-tagging dyes","volume":"9","author":"Xiao","year":"2014","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.stem.2017.11.020_bib64","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1007\/s00125-014-3179-y","article-title":"Pancreatic duct cells as a source of VEGF in mice","volume":"57","author":"Xiao","year":"2014","journal-title":"Diabetologia"},{"key":"10.1016\/j.stem.2017.11.020_bib65","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1210\/en.2015-1986","article-title":"Transient suppression of transforming growth factor beta receptor signaling facilitates human islet transplantation","volume":"157","author":"Xiao","year":"2016","journal-title":"Endocrinology"},{"key":"10.1016\/j.stem.2017.11.020_bib66","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1101\/gad.16875711","article-title":"Context-specific \u03b1- to-\u03b2-cell reprogramming by forced Pdx1 expression","volume":"25","author":"Yang","year":"2011","journal-title":"Genes Dev."},{"key":"10.1016\/j.stem.2017.11.020_bib67","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1126\/science.1161431","article-title":"Generation and regeneration of cells of the liver and pancreas","volume":"322","author":"Zaret","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.stem.2017.11.020_bib68","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1038\/4641132a","article-title":"Diabetes forum: Extreme makeover of pancreatic alpha-cells","volume":"464","author":"Zaret","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.stem.2017.11.020_bib69","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1038\/nature07314","article-title":"In\u00a0vivo reprogramming of adult pancreatic exocrine cells to beta-cells","volume":"455","author":"Zhou","year":"2008","journal-title":"Nature"}],"container-title":["Cell Stem Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1934590917304721?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1934590917304721?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T13:46:04Z","timestamp":1761831964000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1934590917304721"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":69,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["S1934590917304721"],"URL":"https:\/\/doi.org\/10.1016\/j.stem.2017.11.020","relation":{},"ISSN":["1934-5909"],"issn-type":[{"value":"1934-5909","type":"print"}],"subject":[],"published":{"date-parts":[[2018,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Endogenous Reprogramming of Alpha Cells into Beta Cells, Induced by Viral Gene Therapy, Reverses Autoimmune Diabetes","name":"articletitle","label":"Article Title"},{"value":"Cell Stem Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.stem.2017.11.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}