{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T14:57:46Z","timestamp":1792508266800,"version":"4.5.0"},"reference-count":45,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,3,5]],"date-time":"2021-03-05T00:00:00Z","timestamp":1614902400000},"content-version":"vor","delay-in-days":369,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Stem Cell"],"published-print":{"date-parts":[[2020,3]]},"DOI":"10.1016\/j.stem.2019.12.014","type":"journal-article","created":{"date-parts":[[2020,1,23]],"date-time":"2020-01-23T16:35:30Z","timestamp":1579797330000},"page":"346-358.e4","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":245,"title":["Distinct Airway Epithelial Stem Cells Hide among Club Cells but Mobilize to Promote Alveolar Regeneration"],"prefix":"10.1016","volume":"26","author":[{"given":"Jaymin J.","family":"Kathiriya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis N.","family":"Brumwell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia R.","family":"Jackson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodan","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harold A.","family":"Chapman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.stem.2019.12.014_bib1","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.stem.2011.09.001","article-title":"Sox2(+) adult stem and progenitor cells are important for tissue regeneration and survival of mice","volume":"9","author":"Arnold","year":"2011","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.stem.2019.12.014_bib2","doi-asserted-by":"crossref","first-page":"3025","DOI":"10.1172\/JCI68782","article-title":"Type 2 alveolar cells are stem cells in adult lung","volume":"123","author":"Barkauskas","year":"2013","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.stem.2019.12.014_bib3","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1126\/science.1097676","article-title":"Regeneration of male germline stem cells by spermatogonial dedifferentiation in\u00a0vivo","volume":"304","author":"Brawley","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.stem.2019.12.014_bib4","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1038\/nrm881","article-title":"Plasticity and reprogramming of differentiated cells in amphibian regeneration","volume":"3","author":"Brockes","year":"2002","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.stem.2019.12.014_bib5","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1080\/01926230701302558","article-title":"Time-dependent airway epithelial and inflammatory cell responses induced by influenza virus A\/PR\/8\/34 in C57BL\/6 mice","volume":"35","author":"Buchweitz","year":"2007","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.stem.2019.12.014_bib46","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/nbt.4096","article-title":"Integrating single-cell transcriptomic data across different conditions, technologies, and species","volume":"36","author":"Butler","year":"2018","journal-title":"Nature Biotechnology"},{"issue":"Suppl 5","key":"10.1016\/j.stem.2019.12.014_bib7","doi-asserted-by":"crossref","first-page":"S402","DOI":"10.1513\/AnnalsATS.201609-703AW","article-title":"Cellular senescence and lung function during aging. Yin and yang","volume":"13","author":"Campisi","year":"2016","journal-title":"Ann. Am. Thorac. Soc."},{"key":"10.1016\/j.stem.2019.12.014_bib8","doi-asserted-by":"crossref","first-page":"2855","DOI":"10.1172\/JCI57673","article-title":"Integrin \u03b16\u03b24 identifies an adult distal lung epithelial population with regenerative potential in mice","volume":"121","author":"Chapman","year":"2011","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.stem.2019.12.014_bib9","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1038\/ncb3585","article-title":"Origin and regulation of a lung repair kit","volume":"19","author":"Chen","year":"2017","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.stem.2019.12.014_bib10","doi-asserted-by":"crossref","first-page":"RA148","DOI":"10.12659\/MSM.881801","article-title":"Influenza virus and cell signaling pathways","volume":"17","author":"Gaur","year":"2011","journal-title":"Med. Sci. Monit."},{"key":"10.1016\/j.stem.2019.12.014_bib11","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1165\/rcmb.2018-0410TR","article-title":"Cellular senescence: the trojan horse in chronic lung diseases","volume":"61","author":"Hamsanathan","year":"2019","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.stem.2019.12.014_bib12","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.stem.2014.07.012","article-title":"Repair and regeneration of the respiratory system: complexity, plasticity, and mechanisms of lung stem cell function","volume":"15","author":"Hogan","year":"2014","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.stem.2019.12.014_bib13","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1038\/nature02436","article-title":"Differentiating germ cells can revert into functional stem cells in Drosophila melanogaster ovaries","volume":"428","author":"Kai","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.stem.2019.12.014_bib14","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.stem.2018.04.014","article-title":"Single-cell transcriptomics meets lineage tracing","volume":"23","author":"Kester","year":"2018","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.stem.2019.12.014_bib15","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/j.cell.2005.03.032","article-title":"Identification of bronchioalveolar stem cells in normal lung and lung cancer","volume":"121","author":"Kim","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.stem.2019.12.014_bib16","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1038\/nature08152","article-title":"Cells keep a memory of their tissue origin during axolotl limb regeneration","volume":"460","author":"Kragl","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.stem.2019.12.014_bib17","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.cell.2011.10.001","article-title":"Distal airway stem cells yield alveoli in\u00a0vitro and during lung regeneration following H1N1 influenza infection","volume":"147","author":"Kumar","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.stem.2019.12.014_bib18","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1038\/s41586-018-0414-6","article-title":"RNA velocity of single cells","volume":"560","author":"La Manno","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.stem.2019.12.014_bib19","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1016\/j.cell.2017.07.028","article-title":"Anatomically and functionally distinct lung mesenchymal populations marked by Lgr5 and Lgr6","volume":"170","author":"Lee","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.stem.2019.12.014_bib20","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1038\/s41588-019-0346-6","article-title":"Lung regeneration by multipotent stem cells residing at the bronchioalveolar-duct junction","volume":"51","author":"Liu","year":"2019","journal-title":"Nat. Genet."},{"key":"10.1016\/j.stem.2019.12.014_bib21","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/nn.2467","article-title":"A robust and high-throughput Cre reporting and characterization system for the whole mouse brain","volume":"13","author":"Madisen","year":"2010","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.stem.2019.12.014_bib22","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.1016\/j.celrep.2016.11.007","article-title":"p53 regulates progenitor cell quiescence and differentiation in the airway","volume":"17","author":"McConnell","year":"2016","journal-title":"Cell Rep."},{"key":"10.1016\/j.stem.2019.12.014_bib23","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1080\/14712598.2019.1596256","article-title":"Endogenous lung stem cells for lung regeneration","volume":"19","author":"McQualter","year":"2019","journal-title":"Expert Opin. Biol. Ther."},{"key":"10.1016\/j.stem.2019.12.014_bib24","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1073\/pnas.0909207107","article-title":"Evidence of an epithelial stem\/progenitor cell hierarchy in the adult mouse lung","volume":"107","author":"McQualter","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.stem.2019.12.014_bib25","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1002\/dvg.20335","article-title":"A global double-fluorescent Cre reporter mouse","volume":"45","author":"Muzumdar","year":"2007","journal-title":"Genesis"},{"key":"10.1016\/j.stem.2019.12.014_bib26","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1126\/science.aam6603","article-title":"Single-cell Wnt signaling niches maintain stemness of alveolar type 2 cells","volume":"359","author":"Nabhan","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.stem.2019.12.014_bib27","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1038\/nmeth.4498","article-title":"Isolation and 3D expansion of multipotent Sox9+ mouse lung progenitors","volume":"14","author":"Nichane","year":"2017","journal-title":"Nat. Methods"},{"key":"10.1016\/j.stem.2019.12.014_bib28","doi-asserted-by":"crossref","DOI":"10.1242\/dev.160788","article-title":"\u03b2-Catenin maintains lung epithelial progenitors after lung specification","volume":"145","author":"Ostrin","year":"2018","journal-title":"Development"},{"key":"10.1016\/j.stem.2019.12.014_bib29","doi-asserted-by":"crossref","first-page":"e1005544","DOI":"10.1371\/journal.ppat.1005544","article-title":"Influenza virus infects epithelial stem\/progenitor cells of the distal lung: impact on Fgfr2b-driven epithelial repair","volume":"12","author":"Quantius","year":"2016","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.stem.2019.12.014_bib30","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.stem.2009.04.002","article-title":"The role of Scgb1a1+ Clara cells in the long-term maintenance and repair of lung airway, but not alveolar, epithelium","volume":"4","author":"Rawlins","year":"2009","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.stem.2019.12.014_bib31","doi-asserted-by":"crossref","first-page":"2845","DOI":"10.1242\/dev.069088","article-title":"Satellite cells are essential for skeletal muscle regeneration: the cell on the edge returns centre stage","volume":"139","author":"Relaix","year":"2012","journal-title":"Development"},{"key":"10.1016\/j.stem.2019.12.014_bib32","doi-asserted-by":"crossref","first-page":"e102099","DOI":"10.15252\/embj.2019102099","article-title":"Bronchioalveolar stem cells are a main source for regeneration of distal lung epithelia in\u00a0vivo","volume":"38","author":"Salwig","year":"2019","journal-title":"EMBO J."},{"key":"10.1016\/j.stem.2019.12.014_bib33","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1006\/cimm.2001.1895","article-title":"Observation of antigen-dependent CD8+ T-cell\/ dendritic cell interactions in\u00a0vivo","volume":"214","author":"Schaefer","year":"2001","journal-title":"Cell. Immunol."},{"key":"10.1016\/j.stem.2019.12.014_bib34","article-title":"Longitudinal single cell transcriptomics reveals Krt8+ alveolar epithelial progenitors in lung regeneration","author":"Strunz","year":"2019","journal-title":"bioRxiv"},{"key":"10.1016\/j.stem.2019.12.014_bib35","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1016\/j.cell.2019.05.031","article-title":"Comprehensive integration of single-cell data","volume":"177","author":"Stuart","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.stem.2019.12.014_bib36","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1038\/nature12777","article-title":"Dedifferentiation of committed epithelial cells into stem cells in\u00a0vivo","volume":"503","author":"Tata","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.stem.2019.12.014_bib37","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1038\/nature14112","article-title":"Lineage-negative progenitors mobilize to regenerate lung epithelium after major injury","volume":"517","author":"Vaughan","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.stem.2019.12.014_bib38","doi-asserted-by":"crossref","DOI":"10.1038\/s41536-019-0080-9","article-title":"Mesenchyme-free expansion and transplantation of adult alveolar progenitor cells: steps toward cell-based regenerative therapies","author":"Weiner","year":"2019","journal-title":"npj Reg. Med."},{"key":"10.1016\/j.stem.2019.12.014_bib39","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1038\/ncb3580","article-title":"Local lung hypoxia determines epithelial fate decisions during alveolar regeneration","volume":"19","author":"Xi","year":"2017","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.stem.2019.12.014_bib40","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/j.devcel.2018.03.001","article-title":"Spatial-temporal lineage restrictions of embryonic p63+ progenitors establish distinct stem cell pools in adult airways","volume":"44","author":"Yang","year":"2018","journal-title":"Dev. Cell"},{"key":"10.1016\/j.stem.2019.12.014_bib41","doi-asserted-by":"crossref","first-page":"L1315","DOI":"10.1152\/ajplung.00169.2002","article-title":"Growth and differentiation of mouse tracheal epithelial cells: selection of a proliferative population","volume":"283","author":"You","year":"2002","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.stem.2019.12.014_bib42","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/nature25786","article-title":"Regeneration of the lung alveolus by an evolutionarily conserved epithelial progenitor","volume":"555","author":"Zacharias","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.stem.2019.12.014_bib43","doi-asserted-by":"crossref","first-page":"e48451","DOI":"10.1371\/journal.pone.0048451","article-title":"Regeneration of alveolar type I and II cells from Scgb1a1-expressing cells following severe pulmonary damage induced by bleomycin and influenza","volume":"7","author":"Zheng","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.stem.2019.12.014_bib44","doi-asserted-by":"crossref","first-page":"41661","DOI":"10.1038\/srep41661","article-title":"Differentiation of club cells to alveolar epithelial cells in\u00a0vitro","volume":"7","author":"Zheng","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.stem.2019.12.014_bib45","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1038\/nature13903","article-title":"p63(+)Krt5(+) distal airway stem cells are essential for lung regeneration","volume":"517","author":"Zuo","year":"2015","journal-title":"Nature"}],"container-title":["Cell Stem Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1934590919305727?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1934590919305727?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T13:49:40Z","timestamp":1761832180000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1934590919305727"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3]]},"references-count":45,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["S1934590919305727"],"URL":"https:\/\/doi.org\/10.1016\/j.stem.2019.12.014","relation":{},"ISSN":["1934-5909"],"issn-type":[{"value":"1934-5909","type":"print"}],"subject":[],"published":{"date-parts":[[2020,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Distinct Airway Epithelial Stem Cells Hide among Club Cells but Mobilize to Promote Alveolar Regeneration","name":"articletitle","label":"Article Title"},{"value":"Cell Stem Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.stem.2019.12.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}