{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T10:12:48Z","timestamp":1792663968872,"version":"4.5.0"},"reference-count":74,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100010327","name":"Cincinnati Children\u2019s Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010327","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000871","name":"Mayo Clinic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005492","name":"Stanford University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005492","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Stem Cell"],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1016\/j.stem.2020.07.015","type":"journal-article","created":{"date-parts":[[2020,8,17]],"date-time":"2020-08-17T11:02:45Z","timestamp":1597662165000},"page":"574-589.e8","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":170,"title":["Intrinsic Endocardial Defects Contribute to Hypoplastic Left Heart Syndrome"],"prefix":"10.1016","volume":"27","author":[{"given":"Yifei","family":"Miao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcy","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon L.","family":"Paige","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco X.","family":"Galdos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jibiao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alyssa","family":"Klein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuning","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Stewart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soah","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan-Renier","family":"Moonen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Grossfeld","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seema","family":"Mital","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Chitayat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph C.","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marlene","family":"Rabinovitch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy J.","family":"Nelson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuyi","family":"Nie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean M.","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingxia","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.stem.2020.07.015_bib1","doi-asserted-by":"crossref","first-page":"178","DOI":"10.3389\/fcell.2020.00178","article-title":"A Brief Review of Current Maturation Methods for Human Induced Pluripotent Stem Cells-Derived Cardiomyocytes","volume":"8","author":"Ahmed","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.stem.2020.07.015_bib2","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/75556","article-title":"Gene ontology: tool for the unification of biology","volume":"25","author":"Ashburner","year":"2000","journal-title":"Nat. Genet."},{"key":"10.1016\/j.stem.2020.07.015_bib3","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1002\/btm2.10062","article-title":"Human pluripotent stem cell-derived epicardial progenitors can differentiate to endocardial-like endothelial cells","volume":"2","author":"Bao","year":"2017","journal-title":"Bioeng. Transl. Med."},{"key":"10.1016\/j.stem.2020.07.015_bib4","doi-asserted-by":"crossref","first-page":"2545","DOI":"10.1007\/s00018-015-1885-3","article-title":"Blood flow mechanics in cardiovascular development","volume":"72","author":"Boselli","year":"2015","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.stem.2020.07.015_bib5","doi-asserted-by":"crossref","first-page":"E32","DOI":"10.1542\/peds.107.3.e32","article-title":"Racial and temporal variations in the prevalence of heart defects","volume":"107","author":"Botto","year":"2001","journal-title":"Pediatrics"},{"key":"10.1016\/j.stem.2020.07.015_bib6","doi-asserted-by":"crossref","first-page":"4149","DOI":"10.1242\/dev.110007","article-title":"Reciprocal myocardial-endocardial interactions pattern the delay in atrioventricular junction conduction","volume":"141","author":"Bressan","year":"2014","journal-title":"Development"},{"key":"10.1016\/j.stem.2020.07.015_bib7","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1056\/NEJM200001273420407","article-title":"Congenital heart disease in adults. First of two parts","volume":"342","author":"Brickner","year":"2000","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.stem.2020.07.015_bib8","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1038\/nmeth.2999","article-title":"Chemically defined generation of human cardiomyocytes","volume":"11","author":"Burridge","year":"2014","journal-title":"Nat. Methods"},{"key":"10.1016\/j.stem.2020.07.015_bib9","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/nbt.4096","article-title":"Integrating single-cell transcriptomic data across different conditions, technologies, and species","volume":"36","author":"Butler","year":"2018","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.stem.2020.07.015_bib10","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1146\/annurev.ph.53.030191.001113","article-title":"Control of growth and differentiation of vascular cells by extracellular matrix proteins","volume":"53","author":"Carey","year":"1991","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.stem.2020.07.015_bib11","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.ydbio.2015.09.016","article-title":"Fibronectin signals through integrin \u03b15\u03b21 to regulate cardiovascular development in a cell type-specific manner","volume":"407","author":"Chen","year":"2015","journal-title":"Dev. Biol."},{"key":"10.1016\/j.stem.2020.07.015_bib12","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1101\/gad.246173.114","article-title":"Stably paused genes revealed through inhibition of transcription initiation by the TFIIH inhibitor triptolide","volume":"29","author":"Chen","year":"2015","journal-title":"Genes Dev."},{"key":"10.1016\/j.stem.2020.07.015_bib13","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1038\/s41467-017-00405-x","article-title":"VEGF amplifies transcription through ETS1 acetylation to enable angiogenesis","volume":"8","author":"Chen","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.stem.2020.07.015_bib14","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1161\/CIRCRESAHA.109.196469","article-title":"VEGF and RANKL regulation of NFATc1 in heart valve development","volume":"105","author":"Combs","year":"2009","journal-title":"Circ. Res."},{"key":"10.1016\/j.stem.2020.07.015_bib15","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1002\/ajmg.c.31590","article-title":"Clinical and molecular effects of CHD7 in the heart","volume":"175","author":"Corsten-Janssen","year":"2017","journal-title":"Am. J. Med. Genet. C. Semin. Med. Genet."},{"key":"10.1016\/j.stem.2020.07.015_bib16","doi-asserted-by":"crossref","first-page":"1934","DOI":"10.1016\/j.celrep.2019.01.079","article-title":"Single-Cell Transcriptome Analysis Maps the Developmental Track of the Human Heart","volume":"26","author":"Cui","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.stem.2020.07.015_bib17","doi-asserted-by":"crossref","first-page":"4223","DOI":"10.1111\/febs.13773","article-title":"Notch signalling in ventricular chamber development and cardiomyopathy","volume":"283","author":"D\u2019Amato","year":"2016","journal-title":"FEBS J."},{"key":"10.1016\/j.stem.2020.07.015_bib18","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1161\/CIRCRESAHA.112.267849","article-title":"Loss of adenomatous poliposis coli-\u03b13 integrin interaction promotes endothelial apoptosis in mice and humans","volume":"111","author":"de Jesus Perez","year":"2012","journal-title":"Circ. Res."},{"key":"10.1016\/j.stem.2020.07.015_bib19","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.devcel.2012.01.014","article-title":"Coordinating tissue interactions: Notch signaling in cardiac development and disease","volume":"22","author":"de la Pompa","year":"2012","journal-title":"Dev. Cell"},{"key":"10.1016\/j.stem.2020.07.015_bib20","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"key":"10.1016\/j.stem.2020.07.015_bib21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1161\/01.RES.77.1.1","article-title":"Molecular regulation of atrioventricular valvuloseptal morphogenesis","volume":"77","author":"Eisenberg","year":"1995","journal-title":"Circ. Res."},{"key":"10.1016\/j.stem.2020.07.015_bib22","series-title":"GeneAnswers, Integrated Interpretation of Genes","author":"Feng","year":"2018"},{"key":"10.1016\/j.stem.2020.07.015_bib23","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1016\/j.ajpath.2013.05.022","article-title":"Fetal reprogramming and senescence in hypoplastic left heart syndrome and in human pluripotent stem cells during cardiac differentiation","volume":"183","author":"Gaber","year":"2013","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.stem.2020.07.015_bib24","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1002\/dvdy.24661","article-title":"MMP14 Regulates Cranial Neural Crest Epithelial-to-Mesenchymal Transition and Migration","volume":"247","author":"Garmon","year":"2018","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.stem.2020.07.015_bib25","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1161\/CIRCRESAHA.115.304458","article-title":"Increased frequency of de novo copy number variants in congenital heart disease by integrative analysis of single nucleotide polymorphism array and exome sequence data","volume":"115","author":"Glessner","year":"2014","journal-title":"Circ. Res."},{"key":"10.1016\/j.stem.2020.07.015_bib26","article-title":"Hypoplastic Left Heart Syndrome: A New Paradigm for an Old Disease?","volume":"6","author":"Grossfeld","year":"2019","journal-title":"J.\u00a0Cardiovasc. Dev. Dis."},{"key":"10.1016\/j.stem.2020.07.015_bib27","doi-asserted-by":"crossref","DOI":"10.1002\/cphg.64","article-title":"Efficient Differentiation of Human Pluripotent Stem Cells to Endothelial Cells","author":"Gu","year":"2018","journal-title":"Curr. Protoc. Hum. Genet."},{"key":"10.1016\/j.stem.2020.07.015_bib28","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.stem.2016.08.019","article-title":"Patient-Specific iPSC-Derived Endothelial Cells Uncover Pathways that Protect against Pulmonary Hypertension in BMPR2 Mutation Carriers","volume":"20","author":"Gu","year":"2017","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.stem.2020.07.015_bib29","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/s00246-010-9642-8","article-title":"Development of the endocardium","volume":"31","author":"Harris","year":"2010","journal-title":"Pediatr. Cardiol."},{"key":"10.1016\/j.stem.2020.07.015_bib30","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1101\/gr.135350.111","article-title":"GENCODE: the reference human genome annotation for The ENCODE Project","volume":"22","author":"Harrow","year":"2012","journal-title":"Genome Res."},{"key":"10.1016\/j.stem.2020.07.015_bib31","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.molcel.2010.05.004","article-title":"Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities","volume":"38","author":"Heinz","year":"2010","journal-title":"Mol. Cell"},{"key":"10.1016\/j.stem.2020.07.015_bib32","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1016\/S0735-1097(02)01886-7","article-title":"The incidence of congenital heart disease","volume":"39","author":"Hoffman","year":"2002","journal-title":"J.\u00a0Am. Coll. Cardiol."},{"key":"10.1016\/j.stem.2020.07.015_bib33","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1126\/science.aac9396","article-title":"De novo mutations in congenital heart disease with neurodevelopmental and other congenital anomalies","volume":"350","author":"Homsy","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.stem.2020.07.015_bib34","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1161\/01.RES.87.6.508","article-title":"Synthesis of extracellular matrix and adhesion through beta(1) integrins are critical for fetal ventricular myocyte proliferation","volume":"87","author":"Hornberger","year":"2000","journal-title":"Circ. Res."},{"key":"10.1016\/j.stem.2020.07.015_bib35","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1002\/stem.2582","article-title":"NOTCH1-Dependent Nitric Oxide Signaling Deficiency in Hypoplastic Left Heart Syndrome Revealed Through Patient-Specific Phenotypes Detected in Bioengineered Cardiogenesis","volume":"35","author":"Hrstka","year":"2017","journal-title":"Stem Cells"},{"key":"10.1016\/j.stem.2020.07.015_bib36","doi-asserted-by":"crossref","first-page":"dev173047","DOI":"10.1242\/dev.173047","article-title":"Maturation of heart valve cell populations during postnatal remodeling","volume":"146","author":"Hulin","year":"2019","journal-title":"Development"},{"key":"10.1016\/j.stem.2020.07.015_bib37","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.devcel.2008.12.007","article-title":"Cardiac fibroblasts regulate myocardial proliferation through beta1 integrin signaling","volume":"16","author":"Ieda","year":"2009","journal-title":"Dev. Cell"},{"key":"10.1016\/j.stem.2020.07.015_bib38","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/j.tcb.2017.07.001","article-title":"The Mediator Complex: At the Nexus of RNA Polymerase II Transcription","volume":"27","author":"Jeronimo","year":"2017","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.stem.2020.07.015_bib39","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1038\/ng.3970","article-title":"Contribution of rare inherited and de novo variants in 2,871 congenital heart disease probands","volume":"49","author":"Jin","year":"2017","journal-title":"Nat. Genet."},{"key":"10.1016\/j.stem.2020.07.015_bib40","doi-asserted-by":"crossref","DOI":"10.3791\/61126","article-title":"Isolation of Endocardial and Coronary Endothelial Cells from the Ventricular Free Wall of the Rat Heart","author":"Klein","year":"2020","journal-title":"J.\u00a0Vis. Exp."},{"key":"10.1016\/j.stem.2020.07.015_bib41","doi-asserted-by":"crossref","first-page":"e102796","DOI":"10.1371\/journal.pone.0102796","article-title":"Directed differentiation of patient-specific induced pluripotent stem cells identifies the transcriptional repression and epigenetic modification of NKX2-5, HAND1, and NOTCH1 in hypoplastic left heart syndrome","volume":"9","author":"Kobayashi","year":"2014","journal-title":"PLoS ONE"},{"key":"10.1016\/j.stem.2020.07.015_bib42","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1093\/bioinformatics\/btt656","article-title":"featureCounts: an efficient general purpose program for assigning sequence reads to genomic features","volume":"30","author":"Liao","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.stem.2020.07.015_bib43","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1038\/ng.3870","article-title":"The complex genetics of hypoplastic left heart syndrome","volume":"49","author":"Liu","year":"2017","journal-title":"Nat. Genet."},{"key":"10.1016\/j.stem.2020.07.015_bib44","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.stem.2020.07.015_bib45","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1161\/CIRCRESAHA.115.305350","article-title":"Endocardial Notch Signaling in Cardiac Development and Disease","volume":"118","author":"Lux\u00e1n","year":"2016","journal-title":"Circ. Res."},{"key":"10.1016\/j.stem.2020.07.015_bib46","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/S0070-2153(10)92011-5","article-title":"Notch signaling in cardiac development and disease","volume":"92","author":"MacGrogan","year":"2010","journal-title":"Curr. Top. Dev. Biol."},{"key":"10.1016\/j.stem.2020.07.015_bib47","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1038\/s41467-017-02113-y","article-title":"Enhancer-associated long non-coding RNA LEENE regulates endothelial nitric oxide synthase and endothelial function","volume":"9","author":"Miao","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.stem.2020.07.015_bib48","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.ydbio.2013.06.010","article-title":"Fibronectin and integrin alpha 5 play requisite roles in cardiac morphogenesis","volume":"381","author":"Mittal","year":"2013","journal-title":"Dev. Biol."},{"key":"10.1016\/j.stem.2020.07.015_bib49","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1038\/s41467-019-09459-5","article-title":"Human pre-valvular endocardial cells derived from pluripotent stem cells recapitulate cardiac pathophysiological valvulogenesis","volume":"10","author":"Neri","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.stem.2020.07.015_bib50","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1164\/rccm.201412-2291OC","article-title":"Elafin Reverses Pulmonary Hypertension via Caveolin-1-Dependent Bone Morphogenetic Protein Signaling","volume":"191","author":"Nickel","year":"2015","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.stem.2020.07.015_bib51","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1093\/cvr\/cvv043","article-title":"Dual developmental role of transcriptional regulator Ets1 in Xenopus cardiac neural crest vs. heart mesoderm","volume":"106","author":"Nie","year":"2015","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.stem.2020.07.015_bib52","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1161\/CIRCRESAHA.118.312913","article-title":"Large-Scale Single-Cell RNA-Seq Reveals Molecular Signatures of Heterogeneous Populations of Human Induced Pluripotent Stem Cell-Derived Endothelial Cells","volume":"123","author":"Paik","year":"2018","journal-title":"Circ. Res."},{"key":"10.1016\/j.stem.2020.07.015_bib53","doi-asserted-by":"crossref","first-page":"dev163378","DOI":"10.1242\/dev.163378","article-title":"Bmp2 and Notch cooperate to pattern the embryonic endocardium","volume":"145","author":"Papoutsi","year":"2018","journal-title":"Development"},{"key":"10.1016\/j.stem.2020.07.015_bib54","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1007\/s10439-018-02171-3","article-title":"A Review of Integrin-Mediated Endothelial Cell Phenotype in the Design of Cardiovascular Devices","volume":"47","author":"Post","year":"2019","journal-title":"Ann. Biomed. Eng."},{"key":"10.1016\/j.stem.2020.07.015_bib55","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.ydbio.2011.03.026","article-title":"Essential roles of fibronectin in the development of the left-right embryonic body plan","volume":"354","author":"Pulina","year":"2011","journal-title":"Dev. Biol."},{"key":"10.1016\/j.stem.2020.07.015_bib56","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1164\/rccm.201606-1200OC","article-title":"Induced Pluripotent Stem Cell Model of Pulmonary Arterial Hypertension Reveals Novel Gene Expression and Patient Specificity","volume":"195","author":"Sa","year":"2017","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.stem.2020.07.015_bib57","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1007\/s00109-003-0456-5","article-title":"Form and function of developing heart valves: coordination by extracellular matrix and growth factor signaling","volume":"81","author":"Schroeder","year":"2003","journal-title":"J.\u00a0Mol. Med. (Berl.)"},{"key":"10.1016\/j.stem.2020.07.015_bib58","doi-asserted-by":"crossref","first-page":"6618","DOI":"10.1038\/s41598-018-24954-3","article-title":"Stage-specific Effects of Bioactive Lipids on Human iPSC Cardiac Differentiation and Cardiomyocyte Proliferation","volume":"8","author":"Sharma","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.stem.2020.07.015_bib59","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1091\/mbc.9.8.1969","article-title":"Integrin-mediated signaling events in human endothelial cells","volume":"9","author":"Short","year":"1998","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.stem.2020.07.015_bib60","first-page":"214","article-title":"Ectopic Noggin in a Population of Nfatc1 Lineage Endocardial Progenitors Induces Embryonic Lethality","volume":"1","author":"Snider","year":"2014","journal-title":"J.\u00a0Cardiovasc. Dev. Dis."},{"key":"10.1016\/j.stem.2020.07.015_bib61","doi-asserted-by":"crossref","first-page":"E4368","DOI":"10.1073\/pnas.1717920115","article-title":"Live-cell analysis of endogenous GFP-RPB1 uncovers rapid turnover of initiating and promoter-paused RNA Polymerase II","volume":"115","author":"Steurer","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.stem.2020.07.015_bib62","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1038\/s41586-018-0288-7","article-title":"Single-cell analysis of early progenitor cells that build coronary arteries","volume":"559","author":"Su","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.stem.2020.07.015_bib63","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1016\/j.cell.2015.02.035","article-title":"Human disease modeling reveals integrated transcriptional and epigenetic mechanisms of NOTCH1 haploinsufficiency","volume":"160","author":"Theodoris","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.stem.2020.07.015_bib64","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1161\/CIRCRESAHA.116.305097","article-title":"Cellular origin and developmental program of coronary angiogenesis","volume":"116","author":"Tian","year":"2015","journal-title":"Circ. Res."},{"key":"10.1016\/j.stem.2020.07.015_bib65","doi-asserted-by":"crossref","DOI":"10.1101\/mcs.a004010","article-title":"Partial Jacobsen syndrome phenotype in a patient with a de novo frameshift mutation in the ETS1 transcription factor","author":"Tootleman","year":"2019","journal-title":"Cold Spring Harb. Mol. Case Stud."},{"key":"10.1016\/j.stem.2020.07.015_bib66","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2217\/fca-2016-0071","article-title":"A developmental approach to induced pluripotent stem cells-based tissue engineered heart valves","volume":"13","author":"Vander Roest","year":"2017","journal-title":"Future Cardiol."},{"key":"10.1016\/j.stem.2020.07.015_bib67","doi-asserted-by":"crossref","first-page":"e60244","DOI":"10.1371\/journal.pone.0060244","article-title":"Endocardial to myocardial notch-wnt-bmp axis regulates early heart valve development","volume":"8","author":"Wang","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1016\/j.stem.2020.07.015_bib68","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.jvs.2018.06.195","article-title":"Molecular identity of arteries, veins, and lymphatics","volume":"69","author":"Wolf","year":"2019","journal-title":"J.\u00a0Vasc. Surg."},{"key":"10.1016\/j.stem.2020.07.015_bib69","doi-asserted-by":"crossref","first-page":"3031","DOI":"10.1093\/hmg\/ddx140","article-title":"Induced pluripotent stem cell modelling of HLHS underlines the contribution of dysfunctional NOTCH signalling to impaired cardiogenesis","volume":"26","author":"Yang","year":"2017","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.stem.2020.07.015_bib70","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1093\/hmg\/ddp532","article-title":"Deletion of ETS-1, a gene in the Jacobsen syndrome critical region, causes ventricular septal defects and abnormal ventricular morphology in mice","volume":"19","author":"Ye","year":"2010","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.stem.2020.07.015_bib71","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1038\/nature12141","article-title":"De novo mutations in histone-modifying genes in congenital heart disease","volume":"498","author":"Zaidi","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.stem.2020.07.015_bib72","doi-asserted-by":"crossref","first-page":"1880","DOI":"10.1161\/CIRCRESAHA.116.308749","article-title":"Endocardium Minimally Contributes to Coronary Endothelium in the Embryonic Ventricular Free Walls","volume":"118","author":"Zhang","year":"2016","journal-title":"Circ. Res."},{"key":"10.1016\/j.stem.2020.07.015_bib73","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1038\/cr.2017.103","article-title":"Fibroblasts in an endocardial fibroelastosis disease model mainly originate from mesenchymal derivatives of epicardium","volume":"27","author":"Zhang","year":"2017","journal-title":"Cell Res."},{"key":"10.1016\/j.stem.2020.07.015_bib74","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/j.celrep.2018.12.048","article-title":"Endocardial Notch Signaling Promotes Cardiomyocyte Proliferation in the Regenerating Zebrafish Heart through Wnt Pathway Antagonism","volume":"26","author":"Zhao","year":"2019","journal-title":"Cell Rep."}],"container-title":["Cell Stem Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1934590920303532?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1934590920303532?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T13:50:18Z","timestamp":1761832218000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1934590920303532"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10]]},"references-count":74,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["S1934590920303532"],"URL":"https:\/\/doi.org\/10.1016\/j.stem.2020.07.015","relation":{},"ISSN":["1934-5909"],"issn-type":[{"value":"1934-5909","type":"print"}],"subject":[],"published":{"date-parts":[[2020,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Intrinsic Endocardial Defects Contribute to Hypoplastic Left Heart Syndrome","name":"articletitle","label":"Article Title"},{"value":"Cell Stem Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.stem.2020.07.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}