{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T18:12:01Z","timestamp":1790878321581,"version":"4.1.0"},"reference-count":65,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Stem Cell"],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1016\/j.stem.2020.08.002","type":"journal-article","created":{"date-parts":[[2020,8,25]],"date-time":"2020-08-25T10:34:30Z","timestamp":1598351670000},"page":"633-645.e7","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":60,"title":["Defects in mRNA Translation in LRRK2-Mutant hiPSC-Derived Dopaminergic Neurons Lead to Dysregulated Calcium Homeostasis"],"prefix":"10.1016","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0957-7821","authenticated-orcid":false,"given":"Jungwoo Wren","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiling","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0620-7390","authenticated-orcid":false,"given":"Aanishaa","family":"Jhaldiyal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed Repon","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5912-1777","authenticated-orcid":false,"given":"Ian","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhong","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara","family":"Perez-Rosello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manoj","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6292-7886","authenticated-orcid":false,"given":"Leire","family":"Abalde-Atristain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinchong","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9678-1192","authenticated-orcid":false,"given":"Stephen M.","family":"Eacker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. James","family":"Surmeier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas T.","family":"Ingolia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6459-0893","authenticated-orcid":false,"given":"Ted M.","family":"Dawson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valina L.","family":"Dawson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.stem.2020.08.002_bib1","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/nature20414","article-title":"Defects in trafficking bridge Parkinson\u2019s disease pathology and genetics","volume":"539","author":"Abeliovich","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.stem.2020.08.002_bib2","doi-asserted-by":"crossref","first-page":"R106","DOI":"10.1186\/gb-2010-11-10-r106","article-title":"Differential expression analysis for sequence count data","volume":"11","author":"Anders","year":"2010","journal-title":"Genome Biol."},{"key":"10.1016\/j.stem.2020.08.002_bib3","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1093\/bioinformatics\/btu638","article-title":"HTSeq--a Python framework to work with high-throughput sequencing data","volume":"31","author":"Anders","year":"2015","journal-title":"Bioinformatics"},{"key":"10.1016\/j.stem.2020.08.002_bib4","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1038\/nature12104","article-title":"Structures of the human and Drosophila 80S ribosome","volume":"497","author":"Anger","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.stem.2020.08.002_bib5","doi-asserted-by":"crossref","first-page":"107473","DOI":"10.1016\/j.celrep.2020.03.037","article-title":"Dynamics of uS19 C-terminal tail during the translation elongation cycle in human ribosomes","volume":"31","author":"Bhaskar","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.stem.2020.08.002_bib6","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1093\/bioinformatics\/btp101","article-title":"ClueGO: a Cytoscape plug-in to decipher functionally grouped gene ontology and pathway annotation networks","volume":"25","author":"Bindea","year":"2009","journal-title":"Bioinformatics"},{"key":"10.1016\/j.stem.2020.08.002_bib7","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.1182\/blood-2017-09-804401","article-title":"Altered patterns of global protein synthesis and translational fidelity in RPS15-mutated chronic lymphocytic leukemia","volume":"132","author":"Bretones","year":"2018","journal-title":"Blood"},{"key":"10.1016\/j.stem.2020.08.002_bib8","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.15252\/embj.201695810","article-title":"Brain metabolism in health, aging, and neurodegeneration","volume":"36","author":"Camandola","year":"2017","journal-title":"EMBO J."},{"key":"10.1016\/j.stem.2020.08.002_bib9","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.ajpath.2012.10.027","article-title":"Mutant LRRK2 elicits calcium imbalance and depletion of dendritic mitochondria in neurons","volume":"182","author":"Cherra","year":"2013","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.stem.2020.08.002_bib10","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1038\/nrn2935","article-title":"The role of leucine-rich repeat kinase 2 (LRRK2) in Parkinson\u2019s disease","volume":"11","author":"Cookson","year":"2010","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.stem.2020.08.002_bib11","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1042\/BST20160228","article-title":"Cellular functions of LRRK2 implicate vesicular trafficking pathways in Parkinson\u2019s disease","volume":"44","author":"Cookson","year":"2016","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.stem.2020.08.002_bib12","doi-asserted-by":"crossref","first-page":"9","DOI":"10.3389\/fnmol.2017.00009","article-title":"Quantitative nucleotide level analysis of regulation of translation in response to depolarization of cultured neural cells","volume":"10","author":"Dalal","year":"2017","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.stem.2020.08.002_bib13","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1002\/mds.25462","article-title":"Lysosomal impairment in Parkinson\u2019s disease","volume":"28","author":"Dehay","year":"2013","journal-title":"Mov. Disord."},{"key":"10.1016\/j.stem.2020.08.002_bib14","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/nchembio.538","article-title":"Characterization of a selective inhibitor of the Parkinson\u2019s disease kinase LRRK2","volume":"7","author":"Deng","year":"2011","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.stem.2020.08.002_bib15","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1126\/science.1063395","article-title":"Signaling to the nucleus by an L-type calcium channel-calmodulin complex through the MAP kinase pathway","volume":"294","author":"Dolmetsch","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.stem.2020.08.002_bib16","doi-asserted-by":"crossref","first-page":"a015008","DOI":"10.1101\/cshperspect.a015008","article-title":"Mitochondrial biogenesis through activation of nuclear signaling proteins","volume":"5","author":"Dominy","year":"2013","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.stem.2020.08.002_bib17","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/nature11860","article-title":"Activity-dependent neuronal signalling and autism spectrum disorder","volume":"493","author":"Ebert","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.stem.2020.08.002_bib18","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1002\/ana.20484","article-title":"An LRRK2 mutation as a cause for the parkinsonism in the original PARK8 family","volume":"57","author":"Funayama","year":"2005","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.stem.2020.08.002_bib19","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1038\/nature09191","article-title":"Pathogenic LRRK2 negatively regulates microRNA-mediated translational repression","volume":"466","author":"Gehrke","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.stem.2020.08.002_bib20","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1093\/hmg\/ddr481","article-title":"Leucine-rich repeat kinase 2 regulates autophagy through a calcium-dependent pathway involving NAADP","volume":"21","author":"G\u00f3mez-Suaga","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.stem.2020.08.002_bib21","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.nbd.2006.04.001","article-title":"Kinase activity is required for the toxic effects of mutant LRRK2\/dardarin","volume":"23","author":"Greggio","year":"2006","journal-title":"Neurobiol. Dis."},{"issue":"Suppl 1","key":"10.1016\/j.stem.2020.08.002_bib22","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/jnc.13593","article-title":"Genetics in Parkinson disease: Mendelian versus non-Mendelian inheritance","volume":"139","author":"Hernandez","year":"2016","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.stem.2020.08.002_bib23","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1126\/science.aad9868","article-title":"Translational control by 5\u2032-untranslated regions of eukaryotic mRNAs","volume":"352","author":"Hinnebusch","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.stem.2020.08.002_bib24","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.molcel.2006.12.009","article-title":"Control of macroautophagy by calcium, calmodulin-dependent kinase kinase-beta, and Bcl-2","volume":"25","author":"H\u00f8yer-Hansen","year":"2007","journal-title":"Mol. Cell"},{"key":"10.1016\/j.stem.2020.08.002_bib25","doi-asserted-by":"crossref","first-page":"2432","DOI":"10.1038\/emboj.2008.163","article-title":"Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila","volume":"27","author":"Imai","year":"2008","journal-title":"EMBO J."},{"key":"10.1016\/j.stem.2020.08.002_bib26","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1126\/science.1168978","article-title":"Genome-wide analysis in\u00a0vivo of translation with nucleotide resolution using ribosome profiling","volume":"324","author":"Ingolia","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.stem.2020.08.002_bib27","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1038\/nprot.2012.086","article-title":"The ribosome profiling strategy for monitoring translation in\u00a0vivo by deep sequencing of ribosome-protected mRNA fragments","volume":"7","author":"Ingolia","year":"2012","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.stem.2020.08.002_bib28","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1016\/j.biochi.2010.02.031","article-title":"Eukaryote-specific motif of ribosomal protein S15 neighbors A site codon during elongation and termination of translation","volume":"92","author":"Khairulina","year":"2010","journal-title":"Biochimie"},{"key":"10.1016\/j.stem.2020.08.002_bib29","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1038\/nature14427","article-title":"Structure of the human 80S ribosome","volume":"520","author":"Khatter","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.stem.2020.08.002_bib30","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.stemcr.2018.11.021","article-title":"Neurite collapse and altered ER Ca2+ control in human Parkinson disease patient iPSC-derived neurons with LRRK2 G2019S mutation","volume":"12","author":"Korecka","year":"2019","journal-title":"Stem Cell Reports"},{"key":"10.1016\/j.stem.2020.08.002_bib31","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1038\/nature10648","article-title":"Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson\u2019s disease","volume":"480","author":"Kriks","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.stem.2020.08.002_bib32","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nmeth.1923","article-title":"Fast gapped-read alignment with Bowtie 2","volume":"9","author":"Langmead","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.stem.2020.08.002_bib33","doi-asserted-by":"crossref","first-page":"e1003118","DOI":"10.1371\/journal.pcbi.1003118","article-title":"Software for computing and annotating genomic ranges","volume":"9","author":"Lawrence","year":"2013","journal-title":"PLoS Comput. Biol."},{"key":"10.1016\/j.stem.2020.08.002_bib34","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/nature12355","article-title":"The initiation of mammalian protein synthesis and mRNA scanning mechanism","volume":"500","author":"Lomakin","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.stem.2020.08.002_bib35","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/1748-7188-6-26","article-title":"ViennaRNA package 2.0","volume":"6","author":"Lorenz","year":"2011","journal-title":"Algorithms Mol. Biol."},{"key":"10.1016\/j.stem.2020.08.002_bib36","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.stem.2020.08.002_bib37","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.1093\/hmg\/ddm151","article-title":"Mechanistic insight into the dominant mode of the Parkinson\u2019s disease-associated G2019S LRRK2 mutation","volume":"16","author":"Luz\u00f3n-Toro","year":"2007","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.stem.2020.08.002_bib38","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.neuron.2006.10.008","article-title":"The familial parkinsonism gene LRRK2 regulates neurite process morphology","volume":"52","author":"MacLeod","year":"2006","journal-title":"Neuron"},{"key":"10.1016\/j.stem.2020.08.002_bib39","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1111\/jnc.12949","article-title":"LRRK2 pathobiology in Parkinson\u2019s disease","volume":"131","author":"Martin","year":"2014","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.stem.2020.08.002_bib40","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/j.cell.2014.01.064","article-title":"Ribosomal protein s15 phosphorylation mediates LRRK2 neurodegeneration in Parkinson\u2019s disease","volume":"157","author":"Martin","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.stem.2020.08.002_bib41","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.ymeth.2017.05.028","article-title":"Transcriptome-wide measurement of translation by ribosome profiling","volume":"126","author":"McGlincy","year":"2017","journal-title":"Methods"},{"key":"10.1016\/j.stem.2020.08.002_bib42","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1038\/s41596-019-0128-8","article-title":"Protocol update for large-scale genome and gene function analysis with the PANTHER classification system (v.14.0)","volume":"14","author":"Mi","year":"2019","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.stem.2020.08.002_bib43","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1196\/annals.1427.002","article-title":"Oxidative stress and energy crises in neuronal dysfunction","volume":"1147","author":"Nicholls","year":"2008","journal-title":"Ann. N Y Acad. Sci."},{"key":"10.1016\/j.stem.2020.08.002_bib44","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1038\/nn.3350","article-title":"Interplay of LRRK2 with chaperone-mediated autophagy","volume":"16","author":"Orenstein","year":"2013","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.stem.2020.08.002_bib45","doi-asserted-by":"crossref","first-page":"2349","DOI":"10.1016\/j.cub.2015.07.050","article-title":"Elevated mitochondrial bioenergetics and axonal arborization size are key contributors to the vulnerability of dopamine neurons","volume":"25","author":"Pacelli","year":"2015","journal-title":"Curr. Biol."},{"key":"10.1016\/j.stem.2020.08.002_bib46","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.neuron.2004.10.023","article-title":"Cloning of the gene containing mutations that cause PARK8-linked Parkinson\u2019s disease","volume":"44","author":"Pais\u00e1n-Ru\u00edz","year":"2004","journal-title":"Neuron"},{"key":"10.1016\/j.stem.2020.08.002_bib47","doi-asserted-by":"crossref","first-page":"12188","DOI":"10.1038\/ncomms12188","article-title":"LRRK2 regulates retrograde synaptic compensation at the Drosophila neuromuscular junction","volume":"7","author":"Penney","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.stem.2020.08.002_bib48","doi-asserted-by":"crossref","first-page":"a009332","DOI":"10.1101\/cshperspect.a009332","article-title":"Mitochondrial biology and Parkinson\u2019s disease","volume":"2","author":"Perier","year":"2012","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.stem.2020.08.002_bib49","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1002\/jcc.20084","article-title":"UCSF Chimera\u2014a visualization system for exploratory research and analysis","volume":"25","author":"Pettersen","year":"2004","journal-title":"J.\u00a0Comput. Chem."},{"key":"10.1016\/j.stem.2020.08.002_bib50","doi-asserted-by":"crossref","first-page":"17013","DOI":"10.1038\/nrdp.2017.13","article-title":"Parkinson disease","volume":"3","author":"Poewe","year":"2017","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.stem.2020.08.002_bib51","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1021\/cb2002413","article-title":"Chemoproteomics-based design of potent LRRK2-selective lead compounds that attenuate Parkinson\u2019s disease-related toxicity in human neurons","volume":"6","author":"Ramsden","year":"2011","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.stem.2020.08.002_bib52","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1016\/j.bbadis.2009.04.003","article-title":"OXPHOS gene expression and control in mitochondrial disorders","volume":"1792","author":"Reinecke","year":"2009","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.stem.2020.08.002_bib53","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.stem.2013.01.008","article-title":"Genetic correction of a LRRK2 mutation in human iPSCs links parkinsonian neurodegeneration to ERK-dependent changes in gene expression","volume":"12","author":"Reinhardt","year":"2013","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.stem.2020.08.002_bib54","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1016\/j.stemcr.2015.11.004","article-title":"Neurite aggregation and calcium dysfunction in iPSC-derived sensory neurons with Parkinson\u2019s disease-related LRRK2 G2019S mutation","volume":"5","author":"Schwab","year":"2015","journal-title":"Stem Cell Reports"},{"key":"10.1016\/j.stem.2020.08.002_bib55","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1016\/j.bbagrm.2015.06.001","article-title":"Molecular contacts of ribose-phosphate backbone of mRNA with human ribosome","volume":"1849","author":"Sharifulin","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.stem.2020.08.002_bib56","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1038\/nn1776","article-title":"Kinase activity of mutant LRRK2 mediates neuronal toxicity","volume":"9","author":"Smith","year":"2006","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.stem.2020.08.002_bib57","doi-asserted-by":"crossref","first-page":"a009290","DOI":"10.1101\/cshperspect.a009290","article-title":"Physiological phenotype and vulnerability in Parkinson\u2019s disease","volume":"2","author":"Surmeier","year":"2012","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.stem.2020.08.002_bib58","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/j.bbrc.2016.08.168","article-title":"Calcium and Parkinson\u2019s disease","volume":"483","author":"Surmeier","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.stem.2020.08.002_bib59","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1093\/bioinformatics\/btp120","article-title":"TopHat: discovering splice junctions with RNA-seq","volume":"25","author":"Trapnell","year":"2009","journal-title":"Bioinformatics"},{"key":"10.1016\/j.stem.2020.08.002_bib60","doi-asserted-by":"crossref","first-page":"16842","DOI":"10.1073\/pnas.0507360102","article-title":"Parkinson\u2019s disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity","volume":"102","author":"West","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.stem.2020.08.002_bib61","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1093\/hmg\/ddl471","article-title":"Parkinson\u2019s disease-associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicity","volume":"16","author":"West","year":"2007","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.stem.2020.08.002_bib62","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1002\/jcp.21008","article-title":"Identification of activity-dependent gene expression profiles reveals specific subsets of genes induced by different routes of Ca(2+) entry in cultured rat cortical neurons","volume":"212","author":"Xiang","year":"2007","journal-title":"J.\u00a0Cell. Physiol."},{"key":"10.1016\/j.stem.2020.08.002_bib63","doi-asserted-by":"crossref","first-page":"333ra48","DOI":"10.1126\/scitranslmed.aad0623","article-title":"Cultured networks of excitatory projection neurons and inhibitory interneurons for studying human cortical neurotoxicity","volume":"8","author":"Xu","year":"2016","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.stem.2020.08.002_bib64","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.neuron.2018.10.013","article-title":"Activity-regulated transcription: bridging the gap between neural activity and behavior","volume":"100","author":"Yap","year":"2018","journal-title":"Neuron"},{"key":"10.1016\/j.stem.2020.08.002_bib65","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.neuron.2004.11.005","article-title":"Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology","volume":"44","author":"Zimprich","year":"2004","journal-title":"Neuron"}],"container-title":["Cell Stem Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1934590920303982?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1934590920303982?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T13:50:06Z","timestamp":1761832206000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1934590920303982"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10]]},"references-count":65,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["S1934590920303982"],"URL":"https:\/\/doi.org\/10.1016\/j.stem.2020.08.002","relation":{},"ISSN":["1934-5909"],"issn-type":[{"value":"1934-5909","type":"print"}],"subject":[],"published":{"date-parts":[[2020,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Defects in mRNA Translation in LRRK2-Mutant hiPSC-Derived Dopaminergic Neurons Lead to Dysregulated Calcium Homeostasis","name":"articletitle","label":"Article Title"},{"value":"Cell Stem Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.stem.2020.08.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}