{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T10:56:17Z","timestamp":1788432977565,"version":"build-2803163510"},"reference-count":77,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013669","name":"Ionis Pharmaceuticals","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013669","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Stem Cell"],"published-print":{"date-parts":[[2021,4]]},"DOI":"10.1016\/j.stem.2020.12.017","type":"journal-article","created":{"date-parts":[[2021,1,20]],"date-time":"2021-01-20T10:43:05Z","timestamp":1611139385000},"page":"623-636.e9","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":65,"title":["Selective antisense oligonucleotide inhibition of human IRF4 prevents malignant myeloma regeneration via cell cycle disruption"],"prefix":"10.1016","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2758-1701","authenticated-orcid":false,"given":"Phoebe K.","family":"Mondala","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashni A.","family":"Vora","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5496-4839","authenticated-orcid":false,"given":"Tianyuan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Lazzari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisa","family":"Ladel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolin","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7592-1387","authenticated-orcid":false,"given":"Youngsoo","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3405-5937","authenticated-orcid":false,"given":"Caitlin","family":"Costello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. Robert","family":"MacLeod","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catriona H.M.","family":"Jamieson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie A.","family":"Crews","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.stem.2020.12.017_bib1","doi-asserted-by":"crossref","first-page":"3925","DOI":"10.1073\/pnas.0900189106","article-title":"Glycogen synthase kinase 3beta missplicing contributes to leukemia stem cell generation","volume":"106","author":"Abrahamsson","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.stem.2020.12.017_bib2","series-title":"topGO: enrichment analysis for gene ontology, R package version 1.38.1","author":"Alexa","year":"2019"},{"key":"10.1016\/j.stem.2020.12.017_bib3","doi-asserted-by":"crossref","first-page":"R106","DOI":"10.1186\/gb-2010-11-10-r106","article-title":"Differential expression analysis for sequence count data","volume":"11","author":"Anders","year":"2010","journal-title":"Genome Biol."},{"key":"10.1016\/j.stem.2020.12.017_bib4","series-title":"FastQC: a quality control tool for high throughput sequence data","author":"Andrews","year":"2010"},{"key":"10.1016\/j.stem.2020.12.017_bib5","doi-asserted-by":"crossref","first-page":"85392","DOI":"10.18632\/oncotarget.19907","article-title":"Bone marrow IRF4 level in multiple myeloma: an indicator of peripheral blood Th17 and disease","volume":"8","author":"Bai","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.stem.2020.12.017_bib6","doi-asserted-by":"crossref","first-page":"70","DOI":"10.2174\/157339471002141124121404","article-title":"Biological and clinical implications of clonal heterogeneity and clonal evolution in multiple myeloma","volume":"10","author":"Bianchi","year":"2014","journal-title":"Curr. Cancer Ther. Rev."},{"key":"10.1016\/j.stem.2020.12.017_bib7","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1373\/clinchem.2008.112797","article-title":"The MIQE guidelines: minimum information for publication of quantitative real-time PCR experiments","volume":"55","author":"Bustin","year":"2009","journal-title":"Clin. Chem."},{"key":"10.1016\/j.stem.2020.12.017_bib8","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1089\/scd.2012.0168","article-title":"Lengthened G1 phase indicates differentiation status in human embryonic stem cells","volume":"22","author":"Calder","year":"2013","journal-title":"Stem Cells Dev."},{"key":"10.1016\/j.stem.2020.12.017_bib9","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1182\/blood-2012-06-436220","article-title":"Clinical drug resistance linked to interconvertible phenotypic and functional states of tumor-propagating cells in multiple myeloma","volume":"121","author":"Chaidos","year":"2013","journal-title":"Blood"},{"key":"10.1016\/j.stem.2020.12.017_bib10","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1161\/CIRCULATIONAHA.116.026046","article-title":"Interferon regulatory factor 4 inhibits neointima formation by engaging Kr\u00fcppel-like factor 4 signaling","volume":"136","author":"Cheng","year":"2017","journal-title":"Circulation"},{"key":"10.1016\/j.stem.2020.12.017_bib11","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1182\/blood-2002-01-0008","article-title":"A molecular compendium of genes expressed in multiple myeloma","volume":"100","author":"Claudio","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.stem.2020.12.017_bib12","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1038\/leu.2013.6","article-title":"Notch-directed microenvironment reprogramming in myeloma: a single path to multiple outcomes","volume":"27","author":"Colombo","year":"2013","journal-title":"Leukemia"},{"key":"10.1016\/j.stem.2020.12.017_bib13","doi-asserted-by":"crossref","first-page":"56013","DOI":"10.18632\/oncotarget.10820","article-title":"Multiple myeloma-derived Jagged ligands increases autocrine and paracrine interleukin-6 expression in bone marrow niche","volume":"7","author":"Colombo","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.stem.2020.12.017_bib14","doi-asserted-by":"crossref","first-page":"95","DOI":"10.2217\/fon-2017-0493","article-title":"Therapy sequencing strategies in multiple myeloma: who, what and why?","volume":"14","author":"Costello","year":"2018","journal-title":"Future Oncol."},{"key":"10.1016\/j.stem.2020.12.017_bib15","series-title":"Stem Cells Handbook","article-title":"Molecular evolution of leukemia stem cells","author":"Crews","year":"2013"},{"key":"10.1016\/j.stem.2020.12.017_bib16","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/s12967-014-0370-3","article-title":"An RNA editing fingerprint of cancer stem cell reprogramming","volume":"13","author":"Crews","year":"2015","journal-title":"J.\u00a0Transl. Med."},{"key":"10.1016\/j.stem.2020.12.017_bib17","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.stem.2016.08.003","article-title":"RNA splicing modulation selectively impairs leukemia stem cell maintenance in secondary human AML","volume":"19","author":"Crews","year":"2016","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.stem.2020.12.017_bib18","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1089\/nat.2018.0753","article-title":"Integrated assessment of the clinical performance of GalNAc3-conjugated 2\u2032-O-methoxyethyl chimeric antisense oligonucleotides: I. human volunteer experience","volume":"29","author":"Crooke","year":"2019","journal-title":"Nucleic Acid Ther."},{"key":"10.1016\/j.stem.2020.12.017_bib19","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"issue":"D1","key":"10.1016\/j.stem.2020.12.017_bib20","doi-asserted-by":"crossref","first-page":"D649","DOI":"10.1093\/nar\/gkx1132","article-title":"The Reactome Pathway Knowledgebase","volume":"46","author":"Fabregat","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.stem.2020.12.017_bib21","doi-asserted-by":"crossref","first-page":"e8785","DOI":"10.1371\/journal.pone.0008785","article-title":"Molecular signatures of quiescent, mobilized and leukemia-initiating hematopoietic stem cells","volume":"5","author":"Forsberg","year":"2010","journal-title":"PLoS ONE"},{"key":"10.1016\/j.stem.2020.12.017_bib22","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.1016\/j.yexcr.2010.03.013","article-title":"Bone marrow stromal cell interaction reduces syndecan-1 expression and induces kinomic changes in myeloma cells","volume":"316","author":"Fuhler","year":"2010","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.stem.2020.12.017_bib23","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1111\/bjh.12622","article-title":"Measuring cereblon as a biomarker of response or resistance to lenalidomide and pomalidomide requires use of standardized reagents and understanding of gene complexity","volume":"164","author":"Gandhi","year":"2014","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.stem.2020.12.017_bib24","doi-asserted-by":"crossref","first-page":"D492","DOI":"10.1093\/nar\/gkp858","article-title":"The NCBI BioSystems database","volume":"38","author":"Geer","year":"2010","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.stem.2020.12.017_bib25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.canlet.2008.08.005","article-title":"Cancer stem cells in multiple myeloma","volume":"277","author":"Ghosh","year":"2009","journal-title":"Cancer Lett."},{"key":"10.1016\/j.stem.2020.12.017_bib26","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.stem.2010.03.008","article-title":"Cycling toward elimination of leukemic stem cells","volume":"6","author":"Goff","year":"2010","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.stem.2020.12.017_bib27","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.stem.2012.12.011","article-title":"A Pan-BCL2 inhibitor renders bone-marrow-resident human leukemia stem cells sensitive to tyrosine kinase inhibition","volume":"12","author":"Goff","year":"2013","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.stem.2020.12.017_bib28","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.molcel.2010.05.004","article-title":"Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities","volume":"38","author":"Heinz","year":"2010","journal-title":"Mol. Cell"},{"key":"10.1016\/j.stem.2020.12.017_bib29","series-title":"Cran-package fpc","author":"Hennig","year":"2013"},{"key":"10.1016\/j.stem.2020.12.017_bib30","doi-asserted-by":"crossref","first-page":"410","DOI":"10.2967\/jnumed.114.151647","article-title":"Biodistribution and radiation dosimetry for the chemokine receptor CXCR4-targeting probe 68Ga-pentixafor","volume":"56","author":"Herrmann","year":"2015","journal-title":"J.\u00a0Nucl. Med."},{"key":"10.1016\/j.stem.2020.12.017_bib31","doi-asserted-by":"crossref","first-page":"314ra185","DOI":"10.1126\/scitranslmed.aac5272","article-title":"AZD9150, a next-generation antisense oligonucleotide inhibitor of STAT3 with early evidence of clinical activity in lymphoma and lung cancer","volume":"7","author":"Hong","year":"2015","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.stem.2020.12.017_bib32","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1182\/blood-2012-03-415984","article-title":"Prolonged early G(1) arrest by selective CDK4\/CDK6 inhibition sensitizes myeloma cells to cytotoxic killing through cell cycle-coupled loss of IRF4","volume":"120","author":"Huang","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.stem.2020.12.017_bib33","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1073\/pnas.1213021110","article-title":"ADAR1 promotes malignant progenitor reprogramming in chronic myeloid leukemia","volume":"110","author":"Jiang","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.stem.2020.12.017_bib34","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/nrc.2017.23","article-title":"RNA editing-dependent epitranscriptome diversity in cancer stem cells","volume":"17","author":"Jiang","year":"2017","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.stem.2020.12.017_bib35","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.ccell.2018.11.017","article-title":"Hyper-editing of cell-cycle regulatory and tumor suppressor RNA promotes malignant progenitor propagation","volume":"35","author":"Jiang","year":"2019","journal-title":"Cancer Cell"},{"key":"10.1016\/j.stem.2020.12.017_bib36","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.immuni.2007.12.019","article-title":"Regulation of immunoglobulin light-chain recombination by the transcription factor IRF-4 and the attenuation of interleukin-7 signaling","volume":"28","author":"Johnson","year":"2008","journal-title":"Immunity"},{"key":"10.1016\/j.stem.2020.12.017_bib37","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.ccr.2007.07.003","article-title":"Promiscuous mutations activate the noncanonical NF-kappaB pathway in multiple myeloma","volume":"12","author":"Keats","year":"2007","journal-title":"Cancer Cell"},{"key":"10.1016\/j.stem.2020.12.017_bib38","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1038\/ni1357","article-title":"Transcription factor IRF4 controls plasma cell differentiation and class-switch recombination","volume":"7","author":"Klein","year":"2006","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.stem.2020.12.017_bib39","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1182\/blood-2016-02-698092","article-title":"Targeted sequencing of refractory myeloma reveals a high incidence of mutations in CRBN and Ras pathway genes","volume":"128","author":"Kort\u00fcm","year":"2016","journal-title":"Blood"},{"key":"10.1016\/j.stem.2020.12.017_bib40","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.stem.2014.02.006","article-title":"Evolution of the cancer stem cell model","volume":"14","author":"Kreso","year":"2014","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.stem.2020.12.017_bib41","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1126\/science.1244851","article-title":"Lenalidomide causes selective degradation of IKZF1 and IKZF3 in multiple myeloma cells","volume":"343","author":"Kr\u00f6nke","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.stem.2020.12.017_bib42","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.6004\/jnccn.2019.0049","article-title":"NCCN guidelines insights: multiple myeloma, Version 1.2020","volume":"17","author":"Kumar","year":"2019","journal-title":"J.\u00a0Natl. Compr. Canc. Netw."},{"key":"10.1016\/j.stem.2020.12.017_bib43","doi-asserted-by":"crossref","first-page":"1922","DOI":"10.1038\/s41467-017-01890-w","article-title":"Alu-dependent RNA editing of GLI1 promotes malignant regeneration in multiple myeloma","volume":"8","author":"Lazzari","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.stem.2020.12.017_bib44","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1007\/BF01697400","article-title":"Multiparameter analyses of normal and malignant human plasma cells: CD38++, CD56+, CD54+, cIg+ is the common phenotype of myeloma cells","volume":"64","author":"Leo","year":"1992","journal-title":"Ann. Hematol."},{"key":"10.1016\/j.stem.2020.12.017_bib45","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1093\/bioinformatics\/btr260","article-title":"Molecular signatures database (MSigDB) 3.0","volume":"27","author":"Liberzon","year":"2011","journal-title":"Bioinformatics"},{"key":"10.1016\/j.stem.2020.12.017_bib46","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1111\/j.1365-2141.2011.08689.x","article-title":"Lenalidomide downregulates the cell survival factor, interferon regulatory factor-4, providing a potential mechanistic link for predicting response","volume":"154","author":"Lopez-Girona","year":"2011","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.stem.2020.12.017_bib47","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.stem.2020.12.017_bib48","doi-asserted-by":"crossref","first-page":"2634","DOI":"10.1016\/j.celrep.2019.10.097","article-title":"IRF4 activity is required in established plasma cells to regulate gene transcription and mitochondrial homeostasis","volume":"29","author":"Low","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.stem.2020.12.017_bib49","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1038\/sj.leu.2404229","article-title":"Inflammation and multiple myeloma: the Toll connection","volume":"20","author":"Mantovani","year":"2006","journal-title":"Leukemia"},{"key":"10.1016\/j.stem.2020.12.017_bib50","doi-asserted-by":"crossref","first-page":"10","DOI":"10.14806\/ej.17.1.200","article-title":"Cutadapt removes adapter sequences from high-throughput sequencing reads","volume":"17","author":"Martin","year":"2011","journal-title":"EMBnet.journal"},{"key":"10.1016\/j.stem.2020.12.017_bib51","doi-asserted-by":"crossref","first-page":"2332","DOI":"10.1182\/blood-2003-09-3064","article-title":"Characterization of clonogenic multiple myeloma cells","volume":"103","author":"Matsui","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.stem.2020.12.017_bib52","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1158\/0008-5472.CAN-07-3096","article-title":"Clonogenic multiple myeloma progenitors, stem cell properties, and drug resistance","volume":"68","author":"Matsui","year":"2008","journal-title":"Cancer Res."},{"key":"10.1016\/j.stem.2020.12.017_bib53","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1038\/leu.2013.27","article-title":"Anti-Notch treatment prevents multiple myeloma cells localization to the bone marrow via the chemokine system CXCR4\/SDF-1","volume":"27","author":"Mirandola","year":"2013","journal-title":"Leukemia"},{"issue":"D1","key":"10.1016\/j.stem.2020.12.017_bib54","doi-asserted-by":"crossref","first-page":"D351","DOI":"10.1093\/nar\/gky1100","article-title":"InterPro in 2019: improving coverage, classification and access to protein sequence annotations","volume":"47","author":"Mitchell","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.stem.2020.12.017_bib55","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1126\/science.275.5299.540","article-title":"Requirement for the transcription factor LSIRF\/IRF4 for mature B and T lymphocyte function","volume":"275","author":"Mittr\u00fccker","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.stem.2020.12.017_bib56","doi-asserted-by":"crossref","first-page":"4656","DOI":"10.1242\/dev.106575","article-title":"The analysis, roles and regulation of quiescence in hematopoietic stem cells","volume":"141","author":"Nakamura-Ishizu","year":"2014","journal-title":"Development"},{"key":"10.1016\/j.stem.2020.12.017_bib57","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1080\/17474086.2018.1538777","article-title":"Triplet therapies - the new standard of care for multiple myeloma: how to manage common toxicities","volume":"11","author":"Paner","year":"2018","journal-title":"Expert Rev. Hematol."},{"key":"10.1016\/j.stem.2020.12.017_bib58","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.cell.2013.08.031","article-title":"The cell-cycle state of stem cells determines cell fate propensity","volume":"155","author":"Pauklin","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.stem.2020.12.017_bib59","doi-asserted-by":"crossref","first-page":"23885","DOI":"10.1038\/srep23885","article-title":"Tracking of normal and malignant progenitor cell cycle transit in a defined niche","volume":"6","author":"Pineda","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.stem.2020.12.017_bib60","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1084\/jem.20122252","article-title":"PDGFR\u03b1 and CD51 mark human nestin+ sphere-forming mesenchymal stem cells capable of hematopoietic progenitor cell expansion","volume":"210","author":"Pinho","year":"2013","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.stem.2020.12.017_bib61","doi-asserted-by":"crossref","first-page":"eaal5253","DOI":"10.1126\/scitranslmed.aal5253","article-title":"Targeting KRAS-dependent tumors with AZD4785, a high-affinity therapeutic antisense oligonucleotide inhibitor of KRAS","volume":"9","author":"Ross","year":"2017","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.stem.2020.12.017_bib62","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.cell.2007.12.033","article-title":"Visualizing spatiotemporal dynamics of multicellular cell-cycle progression","volume":"132","author":"Sakaue-Sawano","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.stem.2020.12.017_bib63","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1038\/nature07064","article-title":"IRF4 addiction in multiple myeloma","volume":"454","author":"Shaffer","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.stem.2020.12.017_bib64","doi-asserted-by":"crossref","first-page":"2954","DOI":"10.1158\/1078-0432.CCR-08-1845","article-title":"IRF4: immunity. Malignancy! Therapy?","volume":"15","author":"Shaffer","year":"2009","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.stem.2020.12.017_bib65","doi-asserted-by":"crossref","first-page":"5479","DOI":"10.1172\/JCI120156","article-title":"Antisense STAT3 inhibitor decreases viability of myelodysplastic and leukemic stem cells","volume":"128","author":"Shastri","year":"2018","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.stem.2020.12.017_bib66","doi-asserted-by":"crossref","first-page":"3286","DOI":"10.1038\/s41375-020-0813-1","article-title":"Pomalidomide, dexamethasone, and daratumumab in relapsed refractory multiple myeloma after lenalidomide treatment","volume":"34","author":"Siegel","year":"2020","journal-title":"Leukemia"},{"issue":"D1","key":"10.1016\/j.stem.2020.12.017_bib67","doi-asserted-by":"crossref","first-page":"D661","DOI":"10.1093\/nar\/gkx1064","article-title":"WikiPathways: a multifaceted pathway database bridging metabolomics to other omics research","volume":"46","author":"Slenter","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.stem.2020.12.017_bib68","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1056\/NEJMoa1411321","article-title":"Carfilzomib, lenalidomide, and dexamethasone for relapsed multiple myeloma","volume":"372","author":"Stewart","year":"2015","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.stem.2020.12.017_bib69","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.stem.2020.12.017_bib70","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.immuni.2004.05.001","article-title":"Cellular niches controlling B lymphocyte behavior within bone marrow during development","volume":"20","author":"Tokoyoda","year":"2004","journal-title":"Immunity"},{"key":"10.1016\/j.stem.2020.12.017_bib71","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1038\/leu.2011.373","article-title":"Tumor-initiating capacity of CD138- and CD138+ tumor cells in the 5T33 multiple myeloma model","volume":"26","author":"Van Valckenborgh","year":"2012","journal-title":"Leukemia"},{"key":"10.1016\/j.stem.2020.12.017_bib72","doi-asserted-by":"crossref","first-page":"2184","DOI":"10.1093\/bioinformatics\/bts356","article-title":"RSeQC: quality control of RNA-seq experiments","volume":"28","author":"Wang","year":"2012","journal-title":"Bioinformatics"},{"key":"10.1016\/j.stem.2020.12.017_bib73","doi-asserted-by":"crossref","first-page":"7599","DOI":"10.1158\/1078-0432.CCR-05-0523","article-title":"The phenotypic plasticity of myeloma plasma cells as expressed by dedifferentiation into an immature, resilient, and apoptosis-resistant phenotype","volume":"11","author":"Yaccoby","year":"2005","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.stem.2020.12.017_bib74","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.clml.2017.09.020","article-title":"Two states of myeloma stem cells","volume":"18","author":"Yaccoby","year":"2018","journal-title":"Clin. Lymphoma Myeloma Leuk."},{"key":"10.1016\/j.stem.2020.12.017_bib75","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1073\/pnas.75.1.280","article-title":"Inhibition of Rous sarcoma virus replication and cell transformation by a specific oligodeoxynucleotide","volume":"75","author":"Zamecnik","year":"1978","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.stem.2020.12.017_bib76","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/s41408-019-0173-0","article-title":"Identification of lenalidomide resistance pathways in myeloma and targeted resensitization using cereblon replacement, inhibition of STAT3 or targeting of IRF4","volume":"9","author":"Zhu","year":"2019","journal-title":"Blood Cancer J."},{"key":"10.1016\/j.stem.2020.12.017_bib77","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.stem.2016.05.004","article-title":"ADAR1 activation drives leukemia stem cell self-renewal by impairing Let-7 biogenesis","volume":"19","author":"Zipeto","year":"2016","journal-title":"Cell Stem Cell"}],"container-title":["Cell Stem Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1934590920306019?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1934590920306019?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T13:52:06Z","timestamp":1761832326000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1934590920306019"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4]]},"references-count":77,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["S1934590920306019"],"URL":"https:\/\/doi.org\/10.1016\/j.stem.2020.12.017","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.739397574.793582268","asserted-by":"object"}]},"ISSN":["1934-5909"],"issn-type":[{"value":"1934-5909","type":"print"}],"subject":[],"published":{"date-parts":[[2021,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Selective antisense oligonucleotide inhibition of human IRF4 prevents malignant myeloma regeneration via cell cycle disruption","name":"articletitle","label":"Article Title"},{"value":"Cell Stem Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.stem.2020.12.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}