{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T22:52:41Z","timestamp":1790635961730,"version":"4.1.0"},"reference-count":64,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,6]],"date-time":"2023-01-06T00:00:00Z","timestamp":1672963200000},"content-version":"vor","delay-in-days":370,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32070873"],"award-info":[{"award-number":["32070873"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2012CB518700"],"award-info":[{"award-number":["2012CB518700"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2014CB849602"],"award-info":[{"award-number":["2014CB849602"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013290","name":"National Key Research and Development Program of China Stem Cell and Translational Research","doi-asserted-by":"publisher","award":["2017YFA0103500"],"award-info":[{"award-number":["2017YFA0103500"]}],"id":[{"id":"10.13039\/501100013290","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Stem Cell"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1016\/j.stem.2021.09.009","type":"journal-article","created":{"date-parts":[[2021,10,9]],"date-time":"2021-10-09T09:31:30Z","timestamp":1633771890000},"page":"70-85.e6","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":98,"title":["Hair shaft miniaturization causes stem cell depletion through mechanosensory signals mediated by a Piezo1-calcium-TNF-\u03b1 axis"],"prefix":"10.1016","volume":"29","author":[{"given":"Yuhua","family":"Xie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daoming","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4752-7294","authenticated-orcid":false,"given":"Kaiju","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lifang","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nannan","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingxue","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3595-2859","authenticated-orcid":false,"given":"Fengchao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6765-7283","authenticated-orcid":false,"given":"Ting","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.stem.2021.09.009_bib1","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1111\/bjd.12302","article-title":"Novel mutations in the gene HOXC13 underlying pure hair and nail ectodermal dysplasia in consanguineous families","volume":"169","author":"Ali","year":"2013","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.stem.2021.09.009_bib2","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1016\/j.cell.2017.05.002","article-title":"Regulatory T Cells in Skin Facilitate Epithelial Stem Cell Differentiation","volume":"169","author":"Ali","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.stem.2021.09.009_bib3","doi-asserted-by":"crossref","first-page":"17412","DOI":"10.1074\/jbc.M000445200","article-title":"TREK-2, a new member of the mechanosensitive tandem-pore K+ channel family","volume":"275","author":"Bang","year":"2000","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.stem.2021.09.009_bib4","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.cell.2004.08.012","article-title":"Self-renewal, multipotency, and the existence of two cell populations within an epithelial stem cell niche","volume":"118","author":"Blanpain","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.stem.2021.09.009_bib5","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.toxicon.2006.09.030","article-title":"Mechanosensitive ion channels and the peptide inhibitor GsMTx-4: history, properties, mechanisms and pharmacology","volume":"49","author":"Bowman","year":"2007","journal-title":"Toxicon"},{"key":"10.1016\/j.stem.2021.09.009_bib6","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1038\/293302a0","article-title":"Cytochalasin D inhibits actin polymerization and induces depolymerization of actin filaments formed during platelet shape change","volume":"293","author":"Casella","year":"1981","journal-title":"Nature"},{"key":"10.1016\/j.stem.2021.09.009_bib7","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/nature10940","article-title":"An RNA interference screen uncovers a new molecule in stem cell self-renewal and long-term regeneration","volume":"485","author":"Chen","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.stem.2021.09.009_bib8","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/nature12354","article-title":"Ultrasensitive fluorescent proteins for imaging neuronal activity","volume":"499","author":"Chen","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.stem.2021.09.009_bib9","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.cell.2015.02.016","article-title":"Organ-level quorum sensing directs regeneration in hair stem cell populations","volume":"161","author":"Chen","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.stem.2021.09.009_bib10","doi-asserted-by":"crossref","first-page":"14677","DOI":"10.1073\/pnas.0507250102","article-title":"Long-term renewal of hair follicles from clonogenic multipotent stem cells","volume":"102","author":"Claudinot","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.stem.2021.09.009_bib11","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1126\/science.1193270","article-title":"Piezo1 and Piezo2 are essential components of distinct mechanically activated cation channels","volume":"330","author":"Coste","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.stem.2021.09.009_bib12","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/S1471-4914(01)02027-5","article-title":"Towards a molecular understanding of hair loss and its treatment","volume":"7","author":"Cotsarelis","year":"2001","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.stem.2021.09.009_bib13","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1016\/0092-8674(90)90696-C","article-title":"Label-retaining cells reside in the bulge area of pilosebaceous unit: implications for follicular stem cells, hair cycle, and skin carcinogenesis","volume":"61","author":"Cotsarelis","year":"1990","journal-title":"Cell"},{"key":"10.1016\/j.stem.2021.09.009_bib14","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1038\/s41592-019-0435-6","article-title":"High-performance calcium sensors for imaging activity in neuronal populations and microcompartments","volume":"16","author":"Dana","year":"2019","journal-title":"Nat. Methods"},{"key":"10.1016\/j.stem.2021.09.009_bib15","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1101\/gad.949602","article-title":"TRAIL-induced apoptosis requires Bax-dependent mitochondrial release of Smac\/DIABLO","volume":"16","author":"Deng","year":"2002","journal-title":"Genes Dev."},{"key":"10.1016\/j.stem.2021.09.009_bib16","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.tcb.2012.09.006","article-title":"Use the force: membrane tension as an organizer of cell shape and motility","volume":"23","author":"Diz-Mu\u00f1oz","year":"2013","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.stem.2021.09.009_bib17","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1242\/jcs.082446","article-title":"Hair follicle dermal papilla cells at a glance","volume":"124","author":"Driskell","year":"2011","journal-title":"J.\u00a0Cell Sci."},{"key":"10.1016\/j.stem.2021.09.009_bib18","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1038\/nature10999","article-title":"Crowding induces live cell extrusion to maintain homeostatic cell numbers in epithelia","volume":"484","author":"Eisenhoffer","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.stem.2021.09.009_bib19","doi-asserted-by":"crossref","first-page":"E6880","DOI":"10.1073\/pnas.1719548115","article-title":"External light activates hair follicle stem cells through eyes via an ipRGC-SCN-sympathetic neural pathway","volume":"115","author":"Fan","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.stem.2021.09.009_bib20","first-page":"578","article-title":"A homozygous frameshift mutation in the HOXC13 gene underlies pure hair and nail ectodermal dysplasia in a Syrian family","volume":"34","author":"Farooq","year":"2013","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.stem.2021.09.009_bib21","first-page":"126ra134","article-title":"Prostaglandin D2 Inhibits Hair Growth and Is Elevated in Bald Scalp of Men with Androgenetic Alopecia","volume":"4","author":"Garza","year":"2012","journal-title":"Sci. Trasl. Med."},{"key":"10.1016\/j.stem.2021.09.009_bib22","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1101\/gad.12.1.11","article-title":"Hoxc13 mutant mice lack external hair","volume":"12","author":"Godwin","year":"1998","journal-title":"Genes Dev."},{"key":"10.1016\/j.stem.2021.09.009_bib23","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.cell.2004.07.024","article-title":"Evidence for an expansion-based temporal Shh gradient in specifying vertebrate digit identities","volume":"118","author":"Harfe","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.stem.2021.09.009_bib24","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1126\/science.aax9131","article-title":"Dermal sheath contraction powers stem cell niche relocation during hair cycle regression","volume":"367","author":"Heitman","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.stem.2021.09.009_bib25","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1038\/s41419-019-2063-6","article-title":"Activation of Piezo1 sensitizes cells to TRAIL-mediated apoptosis through mitochondrial outer membrane permeability","volume":"10","author":"Hope","year":"2019","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.stem.2021.09.009_bib26","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.cell.2010.11.049","article-title":"Dynamics between stem cells, niche, and progeny in the hair follicle","volume":"144","author":"Hsu","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.stem.2021.09.009_bib27","doi-asserted-by":"crossref","first-page":"3149","DOI":"10.1242\/dev.022202","article-title":"Dlx3 is a crucial regulator of hair follicle differentiation and cycling","volume":"135","author":"Hwang","year":"2008","journal-title":"Development"},{"key":"10.1016\/j.stem.2021.09.009_bib28","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1038\/nm1328","article-title":"Stem cells in the hair follicle bulge contribute to wound repair but not to homeostasis of the epidermis","volume":"11","author":"Ito","year":"2005","journal-title":"Nat. Med."},{"key":"10.1016\/j.stem.2021.09.009_bib29","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1038\/s41586-020-2933-1","article-title":"Discoveries in structure and physiology of mechanically activated ion channels","volume":"587","author":"Kefauver","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.stem.2021.09.009_bib30","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.neuron.2006.03.042","article-title":"TRPA1 contributes to cold, mechanical, and chemical nociception but is not essential for hair-cell transduction","volume":"50","author":"Kwan","year":"2006","journal-title":"Neuron"},{"key":"10.1016\/j.stem.2021.09.009_bib31","doi-asserted-by":"crossref","first-page":"C1400","DOI":"10.1152\/ajpcell.1996.271.4.C1400","article-title":"An equibiaxial strain system for cultured cells","volume":"271","author":"Lee","year":"1996","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.stem.2021.09.009_bib32","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1126\/science.aaf1635","article-title":"STEM CELLS. Aging, alopecia, and stem cells","volume":"351","author":"Lei","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.stem.2021.09.009_bib33","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1016\/j.ajhg.2012.08.029","article-title":"Loss-of-function mutations in HOXC13 cause pure hair and nail ectodermal dysplasia","volume":"91","author":"Lin","year":"2012","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.stem.2021.09.009_bib34","doi-asserted-by":"crossref","first-page":"1810","DOI":"10.1016\/j.celrep.2016.07.020","article-title":"MAPK-Mediated YAP Activation Controls Mechanical-Tension-Induced Pulmonary Alveolar Regeneration","volume":"16","author":"Liu","year":"2016","journal-title":"Cell Rep."},{"key":"10.1016\/j.stem.2021.09.009_bib35","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1074\/jbc.274.3.1381","article-title":"TRAAK is a mammalian neuronal mechano-gated K+ channel","volume":"274","author":"Maingret","year":"1999","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.stem.2021.09.009_bib36","doi-asserted-by":"crossref","first-page":"aad4395","DOI":"10.1126\/science.aad4395","article-title":"Hair follicle aging is driven by transepidermal elimination of stem cells via COL17A1 proteolysis","volume":"351","author":"Matsumura","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.stem.2021.09.009_bib37","doi-asserted-by":"crossref","first-page":"a015180","DOI":"10.1101\/cshperspect.a015180","article-title":"The dermal papilla: an instructive niche for epithelial stem and progenitor cells in development and regeneration of the hair follicle","volume":"4","author":"Morgan","year":"2014","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.stem.2021.09.009_bib38","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/nbt950","article-title":"Capturing and profiling adult hair follicle stem cells","volume":"22","author":"Morris","year":"2004","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.stem.2021.09.009_bib39","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1046\/j.0022-202x.2001.01377.x","article-title":"A comprehensive guide for the accurate classification of murine hair follicles in distinct hair cycle stages","volume":"117","author":"M\u00fcller-R\u00f6ver","year":"2001","journal-title":"J.\u00a0Invest. Dermatol."},{"key":"10.1016\/j.stem.2021.09.009_bib40","doi-asserted-by":"crossref","first-page":"4283","DOI":"10.1093\/emboj\/17.15.4283","article-title":"A mammalian two pore domain mechano-gated S-like K+ channel","volume":"17","author":"Patel","year":"1998","journal-title":"EMBO J."},{"key":"10.1016\/j.stem.2021.09.009_bib41","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1056\/NEJM199908123410706","article-title":"The biology of hair follicles","volume":"341","author":"Paus","year":"1999","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.stem.2021.09.009_bib42","doi-asserted-by":"crossref","first-page":"e01004","DOI":"10.7554\/eLife.01004","article-title":"Apoptotic cells can induce non-autonomous apoptosis through the TNF pathway","volume":"2","author":"P\u00e9rez-Garijo","year":"2013","journal-title":"eLife"},{"key":"10.1016\/j.stem.2021.09.009_bib43","doi-asserted-by":"crossref","first-page":"558","DOI":"10.3389\/fpls.2014.00558","article-title":"Mechanosensitive channels: feeling tension in a world under pressure","volume":"5","author":"Peyronnet","year":"2014","journal-title":"Front. Plant Sci."},{"key":"10.1016\/j.stem.2021.09.009_bib44","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1038\/jid.2010.391","article-title":"The nude mutant gene Foxn1 is a HOXC13 regulatory target during hair follicle and nail differentiation","volume":"131","author":"Potter","year":"2011","journal-title":"J.\u00a0Invest. Dermatol."},{"key":"10.1016\/j.stem.2021.09.009_bib45","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.devcel.2014.10.022","article-title":"Hair follicle dermal stem cells regenerate the dermal sheath, repopulate the dermal papilla, and modulate hair type","volume":"31","author":"Rahmani","year":"2014","journal-title":"Dev. Cell"},{"key":"10.1016\/j.stem.2021.09.009_bib46","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1016\/j.neuron.2015.08.032","article-title":"Mechanically activated ion channels","volume":"87","author":"Ranade","year":"2015","journal-title":"Neuron"},{"key":"10.1016\/j.stem.2021.09.009_bib47","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.cell.2018.11.023","article-title":"ASICs Mediate Food Responses in an Enteric Serotonergic Neuron that Controls Foraging Behaviors","volume":"176","author":"Rhoades","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.stem.2021.09.009_bib48","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1038\/nature12602","article-title":"Spatial organization within a niche as a determinant of stem-cell fate","volume":"502","author":"Rompolas","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.stem.2021.09.009_bib49","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1073\/pnas.77.3.1561","article-title":"Taxol stabilizes microtubules in mouse fibroblast cells","volume":"77","author":"Schiff","year":"1980","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.stem.2021.09.009_bib50","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.neuron.2013.08.002","article-title":"Cellular resolution functional imaging in behaving rats using voluntary head restraint","volume":"80","author":"Scott","year":"2013","journal-title":"Neuron"},{"key":"10.1016\/j.stem.2021.09.009_bib51","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1016\/j.semcdb.2012.08.011","article-title":"Mesenchymal-epithelial interactions during hair follicle morphogenesis and cycling","volume":"23","author":"Sennett","year":"2012","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.stem.2021.09.009_bib52","doi-asserted-by":"crossref","first-page":"e21074","DOI":"10.7554\/eLife.21074","article-title":"Direct measurement of TRPV4 and PIEZO1 activity reveals multiple mechanotransduction pathways in chondrocytes","volume":"6","author":"Servin-Vences","year":"2017","journal-title":"eLife"},{"key":"10.1016\/j.stem.2021.09.009_bib53","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.devcel.2020.03.019","article-title":"Dysfunction of Hair Follicle Mesenchymal Progenitors Contributes to Age-Associated Hair Loss","volume":"53","author":"Shin","year":"2020","journal-title":"Dev. Cell"},{"key":"10.1016\/j.stem.2021.09.009_bib54","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/j.cell.2020.06.031","article-title":"Cell Types Promoting Goosebumps Form a Niche to Regulate Hair Follicle Stem Cells","volume":"182","author":"Shwartz","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.stem.2021.09.009_bib55","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1046\/j.1523-1747.1998.00408.x","article-title":"Analysis of apoptotic cell death in human hair follicles in\u00a0vivo and in\u00a0vitro","volume":"111","author":"Soma","year":"1998","journal-title":"J.\u00a0Invest. Dermatol."},{"key":"10.1016\/j.stem.2021.09.009_bib56","doi-asserted-by":"crossref","first-page":"11345","DOI":"10.1074\/jbc.M109893200","article-title":"Bcl-2 and Bcl-xL inhibit CD95-mediated apoptosis by preventing mitochondrial release of Smac\/DIABLO and subsequent inactivation of X-linked inhibitor-of-apoptosis protein","volume":"277","author":"Sun","year":"2002","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.stem.2021.09.009_bib57","doi-asserted-by":"crossref","first-page":"22664","DOI":"10.1074\/jbc.M302561200","article-title":"Impaired pressure sensation in mice lacking TRPV4","volume":"278","author":"Suzuki","year":"2003","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.stem.2021.09.009_bib58","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1126\/science.1092436","article-title":"Defining the epithelial stem cell niche in skin","volume":"303","author":"Tumbar","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.stem.2021.09.009_bib59","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1038\/nature05394","article-title":"A stomatin-domain protein essential for touch sensation in the mouse","volume":"445","author":"Wetzel","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.stem.2021.09.009_bib60","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1016\/j.cell.2019.01.019","article-title":"Lateral Inhibition in Cell Specification Mediated by Mechanical Signals Modulating TAZ Activity","volume":"176","author":"Xia","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.stem.2021.09.009_bib61","doi-asserted-by":"crossref","first-page":"e10567","DOI":"10.7554\/eLife.10567","article-title":"Embryonic attenuated Wnt\/\u03b2-catenin signaling defines niche location and long-term stem cell fate in hair follicle","volume":"4","author":"Xu","year":"2015","journal-title":"eLife"},{"key":"10.1016\/j.stem.2021.09.009_bib62","doi-asserted-by":"crossref","first-page":"e30249","DOI":"10.7554\/eLife.30249","article-title":"Regional differences","volume":"6","author":"Yu","year":"2017","journal-title":"eLife"},{"key":"10.1016\/j.stem.2021.09.009_bib63","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.stem.2018.07.016","article-title":"Hoxc-Dependent Mesenchymal Niche Heterogeneity Drives Regional Hair Follicle Regeneration","volume":"23","author":"Yu","year":"2018","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.stem.2021.09.009_bib64","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1161\/CIRCRESAHA.115.307202","article-title":"Endocardium Contributes to Cardiac Fat","volume":"118","author":"Zhang","year":"2016","journal-title":"Circ. Res."}],"container-title":["Cell Stem Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1934590921003854?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1934590921003854?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T13:53:44Z","timestamp":1761832424000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1934590921003854"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":64,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["S1934590921003854"],"URL":"https:\/\/doi.org\/10.1016\/j.stem.2021.09.009","relation":{},"ISSN":["1934-5909"],"issn-type":[{"value":"1934-5909","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hair shaft miniaturization causes stem cell depletion through mechanosensory signals mediated by a Piezo1-calcium-TNF-\u03b1 axis","name":"articletitle","label":"Article Title"},{"value":"Cell Stem Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.stem.2021.09.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}