{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T20:03:09Z","timestamp":1791576189105,"version":"4.3.4"},"reference-count":53,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,9,20]],"date-time":"2022-09-20T00:00:00Z","timestamp":1663632000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000185","name":"Defense Advanced Research Projects Agency","doi-asserted-by":"publisher","award":["W911NF-16-C-0050"],"award-info":[{"award-number":["W911NF-16-C-0050"]}],"id":[{"id":"10.13039\/100000185","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000041","name":"American Diabetes Association","doi-asserted-by":"publisher","award":["7-20-COVID-211"],"award-info":[{"award-number":["7-20-COVID-211"]}],"id":[{"id":"10.13039\/100000041","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008237","name":"Department of Surgery","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008237","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012636","name":"New York State Stem Cell Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012636","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007273","name":"Weill Cornell Medical College","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007273","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004856","name":"New York State Department of Health","doi-asserted-by":"publisher","award":["C32599"],"award-info":[{"award-number":["C32599"]}],"id":[{"id":"10.13039\/100004856","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004856","name":"New York State Department of Health","doi-asserted-by":"publisher","award":["C32591"],"award-info":[{"award-number":["C32591"]}],"id":[{"id":"10.13039\/100004856","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004856","name":"New York State Department of Health","doi-asserted-by":"publisher","award":["C29156"],"award-info":[{"award-number":["C29156"]}],"id":[{"id":"10.13039\/100004856","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["DP3DK111907"],"award-info":[{"award-number":["DP3DK111907"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01DK116075"],"award-info":[{"award-number":["R01DK116075"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["U01 DK127777"],"award-info":[{"award-number":["U01 DK127777"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01 DK124463"],"award-info":[{"award-number":["R01 DK124463"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01 DK119667-02S1"],"award-info":[{"award-number":["R01 DK119667-02S1"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Stem Cell"],"published-print":{"date-parts":[[2022,10]]},"DOI":"10.1016\/j.stem.2022.09.008","type":"journal-article","created":{"date-parts":[[2022,10,6]],"date-time":"2022-10-06T13:25:41Z","timestamp":1665062741000},"page":"1475-1490.e6","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"title":["A human iPSC-array-based GWAS identifies a virus susceptibility locus in the NDUFA4 gene and functional variants"],"prefix":"10.1016","volume":"29","author":[{"given":"Yuling","family":"Han","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liuliu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Carrau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauretta A.","family":"Lacko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohsan","family":"Saeed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajun","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeping","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin E.","family":"Nilsson-Payant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filipe Tenorio","family":"Lira Neto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clare","family":"Cahir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice Maria","family":"Giani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin Chou","family":"Chai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorota","family":"Moroziewicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Paull","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuo","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soyeon","family":"Koo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ron","family":"Danziger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Ba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingling","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengming","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilbert J.","family":"Wise","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny Z.","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert E.","family":"Schwartz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin R.","family":"tenOever","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott A.","family":"Noggle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles M.","family":"Rice","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qibin","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd","family":"Evans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuibing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.stem.2022.09.008_bib1","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1186\/s12879-021-06376-1","article-title":"COVID-19 viral load not associated with disease severity: findings from a retrospective cohort study","volume":"21","author":"Abdulrahman","year":"2021","journal-title":"BMC Infect. Dis."},{"key":"10.1016\/j.stem.2022.09.008_bib2","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.cmet.2012.07.015","article-title":"NDUFA4 is a subunit of complex IV of the mammalian electron transport chain","volume":"16","author":"Balsa","year":"2012","journal-title":"Cell Metab"},{"key":"10.1016\/j.stem.2022.09.008_bib4","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1016\/j.cell.2020.04.026","article-title":"Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19","volume":"181","author":"Blanco-Melo","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.stem.2022.09.008_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.109920","article-title":"An airway organoid-based screen identifies a role for the HIF1\u03b1-glycolysis axis in SARS-CoV-2 infection","volume":"37","author":"Duan","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.stem.2022.09.008_bib54","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/nbt.4096","article-title":"Integrating single-cell transcriptomic data across different conditions, technologies, and species","volume":"36","author":"Butler","year":"2018","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.stem.2022.09.008_bib6","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1056\/NEJMoa2020283","article-title":"Genomewide Association Study of Severe Covid-19 with Respiratory Failure","volume":"383","author":"Degenhardt","year":"2020","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.stem.2022.09.008_bib7","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.stem.2016.12.005","article-title":"Recent Zika Virus Isolates Induce Premature Differentiation of Neural Progenitors in Human Brain Organoids","volume":"20","author":"Gabriel","year":"2017","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.stem.2022.09.008_bib8","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1038\/ng0710-558","article-title":"Hints of hidden heritability in GWAS","volume":"42","author":"Gibson","year":"2010","journal-title":"Nat. Genet."},{"key":"10.1016\/j.stem.2022.09.008_bib9","article-title":"The genetic architecture of human infectious diseases and pathogen-induced cellular phenotypes","author":"Hale","year":"2020","journal-title":"medRxiv"},{"key":"10.1016\/j.stem.2022.09.008_bib10","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/s41586-020-2901-9","article-title":"Identification of SARS-CoV-2 inhibitors using lung and colonic organoids","volume":"589","author":"Han","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.stem.2022.09.008_bib11","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.mito.2007.02.001","article-title":"Inhibition of mitochondrial complex IV leads to secondary loss complex II-III activity: implications for the pathogenesis and treatment of mitochondrial encephalomyopathies","volume":"7","author":"Hargreaves","year":"2007","journal-title":"Mitochondrion"},{"key":"10.1016\/j.stem.2022.09.008_bib12","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1186\/1471-2350-13-123","article-title":"Genome-wide sequencing for the identification of rearrangements associated with Tourette syndrome and obsessive-compulsive disorder","volume":"13","author":"Hooper","year":"2012","journal-title":"BMC Med. Genet."},{"key":"10.1016\/j.stem.2022.09.008_bib13","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/j.stem.2017.08.014","article-title":"Differentiation of Human Pluripotent Stem Cells into Functional Lung Alveolar Epithelial Cells","volume":"21","author":"Jacob","year":"2017","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.stem.2022.09.008_bib14","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/j.tem.2017.09.003","article-title":"Regulation of Mammalian 13-Subunit Cytochrome c Oxidase and Binding of other Proteins: Role of NDUFA4","volume":"28","author":"Kadenbach","year":"2017","journal-title":"Trends Endocrinol Metab"},{"key":"10.1016\/j.stem.2022.09.008_bib15","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/1750-1326-6-53","article-title":"High-level inhibition of mitochondrial complexes III and IV is required to increase glutamate release from the nerve terminal","volume":"6","author":"Kilbride","year":"2011","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.stem.2022.09.008_bib16","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1038\/s41587-019-0201-4","article-title":"Graph-based genome alignment and genotyping with HISAT2 and HISAT-genotype","volume":"37","author":"Kim","year":"2019","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.stem.2022.09.008_bib17","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1093\/toxsci\/kfm254","article-title":"Interaction of cyanide and nitric oxide with cytochrome c oxidase: implications for acute cyanide toxicity","volume":"101","author":"Leavesley","year":"2008","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.stem.2022.09.008_bib18","doi-asserted-by":"crossref","first-page":"e47","DOI":"10.1093\/nar\/gkz114","article-title":"The R package Rsubread is easier, faster, cheaper and better for alignment and quantification of RNA sequencing reads","volume":"47","author":"Liao","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.stem.2022.09.008_bib19","doi-asserted-by":"crossref","first-page":"4697","DOI":"10.1172\/JCI121735","article-title":"Zika virus infects human testicular tissue and germ cells","volume":"128","author":"Matusali","year":"2018","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.stem.2022.09.008_bib20","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1038\/gene.2012.53","article-title":"Variation in the TLR10\/TLR1\/TLR6 locus is the major genetic determinant of interindividual difference in TLR1\/2-mediated responses","volume":"14","author":"Mikacenic","year":"2013","journal-title":"Genes Immun"},{"key":"10.1016\/j.stem.2022.09.008_bib21","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1056\/NEJMoa1600651","article-title":"Zika Virus Associated with Microcephaly","volume":"374","author":"Mlakar","year":"2016","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.stem.2022.09.008_bib22","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0176795","article-title":"Selective mitochondrial DNA degradation following double-strand breaks","volume":"12","author":"Moretton","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.stem.2022.09.008_bib23","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.meegid.2017.09.028","article-title":"Genetic susceptibility to infectious diseases: Current status and future perspectives from genome-wide approaches","volume":"66","author":"Mozzi","year":"2018","journal-title":"Infect. Genet. Evol."},{"key":"10.1016\/j.stem.2022.09.008_bib24","first-page":"2816","article-title":"NDUFA4 expression in clear cell renal cell carcinoma is predictive for cancer-specific survival","volume":"5","author":"M\u00fcller","year":"2015","journal-title":"Am J Cancer Res"},{"key":"10.1016\/j.stem.2022.09.008_bib25","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1038\/s41586-021-03767-x","article-title":"Mapping the human genetic architecture of COVID-19","volume":"600","author":"Niemi","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.stem.2022.09.008_bib26","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.01257-21","article-title":"The NF-\u03baB Transcriptional Footprint Is Essential for SARS-CoV-2 Replication","volume":"95","author":"Nilsson-Payant","year":"2021","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.stem.2022.09.008_bib27","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.cell.2013.08.041","article-title":"Genetic variants regulating immune cell levels in health and disease","volume":"155","author":"Orru","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.stem.2022.09.008_bib28","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/s41586-020-03065-y","article-title":"Genetic mechanisms of critical illness in COVID-19","volume":"591","author":"Pairo-Castineira","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.stem.2022.09.008_bib29","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1038\/nmeth.3507","article-title":"Automated, high-throughput derivation, characterization and differentiation of induced pluripotent\u00a0stem cells","volume":"12","author":"Paull","year":"2015","journal-title":"Nat. Methods"},{"key":"10.1016\/j.stem.2022.09.008_bib30","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1016\/j.celrep.2013.05.005","article-title":"NDUFA4 mutations underlie dysfunction of a cytochrome c oxidase subunit linked to human neurological disease","volume":"3","author":"Pitceathly","year":"2013","journal-title":"Cell Rep."},{"key":"10.1016\/j.stem.2022.09.008_bib31","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1016\/j.cell.2016.04.032","article-title":"Brain-Region-Specific Organoids Using Mini-bioreactors for Modeling ZIKV Exposure","volume":"165","author":"Qian","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.stem.2022.09.008_bib32","doi-asserted-by":"crossref","first-page":"2027","DOI":"10.1083\/jcb.201702058","article-title":"Multi-omics analysis identifies ATF4 as a key regulator of the mitochondrial stress response in mammals","volume":"216","author":"Quiros","year":"2017","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.stem.2022.09.008_bib33","doi-asserted-by":"crossref","first-page":"3061","DOI":"10.1002\/jcb.24183","article-title":"Assessing iPSC reprogramming methods for their suitability in translational medicine","volume":"113","author":"Rao","year":"2012","journal-title":"J.\u00a0Cell. Biochem."},{"key":"10.1016\/j.stem.2022.09.008_bib34","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.cell.2017.04.024","article-title":"Recurrent Potent Human Neutralizing Antibodies to Zika Virus in Brazil and Mexico","volume":"169","author":"Robbiani","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.stem.2022.09.008_bib35","doi-asserted-by":"crossref","first-page":"2090","DOI":"10.1038\/s41467-018-04444-w","article-title":"Male germ cells support long-term propagation of Zika virus","volume":"9","author":"Robinson","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.stem.2022.09.008_bib36","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.cell.2015.02.046","article-title":"The genetic architecture of the human immune system: a bioresource for autoimmunity and disease pathogenesis","volume":"161","author":"Roederer","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.stem.2022.09.008_bib37","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-35511-3","article-title":"Identification of a Small Interface between the Methyltransferase and RNA Polymerase of NS5 that is Essential for Zika Virus Replication","volume":"8","author":"Rusanov","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.stem.2022.09.008_bib38","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1038\/nature14899","article-title":"SEC14L2 enables pan-genotype HCV replication in cell culture","volume":"524","author":"Saeed","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.stem.2022.09.008_bib39","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1091\/mbc.e13-06-0294","article-title":"A cellular genome-wide association study reveals human variation in microtubule stability and a role in inflammatory cell death","volume":"25","author":"Salinas","year":"2014","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.stem.2022.09.008_bib40","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/s41556-021-00821-8","article-title":"BRD2 inhibition blocks SARS-CoV-2 infection by reducing transcription of the host cell receptor ACE2","volume":"24","author":"Samelson","year":"2022","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.stem.2022.09.008_bib41","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.stem.2016.02.016","article-title":"Zika Virus Infects Human Cortical Neural Progenitors and Attenuates Their Growth","volume":"18","author":"Tang","year":"2016","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.stem.2022.09.008_bib42","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.1523\/JNEUROSCI.3124-16.2017","article-title":"Zika Virus Targeting in the Developing Brain","volume":"37","author":"van den Pol","year":"2017","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.stem.2022.09.008_bib43","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.chom.2018.07.007","article-title":"An Atlas of Genetic Variation Linking Pathogen-Induced Cellular Traits to Human Disease","volume":"24","author":"Wang","year":"2018","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.stem.2022.09.008_bib44","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/nature14156","article-title":"Mitochondrial DNA stress primes the antiviral innate immune response","volume":"520","author":"West","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.stem.2022.09.008_bib45","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/nri2975","article-title":"Mitochondria in innate immune responses","volume":"11","author":"West","year":"2011","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.stem.2022.09.008_bib46","doi-asserted-by":"crossref","first-page":"dmm036699","DOI":"10.1242\/dmm.036699","article-title":"A novel mutation in the NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 4 (Ndufa4) gene links mitochondrial dysfunction to the development of diabetes in a rodent model","volume":"11","author":"Yagil","year":"2018","journal-title":"Dis Model Mech"},{"key":"10.1016\/j.stem.2022.09.008_bib47","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.stem.2020.06.015","article-title":"A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids","volume":"27","author":"Yang","year":"2020","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.stem.2022.09.008_bib48","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1038\/s41586-020-2818-3","article-title":"The major genetic risk factor for severe COVID-19 is inherited from Neanderthals","volume":"587","author":"Zeberg","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.stem.2022.09.008_bib49","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/nature08780","article-title":"Circulating mitochondrial DAMPs cause inflammatory responses to injury","volume":"464","author":"Zhang","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.stem.2022.09.008_bib50","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.stem.2017.06.017","article-title":"High-Content Screening in hPSC-Neural Progenitors Identifies Drug Candidates that Inhibit Zika Virus Infection in Fetal-like Organoids and Adult Brain","volume":"21","author":"Zhou","year":"2017","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.stem.2022.09.008_bib51","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/j.chom.2020.04.017","article-title":"Heightened Innate Immune Responses in the Respiratory Tract of COVID-19 Patients","volume":"27","author":"Zhou","year":"2020","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.stem.2022.09.008_bib52","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1016\/j.cell.2020.04.035","article-title":"SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues","volume":"181","author":"Ziegler","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.stem.2022.09.008_bib53","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1038\/s41422-018-0071-1","article-title":"Structure of the intact 14-subunit human cytochrome c oxidase","volume":"28","author":"Zong","year":"2018","journal-title":"Cell Res."}],"container-title":["Cell Stem Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S193459092200385X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S193459092200385X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T19:56:03Z","timestamp":1786218963000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S193459092200385X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10]]},"references-count":53,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["S193459092200385X"],"URL":"https:\/\/doi.org\/10.1016\/j.stem.2022.09.008","relation":{},"ISSN":["1934-5909"],"issn-type":[{"value":"1934-5909","type":"print"}],"subject":[],"published":{"date-parts":[[2022,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A human iPSC-array-based GWAS identifies a virus susceptibility locus in the NDUFA4 gene and functional variants","name":"articletitle","label":"Article Title"},{"value":"Cell Stem Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.stem.2022.09.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}