{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T18:43:09Z","timestamp":1793472189076,"version":"4.5.0"},"reference-count":113,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,11,15]],"date-time":"2022-11-15T00:00:00Z","timestamp":1668470400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Stem Cell"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1016\/j.stem.2022.11.004","type":"journal-article","created":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T13:20:52Z","timestamp":1669900852000},"page":"1685-1702.e22","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":367,"title":["A reference human induced pluripotent stem cell line for large-scale collaborative studies"],"prefix":"10.1016","volume":"29","author":[{"given":"Caroline B.","family":"Pantazis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrian","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika","family":"Lara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin A.","family":"McDonough","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelis","family":"Blauwendraat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lirong","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideyuki","family":"Oguro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jitendra","family":"Kanaujiya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jizhong","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Sebesta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gretchen","family":"Pratt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin","family":"Cross","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Blockwick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Buxton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Kinner-Bibeau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constance","family":"Medura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Tompkins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Hughes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianita","family":"Santiana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faraz","family":"Faghri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mike A.","family":"Nalls","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Vitale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shannon","family":"Ballard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue A.","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel M.","family":"Ramos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kailyn M.","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Stadler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priyanka","family":"Narayan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Papademetriou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luke","family":"Reilly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew P.","family":"Nelson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanya","family":"Aggarwal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leah U.","family":"Rosen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Kirwan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Venkat","family":"Pisupati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven L.","family":"Coon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonja W.","family":"Scholz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theresa","family":"Priebe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"\u00d6ttl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marieke","family":"Meijer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara J.M.","family":"Janssen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa S.","family":"Lourenco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rik","family":"van der Kant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis","family":"Crusius","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominik","family":"Paquet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana-Caroline","family":"Raulin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guojun","family":"Bu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron","family":"Held","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian J.","family":"Wainger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca M.C.","family":"Gabriele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jackie M.","family":"Casey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selina","family":"Wray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dad","family":"Abu-Bonsrah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clare L.","family":"Parish","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melinda S.","family":"Beccari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Don W.","family":"Cleveland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmy","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Indigo V.L.","family":"Rose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Kampmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carles","family":"Calatayud Aristoy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrik","family":"Verstreken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurin","family":"Heinrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max Y.","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgitt","family":"Sch\u00fcle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Dou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika L.F.","family":"Holzbaur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Clara","family":"Zanellati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richa","family":"Basundra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohanish","family":"Deshmukh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Cohen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richa","family":"Khanna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malavika","family":"Raman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zachary S.","family":"Nevin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madeline","family":"Matia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas","family":"Van Lent","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Timmerman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce R.","family":"Conklin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Johnson Chase","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salome","family":"Funes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daryl A.","family":"Bosco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lena","family":"Erlebach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Welzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah","family":"Kronenberg-Versteeg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guochang","family":"Lyu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernest","family":"Arenas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Coccia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lily","family":"Sarrafha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim","family":"Ahfeldt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John C.","family":"Marioni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William C.","family":"Skarnes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark R.","family":"Cookson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael E.","family":"Ward","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian T.","family":"Merkle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.stem.2022.11.004_bib1","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.neuron.2019.07.010","article-title":"A Large Panel of Isogenic APP and PSEN1 Mutant Human iPSC Neurons Reveals Shared Endosomal Abnormalities Mediated by APP beta-CTFs, Not Abeta","volume":"104","author":"Kwart","year":"2019","journal-title":"Neuron"},{"key":"10.1016\/j.stem.2022.11.004_bib2","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.stemcr.2019.08.004","article-title":"PSEN1DeltaE9, APPswe, and APOE4 Confer Disparate Phenotypes in Human iPSC-Derived Microglia","volume":"13","author":"Konttinen","year":"2019","journal-title":"Stem Cell Reports"},{"key":"10.1016\/j.stem.2022.11.004_bib3","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/s41593-020-00796-z","article-title":"Fully defined human pluripotent stem cell-derived microglia and tri-culture system model C3 production in Alzheimer's disease","volume":"24","author":"Guttikonda","year":"2021","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.stem.2022.11.004_bib4","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1007\/978-1-59745-471-1_23","article-title":"Influence of genetic background on genetically engineered mouse phenotypes","volume":"530","author":"Doetschman","year":"2009","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.stem.2022.11.004_bib5","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/ng0297-207","article-title":"Mapping of a major genetic modifier of embryonic lethality in TGF beta 1 knockout mice","volume":"15","author":"Bonyadi","year":"1997","journal-title":"Nat Genet"},{"key":"10.1016\/j.stem.2022.11.004_bib6","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1126\/science.7618084","article-title":"Targeted disruption of mouse EGF receptor: effect of genetic background on mutant phenotype","volume":"269","author":"Threadgill","year":"1995","journal-title":"Science"},{"key":"10.1016\/j.stem.2022.11.004_bib7","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.tig.2015.02.009","article-title":"The laboratory domestication of Caenorhabditis elegans","volume":"31","author":"Sterken","year":"2015","journal-title":"Trends Genet"},{"key":"10.1016\/j.stem.2022.11.004_bib8","volume":"7","author":"Mackay","year":"2018"},{"key":"10.1016\/j.stem.2022.11.004_bib9","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1016\/j.neuron.2016.08.013","article-title":"Genetic Background Limits Generalizability of Genotype-Phenotype Relationships","volume":"91","author":"Sittig","year":"2016","journal-title":"Neuron"},{"key":"10.1016\/j.stem.2022.11.004_bib10","doi-asserted-by":"crossref","first-page":"2854","DOI":"10.1091\/mbc.e17-03-0209","article-title":"Systematic gene tagging using CRISPR\/Cas9 in human stem cells to illuminate cell organization","volume":"28","author":"Roberts","year":"2017","journal-title":"Mol Biol Cell"},{"key":"10.1016\/j.stem.2022.11.004_bib11","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1016\/j.stemcr.2019.03.001","article-title":"Fluorescent Gene Tagging of Transcriptionally Silent Genes in hiPSCs","volume":"12","author":"Roberts","year":"2019","journal-title":"Stem Cell Reports"},{"key":"10.1016\/j.stem.2022.11.004_bib12","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1016\/j.neuron.2021.03.022","article-title":"Tackling neurodegenerative diseases with genomic engineering: A new stem cell initiative from the NIH","volume":"109","author":"Ramos","year":"2021","journal-title":"Neuron"},{"key":"10.1016\/j.stem.2022.11.004_bib13","article-title":"A fully automated FAIMS-DIA proteomic pipeline for high-throughput characterization of iPSC-derived neurons","author":"Reilly","year":"2021","journal-title":"bioRxiv"},{"key":"10.1016\/j.stem.2022.11.004_bib14","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.stem.2012.02.014","article-title":"Erosion of dosage compensation impacts human iPSC disease modeling","volume":"10","author":"Mekhoubad","year":"2012","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.stem.2022.11.004_bib15","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.celrep.2019.03.019","article-title":"Global Characterization of X Chromosome Inactivation in Human Pluripotent Stem Cells","volume":"27","author":"Bar","year":"2019","journal-title":"Cell Rep"},{"key":"10.1016\/j.stem.2022.11.004_bib16","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1016\/j.stemcr.2019.11.003","article-title":"Precision Health Resource of Control iPSC Lines for Versatile Multilineage Differentiation","volume":"13","author":"Hildebrandt","year":"2019","journal-title":"Stem Cell Reports"},{"key":"10.1016\/j.stem.2022.11.004_bib17","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/978-1-4939-9432-8_13","article-title":"Directional Genomic Hybridization (dGH) for Detection of Intrachromosomal Rearrangements","volume":"1984","author":"Robinson","year":"2019","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.stem.2022.11.004_bib18","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1186\/s13059-019-1865-2","article-title":"Vireo: Bayesian demultiplexing of pooled single-cell RNA-seq data without genotype reference","volume":"20","author":"Huang","year":"2019","journal-title":"Genome Biol"},{"key":"10.1016\/j.stem.2022.11.004_bib19","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1038\/s41580-020-00292-z","article-title":"Acquired genetic changes in human pluripotent stem cells: origins and consequences","volume":"21","author":"Halliwell","year":"2020","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.stem.2022.11.004_bib20","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1038\/nature22312","article-title":"Human\u00a0pluripotent stem cells recurrently acquire and expand dominant negative P53 mutations","volume":"545","author":"Merkle","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.stem.2022.11.004_bib21","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.stem.2020.11.013","article-title":"Cancer-Related Mutations Identified in Primed Human Pluripotent Stem Cells","volume":"28","author":"Avior","year":"2021","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.stem.2022.11.004_bib22","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1038\/s41591-018-0050-6","article-title":"p53 inhibits CRISPR-Cas9 engineering in human pluripotent stem cells","volume":"24","author":"Ihry","year":"2018","journal-title":"Nat Med"},{"key":"10.1016\/j.stem.2022.11.004_bib23","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1038\/s41586-020-2308-7","article-title":"The mutational constraint spectrum quantified from variation in 141,456 humans","volume":"581","author":"Karczewski","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.stem.2022.11.004_bib24","doi-asserted-by":"crossref","first-page":"2207","DOI":"10.1093\/hmg\/3.12.2207","article-title":"Human dopamine D4 receptor gene: frequent occurrence of a null allele and observation of homozygosity","volume":"3","author":"Nothen","year":"1994","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.stem.2022.11.004_bib25","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1002\/ana.24964","article-title":"The genetic landscape of familial congenital hydrocephalus","volume":"81","author":"Shaheen","year":"2017","journal-title":"Ann Neurol"},{"key":"10.1016\/j.stem.2022.11.004_bib26","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1038\/s41588-019-0358-2","article-title":"Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Abeta, tau, immunity and lipid processing","volume":"51","author":"Kunkle","year":"2019","journal-title":"Nat Genet"},{"key":"10.1016\/j.stem.2022.11.004_bib27","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1016\/S1474-4422(19)30320-5","article-title":"Identification of novel risk loci, causal insights, and heritable risk for Parkinson's disease: a meta-analysis of genome-wide association studies","volume":"18","author":"Nalls","year":"2019","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.stem.2022.11.004_bib28","article-title":"Controlling homology-directed repair outcomes in human stem cells with dCas9","author":"Skarnes","year":"2021","journal-title":"bioRxiv"},{"key":"10.1016\/j.stem.2022.11.004_bib29","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.ymeth.2019.06.016","article-title":"Improving homology-directed repair efficiency in human stem cells","volume":"164-165","author":"Skarnes","year":"2019","journal-title":"Methods"},{"key":"10.1016\/j.stem.2022.11.004_bib30","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1006\/geno.1994.1016","article-title":"Cloning of the cDNA encoding human tissue inhibitor of metalloproteinases-3 (TIMP-3) and mapping of the TIMP3 gene to chromosome 22","volume":"19","author":"Apte","year":"1994","journal-title":"Genomics"},{"key":"10.1016\/j.stem.2022.11.004_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.107689","article-title":"Detection of Deleterious On-Target Effects after HDR-Mediated CRISPR Editing","volume":"31","author":"Weisheit","year":"2020","journal-title":"Cell Rep"},{"key":"10.1016\/j.stem.2022.11.004_bib32","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/j.celrep.2015.04.007","article-title":"Efficient CRISPR-Cas9-mediated generation of knockin human pluripotent stem cells lacking undesired mutations at the targeted locus","volume":"11","author":"Merkle","year":"2015","journal-title":"Cell Rep"},{"key":"10.1016\/j.stem.2022.11.004_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.neurobiolaging.2017.05.009","article-title":"NeuroChip, an updated version of the NeuroX genotyping platform to rapidly screen for variants associated with neurological diseases","volume":"57","author":"Blauwendraat","year":"2017","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.stem.2022.11.004_bib34","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1086\/519795","article-title":"PLINK: a tool set for whole-genome association and population-based linkage analyses","volume":"81","author":"Purcell","year":"2007","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.stem.2022.11.004_bib35","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1038\/nbt.2051","article-title":"Screening ethnically diverse human embryonic stem cells identifies a chromosome 20 minimal amplicon conferring growth advantage","volume":"29","author":"International Stem Cell","year":"2011","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.stem.2022.11.004_bib36","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.stem.2010.12.003","article-title":"Dynamic changes in the copy number of pluripotency and cell proliferation genes in human ESCs and iPSCs during reprogramming and time in culture","volume":"8","author":"Laurent","year":"2011","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.stem.2022.11.004_bib37","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1038\/nbt.1509","article-title":"Human embryonic stem cells reveal recurrent genomic instability at 20q11.21","volume":"26","author":"Lefort","year":"2008","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.stem.2022.11.004_bib38","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1038\/nbt.1615","article-title":"High-resolution DNA analysis of human embryonic stem cell lines reveals culture-induced copy number changes and loss of heterozygosity","volume":"28","author":"Narva","year":"2010","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.stem.2022.11.004_bib39","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1038\/nbt.1510","article-title":"Recurrent chromosomal abnormalities in human embryonic stem cells","volume":"26","author":"Spits","year":"2008","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.stem.2022.11.004_bib40","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1634\/stemcells.2007-0993","article-title":"Copy number variant analysis of human embryonic stem cells","volume":"26","author":"Wu","year":"2008","journal-title":"Stem Cells"},{"key":"10.1016\/j.stem.2022.11.004_bib41","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.stemcr.2019.05.005","article-title":"Gain of 20q11.21 in Human Pluripotent Stem Cells Impairs TGF-beta-Dependent Neuroectodermal Commitment","volume":"13","author":"Markouli","year":"2019","journal-title":"Stem Cell Reports"},{"key":"10.1016\/j.stem.2022.11.004_bib42","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1000718","article-title":"A robust approach to identifying tissue-specific gene expression regulatory variants using personalized human induced pluripotent stem cells","volume":"5","author":"Lee","year":"2009","journal-title":"PLoS Genet"},{"key":"10.1016\/j.stem.2022.11.004_bib43","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1038\/s41588-022-01147-3","article-title":"Substantial somatic genomic variation and selection for BCOR mutations in human induced pluripotent stem cells","volume":"54","author":"Rouhani","year":"2022","journal-title":"Nat Genet"},{"key":"10.1016\/j.stem.2022.11.004_bib44","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1093\/bioinformatics\/btv602","article-title":"LoFtool: a gene intolerance score based on loss-of-function variants in 60 706 individuals","volume":"33","author":"Fadista","year":"2017","journal-title":"Bioinformatics"},{"key":"10.1016\/j.stem.2022.11.004_bib45","doi-asserted-by":"crossref","first-page":"2235","DOI":"10.1056\/NEJMsr1406261","article-title":"ClinGen--the Clinical Genome Resource","volume":"372","author":"Rehm","year":"2015","journal-title":"N Engl J Med"},{"key":"10.1016\/j.stem.2022.11.004_bib46","doi-asserted-by":"crossref","first-page":"4890","DOI":"10.1038\/s41598-019-41259-1","article-title":"Autaptic cultures of human induced neurons as a versatile platform for studying synaptic function and neuronal morphology","volume":"9","author":"Fenske","year":"2019","journal-title":"Sci Rep"},{"key":"10.1016\/j.stem.2022.11.004_bib47","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.1016\/j.celrep.2019.04.059","article-title":"An Autaptic Culture System for Standardized Analyses of iPSC-Derived Human Neurons","volume":"27","author":"Rhee","year":"2019","journal-title":"Cell Rep"},{"key":"10.1016\/j.stem.2022.11.004_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2019.04.058","article-title":"A Single-Cell Model for Synaptic Transmission and Plasticity in Human iPSC-Derived Neurons","volume":"27","author":"Meijer","year":"2019","journal-title":"Cell Rep"},{"key":"10.1016\/j.stem.2022.11.004_bib49","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.cell.2007.11.019","article-title":"Induction of pluripotent stem cells from adult human fibroblasts by defined factors","volume":"131","author":"Takahashi","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.stem.2022.11.004_bib50","doi-asserted-by":"crossref","first-page":"S161","DOI":"10.3233\/JAD-179939","article-title":"Religious Orders Study and Rush Memory and Aging Project","volume":"64","author":"Bennett","year":"2018","journal-title":"J Alzheimers Dis"},{"key":"10.1016\/j.stem.2022.11.004_bib51","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s41232-019-0106-0","article-title":"Overview: an iPS cell stock at CiRA","volume":"39","author":"Umekage","year":"2019","journal-title":"Inflamm Regen"},{"key":"10.1016\/j.stem.2022.11.004_bib52","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1038\/s41588-021-00801-6","article-title":"Population-scale single-cell RNA-seq profiling across dopaminergic neuron differentiation","volume":"53","author":"Jerber","year":"2021","journal-title":"Nat Genet"},{"key":"10.1016\/j.stem.2022.11.004_bib53","article-title":"Mapping genetic effects on cellular phenotypes with \u201ccell villages\u201d","author":"Mitchell","year":"2020","journal-title":"bioRxiv"},{"key":"10.1016\/j.stem.2022.11.004_bib54","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/j.stem.2022.01.011","article-title":"Whole-genome analysis of human embryonic stem cells enables rational line selection based on genetic variation","volume":"29","author":"Merkle","year":"2022","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.stem.2022.11.004_bib55","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1038\/nature22403","article-title":"Common genetic variation drives molecular heterogeneity in human iPSCs","volume":"546","author":"Kilpinen","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.stem.2022.11.004_bib56","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/978-1-4939-9170-9_11","article-title":"Editing the Genome of Human Induced Pluripotent Stem Cells Using CRISPR\/Cas9 Ribonucleoprotein Complexes","volume":"1961","author":"Bruntraeger","year":"2019","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.stem.2022.11.004_bib57","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1038\/s41593-021-00862-0","article-title":"Genome-wide CRISPRi\/a screens in human neurons link lysosomal failure to ferroptosis","volume":"24","author":"Tian","year":"2021","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.stem.2022.11.004_bib58","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.neuron.2019.07.014","article-title":"CRISPR Interference-Based Platform for Multimodal Genetic Screens in Human iPSC-Derived Neurons","volume":"104","author":"Tian","year":"2019","journal-title":"Neuron"},{"key":"10.1016\/j.stem.2022.11.004_bib59","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s00401-019-02066-0","article-title":"The TMEM106B FTLD-protective variant, rs1990621, is also associated with increased neuronal proportion","volume":"139","author":"Li","year":"2020","journal-title":"Acta Neuropathol"},{"key":"10.1016\/j.stem.2022.11.004_bib60","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.stemcr.2019.12.004","article-title":"Recurrent Genetic Abnormalities in Human Pluripotent Stem Cells: Definition and Routine Detection in Culture Supernatant by Targeted Droplet Digital PCR","volume":"14","author":"Assou","year":"2020","journal-title":"Stem Cell Reports"},{"key":"10.1016\/j.stem.2022.11.004_bib61","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/0092-8674(93)90500-P","article-title":"WAF1, a potential mediator of p53 tumor suppression","volume":"75","author":"el-Deiry","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.stem.2022.11.004_bib62","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1073\/pnas.1008322108","article-title":"A hyperactive piggyBac transposase for mammalian applications","volume":"108","author":"Yusa","year":"2011","journal-title":"Proc Natl\u00a0Acad Sci USA"},{"key":"10.1016\/j.stem.2022.11.004_bib63","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s10577-013-9345-0","article-title":"Directional genomic hybridization for chromosomal inversion discovery and detection","volume":"21","author":"Ray","year":"2013","journal-title":"Chromosome Res"},{"key":"10.1016\/j.stem.2022.11.004_bib64","doi-asserted-by":"crossref","DOI":"10.3791\/50203-v","article-title":"Chromosome preparation from cultured cells","author":"Howe","year":"2014","journal-title":"J Vis Exp"},{"key":"10.1016\/j.stem.2022.11.004_bib65","doi-asserted-by":"crossref","first-page":"e164","DOI":"10.1093\/nar\/gkq603","article-title":"ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data","volume":"38","author":"Wang","year":"2010","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.stem.2022.11.004_bib66","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/s41586-018-0579-z","article-title":"The UK Biobank resource with deep phenotyping and genomic data","volume":"562","author":"Bycroft","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.stem.2022.11.004_bib67","doi-asserted-by":"crossref","first-page":"3329","DOI":"10.1093\/bioinformatics\/bts610","article-title":"GWASTools: an R\/Bioconductor package for quality control and analysis of genome-wide association studies","volume":"28","author":"Gogarten","year":"2012","journal-title":"Bioinformatics"},{"key":"10.1016\/j.stem.2022.11.004_bib68","doi-asserted-by":"crossref","DOI":"10.1093\/gigascience\/giab008","article-title":"Twelve years of SAMtools and BCFtools","volume":"10","author":"Danecek","year":"2021","journal-title":"Gigascience"},{"key":"10.1016\/j.stem.2022.11.004_bib69","doi-asserted-by":"crossref","first-page":"e31","DOI":"10.1158\/0008-5472.CAN-17-0337","article-title":"Variant Review with the Integrative Genomics Viewer","volume":"77","author":"Robinson","year":"2017","journal-title":"Cancer Res"},{"key":"10.1016\/j.stem.2022.11.004_bib70","doi-asserted-by":"crossref","first-page":"e51","DOI":"10.1002\/cpcb.51","article-title":"Transcription Factor-Mediated Differentiation of Human iPSCs into Neurons","volume":"79","author":"Fernandopulle","year":"2018","journal-title":"Curr Protoc Cell Biol"},{"key":"10.1016\/j.stem.2022.11.004_bib71","article-title":"Generation and Characterization of Functional Human Hypothalamic Neurons","volume":"81","author":"Kirwan","year":"2017","journal-title":"Curr Protoc Neurosci"},{"key":"10.1016\/j.stem.2022.11.004_bib72","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1242\/dev.117978","article-title":"Generation of neuropeptidergic hypothalamic neurons from human pluripotent stem cells","volume":"142","author":"Merkle","year":"2015","journal-title":"Development"},{"key":"10.1016\/j.stem.2022.11.004_bib73","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1038\/s41592-019-0433-8","article-title":"MULTI-seq: sample multiplexing for single-cell RNA sequencing using lipid-tagged indices","volume":"16","author":"McGinnis","year":"2019","journal-title":"Nat Methods"},{"key":"10.1016\/j.stem.2022.11.004_bib74","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1186\/s13059-019-1662-y","article-title":"EmptyDrops: distinguishing cells from empty droplets in droplet-based single-cell RNA sequencing data","volume":"20","author":"Lun","year":"2019","journal-title":"Genome Biol"},{"key":"10.1016\/j.stem.2022.11.004_bib75","first-page":"2122","article-title":"A step-by-step workflow for low-level analysis of single-cell RNA-seq data with Bioconductor","volume":"5","author":"Lun","year":"2016","journal-title":"F1000Res"},{"key":"10.1016\/j.stem.2022.11.004_bib76","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1126\/science.aad0501","article-title":"Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq","volume":"352","author":"Tirosh","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.stem.2022.11.004_bib77","doi-asserted-by":"crossref","first-page":"3573","DOI":"10.1016\/j.cell.2021.04.048","article-title":"Integrated analysis of multimodal single-cell data","volume":"184","author":"Hao","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.stem.2022.11.004_bib78","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1093\/bioinformatics\/btz698","article-title":"scds: computational annotation of doublets in single-cell RNA sequencing data","volume":"36","author":"Bais","year":"2020","journal-title":"Bioinformatics"},{"key":"10.1016\/j.stem.2022.11.004_bib79","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/nbt.4091","article-title":"Batch effects in single-cell RNA-sequencing data are corrected by matching mutual nearest neighbors","volume":"36","author":"Haghverdi","year":"2018","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.stem.2022.11.004_bib80","series-title":"The Igraph Software Package for Complex Network Research","author":"Cs\u00e1rdi","year":"2006"},{"key":"10.1016\/j.stem.2022.11.004_bib81","series-title":"Umap: Uniform manifold approximation and projection for dimension reduction","author":"McInnes","year":"2018"},{"key":"10.1016\/j.stem.2022.11.004_bib82","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1038\/nbt.1783","article-title":"A functionally characterized test set of human induced pluripotent stem cells","volume":"29","author":"Boulting","year":"2011","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.stem.2022.11.004_bib83","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1038\/s41592-021-01126-2","article-title":"A versatile polypharmacology platform promotes cytoprotection and viability of human pluripotent and differentiated cells","volume":"18","author":"Chen","year":"2021","journal-title":"Nat Methods"},{"key":"10.1016\/j.stem.2022.11.004_bib84","unstructured":"Carles Calatayud, E.M.-P., Sandra Fern\u00e1ndez-Gallego, and Patrik Verstreken (n.d.). Modular Generation of Cortical, Striatal and Ventral Midbrain Progenitor Cells v1."},{"key":"10.1016\/j.stem.2022.11.004_bib85","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1038\/nature10648","article-title":"Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson's disease","volume":"480","author":"Kriks","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.stem.2022.11.004_bib86","doi-asserted-by":"crossref","first-page":"1836","DOI":"10.1038\/nprot.2012.116","article-title":"Directed differentiation of human pluripotent stem cells to cerebral cortex neurons and neural networks","volume":"7","author":"Shi","year":"2012","journal-title":"Nat Protoc"},{"key":"10.1016\/j.stem.2022.11.004_bib87","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1242\/dev.117093","article-title":"Activin A directs striatal projection neuron differentiation of human pluripotent stem cells","volume":"142","author":"Arber","year":"2015","journal-title":"Development"},{"key":"10.1016\/j.stem.2022.11.004_bib88","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1002\/stem.1166","article-title":"Directing differentiation of human embryonic stem cells toward anterior neural ectoderm using small molecules","volume":"30","author":"Surmacz","year":"2012","journal-title":"Stem Cells"},{"key":"10.1016\/j.stem.2022.11.004_bib89","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/j.stemcr.2014.10.004","article-title":"Endogenous WNT signaling regulates hPSC-derived neural progenitor cell heterogeneity and specifies their regional identity","volume":"3","author":"Moya","year":"2014","journal-title":"Stem Cell Reports"},{"key":"10.1016\/j.stem.2022.11.004_bib90","doi-asserted-by":"crossref","DOI":"10.1016\/j.jneumeth.2022.109653","article-title":"Multiplex imaging of human induced pluripotent stem cell-derived neurons with CO-Detection by indEXing (CODEX) technology","volume":"378","author":"Heinrich","year":"2022","journal-title":"J Neurosci Methods"},{"key":"10.1016\/j.stem.2022.11.004_bib91","doi-asserted-by":"crossref","unstructured":"Zafar, F.T., A.; Heinrich, L; Singh, J.; Hempel, C.; Braubch, O.; Schuele, B. (2022). Protocol for CODEX Fixation Steps and Primary Antibody Staining for Induced Pluripotent Stem Cell-Derived Neurons.","DOI":"10.17504\/protocols.io.b3fhqjj6"},{"key":"10.1016\/j.stem.2022.11.004_bib92","doi-asserted-by":"crossref","DOI":"10.21769\/BioProtoc.4283","article-title":"Gene Expression Analysis in Stem Cell-derived Cortical Neuronal Cultures Using Multi-well SYBR Green Quantitative PCR Arrays","volume":"12","author":"Srinivasaraghavan","year":"2022","journal-title":"Bio-Protocol"},{"key":"10.1016\/j.stem.2022.11.004_bib93","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1038\/s41591-020-1043-9","article-title":"Neuronal defects in a human cellular model of 22q11.2 deletion syndrome","volume":"26","author":"Khan","year":"2020","journal-title":"Nat Med"},{"key":"10.1016\/j.stem.2022.11.004_bib94","doi-asserted-by":"crossref","DOI":"10.1016\/j.scr.2021.102240","article-title":"Generation of two gene edited iPSC-lines carrying a DOX-inducible NGN2 expression cassette with and without GFP in the AAVS1 locus","volume":"52","author":"Schmid","year":"2021","journal-title":"Stem Cell Res"},{"key":"10.1016\/j.stem.2022.11.004_bib95","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1038\/nature17664","article-title":"Efficient\u00a0introduction of specific homozygous and heterozygous mutations using CRISPR\/Cas9","volume":"533","author":"Paquet","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.stem.2022.11.004_bib96","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1186\/s13024-018-0297-x","article-title":"Development and validation of a simplified method to generate human microglia from pluripotent stem cells","volume":"13","author":"McQuade","year":"2018","journal-title":"Mol Neurodegener"},{"key":"10.1016\/j.stem.2022.11.004_bib97","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2021109108","article-title":"Loss of TREM2 rescues hyperactivation of microglia, but not lysosomal deficits and neurotoxicity in models of progranulin deficiency","volume":"41","author":"Reifschneider","year":"2022","journal-title":"EMBO J"},{"key":"10.1016\/j.stem.2022.11.004_bib98","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.ymeth.2003.11.023","article-title":"Advanced transfection with Lipofectamine 2000 reagent: primary neurons, siRNA, and high-throughput applications","volume":"33","author":"Dalby","year":"2004","journal-title":"Methods"},{"key":"10.1016\/j.stem.2022.11.004_bib99","doi-asserted-by":"crossref","first-page":"2919","DOI":"10.1038\/s41380-019-0410-8","article-title":"Familial Alzheimer's disease patient-derived neurons reveal distinct mutation-specific effects on amyloid beta","volume":"25","author":"Arber","year":"2020","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.stem.2022.11.004_bib100","doi-asserted-by":"crossref","first-page":"5260","DOI":"10.1093\/hmg\/ddv246","article-title":"Developmental regulation of tau splicing is disrupted in stem cell-derived neurons from frontotemporal dementia patients with the 10 + 16 splice-site mutation in MAPT","volume":"24","author":"Sposito","year":"2015","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.stem.2022.11.004_bib101","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1038\/nprot.2016.110","article-title":"Generation of human muscle fibers and satellite-like cells from human pluripotent stem cells in vitro","volume":"11","author":"Chal","year":"2016","journal-title":"Nat Protoc"},{"key":"10.1016\/j.stem.2022.11.004_bib102","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1016\/j.stemcr.2021.03.014","article-title":"FGF-MAPK signaling regulates human deep-layer corticogenesis","volume":"16","author":"Gantner","year":"2021","journal-title":"Stem Cell Reports"},{"key":"10.1016\/j.stem.2022.11.004_bib103","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1016\/j.neuron.2020.06.027","article-title":"G4C2 Repeat RNA Initiates a POM121-Mediated Reduction in Specific Nucleoporins in C9orf72 ALS\/FTD","volume":"107","author":"Coyne","year":"2020","journal-title":"Neuron"},{"key":"10.1016\/j.stem.2022.11.004_bib104","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1016\/j.neuron.2016.09.050","article-title":"Protein-RNA Networks Regulated by Normal and ALS-Associated Mutant HNRNPA2B1 in the Nervous System","volume":"92","author":"Martinez","year":"2016","journal-title":"Neuron"},{"key":"10.1016\/j.stem.2022.11.004_bib105","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21134808","article-title":"Large-Scale Production of Human iPSC-Derived Macrophages for Drug Screening","volume":"21","author":"Gutbier","year":"2020","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.stem.2022.11.004_bib106","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2024605118","article-title":"ALS-linked PFN1 variants exhibit loss and gain of functions in the context of formin-induced actin polymerization","volume":"118","author":"Schmidt","year":"2021","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.stem.2022.11.004_bib107","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1016\/j.stemcr.2017.06.018","article-title":"An Efficient Platform for Astrocyte Differentiation from Human Induced Pluripotent Stem Cells","volume":"9","author":"Tcw","year":"2017","journal-title":"Stem Cell Reports"},{"key":"10.1016\/j.stem.2022.11.004_bib108","doi-asserted-by":"crossref","first-page":"5084","DOI":"10.1523\/JNEUROSCI.0258-16.2016","article-title":"Conversion of Synthetic Abeta to In Vivo Active Seeds and Amyloid Plaque Formation in a Hippocampal Slice Culture Model","volume":"36","author":"Novotny","year":"2016","journal-title":"J Neurosci"},{"key":"10.1016\/j.stem.2022.11.004_bib109","doi-asserted-by":"crossref","first-page":"11716","DOI":"10.1128\/JVI.79.18.11716-11723.2005","article-title":"Borna disease virus replication in organotypic hippocampal slice\u00a0cultures from rats results in selective damage of dentate granule cells","volume":"79","author":"Mayer","year":"2005","journal-title":"J Virol"},{"key":"10.1016\/j.stem.2022.11.004_bib110","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.immuni.2017.06.017","article-title":"Induced-Pluripotent-Stem-Cell-Derived Primitive Macrophages Provide a Platform for Modeling Tissue-Resident Macrophage Differentiation and Function","volume":"47","author":"Takata","year":"2017","journal-title":"Immunity"},{"key":"10.1016\/j.stem.2022.11.004_bib111","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-17204-5","article-title":"QuPath: Open source software for digital pathology image analysis","volume":"7","author":"Bankhead","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.stem.2022.11.004_bib112","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.stem.2021.01.005","article-title":"Biphasic Activation of WNT Signaling Facilitates the Derivation of Midbrain Dopamine Neurons from hESCs for Translational Use","volume":"28","author":"Kim","year":"2021","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.stem.2022.11.004_bib113","doi-asserted-by":"crossref","DOI":"10.1016\/j.xpro.2021.100463","article-title":"High-throughput generation of midbrain dopaminergic neuron organoids from reporter human pluripotent stem cells","volume":"2","author":"Sarrafha","year":"2021","journal-title":"STAR Protoc"}],"container-title":["Cell Stem Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1934590922004519?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1934590922004519?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T13:56:08Z","timestamp":1761832568000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1934590922004519"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":113,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["S1934590922004519"],"URL":"https:\/\/doi.org\/10.1016\/j.stem.2022.11.004","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2021.12.15.472643","asserted-by":"object"}]},"ISSN":["1934-5909"],"issn-type":[{"value":"1934-5909","type":"print"}],"subject":[],"published":{"date-parts":[[2022,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A reference human induced pluripotent stem cell line for large-scale collaborative studies","name":"articletitle","label":"Article Title"},{"value":"Cell Stem Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.stem.2022.11.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}