{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:59:48Z","timestamp":1787774388181,"version":"build-2784847793"},"reference-count":78,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,8,3]],"date-time":"2024-08-03T00:00:00Z","timestamp":1722643200000},"content-version":"vor","delay-in-days":368,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Stem Cell"],"published-print":{"date-parts":[[2023,8]]},"DOI":"10.1016\/j.stem.2023.07.002","type":"journal-article","created":{"date-parts":[[2023,8,3]],"date-time":"2023-08-03T10:39:15Z","timestamp":1691059155000},"page":"1091-1109.e7","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"title":["Tff2 defines transit-amplifying pancreatic acinar progenitors that lack regenerative potential and are protective against Kras-driven carcinogenesis"],"prefix":"10.1016","volume":"30","author":[{"given":"Zhengyu","family":"Jiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feijing","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pasquale","family":"Laise","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanaka","family":"Takayuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fu","family":"Na","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Woosook","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenju","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryota","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Valenti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaki","family":"Sunagawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth A.","family":"White","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Macchini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard W.","family":"Renz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moritz","family":"Middelhoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoku","family":"Hayakawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zinaida A.","family":"Dubeykovskaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangtian","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy H.","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karan","family":"Nagar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yagnesh","family":"Tailor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryana R.","family":"Belin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akanksha","family":"Anand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Asfaha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael O.","family":"Finlayson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alina C.","family":"Iuga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Califano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy C.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.stem.2023.07.002_bib1","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.stem.2014.11.001","article-title":"Plasticity and dedifferentiation within the pancreas: development, homeostasis, and disease","volume":"16","author":"Puri","year":"2015","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.stem.2023.07.002_bib2","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.devcel.2010.02.005","article-title":"Cellular plasticity within the pancreas--lessons learned from development","volume":"18","author":"Puri","year":"2010","journal-title":"Dev. Cell"},{"key":"10.1016\/j.stem.2023.07.002_bib3","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1242\/dev.056499","article-title":"Sox9+ ductal cells are multipotent progenitors throughout development but do not produce new endocrine cells in the normal or injured adult pancreas","volume":"138","author":"Kopp","year":"2011","journal-title":"Development"},{"key":"10.1016\/j.stem.2023.07.002_bib4","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1242\/dev.053843","article-title":"Lineage tracing reveals the dynamic contribution of Hes1+ cells to the developing and adult pancreas","volume":"138","author":"Kopinke","year":"2011","journal-title":"Development"},{"key":"10.1016\/j.stem.2023.07.002_bib5","doi-asserted-by":"crossref","first-page":"2009","DOI":"10.1016\/j.stem.2021.07.004","article-title":"Continuous clonal labeling reveals uniform progenitor potential in the adult exocrine pancreas","volume":"28","author":"Lodestijn","year":"2021","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.stem.2023.07.002_bib6","doi-asserted-by":"crossref","DOI":"10.3390\/cancers13133295","article-title":"Stem cells in the exocrine pancreas during homeostasis, injury, and cancer","volume":"13","author":"Lodestijn","year":"2021","journal-title":"Cancers"},{"key":"10.1016\/j.stem.2023.07.002_bib7","doi-asserted-by":"crossref","first-page":"7101","DOI":"10.1073\/pnas.0902508106","article-title":"Bmi1 lineage tracing identifies a self-renewing pancreatic acinar cell subpopulation capable of maintaining pancreatic organ homeostasis","volume":"106","author":"Sangiorgi","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.stem.2023.07.002_bib8","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.devcel.2016.10.002","article-title":"Single-cell analysis uncovers clonal acinar cell heterogeneity in the adult pancreas","volume":"39","author":"Wollny","year":"2016","journal-title":"Dev. Cell"},{"key":"10.1016\/j.stem.2023.07.002_bib9","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.stem.2016.03.016","article-title":"Dclk1 defines quiescent pancreatic progenitors that promote injury-induced regeneration and tumorigenesis","volume":"18","author":"Westphalen","year":"2016","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.stem.2023.07.002_bib10","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1038\/s41586-021-03916-2","article-title":"Acinar cell clonal expansion in pancreas homeostasis and carcinogenesis","volume":"597","author":"Neuh\u00f6fer","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.stem.2023.07.002_bib11","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1038\/s41586-018-0088-0","article-title":"Pancreas regeneration","volume":"557","author":"Zhou","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.stem.2023.07.002_bib12","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1146\/annurev-physiol-021014-071727","article-title":"Regeneration and repair of the exocrine pancreas","volume":"77","author":"Murtaugh","year":"2015","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.stem.2023.07.002_bib13","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/j.cell.2014.02.057","article-title":"Transit-amplifying cells orchestrate stem cell activity and tissue regeneration","volume":"157","author":"Hsu","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.stem.2023.07.002_bib14","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.cels.2016.09.002","article-title":"A single-cell transcriptome atlas of the human pancreas","volume":"3","author":"Muraro","year":"2016","journal-title":"Cell Syst."},{"key":"10.1016\/j.stem.2023.07.002_bib15","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1016\/j.molmed.2020.04.003","article-title":"Adult pancreatic acinar progenitor-like populations in regeneration and cancer","volume":"26","author":"Jiang","year":"2020","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.stem.2023.07.002_bib16","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1001\/archotol.1993.01880190028005","article-title":"Cancer prevention","volume":"119","author":"Young","year":"1993","journal-title":"Arch. Otolaryngol. Head Neck Surg."},{"key":"10.1016\/j.stem.2023.07.002_bib17","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/nature19069","article-title":"Defining the clonal dynamics leading to mouse skin tumour initiation","volume":"536","author":"S\u00e1nchez-Dan\u00e9s","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.stem.2023.07.002_bib18","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1053\/j.gastro.2013.01.071","article-title":"Roles for KRAS in pancreatic tumor development and progression","volume":"144","author":"di Magliano","year":"2013","journal-title":"Gastroenterology"},{"key":"10.1016\/j.stem.2023.07.002_bib19","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/j.ccr.2012.10.025","article-title":"Identification of Sox9-dependent acinar-to-ductal reprogramming as the principal mechanism for initiation of pancreatic ductal adenocarcinoma","volume":"22","author":"Kopp","year":"2012","journal-title":"Cancer Cell"},{"key":"10.1016\/j.stem.2023.07.002_bib20","first-page":"2005","article-title":"The mutant K-ras oncogene causes pancreatic periductal lymphocytic infiltration and gastric mucous neck cell hyperplasia in transgenic mice","volume":"63","author":"Brembeck","year":"2003","journal-title":"Cancer Res."},{"key":"10.1016\/j.stem.2023.07.002_bib21","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1016\/j.cell.2015.07.026","article-title":"Hybrid periportal hepatocytes regenerate the injured liver without giving rise to cancer","volume":"162","author":"Font-Burgada","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.stem.2023.07.002_bib22","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.immuni.2011.09.006","article-title":"Tumor promotion via injury- and death-induced inflammation","volume":"35","author":"Kuraishy","year":"2011","journal-title":"Immunity"},{"key":"10.1016\/j.stem.2023.07.002_bib23","doi-asserted-by":"crossref","first-page":"2018","DOI":"10.1053\/j.gastro.2010.08.003","article-title":"TFF2 mRNA transcript expression marks a gland progenitor cell of the gastric oxyntic mucosa","volume":"139","author":"Quante","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1016\/j.stem.2023.07.002_bib24","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1007\/s00018-008-8646-5","article-title":"The trefoil factor family - small peptides with multiple functionalities","volume":"66","author":"Kjellev","year":"2009","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.stem.2023.07.002_bib25","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1038\/s41598-018-38062-9","article-title":"Exocrine tissue-driven TFF2 prevents apoptotic cell death of endocrine lineage during pancreas organogenesis","volume":"9","author":"Hirata","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.stem.2023.07.002_bib26","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.2353\/ajpath.2007.070249","article-title":"Accelerated progression of gastritis to dysplasia in the pyloric antrum of TFF2 -\/- C57BL6 x Sv129 Helicobacter pylori-infected mice","volume":"171","author":"Fox","year":"2007","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.stem.2023.07.002_bib27","doi-asserted-by":"crossref","first-page":"10517","DOI":"10.1038\/ncomms10517","article-title":"Neural innervation stimulates splenic TFF2 to arrest myeloid cell expansion and cancer","volume":"7","author":"Dubeykovskaya","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.stem.2023.07.002_bib28","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1053\/j.gastro.2016.07.045","article-title":"Loss of trefoil factor 2 from pancreatic duct glands promotes formation of intraductal papillary mucinous neoplasms in mice","volume":"151","author":"Yamaguchi","year":"2016","journal-title":"Gastroenterology"},{"key":"10.1016\/j.stem.2023.07.002_bib29","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/0167-0115(82)90126-4","article-title":"Pancreatic spasmolytic polypeptide (PSP): I. Preparation and initial chemical characterization of a new polypeptide from porcine pancreas","volume":"3","author":"J\u00f8rgensen","year":"1982","journal-title":"Regul. Pept."},{"key":"10.1016\/j.stem.2023.07.002_bib30","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/BF00717002","article-title":"Immunohistochemical localization of pancreatic spasmolytic polypeptide (PSP) in the pig","volume":"98","author":"Rasmussen","year":"1992","journal-title":"Histochemistry"},{"key":"10.1016\/j.stem.2023.07.002_bib31","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1016\/S0002-9440(10)61121-2","article-title":"Characterization of gene expression profiles in intraductal papillary-mucinous tumors of the pancreas","volume":"160","author":"Terris","year":"2002","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.stem.2023.07.002_bib32","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1023\/A:1005471005289","article-title":"Differential expression of human spasmolytic polypeptide (trefoil factor family-2) in pancreatic carcinomas, ampullary carcinomas, and mucin-producing tumors of the pancreas","volume":"45","author":"Ohshio","year":"2000","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.stem.2023.07.002_bib33","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1083\/jcb.200105060","article-title":"The bHLH transcription factor Mist1 is required to maintain exocrine pancreas cell organization and acinar cell identity","volume":"155","author":"Pin","year":"2001","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.stem.2023.07.002_bib34","doi-asserted-by":"crossref","first-page":"10500","DOI":"10.1073\/pnas.0704054104","article-title":"Sox9 coordinates a transcriptional network in pancreatic progenitor cells","volume":"104","author":"Lynn","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.stem.2023.07.002_bib35","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1038\/nrgastro.2011.114","article-title":"From tissue turnover to the cell of origin for pancreatic cancer","volume":"8","author":"Kong","year":"2011","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.stem.2023.07.002_bib36","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1038\/nature08712","article-title":"The transcriptional network for mesenchymal transformation of brain tumours","volume":"463","author":"Carro","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.stem.2023.07.002_bib37","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1038\/ng1532","article-title":"Reverse engineering of regulatory networks in human B cells","volume":"37","author":"Basso","year":"2005","journal-title":"Nat. Genet."},{"key":"10.1016\/j.stem.2023.07.002_bib38","doi-asserted-by":"crossref","first-page":"S7","DOI":"10.1186\/1471-2105-7-S1-S7","article-title":"ARACNE: an algorithm for the reconstruction of gene regulatory networks in a mammalian cellular context","volume":"7","author":"Margolin","year":"2006","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.stem.2023.07.002_bib39","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1038\/ng.3593","article-title":"Functional characterization of somatic mutations in cancer using network-based inference of protein activity","volume":"48","author":"Alvarez","year":"2016","journal-title":"Nat. Genet."},{"key":"10.1016\/j.stem.2023.07.002_bib40","doi-asserted-by":"crossref","first-page":"2988","DOI":"10.1016\/j.cell.2021.04.038","article-title":"Single-cell protein activity analysis identifies recurrence-associated renal tumor macrophages","volume":"184","author":"Obradovic","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.stem.2023.07.002_bib41","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1186\/1471-2105-14-128","article-title":"Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool","volume":"14","author":"Chen","year":"2013","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.stem.2023.07.002_bib42","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.stem.2008.03.001","article-title":"Notch signaling activation in human embryonic stem cells is required for embryonic, but not trophoblastic, lineage commitment","volume":"2","author":"Yu","year":"2008","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.stem.2023.07.002_bib43","doi-asserted-by":"crossref","first-page":"G170","DOI":"10.1152\/ajpgi.00492.2007","article-title":"Regulation of transforming growth factor beta-induced responses by protein kinase A in pancreatic acinar cells","volume":"295","author":"Yang","year":"2008","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.stem.2023.07.002_bib44","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/cr.2008.47","article-title":"Wnt signaling and stem cell control","volume":"18","author":"Nusse","year":"2008","journal-title":"Cell Res."},{"key":"10.1016\/j.stem.2023.07.002_bib45","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/nrm3721","article-title":"Adult intestinal stem cells: critical drivers of epithelial homeostasis and regeneration","volume":"15","author":"Barker","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.stem.2023.07.002_bib46","doi-asserted-by":"crossref","first-page":"2225","DOI":"10.1038\/s41467-019-10194-0","article-title":"Krt5(+)\/Krt15(+) foregut basal progenitors give rise to cyclooxygenase-2-dependent tumours in response to gastric acid stress","volume":"10","author":"Moon","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.stem.2023.07.002_bib47","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.ccr.2009.09.027","article-title":"Context-dependent transformation of adult pancreatic cells by oncogenic K-Ras","volume":"16","author":"Gidekel Friedlander","year":"2009","journal-title":"Cancer Cell"},{"key":"10.1016\/j.stem.2023.07.002_bib48","doi-asserted-by":"crossref","first-page":"eabj0486","DOI":"10.1126\/science.abj0486","article-title":"Epithelial memory of inflammation limits tissue damage while promoting pancreatic tumorigenesis","volume":"373","author":"Del Poggetto","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.stem.2023.07.002_bib49","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.jcmgh.2016.09.009","article-title":"Mitogen-activated protein kinase kinase activity maintains acinar-to-ductal metaplasia and is required for organ regeneration in pancreatitis","volume":"3","author":"Halbrook","year":"2017","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"10.1016\/j.stem.2023.07.002_bib50","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.cell.2011.11.025","article-title":"EMT and dissemination precede pancreatic tumor formation","volume":"148","author":"Rhim","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.stem.2023.07.002_bib51","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1038\/s41417-018-0036-z","article-title":"Therapeutic potential of adenovirus-mediated TFF2-CTP-Flag peptide for treatment of colorectal cancer","volume":"26","author":"Dubeykovskaya","year":"2019","journal-title":"Cancer Gene Ther."},{"key":"10.1016\/j.stem.2023.07.002_bib52","doi-asserted-by":"crossref","first-page":"2378","DOI":"10.1172\/JCI88941","article-title":"Long-lived keratin 15+ esophageal progenitor cells contribute to homeostasis and regeneration","volume":"127","author":"Giroux","year":"2017","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.stem.2023.07.002_bib53","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1172\/JCI29988","article-title":"Preexisting pancreatic acinar cells contribute to acinar cell, but not islet beta cell, regeneration","volume":"117","author":"Desai","year":"2007","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.stem.2023.07.002_bib54","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1053\/j.gastro.2021.10.027","article-title":"Single-cell transcriptomics reveals a conserved metaplasia program in pancreatic injury","volume":"162","author":"Ma","year":"2022","journal-title":"Gastroenterology"},{"key":"10.1016\/j.stem.2023.07.002_bib55","doi-asserted-by":"crossref","first-page":"9286","DOI":"10.1073\/pnas.0900668106","article-title":"Stem cells are dispensable for lung homeostasis but restore airways after injury","volume":"106","author":"Giangreco","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.stem.2023.07.002_bib56","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s12015-008-9022-4","article-title":"The skin: a home to multiple classes of epithelial progenitor cells","volume":"4","author":"Yan","year":"2008","journal-title":"Stem Cell Rev."},{"key":"10.1016\/j.stem.2023.07.002_bib57","doi-asserted-by":"crossref","first-page":"18913","DOI":"10.1073\/pnas.0810097105","article-title":"Spontaneous induction of murine pancreatic intraepithelial neoplasia (mPanIN) by acinar cell targeting of oncogenic Kras in adult mice","volume":"105","author":"Habbe","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.stem.2023.07.002_bib58","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.ccr.2007.01.012","article-title":"Chronic pancreatitis is essential for induction of pancreatic ductal adenocarcinoma by K-Ras oncogenes in adult mice","volume":"11","author":"Guerra","year":"2007","journal-title":"Cancer Cell"},{"key":"10.1016\/j.stem.2023.07.002_bib59","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1158\/0008-5472.CAN-05-2305","article-title":"Mist1-KrasG12D knock-in mice develop mixed differentiation metastatic exocrine pancreatic carcinoma and hepatocellular carcinoma","volume":"66","author":"Tuveson","year":"2006","journal-title":"Cancer Res."},{"key":"10.1016\/j.stem.2023.07.002_bib60","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1053\/j.gastro.2011.06.045","article-title":"Extensive pancreas regeneration following acinar-specific disruption of Xbp1 in mice","volume":"141","author":"Hess","year":"2011","journal-title":"Gastroenterology"},{"key":"10.1016\/j.stem.2023.07.002_bib61","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.ccr.2012.07.024","article-title":"EGF receptor is required for KRAS-induced pancreatic tumorigenesis","volume":"22","author":"Ardito","year":"2012","journal-title":"Cancer Cell"},{"key":"10.1016\/j.stem.2023.07.002_bib62","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.ccr.2012.08.001","article-title":"EGF receptor signaling is essential for k-ras oncogene-driven pancreatic ductal adenocarcinoma","volume":"22","author":"Navas","year":"2012","journal-title":"Cancer Cell"},{"key":"10.1016\/j.stem.2023.07.002_bib63","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.ccr.2011.03.002","article-title":"Stat3 and MMP7 contribute to pancreatic ductal adenocarcinoma initiation and progression","volume":"19","author":"Fukuda","year":"2011","journal-title":"Cancer Cell"},{"key":"10.1016\/j.stem.2023.07.002_bib64","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.ccr.2011.05.011","article-title":"Pancreatitis-induced inflammation contributes to pancreatic cancer by inhibiting oncogene-induced senescence","volume":"19","author":"Guerra","year":"2011","journal-title":"Cancer Cell"},{"key":"10.1016\/j.stem.2023.07.002_bib65","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/j.cell.2010.01.025","article-title":"Immunity, inflammation, and cancer","volume":"140","author":"Grivennikov","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.stem.2023.07.002_bib77","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1038\/nprot.2013.079","article-title":"Isolation, culture and genetic manipulation of mouse pancreatic ductal cells","volume":"8","author":"Reichert","year":"2013","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.stem.2023.07.002_bib78","doi-asserted-by":"crossref","DOI":"10.15252\/msb.20188746","article-title":"Current best practices in single-cell RNA-seq analysis: a tutorial","volume":"15","author":"Luecken","year":"2019","journal-title":"Mol. Syst. Biol."},{"key":"10.1016\/j.stem.2023.07.002_bib66","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1053\/j.gastro.2008.12.066","article-title":"Loss of the acinar-restricted transcription factor Mist1 accelerates Kras-induced pancreatic intraepithelial neoplasia","volume":"136","author":"Shi","year":"2009","journal-title":"Gastroenterology"},{"key":"10.1016\/j.stem.2023.07.002_bib67","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.ccell.2016.11.005","article-title":"Nerve growth factor promotes gastric tumorigenesis through aberrant cholinergic signaling","volume":"31","author":"Hayakawa","year":"2017","journal-title":"Cancer Cell"},{"key":"10.1016\/j.stem.2023.07.002_bib68","series-title":"R: A Language and Environment for Statistical Computing","author":"Team","year":"2022"},{"key":"10.1016\/j.stem.2023.07.002_bib69","doi-asserted-by":"crossref","first-page":"2233","DOI":"10.1093\/bioinformatics\/btw216","article-title":"ARACNe-AP: gene network reverse engineering through adaptive partitioning inference of mutual information","volume":"32","author":"Lachmann","year":"2016","journal-title":"Bioinformatics"},{"key":"10.1016\/j.stem.2023.07.002_bib70","doi-asserted-by":"crossref","first-page":"3573","DOI":"10.1016\/j.cell.2021.04.048","article-title":"Integrated analysis of multimodal single-cell data","volume":"184","author":"Hao","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.stem.2023.07.002_bib71","series-title":"cluster: Cluster Analysis Basics and Extensions","author":"Maechler","year":"2022"},{"key":"10.1016\/j.stem.2023.07.002_bib72","doi-asserted-by":"crossref","first-page":"2847","DOI":"10.1093\/bioinformatics\/btw313","article-title":"Complex heatmaps reveal patterns and correlations in multidimensional genomic data","volume":"32","author":"Gu","year":"2016","journal-title":"Bioinformatics"},{"key":"10.1016\/j.stem.2023.07.002_bib73","doi-asserted-by":"crossref","first-page":"e90","DOI":"10.1002\/cpz1.90","article-title":"Gene set knowledge discovery with Enrichr","volume":"1","author":"Xie","year":"2021","journal-title":"Curr. Protoc."},{"key":"10.1016\/j.stem.2023.07.002_bib74","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/nbt.2859","article-title":"The dynamics and regulators of cell fate decisions are revealed by pseudotemporal ordering of single cells","volume":"32","author":"Trapnell","year":"2014","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.stem.2023.07.002_bib75","series-title":"ggplot2: Elegant Graphics for Data Analysis","author":"Wickham","year":"2016"},{"key":"10.1016\/j.stem.2023.07.002_bib76","first-page":"e54","article-title":"SLICE: determining cell differentiation and lineage based on single cell entropy","volume":"45","author":"Guo","year":"2017","journal-title":"Nucleic Acids Res."}],"container-title":["Cell Stem Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1934590923002473?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1934590923002473?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T13:56:45Z","timestamp":1761832605000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1934590923002473"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":78,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["S1934590923002473"],"URL":"https:\/\/doi.org\/10.1016\/j.stem.2023.07.002","relation":{},"ISSN":["1934-5909"],"issn-type":[{"value":"1934-5909","type":"print"}],"subject":[],"published":{"date-parts":[[2023,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tff2 defines transit-amplifying pancreatic acinar progenitors that lack regenerative potential and are protective against Kras-driven carcinogenesis","name":"articletitle","label":"Article Title"},{"value":"Cell Stem Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.stem.2023.07.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}