{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T08:16:07Z","timestamp":1790842567993,"version":"4.1.0"},"reference-count":10,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,8,3]],"date-time":"2024-08-03T00:00:00Z","timestamp":1722643200000},"content-version":"vor","delay-in-days":368,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006426","name":"New Jersey Department of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006426","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Stem Cell"],"published-print":{"date-parts":[[2023,8]]},"DOI":"10.1016\/j.stem.2023.07.005","type":"journal-article","created":{"date-parts":[[2023,8,3]],"date-time":"2023-08-03T10:35:22Z","timestamp":1691058922000},"page":"1001-1003","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["Replacing microglia to treat Alzheimer\u2019s disease"],"prefix":"10.1016","volume":"30","author":[{"given":"Peng","family":"Jiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengmeng","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.stem.2023.07.005_bib1","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/j.stem.2023.07.006","article-title":"A systemic cell therapy for Trem2-dependent Alzheimer\u2019s disease","volume":"30","author":"Yoo","year":"2023","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.stem.2023.07.005_bib2","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/s13024-017-0184-x","article-title":"Late onset Alzheimer\u2019s disease genetics implicates microglial pathways in disease risk","volume":"12","author":"Efthymiou","year":"2017","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.stem.2023.07.005_bib3","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/j.neuron.2020.09.029","article-title":"Emerging Microglia Biology Defines Novel Therapeutic Approaches for Alzheimer's Disease","volume":"108","author":"Lewcock","year":"2020","journal-title":"Neuron"},{"key":"10.1016\/j.stem.2023.07.005_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.108443","article-title":"Efficient Strategies for Microglia Replacement in the Central Nervous System","volume":"33","author":"Xu","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.stem.2023.07.005_bib5","doi-asserted-by":"crossref","first-page":"11524","DOI":"10.1073\/pnas.1710311114","article-title":"TREM2 deficiency attenuates neuroinflammation and protects against neurodegeneration in a mouse model\u00a0of tauopathy","volume":"114","author":"Leyns","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.stem.2023.07.005_bib6","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s13619-022-00135-6","article-title":"Rise of the human-mouse chimeric brain models","volume":"11","author":"Jiang","year":"2022","journal-title":"Cell Regen."},{"key":"10.1016\/j.stem.2023.07.005_bib7","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1016\/j.cell.2023.04.022","article-title":"An in\u00a0vivo neuroimmune organoid model to study human microglia phenotypes","volume":"186","author":"Schafer","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.stem.2023.07.005_bib8","first-page":"1135","article-title":"Type-I-interferon signaling drives microglial dysfunction and senescence in human iPSC models of Down\u00a0syndrome and Alzheimer's disease","volume":"29","author":"Jin","year":"2022","journal-title":"Cell Stem\u00a0Cell"},{"key":"10.1016\/j.stem.2023.07.005_bib9","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.tins.2022.02.005","article-title":"Translational approaches to understanding resilience to Alzheimer's disease","volume":"45","author":"Neuner","year":"2022","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.stem.2023.07.005_bib10","doi-asserted-by":"crossref","DOI":"10.1038\/s41591-023-02397-2","article-title":"Clonal hematopoiesis is associated with protection from Alzheimer's disease","author":"Bouzid","year":"2023","journal-title":"Nat. Med."}],"container-title":["Cell Stem Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1934590923002503?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1934590923002503?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T13:57:14Z","timestamp":1761832634000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1934590923002503"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":10,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["S1934590923002503"],"URL":"https:\/\/doi.org\/10.1016\/j.stem.2023.07.005","relation":{},"ISSN":["1934-5909"],"issn-type":[{"value":"1934-5909","type":"print"}],"subject":[],"published":{"date-parts":[[2023,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Replacing microglia to treat Alzheimer\u2019s disease","name":"articletitle","label":"Article Title"},{"value":"Cell Stem Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.stem.2023.07.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}