{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T09:06:53Z","timestamp":1792141613336,"version":"4.4.0"},"reference-count":98,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100014599","name":"Mark Foundation For Cancer Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014599","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL157387"],"award-info":[{"award-number":["R01HL157387"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01CA262496"],"award-info":[{"award-number":["R01CA262496"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01CA284595"],"award-info":[{"award-number":["R01CA284595"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL128239"],"award-info":[{"award-number":["R01HL128239"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01CA283574"],"award-info":[{"award-number":["R01CA283574"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01 LM013879"],"award-info":[{"award-number":["R01 LM013879"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000048","name":"American Cancer Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000048","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005968","name":"Leukemia Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000861","name":"Burroughs Wellcome Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000861","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005189","name":"Leukemia and Lymphoma Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005189","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["F31-CA254130"],"award-info":[{"award-number":["F31-CA254130"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001021","name":"Damon Runyon Cancer Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001021","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000884","name":"Cancer Research Institute","doi-asserted-by":"publisher","award":["CRI5751"],"award-info":[{"award-number":["CRI5751"]}],"id":[{"id":"10.13039\/100000884","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012636","name":"New York State Stem Cell Science","doi-asserted-by":"publisher","award":["C322560GG"],"award-info":[{"award-number":["C322560GG"]}],"id":[{"id":"10.13039\/100012636","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012636","name":"New York State Stem Cell Science","doi-asserted-by":"publisher","award":["R01CA271418"],"award-info":[{"award-number":["R01CA271418"]}],"id":[{"id":"10.13039\/100012636","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012636","name":"New York State Stem Cell Science","doi-asserted-by":"publisher","award":["K08CA241371"],"award-info":[{"award-number":["K08CA241371"]}],"id":[{"id":"10.13039\/100012636","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012636","name":"New York State Stem Cell Science","doi-asserted-by":"publisher","award":["C32558GG"],"award-info":[{"award-number":["C32558GG"]}],"id":[{"id":"10.13039\/100012636","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012636","name":"New York State Stem Cell Science","doi-asserted-by":"publisher","award":["R01CA260711"],"award-info":[{"award-number":["R01CA260711"]}],"id":[{"id":"10.13039\/100012636","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012636","name":"New York State Stem Cell Science","doi-asserted-by":"publisher","award":["R01CA271331"],"award-info":[{"award-number":["R01CA271331"]}],"id":[{"id":"10.13039\/100012636","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013730","name":"Henry and Marilyn Taub Foundation","doi-asserted-by":"publisher","award":["P50 CA254838-01"],"award-info":[{"award-number":["P50 CA254838-01"]}],"id":[{"id":"10.13039\/100013730","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013730","name":"Henry and Marilyn Taub Foundation","doi-asserted-by":"publisher","award":["1RO1CA271455"],"award-info":[{"award-number":["1RO1CA271455"]}],"id":[{"id":"10.13039\/100013730","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013730","name":"Henry and Marilyn Taub Foundation","doi-asserted-by":"publisher","award":["5RO1CA228135"],"award-info":[{"award-number":["5RO1CA228135"]}],"id":[{"id":"10.13039\/100013730","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013730","name":"Henry and Marilyn Taub Foundation","doi-asserted-by":"publisher","award":["1RO1HL159175"],"award-info":[{"award-number":["1RO1HL159175"]}],"id":[{"id":"10.13039\/100013730","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013730","name":"Henry and Marilyn Taub Foundation","doi-asserted-by":"publisher","award":["5RO1CA242020"],"award-info":[{"award-number":["5RO1CA242020"]}],"id":[{"id":"10.13039\/100013730","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["T32GM007739"],"award-info":[{"award-number":["T32GM007739"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Stem Cell"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.stem.2025.04.012","type":"journal-article","created":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T10:39:25Z","timestamp":1747910365000},"page":"1102-1121.e5","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"title":["Deconvoluting clonal and cellular architecture in IDH-mutant acute myeloid leukemia"],"prefix":"10.1016","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7816-8071","authenticated-orcid":false,"given":"Maria","family":"Sirenko","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soobeom","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengxi","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronan","family":"Chaligne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanam","family":"Loghavi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgios","family":"Asimomitis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte K.","family":"Brierley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elsa","family":"Bernard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng F.","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert M.","family":"Myers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bettina","family":"Nadorp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junya","family":"Sango","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morgan","family":"Lallo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max F.","family":"Levine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dylan","family":"Domenico","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan E.","family":"Arango Ossa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan S.","family":"Medina-Martinez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamal","family":"Menghrajani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey","family":"Lasry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice S.","family":"Mims","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helee","family":"Desai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Laganson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Famulare","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minal","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard","family":"Lozanski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly L.","family":"Bolton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron D.","family":"Viny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikhail","family":"Roshal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ross L.","family":"Levine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eirini P.","family":"Papapetrou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eytan M.","family":"Stein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan A.","family":"Landau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann-Kathrin","family":"Eisfeld","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iannis","family":"Aifantis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elli","family":"Papaemmanuil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.stem.2025.04.012_bib1","doi-asserted-by":"crossref","DOI":"10.1038\/s41408-021-00425-3","article-title":"Acute myeloid leukemia: current progress and future directions","volume":"11","author":"Kantarjian","year":"2021","journal-title":"Blood Cancer J."},{"key":"10.1016\/j.stem.2025.04.012_bib2","doi-asserted-by":"crossref","first-page":"2209","DOI":"10.1056\/NEJMoa1516192","article-title":"Genomic Classification and Prognosis in Acute Myeloid Leukemia","volume":"374","author":"Papaemmanuil","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.stem.2025.04.012_bib3","doi-asserted-by":"crossref","first-page":"3636","DOI":"10.1200\/JCO.2010.28.3762","article-title":"IDH1 and IDH2 mutations are frequent genetic alterations in acute myeloid leukemia and confer adverse prognosis in cytogenetically normal acute myeloid leukemia with NPM1 mutation without FLT3 internal tandem duplication","volume":"28","author":"Paschka","year":"2010","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.stem.2025.04.012_bib4","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1038\/s41591-018-0081-z","article-title":"Somatic mutations precede acute myeloid leukemia years before diagnosis","volume":"24","author":"Desai","year":"2018","journal-title":"Nat. Med."},{"key":"10.1016\/j.stem.2025.04.012_bib5","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1038\/s41586-018-0317-6","article-title":"Prediction of acute myeloid leukaemia risk in healthy individuals","volume":"559","author":"Abelson","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.stem.2025.04.012_bib6","doi-asserted-by":"crossref","first-page":"2410","DOI":"10.3324\/haematol.2018.215269","article-title":"Clonal hematopoiesis and risk of acute myeloid leukemia","volume":"104","author":"Young","year":"2019","journal-title":"Haematologica"},{"key":"10.1016\/j.stem.2025.04.012_bib7","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/j.ccr.2010.11.015","article-title":"Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation","volume":"18","author":"Figueroa","year":"2010","journal-title":"Cancer Cell"},{"key":"10.1016\/j.stem.2025.04.012_bib8","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.ccr.2010.12.014","article-title":"Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of \u03b1-ketoglutarate-dependent dioxygenases","volume":"19","author":"Xu","year":"2011","journal-title":"Cancer Cell"},{"key":"10.1016\/j.stem.2025.04.012_bib9","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1038\/nature10860","article-title":"IDH mutation impairs histone demethylation and results in a block to cell differentiation","volume":"483","author":"Lu","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.stem.2025.04.012_bib10","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.stem.2013.12.016","article-title":"Proto-Oncogenic Role of Mutant IDH2 in Leukemia Initiation and Maintenance","volume":"14","author":"Kats","year":"2014","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.stem.2025.04.012_bib11","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1182\/blood-2017-04-779405","article-title":"Enasidenib in mutant IDH2 relapsed or refractory acute myeloid leukemia","volume":"130","author":"Stein","year":"2017","journal-title":"Blood"},{"key":"10.1016\/j.stem.2025.04.012_bib12","doi-asserted-by":"crossref","first-page":"2386","DOI":"10.1056\/NEJMoa1716984","article-title":"Durable Remissions with Ivosidenib in IDH1-Mutated Relapsed or Refractory AML","volume":"378","author":"DiNardo","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.stem.2025.04.012_bib13","doi-asserted-by":"crossref","first-page":"6336","DOI":"10.1002\/cam4.4182","article-title":"Improved survival with enasidenib versus standard of care in relapsed\/refractory acute myeloid leukemia associated with IDH2 mutations using historical data and propensity score matching analysis","volume":"10","author":"de Botton","year":"2021","journal-title":"Cancer Med."},{"key":"10.1016\/j.stem.2025.04.012_bib14","doi-asserted-by":"crossref","first-page":"2575","DOI":"10.1038\/s41375-019-0472-2","article-title":"Enasidenib, an inhibitor of mutant IDH2 proteins, induces durable remissions in older patients with newly diagnosed acute myeloid leukemia","volume":"33","author":"Pollyea","year":"2019","journal-title":"Leukemia"},{"key":"10.1016\/j.stem.2025.04.012_bib15","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1182\/blood.2019002140","article-title":"Ivosidenib induces deep durable remissions in patients with newly diagnosed IDH1-mutant acute myeloid leukemia","volume":"135","author":"Roboz","year":"2020","journal-title":"Blood"},{"key":"10.1016\/j.stem.2025.04.012_bib16","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1182\/blood.2020007233","article-title":"Ivosidenib or enasidenib combined with intensive chemotherapy in patients with newly diagnosed AML: a phase 1 study","volume":"137","author":"Stein","year":"2021","journal-title":"Blood"},{"key":"10.1016\/j.stem.2025.04.012_bib17","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1016\/S1470-2045(21)00494-0","article-title":"Enasidenib plus azacitidine versus azacitidine alone in patients with newly diagnosed, mutant-IDH2 acute myeloid leukaemia (AG221-AML-005): a single-arm, phase 1b and randomised, phase 2 trial","volume":"22","author":"DiNardo","year":"2021","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.stem.2025.04.012_bib18","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1056\/NEJMoa2117344","article-title":"Ivosidenib and Azacitidine in IDH1-Mutated Acute Myeloid Leukemia","volume":"386","author":"Montesinos","year":"2022","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.stem.2025.04.012_bib19","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1182\/blood-2017-04-779447","article-title":"Enasidenib induces acute myeloid leukemia cell differentiation to promote clinical response","volume":"130","author":"Amatangelo","year":"2017","journal-title":"Blood"},{"key":"10.1016\/j.stem.2025.04.012_bib20","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1126\/science.1234769","article-title":"Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation","volume":"340","author":"Wang","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.stem.2025.04.012_bib21","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1158\/2159-8290.CD-16-1034","article-title":"AG-221, a First-in-Class Therapy Targeting Acute Myeloid Leukemia Harboring Oncogenic IDH2 MutationsAG-221 Therapy for IDH2-Mutant AML","volume":"7","author":"Yen","year":"2017","journal-title":"Cancer Discov."},{"key":"10.1016\/j.stem.2025.04.012_bib22","doi-asserted-by":"crossref","first-page":"1894","DOI":"10.1182\/bloodadvances.2020001503","article-title":"Molecular mechanisms mediating relapse following ivosidenib monotherapy in IDH1-mutant relapsed or refractory AML","volume":"4","author":"Choe","year":"2020","journal-title":"Blood Adv."},{"key":"10.1016\/j.stem.2025.04.012_bib23","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1016\/j.cell.2019.01.031","article-title":"Single-Cell RNA-Seq Reveals AML Hierarchies Relevant to Disease Progression and Immunity","volume":"176","author":"van Galen","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.stem.2025.04.012_bib24","first-page":"27","article-title":"An inflammatory state remodels the immune microenvironment and improves risk stratification in acute myeloid leukemia","volume":"4","author":"Lasry","year":"2023","journal-title":"Nat. Cancer"},{"key":"10.1016\/j.stem.2025.04.012_bib25","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/s41586-019-1367-0","article-title":"Somatic mutations and cell identity linked by Genotyping of Transcriptomes","volume":"571","author":"Nam","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.stem.2025.04.012_bib26","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1016\/j.molcel.2019.01.009","article-title":"Unravelling Intratumoral Heterogeneity through High-Sensitivity Single-Cell Mutational Analysis and Parallel RNA sequencing","volume":"73","author":"Rodriguez-Meira","year":"2019","journal-title":"Mol. Cell"},{"key":"10.1016\/j.stem.2025.04.012_bib27","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-021-21650-1","article-title":"Identification of leukemic and pre-leukemic stem cells by clonal tracking from single-cell transcriptomics","volume":"12","author":"Velten","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.stem.2025.04.012_bib28","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-019-11591-1","article-title":"A general approach for detecting expressed mutations in AML cells using single cell RNA-sequencing","volume":"10","author":"Petti","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.stem.2025.04.012_bib29","unstructured":"Tickle, T., Tirosh, I., Georgescu, C., Brown, M., and Haas, B. inferCNV of the Trinity CTAT Project (Broad Institute of MIT and Harvard)."},{"key":"10.1016\/j.stem.2025.04.012_bib30","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1101\/gr.228080.117","article-title":"Linking transcriptional and genetic tumor heterogeneity through allele analysis of single-cell RNA-seq data","volume":"28","author":"Fan","year":"2018","journal-title":"Genome Res."},{"key":"10.1016\/j.stem.2025.04.012_bib31","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/s41587-022-01468-y","article-title":"Haplotype-aware analysis of somatic copy number variations from single-cell transcriptomes","volume":"41","author":"Gao","year":"2023","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.stem.2025.04.012_bib32","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1056\/NEJMoa0903840","article-title":"Recurring mutations found by sequencing an acute myeloid leukemia genome","volume":"361","author":"Mardis","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.stem.2025.04.012_bib33","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1056\/NEJMoa1301689","article-title":"Genomic and Epigenomic Landscapes of Adult De Novo Acute Myeloid Leukemia","volume":"368","author":"Ley","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.stem.2025.04.012_bib34","doi-asserted-by":"crossref","first-page":"4622","DOI":"10.1038\/s41467-022-32103-8","article-title":"Unified classification and risk-stratification in acute myeloid leukemia","volume":"13","author":"Tazi","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.stem.2025.04.012_bib35","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1038\/s41586-020-2864-x","article-title":"Single-cell mutation analysis of clonal evolution in myeloid malignancies","volume":"587","author":"Miles","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.stem.2025.04.012_bib36","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1038\/s41588-020-00710-0","article-title":"Cancer therapy shapes the fitness landscape of clonal hematopoiesis","volume":"52","author":"Bolton","year":"2020","journal-title":"Nat. Genet."},{"key":"10.1016\/j.stem.2025.04.012_bib37","doi-asserted-by":"crossref","DOI":"10.15252\/msb.20178041","article-title":"Molecular transitions in early progenitors during human cord blood hematopoiesis","volume":"14","author":"Zheng","year":"2018","journal-title":"Mol. Syst. Biol."},{"key":"10.1016\/j.stem.2025.04.012_bib38","doi-asserted-by":"crossref","first-page":"3514","DOI":"10.1016\/j.celrep.2017.11.084","article-title":"Hepatic Leukemia Factor Maintains Quiescence of Hematopoietic Stem Cells and Protects the Stem Cell Pool during Regeneration","volume":"21","author":"Komorowska","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.stem.2025.04.012_bib39","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/s41590-017-0001-2","article-title":"Single-cell analysis reveals the continuum of human lympho-myeloid progenitor cells","volume":"19","author":"Karamitros","year":"2018","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.stem.2025.04.012_bib40","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-019-10291-0","article-title":"A comprehensive single cell transcriptional landscape of human hematopoietic progenitors","volume":"10","author":"Pellin","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.stem.2025.04.012_bib41","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/ncb3493","article-title":"Human haematopoietic stem cell lineage commitment is a continuous process","volume":"19","author":"Velten","year":"2017","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.stem.2025.04.012_bib42","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1038\/s41586-019-1652-y","article-title":"Decoding human fetal liver haematopoiesis","volume":"574","author":"Popescu","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.stem.2025.04.012_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2018.10.084","article-title":"The Molecular Signature of Megakaryocyte-Erythroid Progenitors Reveals a Role for the Cell Cycle in Fate Specification","volume":"25","author":"Lu","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.stem.2025.04.012_bib44","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1038\/nmeth.4380","article-title":"Simultaneous epitope and transcriptome measurement in single cells","volume":"14","author":"Stoeckius","year":"2017","journal-title":"Nat. Methods"},{"key":"10.1016\/j.stem.2025.04.012_bib45","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1038\/s41590-021-01059-0","article-title":"Single-cell proteo-genomic reference maps of the hematopoietic system enable the purification and massive profiling of precisely defined cell states","volume":"22","author":"Triana","year":"2021","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.stem.2025.04.012_bib46","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1038\/s41591-022-01819-x","article-title":"A cellular hierarchy framework for understanding heterogeneity and predicting drug response in acute myeloid leukemia","volume":"28","author":"Zeng","year":"2022","journal-title":"Nat. Med."},{"key":"10.1016\/j.stem.2025.04.012_bib47","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1016\/j.stem.2023.04.001","article-title":"Clonally resolved single-cell multi-omics identifies routes of cellular differentiation in acute myeloid leukemia","volume":"30","author":"Beneyto-Calabuig","year":"2023","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.stem.2025.04.012_bib48","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1182\/blood.2019003330","article-title":"Dnmt3a loss and Idh2 neomorphic mutations mutually potentiate malignant hematopoiesis","volume":"135","author":"Zhang","year":"2020","journal-title":"Blood"},{"key":"10.1016\/j.stem.2025.04.012_bib49","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1038\/leu.2017.84","article-title":"A pharmacogenomic approach validates AG-221 as an effective and on-target therapy in IDH2 mutant AML","volume":"31","author":"Kats","year":"2017","journal-title":"Leukemia"},{"key":"10.1016\/j.stem.2025.04.012_bib50","doi-asserted-by":"crossref","first-page":"2261","DOI":"10.18632\/oncotarget.13664","article-title":"The tissue inhibitor of metalloproteinases-1 (TIMP-1) promotes survival and migration of acute myeloid leukemia cells through CD63\/PI3K\/Akt\/p21 signaling","volume":"8","author":"Forte","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.stem.2025.04.012_bib51","doi-asserted-by":"crossref","first-page":"E171","DOI":"10.1002\/ajh.26146","article-title":"The prognosis and durable clearance of RAS mutations in patients with acute myeloid leukemia receiving induction chemotherapy","volume":"96","author":"Ball","year":"2021","journal-title":"Am. J. Hematol."},{"key":"10.1016\/j.stem.2025.04.012_bib52","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1126\/science.aba9304","article-title":"Resistance to inflammation underlies enhanced fitness in clonal hematopoiesis","volume":"374","author":"Avagyan","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.stem.2025.04.012_bib53","doi-asserted-by":"crossref","first-page":"1946","DOI":"10.1038\/leu.2016.93","article-title":"Frequent reconstitution of IDH2R140Q mutant clonal multilineage hematopoiesis following chemotherapy for acute myeloid leukemia","volume":"30","author":"Wiseman","year":"2016","journal-title":"Leukemia"},{"key":"10.1016\/j.stem.2025.04.012_bib54","doi-asserted-by":"crossref","first-page":"3105","DOI":"10.1080\/10428194.2022.2118533","article-title":"Clinical and molecular profiling of AML patients with chromosome 7 or 7q deletions in the context of TP53 alterations and venetoclax treatment","volume":"63","author":"Abbas","year":"2022","journal-title":"Leuk. Lymphoma"},{"key":"10.1016\/j.stem.2025.04.012_bib55","doi-asserted-by":"crossref","first-page":"2900","DOI":"10.1002\/cncr.29475","article-title":"Prognostic significance of acquired copy-neutral loss of heterozygosity in acute myeloid leukemia","volume":"121","author":"Gronseth","year":"2015","journal-title":"Cancer"},{"key":"10.1016\/j.stem.2025.04.012_bib56","doi-asserted-by":"crossref","first-page":"6524","DOI":"10.1158\/1078-0432.CCR-19-0725","article-title":"Genetic characterization and prognostic relevance of acquired uniparental disomies in cytogenetically normal acute myeloid leukemia","volume":"25","author":"Walker","year":"2019","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.stem.2025.04.012_bib57","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-018-06208-y","article-title":"EVI1 overexpression reprograms hematopoiesis via upregulation of Spi1 transcription","volume":"9","author":"Ayoub","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.stem.2025.04.012_bib58","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/nature20598","article-title":"A 17-gene stemness score for rapid determination of risk in acute leukaemia","volume":"540","author":"Ng","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.stem.2025.04.012_bib59","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1038\/s41587-019-0206-z","article-title":"Massively parallel single-cell chromatin landscapes of human immune cell development and intratumoral T cell exhaustion","volume":"37","author":"Satpathy","year":"2019","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.stem.2025.04.012_bib60","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/nrc3638","article-title":"The ID proteins: master regulators of cancer stem cells and tumour aggressiveness","volume":"14","author":"Lasorella","year":"2014","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.stem.2025.04.012_bib61","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.stem.2017.07.010","article-title":"Therapy-Related Clonal Hematopoiesis in Patients with Non-hematologic Cancers Is Common and Associated with Adverse Clinical Outcomes","volume":"21","author":"Coombs","year":"2017","journal-title":"Cell Stem Cell."},{"key":"10.1016\/j.stem.2025.04.012_bib62","doi-asserted-by":"crossref","first-page":"1974","DOI":"10.1101\/gad.226613.113","article-title":"Cancer-associated IDH2 mutants drive an acute myeloid leukemia that is susceptible to Brd4 inhibition","volume":"27","author":"Chen","year":"2013","journal-title":"Genes Dev."},{"key":"10.1016\/j.stem.2025.04.012_bib63","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1038\/leu.2014.18","article-title":"Isocitrate dehydrogenase (IDH)2 R140Q mutation induces myeloid and lymphoid neoplasms in mice","volume":"28","author":"Mylonas","year":"2014","journal-title":"Leukemia"},{"key":"10.1016\/j.stem.2025.04.012_bib64","doi-asserted-by":"crossref","first-page":"2392","DOI":"10.1158\/2159-8290.CD-21-1146","article-title":"The Impact of Inflammation-Induced Tumor Plasticity during Myeloid Transformation","volume":"12","author":"Yeaton","year":"2022","journal-title":"Cancer Discov."},{"key":"10.1016\/j.stem.2025.04.012_bib65","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.111182","article-title":"Inhibition of mutant IDH1 promotes cycling of acute myeloid leukemia stem cells","volume":"40","author":"Gruber","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.stem.2025.04.012_bib66","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1038\/nature11323","article-title":"IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics","volume":"488","author":"Sasaki","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.stem.2025.04.012_bib67","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/ana.22390","article-title":"IDH1 R132H decreases proliferation of glioma cell lines in vitro and in vivo","volume":"69","author":"Bralten","year":"2011","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.stem.2025.04.012_bib68","doi-asserted-by":"crossref","first-page":"2038","DOI":"10.1101\/gad.198200.112","article-title":"D-2-hydroxyglutarate produced by mutant IDH1 perturbs collagen maturation and basement membrane function","volume":"26","author":"Sasaki","year":"2012","journal-title":"Genes Dev."},{"key":"10.1016\/j.stem.2025.04.012_bib69","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/j.cmet.2015.06.009","article-title":"2-Hydroxyglutarate Inhibits ATP Synthase and mTOR Signaling","volume":"22","author":"Fu","year":"2015","journal-title":"Cell Metab."},{"key":"10.1016\/j.stem.2025.04.012_bib70","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.cell.2017.11.031","article-title":"R-2HG Exhibits Anti-tumor Activity by Targeting FTO\/m6A\/MYC\/CEBPA Signaling","volume":"172","author":"Su","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.stem.2025.04.012_bib71","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s13045-022-01245-z","article-title":"Reductive TCA cycle catalyzed by wild-type IDH2 promotes acute myeloid leukemia and is a metabolic vulnerability for potential targeted therapy","volume":"15","author":"Zeng","year":"2022","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.stem.2025.04.012_bib72","doi-asserted-by":"crossref","first-page":"eaal2463","DOI":"10.1126\/scitranslmed.aal2463","article-title":"2-Hydroxyglutarate produced by neomorphic IDH mutations suppresses homologous recombination and induces PARP inhibitor sensitivity","volume":"9","author":"Sulkowski","year":"2017","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.stem.2025.04.012_bib73","doi-asserted-by":"crossref","DOI":"10.1182\/blood-2019-130814","article-title":"PARP Inhibitors Are Effective in IDH1\/2 Mutant MDS and AML Resistant to Targeted IDH Inhibitors","volume":"134","author":"Gbyli","year":"2019","journal-title":"Blood"},{"key":"10.1016\/j.stem.2025.04.012_bib74","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1038\/s41375-022-01536-x","article-title":"In vivo anti-tumor effect of PARP inhibition in IDH1\/2 mutant MDS\/AML resistant to targeted inhibitors of mutant IDH1\/2","volume":"36","author":"Gbyli","year":"2022","journal-title":"Leukemia"},{"key":"10.1016\/j.stem.2025.04.012_bib75","doi-asserted-by":"crossref","first-page":"2347","DOI":"10.1016\/j.molcel.2023.05.026","article-title":"Oncogenic IDH mutations increase heterochromatin-related replication stress without impacting homologous recombination","volume":"83","author":"Schvartzman","year":"2023","journal-title":"Mol. Cell"},{"key":"10.1016\/j.stem.2025.04.012_bib76","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/s41586-024-08137-x","article-title":"RAS-mutant leukaemia stem cells drive clinical resistance to venetoclax","volume":"636","author":"Sango","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.stem.2025.04.012_bib77","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/s41408-021-00603-3","article-title":"Effective Menin inhibitor-based combinations against AML with MLL rearrangement or NPM1 mutation (NPM1c)","volume":"12","author":"Fiskus","year":"2022","journal-title":"Blood Cancer J."},{"key":"10.1016\/j.stem.2025.04.012_bib78","doi-asserted-by":"crossref","DOI":"10.1182\/blood-2022-168834","article-title":"Combination of Menin and IDH Mutant Inhibition in Acute Myeloid Leukemia","volume":"140","author":"Yoon","year":"2022","journal-title":"Blood"},{"key":"10.1016\/j.stem.2025.04.012_bib79","article-title":"Leukemia stemness and co-occurring mutations drive resistance to IDH inhibitors in acute myeloid leukemia","volume":"12","author":"Wang","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.stem.2025.04.012_bib80","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20200924","article-title":"Mitochondrial metabolism supports resistance to IDH mutant inhibitors in acute myeloid leukemia","volume":"218","author":"Stuani","year":"2021","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.stem.2025.04.012_bib81","doi-asserted-by":"crossref","first-page":"2330","DOI":"10.1056\/NEJMoa1808777","article-title":"Immune Escape of Relapsed AML Cells after Allogeneic Transplantation","volume":"379","author":"Christopher","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.stem.2025.04.012_bib82","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1038\/s41591-019-0400-z","article-title":"Immune signature drives leukemia escape and relapse after hematopoietic cell transplantation","volume":"25","author":"Toffalori","year":"2019","journal-title":"Nat. Med."},{"key":"10.1016\/j.stem.2025.04.012_bib83","doi-asserted-by":"crossref","first-page":"10209","DOI":"10.1182\/blood-2022-162436","article-title":"Immune Escape after Allogeneic Hematopoietic Cell Transplantation in Pediatric Patients with Acute Myeloid Leukemia","volume":"140","author":"Shahid","year":"2022","journal-title":"Blood"},{"key":"10.1016\/j.stem.2025.04.012_bib84","doi-asserted-by":"crossref","first-page":"2488","DOI":"10.1056\/NEJMoa1408617","article-title":"Age-related clonal hematopoiesis associated with adverse outcomes","volume":"371","author":"Jaiswal","year":"2014","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.stem.2025.04.012_bib85","doi-asserted-by":"crossref","DOI":"10.1056\/EVIDoa2200310","article-title":"Prediction of Risk for Myeloid Malignancy in Clonal Hematopoiesis","volume":"2","author":"Weeks","year":"2023","journal-title":"NEJM Evid."},{"key":"10.1016\/j.stem.2025.04.012_bib86","doi-asserted-by":"crossref","DOI":"10.1126\/science.aan4673","article-title":"Clonal hematopoiesis in human aging and disease","volume":"366","author":"Jaiswal","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.stem.2025.04.012_bib87","unstructured":"Ivosidenib for Patients With Clonal Cytopenia of Undetermined Significance and Mutations in IDH1. https:\/\/clinicaltrials.gov\/ct2\/show\/NCT05030441."},{"key":"10.1016\/j.stem.2025.04.012_bib88","unstructured":"A Study of Enasidenib in People With Clonal Cytopenia of Undetermined Significance. https:\/\/clinicaltrials.gov\/ct2\/show\/NCT05102370."},{"key":"10.1016\/j.stem.2025.04.012_bib89","doi-asserted-by":"crossref","DOI":"10.1038\/s41591-021-01367-w","article-title":"Author Correction: Implications of TP53 allelic state for genome stability, clinical presentation and outcomes in myelodysplastic syndromes","volume":"27","author":"Bernard","year":"2021","journal-title":"Nat. Med."},{"key":"10.1016\/j.stem.2025.04.012_bib90","doi-asserted-by":"crossref","DOI":"10.1186\/s12859-020-03879-7","article-title":"Isabl Platform, a digital biobank for processing multimodal patient data","volume":"21","author":"Medina-Mart\u00ednez","year":"2020","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.stem.2025.04.012_bib91","doi-asserted-by":"crossref","first-page":"3573","DOI":"10.1016\/j.cell.2021.04.048","article-title":"Integrated analysis of multimodal single-cell data","volume":"184","author":"Hao","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.stem.2025.04.012_bib92","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/nbt.4096","article-title":"Integrating single-cell transcriptomic data across different conditions, technologies, and species","volume":"36","author":"Butler","year":"2018","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.stem.2025.04.012_bib93","doi-asserted-by":"crossref","DOI":"10.1186\/s13059-016-0939-7","article-title":"Single-cell profiling of human megakaryocyte-erythroid progenitors identifies distinct megakaryocyte and erythroid differentiation pathways","volume":"17","author":"Psaila","year":"2016","journal-title":"Genome Biol."},{"key":"10.1016\/j.stem.2025.04.012_bib94","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1038\/nmeth.4463","article-title":"SCENIC: single-cell regulatory network inference and clustering","volume":"14","author":"Aibar","year":"2017","journal-title":"Nat. Methods"},{"key":"10.1016\/j.stem.2025.04.012_bib95","doi-asserted-by":"crossref","first-page":"3796","DOI":"10.1016\/j.csbj.2021.06.043","article-title":"UCell: Robust and scalable single-cell gene signature scoring","volume":"19","author":"Andreatta","year":"2021","journal-title":"Comput. Struct. Biotechnol. J."},{"key":"10.1016\/j.stem.2025.04.012_bib96","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.cels.2015.12.004","article-title":"The Molecular Signatures Database (MSigDB) hallmark gene set collection","volume":"1","author":"Liberzon","year":"2015","journal-title":"Cell Syst."},{"key":"10.1016\/j.stem.2025.04.012_bib97","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1038\/nature20123","article-title":"Single-cell RNA-seq supports a developmental hierarchy in human oligodendroglioma","volume":"539","author":"Tirosh","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.stem.2025.04.012_bib98","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1126\/science.aad0501","article-title":"Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq.","volume":"352","author":"Tirosh","year":"2016","journal-title":"Science"}],"container-title":["Cell Stem Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1934590925001791?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1934590925001791?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T20:34:17Z","timestamp":1779914057000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1934590925001791"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":98,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["S1934590925001791"],"URL":"https:\/\/doi.org\/10.1016\/j.stem.2025.04.012","relation":{},"ISSN":["1934-5909"],"issn-type":[{"value":"1934-5909","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Deconvoluting clonal and cellular architecture in IDH-mutant acute myeloid leukemia","name":"articletitle","label":"Article Title"},{"value":"Cell Stem Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.stem.2025.04.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}