{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T00:43:24Z","timestamp":1792457004092,"version":"4.5.0"},"reference-count":91,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,18]],"date-time":"2025-07-18T00:00:00Z","timestamp":1752796800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000923","name":"Silicon Valley Community Foundation","doi-asserted-by":"publisher","award":["DAF2021-238797"],"award-info":[{"award-number":["DAF2021-238797"]}],"id":[{"id":"10.13039\/100000923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"NIH National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["R01 GM126112"],"award-info":[{"award-number":["R01 GM126112"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000051","name":"National Human Genome Research Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000051","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006492","name":"National Institute of Allergy and Infectious Diseases Division of Intramural Research","doi-asserted-by":"publisher","award":["R21 AR077825"],"award-info":[{"award-number":["R21 AR077825"]}],"id":[{"id":"10.13039\/100006492","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007268","name":"Washington University in St. Louis","doi-asserted-by":"publisher","award":["NIH-T32HG000045-21"],"award-info":[{"award-number":["NIH-T32HG000045-21"]}],"id":[{"id":"10.13039\/100007268","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017023","name":"The Paul G Allen Frontiers Group","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017023","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100003194","name":"New York Stem Cell Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100003194","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014989","name":"Chan Zuckerberg Initiative","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014989","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000879","name":"Alfred P Sloan Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000879","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015705","name":"Center of Regenerative Medicine, Washington University in St. Louis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015705","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014451","name":"Center for Cellular Imaging, Washington University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014451","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011912","name":"School of Medicine, Washington University in St. Louis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011912","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007204","name":"Bert L and N Kuggie Vallee Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007204","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Stem Cell"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.stem.2025.07.004","type":"journal-article","created":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T14:41:05Z","timestamp":1753886465000},"page":"1267-1284.e8","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Comparative single-cell lineage tracing identifies distinct adipocyte precursor dynamics in skin and inguinal fat"],"prefix":"10.1016","volume":"32","author":[{"given":"Guillermo C.","family":"Rivera-Gonzalez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily G.","family":"Butka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolynn E.","family":"Gonzalez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel L.","family":"Mintz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah S.","family":"Kleb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Violet","family":"Josephson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjun","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunal","family":"Jindal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Kamimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brett A.","family":"Shook","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew S.","family":"Rodeheffer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8561-4340","authenticated-orcid":false,"given":"Samantha A.","family":"Morris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.stem.2025.07.004_bib1","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1126\/science.1260972","article-title":"Innate immunity. Dermal adipocytes protect against invasive Staphylococcus aureus skin infection","volume":"347","author":"Zhang","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.stem.2025.07.004_bib2","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1126\/science.aai8792","article-title":"Regeneration of fat cells from myofibroblasts during wound healing","volume":"355","author":"Plikus","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.stem.2025.07.004_bib3","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1146\/annurev-cellbio-111315-125426","article-title":"The role of adipocytes in tissue regeneration and stem cell niches.Annu","volume":"32","author":"Shook","year":"2016","journal-title":"Rev. Cell Dev. Biol."},{"key":"10.1016\/j.stem.2025.07.004_bib4","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/j.cell.2011.07.019","article-title":"Adipocyte lineage cells contribute to the skin stem cell niche to drive hair cycling","volume":"146","author":"Festa","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.stem.2025.07.004_bib5","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-018-03196-x","article-title":"De novo adipocyte differentiation from Pdgfr\u03b2+ preadipocytes protects against pathologic visceral adipose expansion in obesity","volume":"9","author":"Shao","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.stem.2025.07.004_bib6","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/s11154-014-9301-0","article-title":"Adipocyte dysfunction, inflammation and metabolic syndrome","volume":"15","author":"Kl\u00f6ting","year":"2014","journal-title":"Rev. Endocr. Metab. Disord."},{"key":"10.1016\/j.stem.2025.07.004_bib7","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.cmet.2013.10.003","article-title":"Weighing in on Adipocyte Precursors","volume":"19","author":"Berry","year":"2014","journal-title":"Cell Metab."},{"key":"10.1016\/j.stem.2025.07.004_bib8","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1016\/j.stem.2020.03.013","article-title":"Dermal Adipocyte Lipolysis and Myofibroblast Conversion Are Required for Efficient Skin Repair","volume":"26","author":"Shook","year":"2020","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.stem.2025.07.004_bib9","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/j.celrep.2014.09.049","article-title":"Independent stem cell lineages regulate adipose organogenesis and adipose homeostasis","volume":"9","author":"Jiang","year":"2014","journal-title":"Cell Rep."},{"key":"10.1016\/j.stem.2025.07.004_bib10","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.cmet.2012.01.010","article-title":"Zfp423 expression identifies committed preadipocytes and localizes to adipose endothelial and perivascular cells","volume":"15","author":"Gupta","year":"2012","journal-title":"Cell Metab."},{"key":"10.1016\/j.stem.2025.07.004_bib11","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1126\/science.1156232","article-title":"White Fat Progenitor Cells Reside in the Adipose Vasculature","volume":"322","author":"Tang","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.stem.2025.07.004_bib12","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.cell.2008.09.036","article-title":"Identification of White Adipocyte Progenitor Cells In Vivo","volume":"135","author":"Rodeheffer","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.stem.2025.07.004_bib13","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/s41586-018-0226-8","article-title":"A stromal cell population that inhibits adipogenesis in mammalian fat depots","volume":"559","author":"Schwalie","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.stem.2025.07.004_bib14","doi-asserted-by":"crossref","DOI":"10.1126\/science.aav2501","article-title":"Identification of a mesenchymal progenitor cell hierarchy in adipose tissue","volume":"364","author":"Merrick","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.stem.2025.07.004_bib15","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1038\/s41586-022-04518-2","article-title":"A single-cell atlas of human and mouse white adipose tissue","volume":"603","author":"Emont","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.stem.2025.07.004_bib16","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.cmet.2020.12.004","article-title":"Plasticity of Epididymal Adipose Tissue in Response to Diet-Induced Obesity at Single-Nucleus Resolution","volume":"33","author":"S\u00e1rv\u00e1ri","year":"2021","journal-title":"Cell Metab."},{"key":"10.1016\/j.stem.2025.07.004_bib17","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.39636","article-title":"Identification of functionally distinct fibro-inflammatory and adipogenic stromal subpopulations in visceral adipose tissue of adult mice","volume":"7","author":"Hepler","year":"2018","journal-title":"Elife"},{"key":"10.1016\/j.stem.2025.07.004_bib18","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.cmet.2018.05.025","article-title":"Deconstructing Adipogenesis Induced by \u03b23-Adrenergic Receptor Activation with Single-Cell Expression Profiling","volume":"28","author":"Burl","year":"2018","journal-title":"Cell Metab."},{"key":"10.1016\/j.stem.2025.07.004_bib19","doi-asserted-by":"crossref","first-page":"3990","DOI":"10.1172\/JCI129187","article-title":"Altered adipose tissue and adipocyte function in the pathogenesis of metabolic syndrome","volume":"129","author":"Kahn","year":"2019","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.stem.2025.07.004_bib20","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1038\/ncb3122","article-title":"Rapid depot-specific activation of adipocyte precursor cells at the onset of obesity","volume":"17","author":"Jeffery","year":"2015","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.stem.2025.07.004_bib21","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1038\/nm.3324","article-title":"Tracking adipogenesis during white adipose tissue development, expansion and regeneration","volume":"19","author":"Wang","year":"2013","journal-title":"Nat. Med."},{"key":"10.1016\/j.stem.2025.07.004_bib22","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-018-05911-0","article-title":"Adipocyte hypertrophy and lipid dynamics underlie mammary gland remodeling after lactation","volume":"9","author":"Zwick","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.stem.2025.07.004_bib23","doi-asserted-by":"crossref","first-page":"2325","DOI":"10.1101\/gad.285429.116","article-title":"Hair follicles\u2019 transit-amplifying cells govern concurrent dermal adipocyte production through sonic hedgehog","volume":"30","author":"Zhang","year":"2016","journal-title":"Genes Dev."},{"key":"10.1016\/j.stem.2025.07.004_bib24","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1016\/j.stem.2016.09.002","article-title":"Skin Adipocyte Stem Cell Self-Renewal Is Regulated by a PDGFA\/AKT-Signaling Axis","volume":"19","author":"Rivera-Gonzalez","year":"2016","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.stem.2025.07.004_bib25","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.cmet.2022.03.012","article-title":"Multilayered omics reveal sex- and depot-dependent adipose progenitor cell heterogeneity","volume":"34","author":"Shan","year":"2022","journal-title":"Cell Metab."},{"key":"10.1016\/j.stem.2025.07.004_bib26","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1038\/s41586-018-0744-4","article-title":"Single-cell mapping of lineage and identity in direct reprogramming","volume":"564","author":"Biddy","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.stem.2025.07.004_bib27","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1038\/s41596-019-0247-2","article-title":"CellTagging: combinatorial indexing to simultaneously map lineage and identity at single-cell resolution","volume":"15","author":"Kong","year":"2020","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.stem.2025.07.004_bib28","doi-asserted-by":"crossref","DOI":"10.1186\/s13059-019-1699-y","article-title":"CellTag Indexing: Genetic barcode-based sample multiplexing for single-cell genomics","volume":"20","author":"Guo","year":"2019","journal-title":"Genome Biol."},{"key":"10.1016\/j.stem.2025.07.004_bib29","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1038\/s41587-023-01931-4","article-title":"Single-cell lineage capture across genomic modalities with CellTag-multi reveals fate-specific gene regulatory changes","volume":"42","author":"Jindal","year":"2024","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.stem.2025.07.004_bib30","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1038\/ncb2696","article-title":"Characterization of the adipocyte cellular lineage in vivo","volume":"15","author":"Berry","year":"2013","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.stem.2025.07.004_bib31","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.stem.2022.03.001","article-title":"Capybara: A computational tool to measure cell identity and fate transitions","volume":"29","author":"Kong","year":"2022","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.stem.2025.07.004_bib32","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1038\/s41586-021-03549-5","article-title":"Cross-tissue organization of the fibroblast lineage","volume":"593","author":"Buechler","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.stem.2025.07.004_bib33","doi-asserted-by":"crossref","first-page":"2140","DOI":"10.1016\/j.devcel.2023.07.015","article-title":"Molecular and spatial landmarks of early mouse skin development","volume":"58","author":"Jacob","year":"2023","journal-title":"Dev. Cell"},{"key":"10.1016\/j.stem.2025.07.004_bib34","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.60066","article-title":"Lef1 expression in fibroblasts maintains developmental potential in adult skin to regenerate wounds","volume":"9","author":"Phan","year":"2020","journal-title":"eLife"},{"key":"10.1016\/j.stem.2025.07.004_bib35","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1038\/nmeth.4401","article-title":"ChromVAR: Inferring transcription-factor-associated accessibility from single-cell epigenomic data","volume":"14","author":"Schep","year":"2017","journal-title":"Nat. Methods"},{"key":"10.1016\/j.stem.2025.07.004_bib36","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1016\/j.celrep.2018.09.086","article-title":"Sox9-Meis1 Inactivation Is Required for Adipogenesis, Advancing Pref-1+ to PDGFR\u03b1+ Cells","volume":"25","author":"Gulyaeva","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.stem.2025.07.004_bib37","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.celrep.2019.12.046","article-title":"Parallel Lineage-Tracing Studies Establish Fibroblasts as the Prevailing In Vivo Adipocyte Progenitor","volume":"30","author":"Cattaneo","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.stem.2025.07.004_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2021.101357","article-title":"Dpp4+ interstitial progenitor cells contribute to basal and high fat diet-induced adipogenesis","volume":"54","author":"Stefkovich","year":"2021","journal-title":"Mol. Metab."},{"key":"10.1016\/j.stem.2025.07.004_bib39","doi-asserted-by":"crossref","first-page":"3168","DOI":"10.1101\/gad.12.20.3168","article-title":"Life without white fat: a transgenic mouse","volume":"12","author":"Moitra","year":"1998","journal-title":"Genes Dev."},{"key":"10.1016\/j.stem.2025.07.004_bib40","doi-asserted-by":"crossref","DOI":"10.1126\/science.aar2971","article-title":"Myofibroblast proliferation and heterogeneity are supported by macrophages during skin repair","volume":"362","author":"Shook","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.stem.2025.07.004_bib41","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.stem.2020.03.004","article-title":"Mosaic Mutant Analysis Identifies PDGFR\u03b1\/PDGFR\u03b2 as Negative Regulators of Adipogenesis","volume":"26","author":"Sun","year":"2020","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.stem.2025.07.004_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2020.109735","article-title":"Suppression of GATA-3 increases adipogenesis, reduces inflammation and improves insulin sensitivity in 3T3L-1 preadipocytes","volume":"75","author":"Al-Mansoori","year":"2020","journal-title":"Cell. Signal."},{"key":"10.1016\/j.stem.2025.07.004_bib43","doi-asserted-by":"crossref","first-page":"26287","DOI":"10.1074\/jbc.274.37.26287","article-title":"Transmembrane tumor necrosis factor (TNF)-\u03b1 inhibits adipocyte differentiation by selectively activating TNF receptor 1","volume":"274","author":"Xu","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.stem.2025.07.004_bib44","doi-asserted-by":"crossref","first-page":"12670","DOI":"10.1073\/pnas.0906266106","article-title":"BMP signaling pathway is required for commitment of C3H10T1\/2 pluripotent stem cells to the adipocyte lineage","volume":"106","author":"Huang","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.stem.2025.07.004_bib45","doi-asserted-by":"crossref","first-page":"13022","DOI":"10.1073\/pnas.0605789103","article-title":"Stable stem cell commitment to the adipocyte lineage by inhibition of DNA methylation: Role of the BMP-4 gene","volume":"103","author":"Bowers","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.stem.2025.07.004_bib46","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.molmet.2016.11.009","article-title":"Fetal development of subcutaneous white adipose tissue is dependent on Zfp423","volume":"6","author":"Shao","year":"2017","journal-title":"Mol. Metab."},{"key":"10.1016\/j.stem.2025.07.004_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2023.106289","article-title":"Suppression of preadipocyte determination by SOX4 limits white adipocyte hyperplasia in obesity","volume":"26","author":"He","year":"2023","journal-title":"iScience"},{"key":"10.1016\/j.stem.2025.07.004_bib48","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1038\/s41586-022-05688-9","article-title":"Dissecting cell identity via network inference and in silico gene perturbation","volume":"614","author":"Kamimoto","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.stem.2025.07.004_bib49","doi-asserted-by":"crossref","first-page":"2038","DOI":"10.1210\/me.2007-0454","article-title":"Inhibitor of DNA binding 2 is a small molecule-inducible modulator of peroxisome proliferator-activated receptor-\u03b3 expression and adipocyte differentiation","volume":"22","author":"Park","year":"2008","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.stem.2025.07.004_bib50","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1038\/nmeth.4402","article-title":"Reversed graph embedding resolves complex single-cell trajectories","volume":"14","author":"Qiu","year":"2017","journal-title":"Nat. Methods"},{"key":"10.1016\/j.stem.2025.07.004_bib51","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1038\/s12276-021-00628-5","article-title":"Proto-oncoprotein Zbtb7c and SIRT1 repression: implications in high-fat diet-induced and age-dependent obesity","volume":"53","author":"Choi","year":"2021","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.stem.2025.07.004_bib52","doi-asserted-by":"crossref","first-page":"2596","DOI":"10.1210\/me.2008-0161","article-title":"Inhibition of adipocyte differentiation by Nur77, Nurr1, and Nor1","volume":"22","author":"Chao","year":"2008","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.stem.2025.07.004_bib53","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.1074\/jbc.M115.675645","article-title":"SIRT1 limits adipocyte hyperplasia through c-Myc inhibition","volume":"291","author":"Abdesselem","year":"2016","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.stem.2025.07.004_bib54","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.cmet.2007.11.002","article-title":"Interferon Regulatory Factors Are Transcriptional Regulators of Adipogenesis","volume":"7","author":"Eguchi","year":"2008","journal-title":"Cell Metab."},{"key":"10.1016\/j.stem.2025.07.004_bib55","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1128\/MCB.01557-06","article-title":"Critical Role for Ebf1 and Ebf2 in the Adipogenic Transcriptional Cascade","volume":"27","author":"Jimenez","year":"2007","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.stem.2025.07.004_bib56","doi-asserted-by":"crossref","DOI":"10.1210\/endocr\/bqab096","article-title":"An RNAi Screening of Clinically Relevant Transcription Factors Regulating Human Adipogenesis and Adipocyte Metabolism","volume":"162","author":"Bj\u00f6rk","year":"2021","journal-title":"Endocrinology"},{"key":"10.1016\/j.stem.2025.07.004_bib57","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.cmet.2009.01.013","article-title":"Pref-1 Regulates Mesenchymal Cell Commitment and Differentiation through Sox9","volume":"9","author":"Wang","year":"2009","journal-title":"Cell Metab."},{"key":"10.1016\/j.stem.2025.07.004_bib58","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1080\/07853890310009999","article-title":"Adipogenesis: A Cross-Talk between Cell Proliferation and Cell Differentiation","volume":"35","author":"Fajas","year":"2003","journal-title":"Ann. Med."},{"key":"10.1016\/j.stem.2025.07.004_bib59","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.cmet.2016.05.012","article-title":"The Adipose Tissue Microenvironment Regulates Depot-Specific Adipogenesis in Obesity","volume":"24","author":"Jeffery","year":"2016","journal-title":"Cell Metab."},{"key":"10.1016\/j.stem.2025.07.004_bib60","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.cmet.2021.11.014","article-title":"Distinct properties of adipose stem cell subpopulations determine fat depot-specific characteristics","volume":"34","author":"Nahmgoong","year":"2022","journal-title":"Cell Metab."},{"key":"10.1016\/j.stem.2025.07.004_bib61","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.cmet.2014.05.005","article-title":"Adipocyte inflammation is essential for healthy adipose tissue expansion and remodeling","volume":"20","author":"Wernstedt Asterholm","year":"2014","journal-title":"Cell Metab."},{"key":"10.1016\/j.stem.2025.07.004_bib62","doi-asserted-by":"crossref","first-page":"30254","DOI":"10.1016\/S0021-9258(18)43805-7","article-title":"\u03b12-adrenergic stimulation promotes preadipocyte proliferation: Involvement of mitogen-activated protein kinases","volume":"269","author":"Bouloumi\u00e9","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.stem.2025.07.004_bib63","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-018-08247-x","article-title":"Single-cell analysis reveals fibroblast heterogeneity and myeloid-derived adipocyte progenitors in murine skin wounds","volume":"10","author":"Guerrero-Juarez","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.stem.2025.07.004_bib64","doi-asserted-by":"crossref","first-page":"5327","DOI":"10.1172\/JCI130239","article-title":"Dermal adipose tissue has high plasticity and undergoes reversible dedifferentiation in mice","volume":"129","author":"Zhang","year":"2019","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.stem.2025.07.004_bib65","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.1016\/j.jid.2021.11.032","article-title":"Parallel Single-Cell Multiomics Analysis of Neonatal Skin Reveals the Transitional Fibroblast States that Restrict Differentiation into Distinct Fates","volume":"142","author":"Thompson","year":"2022","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.stem.2025.07.004_bib66","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2110025118","article-title":"Integrated spatial multiomics reveals fibroblast fate during tissue repair","volume":"118","author":"Foster","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.stem.2025.07.004_bib67","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.devcel.2020.10.021","article-title":"Next-Generation Lineage Tracing and Fate Mapping to Interrogate Development","volume":"56","author":"VanHorn","year":"2021","journal-title":"Dev. Cell"},{"key":"10.1016\/j.stem.2025.07.004_bib68","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1016\/j.cell.2013.08.007","article-title":"XClonal analysis unveils self-renewing lineage-restricted progenitors generated directly from hematopoietic stem cells","volume":"154","author":"Yamamoto","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.stem.2025.07.004_bib69","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1038\/nature12013","article-title":"Diverse and heritable lineage imprinting of early haematopoietic progenitors","volume":"496","author":"Naik","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.stem.2025.07.004_bib70","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1038\/s41556-018-0232-y","article-title":"Flexible fate determination ensures robust differentiation in the hair follicle","volume":"20","author":"Xin","year":"2018","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.stem.2025.07.004_bib71","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1002356","article-title":"SOX9 governs differentiation stage-specific gene expression in growth plate chondrocytes via direct concomitant transactivation and repression","volume":"7","author":"Leung","year":"2011","journal-title":"PLoS Genet."},{"key":"10.1016\/j.stem.2025.07.004_bib72","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1016\/j.celrep.2015.07.034","article-title":"Sox9 Activation Highlights a Cellular Pathway of Renal Repair in the Acutely Injured Mammalian Kidney","volume":"12","author":"Kumar","year":"2015","journal-title":"Cell Rep."},{"key":"10.1016\/j.stem.2025.07.004_bib73","article-title":"SOX9 elongates cell cycle phases and biases fate decisions in human intestinal stem cells","author":"Burclaff","year":"2022","journal-title":"Preprint at bioRxiv"},{"key":"10.1016\/j.stem.2025.07.004_bib74","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1073\/pnas.0137044100","article-title":"Mitotic Clonal Expansion: A Synchronous Process Required for Adipogenesis","volume":"100","author":"Tang","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.stem.2025.07.004_bib75","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.2337\/db11-1753","article-title":"Intrinsic differences in adipocyte precursor cells from different white fat depots","volume":"61","author":"Macotela","year":"2012","journal-title":"Diabetes"},{"key":"10.1016\/j.stem.2025.07.004_bib76","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.jid.2017.10.019","article-title":"Adipose and Hair Function: An aPPARent Connection","volume":"138","author":"Islam","year":"2018","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.stem.2025.07.004_bib77","doi-asserted-by":"crossref","first-page":"4022","DOI":"10.1172\/JCI129191","article-title":"Contribution of adipogenesis to healthy adipose tissue expansion in obesity","volume":"129","author":"Vishvanath","year":"2019","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.stem.2025.07.004_bib78","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0017637","article-title":"Rapid cellular turnover in adipose tissue","volume":"6","author":"Rigamonti","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.stem.2025.07.004_bib79","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1016\/j.cell.2020.04.048","article-title":"An Engineered CRISPR-Cas9 Mouse Line for Simultaneous Readout of Lineage Histories and Gene Expression Profiles in Single Cells","volume":"181","author":"Bowling","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.stem.2025.07.004_bib80","doi-asserted-by":"crossref","first-page":"5183","DOI":"10.1016\/j.cell.2023.09.019","article-title":"A mouse model with high clonal barcode diversity for joint lineage, transcriptomic, and epigenomic profiling in single cells","volume":"186","author":"Li","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.stem.2025.07.004_bib85","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1128\/MCB.18.2.967","article-title":"A dominant-negative inhibitor of CREB reveals that it is a general mediator of stimulus-dependent transcription of c-fos","volume":"18","author":"Ahn","year":"1998","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.stem.2025.07.004_bib91","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/j.cell.2012.02.008","article-title":"Slug and Sox9 cooperatively determine the mammary stem cell state","volume":"148","author":"Guo","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.stem.2025.07.004_bib87","doi-asserted-by":"crossref","first-page":"5041","DOI":"10.1038\/s41467-018-07464-8","article-title":"The phospholipid PI(3,4)P2 is an apical identity determinant","volume":"9","author":"Rom\u00e1n-Fern\u00e1ndez","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.stem.2025.07.004_bib88","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1261\/rna.2192803","article-title":"Lentivirus-delivered stable gene silencing by RNAi in primary cells","volume":"9","author":"Stewart","year":"2003","journal-title":"RNA"},{"key":"10.1016\/j.stem.2025.07.004_bib89","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/nbt.3192","article-title":"Spatial reconstruction of single-cell gene expression data","volume":"33","author":"Satija","year":"2015","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.stem.2025.07.004_bib90","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/nbt.4096","article-title":"Integrating single-cell transcriptomic data across different conditions, technologies, and species","volume":"36","author":"Butler","year":"2018","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.stem.2025.07.004_bib86","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1016\/j.cell.2019.05.031","article-title":"Comprehensive Integration of Single-Cell Data","volume":"177","author":"Stuart","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.stem.2025.07.004_bib84","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.stemcr.2022.11.010","article-title":"Gene regulatory network reconfiguration in direct lineage reprogramming","volume":"18","author":"Kamimoto","year":"2023","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.stem.2025.07.004_bib81","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1038\/nbt.1977","article-title":"Tracking single hematopoietic stem cells in vivo using high-throughput sequencing in conjunction with viral genetic barcoding","volume":"29","author":"Lu","year":"2011","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.stem.2025.07.004_bib82","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.1093\/bioinformatics\/btaa956","article-title":"Evaluating single-cell cluster stability using the Jaccard similarity index","volume":"37","author":"Tang","year":"2021","journal-title":"Bioinformatics"},{"key":"10.1016\/j.stem.2025.07.004_bib83","unstructured":"Iglewicz, B., and Hoaglin, D.C. (1993) How to Detect and Handle Outliers (American Society for Quality Control). https:\/\/asq.org\/quality-press\/display-item?item=E0801."}],"container-title":["Cell Stem Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1934590925002619?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1934590925002619?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T15:13:17Z","timestamp":1754579597000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1934590925002619"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":91,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["S1934590925002619"],"URL":"https:\/\/doi.org\/10.1016\/j.stem.2025.07.004","relation":{},"ISSN":["1934-5909"],"issn-type":[{"value":"1934-5909","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comparative single-cell lineage tracing identifies distinct adipocyte precursor dynamics in skin and inguinal fat","name":"articletitle","label":"Article Title"},{"value":"Cell Stem Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.stem.2025.07.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}