{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:17:24Z","timestamp":1790788644970,"version":"4.1.0"},"reference-count":59,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100007219","name":"Shanghai Municipal Natural Science Foundation","doi-asserted-by":"publisher","award":["22TQ016"],"award-info":[{"award-number":["22TQ016"]}],"id":[{"id":"10.13039\/100007219","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007219","name":"Shanghai Municipal Natural Science Foundation","doi-asserted-by":"publisher","award":["22XD1420800"],"award-info":[{"award-number":["22XD1420800"]}],"id":[{"id":"10.13039\/100007219","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007219","name":"Shanghai Municipal Natural Science Foundation","doi-asserted-by":"publisher","award":["23JS1401400"],"award-info":[{"award-number":["23JS1401400"]}],"id":[{"id":"10.13039\/100007219","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People&apos;s Republic of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2024YFC2707703"],"award-info":[{"award-number":["2024YFC2707703"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2024YFA1802603"],"award-info":[{"award-number":["2024YFA1802603"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["92368204"],"award-info":[{"award-number":["92368204"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82222021"],"award-info":[{"award-number":["82222021"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82425022"],"award-info":[{"award-number":["82425022"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32270849"],"award-info":[{"award-number":["32270849"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32170806"],"award-info":[{"award-number":["32170806"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016096","name":"Shanghai Key Basic Research Program","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016096","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Stem Cell"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.stem.2025.10.001","type":"journal-article","created":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T10:16:54Z","timestamp":1761646614000},"page":"1758-1772.e8","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["3D-generation of high-purity midbrain dopaminergic progenitors and lineage-guided refinement of grafts supports Parkinson\u2019s disease cell therapy"],"prefix":"10.1016","volume":"32","author":[{"given":"Xinyue","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qike","family":"Ouyang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongjing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianshun","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingying","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ban","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zinan","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peibo","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiling","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqiao","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangjie","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changyin","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinqin","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanzheng","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Man","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4625-2604","authenticated-orcid":false,"given":"Yuejun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.stem.2025.10.001_bib1","doi-asserted-by":"crossref","DOI":"10.1038\/nrdp.2017.13","article-title":"Parkinson disease","volume":"3","author":"Poewe","year":"2017","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.stem.2025.10.001_bib2","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1038\/s41551-022-00987-y","article-title":"Challenges in the clinical advancement of cell therapies for Parkinson\u2019s disease","volume":"7","author":"Skidmore","year":"2023","journal-title":"Nat. Biomed. Eng."},{"key":"10.1016\/j.stem.2025.10.001_bib3","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.stem.2024.12.005","article-title":"Pluripotent stem-cell-derived therapies in clinical trial: A 2025 update","volume":"32","author":"Kirkeby","year":"2025","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.stem.2025.10.001_bib4","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.stem.2021.01.004","article-title":"Preclinical Efficacy and Safety of a Human Embryonic Stem Cell-Derived Midbrain Dopamine Progenitor Product, MSK-DA01","volume":"28","author":"Piao","year":"2021","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.stem.2025.10.001_bib5","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.stem.2023.11.009","article-title":"Preclinical and dose-ranging assessment of hESC-derived dopaminergic progenitors for a clinical trial on Parkinson\u2019s disease","volume":"31","author":"Park","year":"2024","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.stem.2025.10.001_bib6","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1016\/j.stem.2023.08.014","article-title":"Preclinical quality, safety, and efficacy of a human embryonic stem cell-derived product for the treatment of Parkinson\u2019s disease, STEM-PD","volume":"30","author":"Kirkeby","year":"2023","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.stem.2025.10.001_bib7","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-020-17165-w","article-title":"Pre-clinical study of induced pluripotent stem cell-derived dopaminergic progenitor cells for Parkinson\u2019s disease","volume":"11","author":"Doi","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.stem.2025.10.001_bib8","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1172\/JCI130767","article-title":"Human autologous iPSC-derived dopaminergic progenitors restore motor function in Parkinson\u2019s disease models","volume":"130","author":"Song","year":"2020","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.stem.2025.10.001_bib9","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.stem.2016.09.004","article-title":"Predictive Markers Guide Differentiation to Improve Graft Outcome in Clinical Translation of hESC-Based Therapy for Parkinson\u2019s Disease","volume":"20","author":"Kirkeby","year":"2017","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.stem.2025.10.001_bib10","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1038\/s41596-021-00673-4","article-title":"Spotting-based differentiation of functional dopaminergic progenitors from human pluripotent stem cells","volume":"17","author":"Kim","year":"2022","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.stem.2025.10.001_bib11","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.stem.2025.01.006","article-title":"Pre-clinical safety and efficacy of human induced pluripotent stem cell-derived products for autologous cell therapy in Parkinson\u2019s disease","volume":"32","author":"Jeon","year":"2025","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.stem.2025.10.001_bib12","doi-asserted-by":"crossref","DOI":"10.1172\/JCI156768","article-title":"Human midbrain dopaminergic neuronal differentiation markers predict cell therapy outcomes in a Parkinson\u2019s disease model","volume":"132","author":"Xu","year":"2022","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.stem.2025.10.001_bib13","article-title":"Single cell transcriptomics identifies stem cell-derived graft composition in a model of Parkinson\u2019s disease","volume":"11","author":"Tiklov\u00e1","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.stem.2025.10.001_bib14","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.omtm.2023.04.008","article-title":"Deconvolution of spatial sequencing provides accurate characterization of hESC-derived DA transplants in vivo","volume":"29","author":"R\u00e1jov\u00e1","year":"2023","journal-title":"Mol. Ther. Methods Clin. Dev."},{"key":"10.1016\/j.stem.2025.10.001_bib15","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adn3057","article-title":"Lineage tracing of stem cell-derived dopamine grafts in a Parkinson\u2019s model reveals shared origin of all graft-derived cells","volume":"10","author":"Storm","year":"2024","journal-title":"Sci. Adv."},{"key":"10.1016\/j.stem.2025.10.001_bib16","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.cell.2005.10.037","article-title":"Identification of intrinsic determinants of midbrain dopamine neurons","volume":"124","author":"Andersson","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.stem.2025.10.001_bib17","doi-asserted-by":"crossref","first-page":"3399","DOI":"10.1242\/dev.065482","article-title":"Specific and integrated roles of Lmx1a, Lmx1b and Phox2a in ventral midbrain development","volume":"138","author":"Deng","year":"2011","journal-title":"Development"},{"key":"10.1016\/j.stem.2025.10.001_bib18","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/1749-8104-6-23","article-title":"En1 and Wnt signaling in midbrain dopaminergic neuronal development","volume":"6","author":"Alves dos Santos","year":"2011","journal-title":"Neural Dev."},{"key":"10.1016\/j.stem.2025.10.001_bib19","first-page":"916","article-title":"A novel floor plate boundary defined by adjacent En1 and Dbx1 microdomains distinguishes midbrain dopamine and hypothalamic neurons","volume":"144","author":"Nouri","year":"2017","journal-title":"Development"},{"key":"10.1016\/j.stem.2025.10.001_bib20","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.stem.2023.02.007","article-title":"Mapping of clonal lineages across developmental stages in human neural differentiation","volume":"30","author":"You","year":"2023","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.stem.2025.10.001_bib21","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/j.stem.2016.03.014","article-title":"Chemical Control of Grafted Human PSC-Derived Neurons in a Mouse Model of Parkinson\u2019s Disease","volume":"18","author":"Chen","year":"2016","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.stem.2025.10.001_bib22","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.stem.2020.08.014","article-title":"Human Stem Cell-Derived Neurons Repair Circuits and Restore Neural Function","volume":"28","author":"Xiong","year":"2021","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.stem.2025.10.001_bib23","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/j.celrep.2012.04.009","article-title":"Generation of regionally specified neural progenitors and functional neurons from human embryonic stem cells under defined conditions","volume":"1","author":"Kirkeby","year":"2012","journal-title":"Cell Rep."},{"key":"10.1016\/j.stem.2025.10.001_bib24","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1038\/nature10648","article-title":"Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson\u2019s disease","volume":"480","author":"Kriks","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.stem.2025.10.001_bib25","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1002\/stem.1152","article-title":"Specification of midbrain dopamine neurons from primate pluripotent stem cells","volume":"30","author":"Xi","year":"2012","journal-title":"Stem Cells"},{"key":"10.1016\/j.stem.2025.10.001_bib26","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1038\/s41587-020-0525-0","article-title":"Modeling neural tube development by differentiation of human embryonic stem cells in a microfluidic WNT gradient","volume":"38","author":"Rifes","year":"2020","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.stem.2025.10.001_bib27","doi-asserted-by":"crossref","first-page":"1962","DOI":"10.1038\/nprot.2017.078","article-title":"Generation of high-purity human ventral midbrain dopaminergic progenitors for in vitro maturation and intracerebral transplantation","volume":"12","author":"Nolbrant","year":"2017","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.stem.2025.10.001_bib28","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1242\/dev.126.6.1189","article-title":"FGF8 induces formation of an ectopic isthmic organizer and isthmocerebellar development via a repressive effect on Otx2 expression","volume":"126","author":"Martinez","year":"1999","journal-title":"Development"},{"key":"10.1016\/j.stem.2025.10.001_bib29","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.cell.2016.09.027","article-title":"Molecular Diversity of Midbrain Development in Mouse, Human, and Stem Cells","volume":"167","author":"La Manno","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.stem.2025.10.001_bib30","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2020.00463","article-title":"Midbrain Dopaminergic Neuron Development at the Single Cell Level: In vivo and in Stem Cells","volume":"8","author":"\u00c1sgr\u00edmsd\u00f3ttir","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.stem.2025.10.001_bib31","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1016\/j.neuron.2008.01.022","article-title":"Unique properties of mesoprefrontal neurons within a dual mesocorticolimbic dopamine system","volume":"57","author":"Lammel","year":"2008","journal-title":"Neuron"},{"key":"10.1016\/j.stem.2025.10.001_bib32","doi-asserted-by":"crossref","first-page":"3704","DOI":"10.1523\/JNEUROSCI.0117-17.2017","article-title":"Dopamine Inhibition Differentially Controls Excitability of Substantia Nigra Dopamine Neuron Subpopulations through T-Type Calcium Channels","volume":"37","author":"Evans","year":"2017","journal-title":"J. Neurosci."},{"key":"10.1016\/j.stem.2025.10.001_bib33","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1523\/JNEUROSCI.22-04-01290.2002","article-title":"I(h) channels contribute to the different functional properties of identified dopaminergic subpopulations in the midbrain","volume":"22","author":"Neuhoff","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1016\/j.stem.2025.10.001_bib34","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.neuroscience.2014.01.025","article-title":"The role of D2-autoreceptors in regulating dopamine neuron activity and transmission","volume":"282","author":"Ford","year":"2014","journal-title":"Neuroscience"},{"key":"10.1016\/j.stem.2025.10.001_bib35","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.stem.2022.01.013","article-title":"A combined cell and gene therapy approach for homotopic reconstruction of midbrain dopamine pathways using human pluripotent stem cells","volume":"29","author":"Moriarty","year":"2022","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.stem.2025.10.001_bib36","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.stem.2016.10.003","article-title":"Single-Cell Analysis Reveals a Close Relationship between Differentiating Dopamine and Subthalamic Nucleus Neuronal Lineages","volume":"20","author":"Kee","year":"2017","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.stem.2025.10.001_bib37","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.stem.2021.01.005","article-title":"Biphasic Activation of WNT Signaling Facilitates the Derivation of Midbrain Dopamine Neurons from hESCs for Translational Use","volume":"28","author":"Kim","year":"2021","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.stem.2025.10.001_bib38","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1002\/dvdy.22532","article-title":"GABAergic and glutamatergic identities of developing midbrain Pitx2 neurons","volume":"240","author":"Waite","year":"2011","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.stem.2025.10.001_bib39","doi-asserted-by":"crossref","first-page":"4701","DOI":"10.1242\/dev.127.21.4701","article-title":"Members of the bHLH-PAS family regulate Shh transcription in forebrain regions of the mouse CNS","volume":"127","author":"Epstein","year":"2000","journal-title":"Development"},{"key":"10.1016\/j.stem.2025.10.001_bib40","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1093\/brain\/awh510","article-title":"Cell type analysis of functional fetal dopamine cell suspension transplants in the striatum and substantia nigra of patients with Parkinson\u2019s disease","volume":"128","author":"Mendez","year":"2005","journal-title":"Brain"},{"key":"10.1016\/j.stem.2025.10.001_bib41","article-title":"Autologous Induced Pluripotent Stem Cell-Based Cell Therapies: Promise, Progress, and Challenges","volume":"1","author":"Madrid","year":"2021","journal-title":"Curr. Protoc."},{"key":"10.1016\/j.stem.2025.10.001_bib42","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/j.neuron.2017.09.056","article-title":"Cell Biology of Astrocyte-Synapse Interactions","volume":"96","author":"Allen","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/j.stem.2025.10.001_bib43","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1172\/JCI93924","article-title":"Cografting astrocytes improves cell therapeutic outcomes in a Parkinson\u2019s disease model","volume":"128","author":"Song","year":"2018","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.stem.2025.10.001_bib44","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/j.gpb.2021.08.001","article-title":"The Genome Sequence Archive Family: Toward Explosive Data Growth and Diverse Data Types","volume":"19","author":"Chen","year":"2021","journal-title":"Genomics Proteomics Bioinformatics"},{"key":"10.1016\/j.stem.2025.10.001_bib45","doi-asserted-by":"crossref","first-page":"D18","DOI":"10.1093\/nar\/gkad1078","article-title":"Database Resources of the National Genomics Data Center, China National Center for Bioinformation in 2024","volume":"52","year":"2024","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.stem.2025.10.001_bib46","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.stem.2013.03.006","article-title":"Enhanced efficiency of human pluripotent stem cell genome editing through replacing TALENs with CRISPRs","volume":"12","author":"Ding","year":"2013","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.stem.2025.10.001_bib47","series-title":"Medical Image Computing and Computer Assisted Intervention \u2013 MICCAI 2018","first-page":"265","article-title":"Cell Detection with Star-Convex Polygons","author":"Schmidt","year":"2018"},{"key":"10.1016\/j.stem.2025.10.001_bib48","doi-asserted-by":"crossref","first-page":"3573","DOI":"10.1016\/j.cell.2021.04.048","article-title":"Integrated analysis of multimodal single-cell data","volume":"184","author":"Hao","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.stem.2025.10.001_bib49","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.cels.2019.03.003","article-title":"DoubletFinder: Doublet Detection in Single-Cell RNA Sequencing Data Using Artificial Nearest Neighbors","volume":"8","author":"McGinnis","year":"2019","journal-title":"Cell Syst."},{"key":"10.1016\/j.stem.2025.10.001_bib50","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-018-03282-0","article-title":"Characterizing the replicability of cell types defined by single cell RNA-sequencing data using MetaNeighbor","volume":"9","author":"Crow","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.stem.2025.10.001_bib51","author":"Kassambara"},{"key":"10.1016\/j.stem.2025.10.001_bib52","author":"Zhang"},{"key":"10.1016\/j.stem.2025.10.001_bib53","doi-asserted-by":"crossref","first-page":"2847","DOI":"10.1093\/bioinformatics\/btw313","article-title":"Complex heatmaps reveal patterns and correlations in multidimensional genomic data","volume":"32","author":"Gu","year":"2016","journal-title":"Bioinformatics"},{"key":"10.1016\/j.stem.2025.10.001_bib54","article-title":"clusterProfiler 4.0: A universal enrichment tool for interpreting omics data","volume":"2","author":"Wu","year":"2021","journal-title":"Innovation (Camb.)"},{"key":"10.1016\/j.stem.2025.10.001_bib55","author":"Se"},{"key":"10.1016\/j.stem.2025.10.001_bib56","doi-asserted-by":"crossref","DOI":"10.1093\/bib\/bbab579","article-title":"Accurate and fast cell marker gene identification with COSG","volume":"23","author":"Dai","year":"2022","journal-title":"Brief. Bioinform."},{"key":"10.1016\/j.stem.2025.10.001_bib57","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-025-58079-9","article-title":"Stereopy: modeling comparative and spatiotemporal cellular heterogeneity via multi-sample spatial transcriptomics","volume":"16","author":"Fang","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.stem.2025.10.001_bib58","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.stem.2015.06.001","article-title":"Engineering Human Stem Cell Lines with Inducible Gene Knockout using CRISPR\/Cas9","volume":"17","author":"Chen","year":"2015","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.stem.2025.10.001_bib59","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1038\/s41592-023-01947-3","article-title":"Comprehensive spatiotemporal mapping of single-cell lineages in developing mouse brain by CRISPR-based barcoding","volume":"20","author":"Xie","year":"2023","journal-title":"Nat. Methods"}],"container-title":["Cell Stem Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1934590925003698?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1934590925003698?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T00:06:32Z","timestamp":1773273992000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1934590925003698"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":59,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["S1934590925003698"],"URL":"https:\/\/doi.org\/10.1016\/j.stem.2025.10.001","relation":{},"ISSN":["1934-5909"],"issn-type":[{"value":"1934-5909","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"3D-generation of high-purity midbrain dopaminergic progenitors and lineage-guided refinement of grafts supports Parkinson\u2019s disease cell therapy","name":"articletitle","label":"Article Title"},{"value":"Cell Stem Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.stem.2025.10.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}