{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T05:42:14Z","timestamp":1792302134665,"version":"4.4.0"},"reference-count":106,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,1,8]],"date-time":"2027-01-08T00:00:00Z","timestamp":1799366400000},"content-version":"am","delay-in-days":372,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100011485","name":"The University of North Carolina at Chapel Hill North Carolina Translational and Clinical Sciences Institute","doi-asserted-by":"publisher","award":["550KR262111"],"award-info":[{"award-number":["550KR262111"]}],"id":[{"id":"10.13039\/100011485","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["R01 HD055741"],"award-info":[{"award-number":["R01 HD055741"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008615","name":"The University of North Carolina at Chapel Hill Lineberger Comprehensive Cancer Center","doi-asserted-by":"publisher","award":["P30 CA016086"],"award-info":[{"award-number":["P30 CA016086"]}],"id":[{"id":"10.13039\/100008615","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007857","name":"Intellectual and Developmental Disabilities Research Center","doi-asserted-by":"publisher","award":["P50 HD103573"],"award-info":[{"award-number":["P50 HD103573"]}],"id":[{"id":"10.13039\/100007857","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011082","name":"The University of North Carolina at Chapel Hill School of Medicine","doi-asserted-by":"publisher","award":["R01 HD055741"],"award-info":[{"award-number":["R01 HD055741"]}],"id":[{"id":"10.13039\/100011082","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011082","name":"The University of North Carolina at Chapel Hill School of Medicine","doi-asserted-by":"publisher","award":["P30-ES010126"],"award-info":[{"award-number":["P30-ES010126"]}],"id":[{"id":"10.13039\/100011082","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["P50 HD103573"],"award-info":[{"award-number":["P50 HD103573"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["R01 MH130441"],"award-info":[{"award-number":["R01 MH130441"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["R01 MH121433"],"award-info":[{"award-number":["R01 MH121433"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["R01 MH120125"],"award-info":[{"award-number":["R01 MH120125"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["R01 MH118349"],"award-info":[{"award-number":["R01 MH118349"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010416","name":"Rollins School of Public Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010416","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006808","name":"University of North Carolina","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006808","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018776","name":"Cancer Center, University of Florida Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018776","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005562","name":"North Carolina Biotechnology Center","doi-asserted-by":"publisher","award":["SCR_019060"],"award-info":[{"award-number":["SCR_019060"]}],"id":[{"id":"10.13039\/100005562","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005562","name":"North Carolina Biotechnology Center","doi-asserted-by":"publisher","award":["2016-IDG-1016"],"award-info":[{"award-number":["2016-IDG-1016"]}],"id":[{"id":"10.13039\/100005562","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018784","name":"Foundation of Hope for Research and Treatment of Mental Illness","doi-asserted-by":"publisher","award":["A19-1040"],"award-info":[{"award-number":["A19-1040"]}],"id":[{"id":"10.13039\/100018784","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100023004","name":"Center for Environmental Health and Susceptibility, University of North Carolina at Chapel Hill","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100023004","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007327","name":"The University of North Carolina at Chapel Hill Gillings School of Global Public Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007327","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["F31MH124427-01A1"],"award-info":[{"award-number":["F31MH124427-01A1"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["T-32 7431-20"],"award-info":[{"award-number":["T-32 7431-20"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Stem Cell"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.stem.2025.12.001","type":"journal-article","created":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T15:43:24Z","timestamp":1766418204000},"page":"142-156.e7","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Human cortical organoids recapitulate inter-individual variability in infant brain-growth trajectories"],"prefix":"10.1016","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9722-2811","authenticated-orcid":false,"given":"Madison R.","family":"Glass","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nana","family":"Matoba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alvaro A.","family":"Beltran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niyanta K.","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tala M.","family":"Farah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karthik","family":"Eswar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shivam","family":"Bhargava","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"Curtin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Srivastava","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Drake","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liam T.","family":"Davis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meghana","family":"Yeturi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kexin","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael I.","family":"Love","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy M.","family":"Simon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanya St.","family":"John","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natasha","family":"Marrus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juhi","family":"Pandey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette","family":"Estes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Dager","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert T.","family":"Schultz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly","family":"Botteron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Evans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sun Hyung","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Styner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert C.","family":"McKinstry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. Louis","family":"Collins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather","family":"Volk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly","family":"Benke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lonnie","family":"Zwaigenbaum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather","family":"Hazlett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana S.","family":"Beltran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica B.","family":"Girault","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark D.","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Piven","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4829-0513","authenticated-orcid":false,"given":"Jason L.","family":"Stein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.stem.2025.12.001_bib1","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/s41593-021-00802-y","article-title":"Long-term maturation of human cortical organoids matches key early postnatal transitions","volume":"24","author":"Gordon","year":"2021","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.stem.2025.12.001_bib2","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.cell.2021.10.003","article-title":"Human brain organogenesis: Toward a cellular understanding of development and disease","volume":"185","author":"Kelley","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.stem.2025.12.001_bib3","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1038\/nrn.2017.107","article-title":"The use of brain organoids to investigate neural development and disease","volume":"18","author":"Di Lullo","year":"2017","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.stem.2025.12.001_bib4","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1016\/j.stemcr.2024.07.008","article-title":"Cross-site reproducibility of human cortical organoids reveals consistent cell type composition and architecture","volume":"19","author":"Glass","year":"2024","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.stem.2025.12.001_bib5","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1038\/s41592-018-0255-0","article-title":"Reliability of human cortical organoid generation","volume":"16","author":"Yoon","year":"2019","journal-title":"Nat. Methods"},{"key":"10.1016\/j.stem.2025.12.001_bib6","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/s41586-019-1289-x","article-title":"Individual brain organoids reproducibly form cell diversity of the human cerebral cortex","volume":"570","author":"Velasco","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.stem.2025.12.001_bib7","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1038\/s41586-020-1962-0","article-title":"Cell stress in cortical organoids impairs molecular subtype specification","volume":"578","author":"Bhaduri","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.stem.2025.12.001_bib8","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1038\/s41586-024-07578-8","article-title":"Brain Chimeroids reveal individual susceptibility to neurotoxic triggers","volume":"631","author":"Ant\u00f3n-Bola\u00f1os","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.stem.2025.12.001_bib9","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.71361","article-title":"Human embryoid bodies as a novel system for genomic studies of functionally diverse cell types","volume":"11","author":"Rhodes","year":"2022","journal-title":"eLife"},{"key":"10.1016\/j.stem.2025.12.001_bib10","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1038\/s41592-024-02555-5","article-title":"Multiplexing cortical brain organoids for the longitudinal dissection of developmental traits at single-cell resolution","volume":"22","author":"Caporale","year":"2024","journal-title":"Nat. Methods"},{"key":"10.1016\/j.stem.2025.12.001_bib11","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1038\/s41588-021-00801-6","article-title":"Population-scale single-cell RNA-seq profiling across dopaminergic neuron differentiation","volume":"53","author":"Jerber","year":"2021","journal-title":"Nat. Genet."},{"key":"10.1016\/j.stem.2025.12.001_bib12","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.stem.2016.11.017","article-title":"Induction of Expansion and Folding in Human Cerebral Organoids","volume":"20","author":"Li","year":"2017","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.stem.2025.12.001_bib13","doi-asserted-by":"crossref","first-page":"7560","DOI":"10.1038\/s41380-021-01243-6","article-title":"Cortical organoids model early brain development disrupted by 16p11.2 copy number variants in autism","volume":"26","author":"Urresti","year":"2021","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.stem.2025.12.001_bib14","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1038\/s41593-018-0295-x","article-title":"Pathological priming causes developmental gene network heterochronicity in autistic subject-derived neurons","volume":"22","author":"Schafer","year":"2019","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.stem.2025.12.001_bib15","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.cell.2015.06.034","article-title":"FOXG1-Dependent Dysregulation of GABA\/Glutamate Neuron Differentiation in Autism Spectrum Disorders","volume":"162","author":"Mariani","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.stem.2025.12.001_bib16","doi-asserted-by":"crossref","DOI":"10.1186\/s13229-024-00602-8","article-title":"Embryonic origin of two ASD subtypes of social symptom severity: the larger the brain cortical organoid size, the more severe the social symptoms","volume":"15","author":"Courchesne","year":"2024","journal-title":"Mol. Autism"},{"key":"10.1016\/j.stem.2025.12.001_bib17","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1038\/s41593-023-01399-0","article-title":"Modeling idiopathic autism in forebrain organoids reveals an imbalance of excitatory cortical neuron subtypes during early neurogenesis","volume":"26","author":"Jourdon","year":"2023","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.stem.2025.12.001_bib18","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1038\/nature21369","article-title":"Early brain development in infants at high risk for autism spectrum disorder","volume":"542","author":"Hazlett","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.stem.2025.12.001_bib19","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1001\/archgenpsychiatry.2011.39","article-title":"Early Brain Overgrowth in Autism Associated with an Increase in Cortical Surface Area before Age 2 Years","volume":"68","author":"Hazlett","year":"2011","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.stem.2025.12.001_bib20","doi-asserted-by":"crossref","first-page":"2825","DOI":"10.1093\/brain\/awt166","article-title":"Early brain enlargement and elevated extra-axial fluid in infants who develop autism spectrum disorder","volume":"136","author":"Shen","year":"2013","journal-title":"Brain"},{"key":"10.1016\/j.stem.2025.12.001_bib21","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1038\/nrn2719","article-title":"Evolution of the neocortex: A perspective from developmental biology","volume":"10","author":"Rakic","year":"2009","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.stem.2025.12.001_bib22","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1038\/mp.2017.131","article-title":"Toward a conceptual framework for early brain and behavior development in autism","volume":"22","author":"Piven","year":"2017","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.stem.2025.12.001_bib107","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s11689-015-9117-6","article-title":"Behavioral, cognitive, and adaptive development in infants with autism spectrum disorder in the first 2 years of life","volume":"7","author":"Estes","year":"2015","journal-title":"J Neurodev Disord"},{"key":"10.1016\/j.stem.2025.12.001_bib108","doi-asserted-by":"crossref","first-page":"e488","DOI":"10.1542\/peds.2010-2825","article-title":"Recurrence risk for autism spectrum disorders: a Baby Siblings Research Consortium study","volume":"128","author":"Ozonoff","year":"2011","journal-title":"Pediatrics"},{"key":"10.1016\/j.stem.2025.12.001_bib25","first-page":"971","article-title":"Individual variation of human cortical structure is established in the first year of life","volume":"5","author":"Gilmore","year":"2020","journal-title":"Biol. Psychiatry Cogn. Neurosci. Neuroimaging"},{"key":"10.1016\/j.stem.2025.12.001_bib26","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1038\/nrn.2018.1","article-title":"Imaging structural and functional brain development in early childhood","volume":"19","author":"Gilmore","year":"2018","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.stem.2025.12.001_bib27","series-title":"StemBook","article-title":"iPSC Reprogramming from Human Peripheral Blood Using Sendai Virus Mediated Gene Transfer","author":"Yang","year":"2014"},{"key":"10.1016\/j.stem.2025.12.001_bib28","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/7651_2014_109","article-title":"Characterizing Pluripotent Stem Cells Using the TaqMan\u00ae hPSC Scorecard(TM) Panel","volume":"1307","author":"Fergus","year":"2016","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.stem.2025.12.001_bib29","doi-asserted-by":"crossref","DOI":"10.1002\/cpz1.606","article-title":"Single nucleotide polymorphism (SNP) arrays and their sensitivity for detection of genetic changes in human pluripotent stem cell cultures","volume":"2","author":"Steventon-Jones","year":"2022","journal-title":"Curr. Protoc."},{"key":"10.1016\/j.stem.2025.12.001_bib30","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/nprot.2017.152","article-title":"Generation of human brain region\u2013specific organoids using a miniaturized spinning bioreactor","volume":"13","author":"Qian","year":"2018","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.stem.2025.12.001_bib31","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1016\/j.cell.2016.04.032","article-title":"Brain-Region-Specific Organoids Using Mini-bioreactors for Modeling ZIKV Exposure","volume":"165","author":"Qian","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.stem.2025.12.001_bib32","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1126\/science.aam8999","article-title":"Single-cell profiling of the developing mouse brain and spinal cord with split-pool barcoding","volume":"360","author":"Rosenberg","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.stem.2025.12.001_bib33","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.cels.2019.03.003","article-title":"DoubletFinder: Doublet Detection in Single-Cell RNA Sequencing Data Using Artificial Nearest Neighbors","volume":"8","author":"McGinnis","year":"2019","journal-title":"Cell Syst."},{"key":"10.1016\/j.stem.2025.12.001_bib34","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2022111118","article-title":"Gruffi: an algorithm for computational removal of stressed cells from brain organoid transcriptomic datasets","volume":"41","author":"V\u00e9rtesy","year":"2022","journal-title":"EMBO J."},{"key":"10.1016\/j.stem.2025.12.001_bib35","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/s41587-023-01767-y","article-title":"Dictionary learning for integrative, multimodal and scalable single-cell analysis","volume":"42","author":"Hao","year":"2023","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.stem.2025.12.001_bib36","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/s41586-024-08351-7","article-title":"Molecular and cellular dynamics of the developing human neocortex","volume":"647","author":"Wang","year":"2025","journal-title":"Nature"},{"key":"10.1016\/j.stem.2025.12.001_bib37","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1126\/science.aap8809","article-title":"Spatiotemporal gene expression trajectories reveal developmental hierarchies of the human cortex","volume":"358","author":"Nowakowski","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.stem.2025.12.001_bib38","doi-asserted-by":"crossref","first-page":"3770","DOI":"10.1016\/j.cell.2022.09.010","article-title":"Proper acquisition of cell class identity in organoids allows definition of fate specification programs of the human cerebral cortex","volume":"185","author":"Uzquiano","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.stem.2025.12.001_bib39","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1009355","article-title":"Integrative genomic analysis of early neurogenesis reveals a temporal genetic program for differentiation and specification of preplate and Cajal-Retzius neurons","volume":"17","author":"Li","year":"2021","journal-title":"PLoS Genet."},{"key":"10.1016\/j.stem.2025.12.001_bib40","doi-asserted-by":"crossref","DOI":"10.3389\/fnana.2019.00016","article-title":"Genetic Elimination of Connective Tissue Growth Factor in the Forebrain Affects Subplate Neurons in the Cortex and Oligodendrocytes in the Underlying White Matter","volume":"13","author":"Yu","year":"2019","journal-title":"Front. Neuroanat."},{"key":"10.1016\/j.stem.2025.12.001_bib41","doi-asserted-by":"crossref","DOI":"10.1126\/science.adf3786","article-title":"Molecular programs of regional specification and neural stem cell fate progression in macaque telencephalon","volume":"382","author":"Micali","year":"2023","journal-title":"Science"},{"key":"10.1016\/j.stem.2025.12.001_bib42","doi-asserted-by":"crossref","DOI":"10.1098\/rsob.210042","article-title":"Development of the mammalian cortical hem and its derivatives: the choroid plexus, Cajal-Retzius cells and hippocampus","volume":"11","author":"Moore","year":"2021","journal-title":"Open Biol."},{"key":"10.1016\/j.stem.2025.12.001_bib43","doi-asserted-by":"crossref","first-page":"3056","DOI":"10.1016\/j.cell.2021.04.003","article-title":"A cellular and spatial map of the choroid plexus across brain ventricles and ages","volume":"184","author":"Dani","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.stem.2025.12.001_bib44","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1016\/j.stemcr.2024.09.005","article-title":"Validation of non-destructive morphology-based selection of cerebral cortical organoids by paired morphological and single-cell RNA-seq analyses","volume":"19","author":"Ikeda","year":"2024","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.stem.2025.12.001_bib45","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/nature12517","article-title":"Cerebral organoids model human brain development and microcephaly","volume":"501","author":"Lancaster","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.stem.2025.12.001_bib46","doi-asserted-by":"crossref","DOI":"10.1126\/science.aaz5626","article-title":"Human CNS barrier-forming organoids with cerebrospinal fluid production","volume":"369","author":"Pellegrini","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.stem.2025.12.001_bib47","doi-asserted-by":"crossref","first-page":"2220","DOI":"10.1016\/j.stemcr.2022.08.013","article-title":"TGF\u03b2 superfamily signaling regulates the state of human stem cell pluripotency and capacity to create well-structured telencephalic organoids","volume":"17","author":"Watanabe","year":"2022","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.stem.2025.12.001_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.107599","article-title":"Variation of human neural stem cells generating organizer states in vitro before committing to cortical excitatory or inhibitory neuronal fates","volume":"31","author":"Micali","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.stem.2025.12.001_bib49","doi-asserted-by":"crossref","DOI":"10.1002\/cpz1.70022","article-title":"A hybrid 2D-to-3D in vitro differentiation platform improves outcomes of cerebral cortical organoid generation in hiPSCs","volume":"4","author":"Whye","year":"2024","journal-title":"Curr. Protoc."},{"key":"10.1016\/j.stem.2025.12.001_bib50","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1146\/annurev-cellbio-092910-154026","article-title":"Neurogenesis at the brain-cerebrospinal fluid interface","volume":"27","author":"Lehtinen","year":"2011","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.stem.2025.12.001_bib51","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.58737","article-title":"mTOR signaling regulates the morphology and migration of outer radial glia in developing human cortex","volume":"9","author":"Andrews","year":"2020","journal-title":"eLife"},{"key":"10.1016\/j.stem.2025.12.001_bib52","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1086\/514346","article-title":"Mendelian Inheritance in Man and its online version, OMIM","volume":"80","author":"McKusick","year":"2007","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.stem.2025.12.001_bib53","doi-asserted-by":"crossref","DOI":"10.1186\/2040-2392-4-36","article-title":"SFARI Gene 2.0: a community-driven knowledgebase for the autism spectrum disorders (ASDs)","volume":"4","author":"Abrahams","year":"2013","journal-title":"Mol. Autism"},{"key":"10.1016\/j.stem.2025.12.001_bib54","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1146\/annurev-genom-102822-100509","article-title":"DECIPHER: Improving genetic diagnosis through dynamic integration of genomic and clinical data","volume":"24","author":"Foreman","year":"2023","journal-title":"Annu. Rev. Genomics Hum. Genet."},{"key":"10.1016\/j.stem.2025.12.001_bib55","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1038\/s41588-022-01104-0","article-title":"Rare coding variation provides insight into the genetic architecture and phenotypic context of autism","volume":"54","author":"Fu","year":"2022","journal-title":"Nat. Genet."},{"key":"10.1016\/j.stem.2025.12.001_bib56","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1038\/s41596-024-01045-4","article-title":"CellChat for systematic analysis of cell-cell communication from single-cell transcriptomics","volume":"20","author":"Jin","year":"2025","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.stem.2025.12.001_bib57","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-021-21246-9","article-title":"Inference and analysis of cell-cell communication using CellChat","volume":"12","author":"Jin","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.stem.2025.12.001_bib58","doi-asserted-by":"crossref","first-page":"3884","DOI":"10.1007\/s12035-021-02367-0","article-title":"Fibroblast growth factor signalling in the diseased nervous system","volume":"58","author":"Klimaschewski","year":"2021","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.stem.2025.12.001_bib59","doi-asserted-by":"crossref","DOI":"10.1186\/1743-8454-5-20","article-title":"Fgf2 is expressed in human and murine embryonic choroid plexus and affects choroid plexus epithelial cell behaviour","volume":"5","author":"Greenwood","year":"2008","journal-title":"Cerebrospinal Fluid Res."},{"key":"10.1016\/j.stem.2025.12.001_bib60","article-title":"Overexpression of CD47 is associated with brain overgrowth and 16p11.2 deletion syndrome","volume":"118","author":"Li","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.stem.2025.12.001_bib61","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1016\/j.stemcr.2021.03.025","article-title":"Balancing serendipity and reproducibility: Pluripotent stem cells as experimental systems for intellectual and developmental disorders","volume":"16","author":"Anderson","year":"2021","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.stem.2025.12.001_bib62","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1038\/mp.2016.95","article-title":"Altered proliferation and networks in neural cells derived from idiopathic autistic individuals","volume":"22","author":"Marchetto","year":"2017","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.stem.2025.12.001_bib63","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2109395119","article-title":"Electrophysiological measures from human iPSC-derived neurons are associated with schizophrenia clinical status and predict individual cognitive performance","volume":"119","author":"Page","year":"2022","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.stem.2025.12.001_bib64","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1038\/s41593-025-01972-9","article-title":"Choroid plexus apocrine secretion shapes CSF proteome during mouse brain development","volume":"28","author":"Courtney","year":"2025","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.stem.2025.12.001_bib65","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1152\/physrev.00060.2021","article-title":"The choroid plexus: a missing link in our understanding of brain development and function","volume":"103","author":"Saunders","year":"2023","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.stem.2025.12.001_bib66","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-019-09298-4","article-title":"WNT5A is transported via lipoprotein particles in the cerebrospinal fluid to regulate hindbrain morphogenesis","volume":"10","author":"Kaiser","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.stem.2025.12.001_bib67","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2014.00340","article-title":"The choroid plexuses and their impact on developmental neurogenesis","volume":"8","author":"Johansson","year":"2014","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.stem.2025.12.001_bib68","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1126\/science.1074192","article-title":"Regulation of cerebral cortical size by control of cell cycle exit in neural precursors","volume":"297","author":"Chenn","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.stem.2025.12.001_bib69","doi-asserted-by":"crossref","first-page":"2430","DOI":"10.1038\/s41593-024-01773-6","article-title":"Stimulating Wnt signaling reveals context-dependent genetic effects on gene regulation in primary human neural progenitors","volume":"27","author":"Matoba","year":"2024","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.stem.2025.12.001_bib70","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1002\/jnr.24200","article-title":"Abnormalities in interactions of Rho GTPases with scaffolding proteins contribute to neurodevelopmental disorders","volume":"96","author":"Reichova","year":"2018","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.stem.2025.12.001_bib71","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1093\/cercor\/bhy033","article-title":"Cytoskeletal associated filamin A and RhoA affect neural progenitor specification during mitosis","volume":"29","author":"Lian","year":"2019","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.stem.2025.12.001_bib72","doi-asserted-by":"crossref","first-page":"7607","DOI":"10.1073\/pnas.1101347108","article-title":"Loss of RhoA in neural progenitor cells causes the disruption of adherens junctions and hyperproliferation","volume":"108","author":"Katayama","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.stem.2025.12.001_bib73","doi-asserted-by":"crossref","DOI":"10.1126\/science.aay6690","article-title":"The genetic architecture of the human cerebral cortex","volume":"367","author":"Grasby","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.stem.2025.12.001_bib74","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1016\/j.stem.2023.09.003","article-title":"Tissue morphology influences the temporal program of human brain organoid development","volume":"30","author":"Chiaradia","year":"2023","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.stem.2025.12.001_bib75","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1093\/cercor\/bhab213","article-title":"Genetic Influences on Longitudinal Trajectories of Cortical Thickness and Surface Area during the First 2 Years of Life","volume":"32","author":"Xia","year":"2022","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.stem.2025.12.001_bib95","doi-asserted-by":"crossref","DOI":"10.1186\/s12859-021-04344-9","article-title":"CellProfiler 4: improvements in speed, utility and usability","volume":"22","author":"Stirling","year":"2021","journal-title":"BMC Bioinform."},{"key":"10.1016\/j.stem.2025.12.001_bib91","doi-asserted-by":"crossref","DOI":"10.1186\/s13742-015-0047-8","article-title":"Second-generation PLINK: rising to the challenge of larger and richer datasets","volume":"4","author":"Chang","year":"2015","journal-title":"GigaScience"},{"key":"10.1016\/j.stem.2025.12.001_bib96","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/nmeth.4197","article-title":"Salmon provides fast and bias-aware quantification of transcript expression","volume":"14","author":"Patro","year":"2017","journal-title":"Nat. Methods"},{"key":"10.1016\/j.stem.2025.12.001_bib98","doi-asserted-by":"crossref","first-page":"3573","DOI":"10.1016\/j.cell.2021.04.048","article-title":"Integrated analysis of multimodal single-cell data","volume":"184","author":"Hao","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.stem.2025.12.001_bib80","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-020-19894-4","article-title":"muscat detects subpopulation-specific state transitions from multi-sample multi-condition single-cell transcriptomics data","volume":"11","author":"Crowell","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.stem.2025.12.001_bib103","doi-asserted-by":"crossref","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.stem.2025.12.001_bib106","doi-asserted-by":"crossref","DOI":"10.1186\/s12864-018-4772-0","article-title":"Slingshot: cell lineage and pseudotime inference for single-cell transcriptomics","volume":"19","author":"Street","year":"2018","journal-title":"BMC Genomics"},{"key":"10.1016\/j.stem.2025.12.001_bib81","doi-asserted-by":"crossref","first-page":"W193","DOI":"10.1093\/nar\/gkm226","article-title":"g: Profiler\u2014a web-based toolset for functional profiling of gene lists from large-scale experiments","volume":"35","author":"Reimand","year":"2007","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.stem.2025.12.001_bib83","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.biopsych.2017.02.1095","article-title":"Increased Extra-axial Cerebrospinal Fluid in High-Risk Infants Who Later Develop Autism","volume":"82","author":"Shen","year":"2017","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.stem.2025.12.001_bib84","doi-asserted-by":"crossref","DOI":"10.1186\/s11689-020-9308-7","article-title":"Quantitative trait variation in ASD probands and toddler sibling outcomes at 24\u2009months","volume":"12","author":"Girault","year":"2020","journal-title":"J. Neurodev. Disord."},{"key":"10.1016\/j.stem.2025.12.001_bib85","series-title":"Diagnostic and Statistical Manual of Mental Disorders","year":"2000"},{"key":"10.1016\/j.stem.2025.12.001_bib86","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1023\/A:1005592401947","article-title":"The autism diagnostic observation schedule-generic: a standard measure of social and communication deficits associated with the spectrum of autism","volume":"30","author":"Lord","year":"2000","journal-title":"J. Autism Dev. Disord."},{"key":"10.1016\/j.stem.2025.12.001_bib87","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1007\/BF02172145","article-title":"Autism Diagnostic Interview-Revised: a revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders","volume":"24","author":"Lord","year":"1994","journal-title":"J. Autism Dev. Disord."},{"key":"10.1016\/j.stem.2025.12.001_bib88","doi-asserted-by":"crossref","first-page":"3586","DOI":"10.1523\/JNEUROSCI.5309-07.2008","article-title":"Neurodevelopmental trajectories of the human cerebral cortex","volume":"28","author":"Shaw","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.stem.2025.12.001_bib89","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.biopsych.2012.01.031","article-title":"Development of cortical surface area and gyrification in attention-deficit\/hyperactivity disorder","volume":"72","author":"Shaw","year":"2012","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.stem.2025.12.001_bib77","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1006\/nimg.2001.0978","article-title":"Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain","volume":"15","author":"Tzourio-Mazoyer","year":"2002","journal-title":"Neuroimage"},{"key":"10.1016\/j.stem.2025.12.001_bib90","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.jneumeth.2012.09.018","article-title":"Adaptive prior probability and spatial temporal intensity change estimation for segmentation of the one-year-old human brain","volume":"212","author":"Kim","year":"2013","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.stem.2025.12.001_bib92","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1111\/j.1556-4029.2009.01110.x","article-title":"A 26plex autosomal STR assay to aid human identity testing","volume":"54","author":"Hill","year":"2009","journal-title":"J. Forensic Sci."},{"key":"10.1016\/j.stem.2025.12.001_bib76","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.stemcr.2018.06.019","article-title":"MSX2 initiates and accelerates mesenchymal stem\/stromal cell specification of hPSCs by regulating TWIST1 and PRAME","volume":"11","author":"Zhang","year":"2018","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.stem.2025.12.001_bib93","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1016\/j.stem.2017.02.014","article-title":"Comprehensive Cell Surface Protein Profiling Identifies Specific Markers of Human Naive and Primed Pluripotent States","volume":"20","author":"Collier","year":"2017","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.stem.2025.12.001_bib94","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.stemcr.2015.01.009","article-title":"Retinoic acid regulates hematopoietic development from human pluripotent stem cells","volume":"4","author":"R\u00f6nn","year":"2015","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.stem.2025.12.001_bib78","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/j.cell.2014.10.010","article-title":"iDISCO: A Simple, Rapid Method to Immunolabel Large Tissue Samples for Volume Imaging","volume":"159","author":"Renier","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.stem.2025.12.001_bib97","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1038\/s41592-022-01408-3","article-title":"Alevin-fry unlocks rapid, accurate and memory-frugal quantification of single-cell RNA-seq data","volume":"19","author":"He","year":"2022","journal-title":"Nat. Methods"},{"key":"10.1016\/j.stem.2025.12.001_bib99","article-title":"Single-cell RNA-sequencing of differentiating iPS cells reveals dynamic genetic effects on gene expression","volume":"11","author":"Cuomo","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.stem.2025.12.001_bib100","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1038\/s41593-021-00858-w","article-title":"Cell-type-specific effects of genetic variation on chromatin accessibility during human neuronal differentiation","volume":"24","author":"Liang","year":"2021","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.stem.2025.12.001_bib101","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1016\/j.ajhg.2021.07.011","article-title":"Brain-trait-associated variants impact cell-type-specific gene regulation during neurogenesis","volume":"108","author":"Ayg\u00fcn","year":"2021","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.stem.2025.12.001_bib102","doi-asserted-by":"crossref","first-page":"4720","DOI":"10.1093\/bioinformatics\/btac582","article-title":"propeller: testing for differences in cell type proportions in single cell data","volume":"38","author":"Phipson","year":"2022","journal-title":"Bioinformatics"},{"key":"10.1016\/j.stem.2025.12.001_bib79","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v067.i01","article-title":"Fitting linear mixed-effects models Using lme4","volume":"67","author":"Bates","year":"2015","journal-title":"J. Stat. Softw."},{"key":"10.1016\/j.stem.2025.12.001_bib104","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkv007","article-title":"limma powers differential expression analyses for RNA-sequencing and microarray studies","volume":"43","author":"Ritchie","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.stem.2025.12.001_bib82","doi-asserted-by":"crossref","first-page":"D691","DOI":"10.1093\/nar\/gkq1018","article-title":"Reactome: a database of reactions, pathways and biological processes","volume":"39","author":"Croft","year":"2011","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.stem.2025.12.001_bib105","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1093\/nar\/27.1.29","article-title":"KEGG: Kyoto Encyclopedia of Genes and Genomes","volume":"27","author":"Ogata","year":"1999","journal-title":"Nucleic Acids Res."}],"container-title":["Cell Stem Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1934590925004357?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1934590925004357?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T21:07:02Z","timestamp":1769202422000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1934590925004357"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":106,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["S1934590925004357"],"URL":"https:\/\/doi.org\/10.1016\/j.stem.2025.12.001","relation":{},"ISSN":["1934-5909"],"issn-type":[{"value":"1934-5909","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Human cortical organoids recapitulate inter-individual variability in infant brain-growth trajectories","name":"articletitle","label":"Article Title"},{"value":"Cell Stem Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.stem.2025.12.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}