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Med."},{"key":"10.1016\/j.stem.2026.01.010_bib61","doi-asserted-by":"crossref","DOI":"10.1182\/blood-2023-180085","article-title":"The Role of Macrophage Migration Inhibitory Factor (MIF) in Regulation of T-Cell Activity in Multiple Myeloma","volume":"142","author":"Gunes","year":"2023","journal-title":"Blood"},{"key":"10.1016\/j.stem.2026.01.010_bib62","doi-asserted-by":"crossref","first-page":"2557","DOI":"10.1182\/blood.2020005795","article-title":"MIF as a biomarker and therapeutic target for overcoming resistance to proteasome inhibitors in human myeloma","volume":"136","author":"Wang","year":"2020","journal-title":"Blood"},{"key":"10.1016\/j.stem.2026.01.010_bib63","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1161\/CIRCRESAHA.125.326823","article-title":"Human Multi-Organoid Platform to Model Immune Dynamics in Cardiac Injury and Disease","volume":"137","author":"Reyat","year":"2025","journal-title":"Circ. 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