{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T13:02:15Z","timestamp":1791810135572,"version":"4.3.4"},"reference-count":199,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T00:00:00Z","timestamp":1775692800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["25J32800100"],"award-info":[{"award-number":["25J32800100"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018537","name":"National Science and Technology Major Project","doi-asserted-by":"publisher","award":["2024ZD0525404"],"award-info":[{"award-number":["2024ZD0525404"]}],"id":[{"id":"10.13039\/501100018537","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32400606"],"award-info":[{"award-number":["32400606"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002367","name":"Chinese Academy of Sciences","doi-asserted-by":"publisher","award":["XDB1150000"],"award-info":[{"award-number":["XDB1150000"]}],"id":[{"id":"10.13039\/501100002367","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Stem Cell"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.stem.2026.04.007","type":"journal-article","created":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T15:03:53Z","timestamp":1778166233000},"page":"726-746","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Advancing hepatocyte-based therapies: A translational perspective"],"prefix":"10.1016","volume":"33","author":[{"given":"Zhen","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3409-9996","authenticated-orcid":false,"given":"Lijian","family":"Hui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.stem.2026.04.007_bib1","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/ng0396-266","article-title":"Hepatocytes corrected by gene therapy are selected in vivo in a murine model of hereditary tyrosinaemia type I","volume":"12","author":"Overturf","year":"1996","journal-title":"Nat. Genet."},{"key":"10.1016\/j.stem.2026.04.007_bib2","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.4254\/wjh.v13.i10.1351","article-title":"Liver transplantation for pediatric inherited metabolic liver diseases","volume":"13","author":"Vimalesvaran","year":"2021","journal-title":"World J. Hepatol."},{"key":"10.1016\/j.stem.2026.04.007_bib3","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1056\/NEJM199805143382004","article-title":"Treatment of the Crigler-Najjar syndrome type I with hepatocyte transplantation","volume":"338","author":"Fox","year":"1998","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.stem.2026.04.007_bib4","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1097\/00007890-199702270-00014","article-title":"Hepatocyte transplantation as a bridge to orthotopic liver transplantation in terminal liver failure","volume":"63","author":"Strom","year":"1997","journal-title":"Transplantation"},{"key":"10.1016\/j.stem.2026.04.007_bib5","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.1016\/S0041-1345(97)00252-2","article-title":"Transplantation of human hepatocytes","volume":"29","author":"Strom","year":"1997","journal-title":"Transplant. Proc."},{"key":"10.1016\/j.stem.2026.04.007_bib6","doi-asserted-by":"crossref","DOI":"10.1097\/HC9.0000000000000266","article-title":"Hepatocyte transplantation: The progress and the challenges","volume":"7","author":"Sun","year":"2023","journal-title":"Hepatol. Commun."},{"key":"10.1016\/j.stem.2026.04.007_bib7","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1002\/hep.27651","article-title":"Potential of human induced pluripotent stem cells in studies of liver disease","volume":"62","author":"Sampaziotis","year":"2015","journal-title":"Hepatology"},{"key":"10.1016\/j.stem.2026.04.007_bib8","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.stem.2014.01.003","article-title":"Direct reprogramming of human fibroblasts to functional and expandable hepatocytes","volume":"14","author":"Huang","year":"2014","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.stem.2026.04.007_bib9","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.stem.2014.01.008","article-title":"Human hepatocytes with drug metabolic function induced from fibroblasts by lineage reprogramming","volume":"14","author":"Du","year":"2014","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.stem.2026.04.007_bib10","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1016\/j.stem.2018.10.018","article-title":"In Vitro Expansion of Primary Human Hepatocytes with Efficient Liver Repopulation Capacity","volume":"23","author":"Zhang","year":"2018","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.stem.2026.04.007_bib11","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1016\/j.cell.2018.11.013","article-title":"Long-Term Expansion of Functional Mouse and Human Hepatocytes as 3D Organoids","volume":"175","author":"Hu","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.stem.2026.04.007_bib12","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1038\/s41422-018-0103-x","article-title":"Expansion and differentiation of human hepatocyte-derived liver progenitor-like cells and their use for the study of hepatotropic pathogens","volume":"29","author":"Fu","year":"2019","journal-title":"Cell Res."},{"key":"10.1016\/j.stem.2026.04.007_bib13","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.jhep.2018.09.007","article-title":"Small molecule-mediated reprogramming of human hepatocytes into bipotent progenitor cells","volume":"70","author":"Kim","year":"2019","journal-title":"J. Hepatol."},{"key":"10.1016\/j.stem.2026.04.007_bib14","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.47313","article-title":"Generation of human hepatic progenitor cells with regenerative and metabolic capacities from primary hepatocytes","volume":"8","author":"Katsuda","year":"2019","journal-title":"eLife"},{"key":"10.1016\/j.stem.2026.04.007_bib15","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.stem.2023.03.013","article-title":"Reversal of liver failure using a bioartificial liver device implanted with clinical-grade human-induced hepatocytes","volume":"30","author":"Wang","year":"2023","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.stem.2026.04.007_bib16","doi-asserted-by":"crossref","DOI":"10.1186\/s13287-025-04162-3","article-title":"First-in-human clinical study of an embryonic stem cell product for urea cycle disorders","volume":"16","author":"Umezawa","year":"2025","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.stem.2026.04.007_bib17","article-title":"Treatment of liver cirrhosis using hepatocyte-derived liver progenitor-like cells: a prospective, open-label, single-arm, safety trial","volume":"11","author":"He","year":"2025","journal-title":"Cell Discov."},{"key":"10.1016\/j.stem.2026.04.007_bib18","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/S0168-8278(03)00348-9","article-title":"Extracorporeal liver support based on primary human liver cells and albumin dialysis--treatment of a patient with primary graft non-function","volume":"39","author":"Sauer","year":"2003","journal-title":"J. Hepatol."},{"key":"10.1016\/j.stem.2026.04.007_bib19","doi-asserted-by":"crossref","first-page":"S10","DOI":"10.1002\/lt.23506","article-title":"Bridging the gap: advances in artificial liver support","volume":"18","author":"Nyberg","year":"2012","journal-title":"Liver Transpl."},{"key":"10.1016\/j.stem.2026.04.007_bib20","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1517\/14712598.2014.950651","article-title":"Bioartificial livers in vitro and in vivo: tailoring biocomponents to the expanding variety of applications","volume":"14","author":"van Wenum","year":"2014","journal-title":"Expert Opin. Biol. Ther."},{"key":"10.1016\/j.stem.2026.04.007_bib21","doi-asserted-by":"crossref","DOI":"10.1186\/s13287-022-02882-4","article-title":"The assessment of mesenchymal stem cells therapy in acute on chronic liver failure and chronic liver disease: a systematic review and meta-analysis of randomized controlled clinical trials","volume":"13","author":"Liu","year":"2022","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.stem.2026.04.007_bib22","article-title":"Dose-escalation studies of mesenchymal stromal cell therapy for decompensated liver cirrhosis: phase Ia\/Ib results and immune modulation insights","volume":"10","author":"Shi","year":"2025","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.stem.2026.04.007_bib23","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.1038\/s41591-019-0599-8","article-title":"Safety profile of autologous macrophage therapy for liver cirrhosis","volume":"25","author":"Moroni","year":"2019","journal-title":"Nat. Med."},{"key":"10.1016\/j.stem.2026.04.007_bib24","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2021-053190","article-title":"Study protocol: a multicentre, open-label, parallel-group, phase 2, randomised controlled trial of autologous macrophage therapy for liver cirrhosis (MATCH)","volume":"11","author":"Brennan","year":"2021","journal-title":"BMJ Open"},{"key":"10.1016\/j.stem.2026.04.007_bib25","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1038\/s41591-024-03406-8","article-title":"Autologous macrophage therapy for liver cirrhosis: a phase 2 open-label randomized controlled trial","volume":"31","author":"Brennan","year":"2025","journal-title":"Nat. Med."},{"key":"10.1016\/j.stem.2026.04.007_bib26","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1083\/jcb.43.3.506","article-title":"High-yield preparation of isolated rat liver parenchymal cells: a biochemical and fine structural study","volume":"43","author":"Berry","year":"1969","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.stem.2026.04.007_bib27","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/nrg2318","article-title":"Genetic programming of liver and pancreas progenitors: lessons for stem-cell differentiation","volume":"9","author":"Zaret","year":"2008","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.stem.2026.04.007_bib28","doi-asserted-by":"crossref","first-page":"3285","DOI":"10.1242\/dev.090266","article-title":"Three-dimensional culture and cAMP signaling promote the maturation of human pluripotent stem cell-derived hepatocytes","volume":"140","author":"Ogawa","year":"2013","journal-title":"Development"},{"key":"10.1016\/j.stem.2026.04.007_bib29","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/nature12271","article-title":"Vascularized and functional human liver from an iPSC-derived organ bud transplant","volume":"499","author":"Takebe","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.stem.2026.04.007_bib30","doi-asserted-by":"crossref","first-page":"4526","DOI":"10.1016\/j.biomaterials.2012.03.011","article-title":"The promotion of hepatic maturation of human pluripotent stem cells in 3D co-culture using type I collagen and Swiss 3T3 cell sheets","volume":"33","author":"Nagamoto","year":"2012","journal-title":"Biomaterials"},{"key":"10.1016\/j.stem.2026.04.007_bib31","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1038\/nbt1361","article-title":"Microscale culture of human liver cells for drug development","volume":"26","author":"Khetani","year":"2008","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.stem.2026.04.007_bib32","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.bbrc.2015.12.007","article-title":"Hepatic maturation of human iPS cell-derived hepatocyte-like cells by ATF5, c\/EBP\u03b1, and PROX1 transduction","volume":"469","author":"Nakamori","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.stem.2026.04.007_bib33","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-020-15058-6","article-title":"Amino acid levels determine metabolism and CYP450 function of hepatocytes and hepatoma cell lines","volume":"11","author":"Boon","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.stem.2026.04.007_bib34","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.stem.2022.03.015","article-title":"The nuclear receptor THRB facilitates differentiation of human PSCs into more mature hepatocytes","volume":"29","author":"Ma","year":"2022","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.stem.2026.04.007_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.108455","article-title":"Large-scale Generation of Functional and Transplantable Hepatocytes and Cholangiocytes from Human Endoderm Stem Cells","volume":"33","author":"Feng","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.stem.2026.04.007_bib36","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/s41422-019-0261-5","article-title":"Hepatic spheroids derived from human induced pluripotent stem cells in bio-artificial liver rescue porcine acute liver failure","volume":"30","author":"Chen","year":"2020","journal-title":"Cell Res."},{"key":"10.1016\/j.stem.2026.04.007_bib37","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1002\/hep.21441","article-title":"Hepatic precursors derived from murine embryonic stem cells contribute to regeneration of injured liver","volume":"44","author":"Heo","year":"2006","journal-title":"Hepatology"},{"key":"10.1016\/j.stem.2026.04.007_bib38","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1007\/s12015-011-9330-y","article-title":"Differentiation and transplantation of human induced pluripotent stem cell-derived hepatocyte-like cells","volume":"9","author":"Asgari","year":"2013","journal-title":"Stem Cell Rev. Rep."},{"key":"10.1016\/j.stem.2026.04.007_bib39","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.stemcr.2015.04.017","article-title":"Amelioration of Hyperbilirubinemia in Gunn Rats after Transplantation of Human Induced Pluripotent Stem Cell-Derived Hepatocytes","volume":"5","author":"Chen","year":"2015","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.stem.2026.04.007_bib40","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1038\/s41422-019-0242-8","article-title":"Human ESC-derived expandable hepatic organoids enable therapeutic liver repopulation and pathophysiological modeling of alcoholic liver injury","volume":"29","author":"Wang","year":"2019","journal-title":"Cell Res."},{"key":"10.1016\/j.stem.2026.04.007_bib41","doi-asserted-by":"crossref","first-page":"2317","DOI":"10.1007\/s00018-006-6095-6","article-title":"The Foxa family of transcription factors in development and metabolism","volume":"63","author":"Friedman","year":"2006","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.stem.2026.04.007_bib42","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.apsb.2016.07.003","article-title":"Crosstalk of HNF4alpha with extracellular and intracellular signaling pathways in the regulation of hepatic metabolism of drugs and lipids","volume":"6","author":"Lu","year":"2016","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.stem.2026.04.007_bib43","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2199-10-68","article-title":"Expression of HNF4alpha in the human and rat choroid plexus: implications for drug transport across the blood-cerebrospinal-fluid (CSF) barrier","volume":"10","author":"Niehof","year":"2009","journal-title":"BMC Mol. Biol."},{"key":"10.1016\/j.stem.2026.04.007_bib44","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1002\/hep.24280","article-title":"The stable repression of mesenchymal program is required for hepatocyte identity: a novel role for hepatocyte nuclear factor 4alpha","volume":"53","author":"Santangelo","year":"2011","journal-title":"Hepatology"},{"key":"10.1016\/j.stem.2026.04.007_bib45","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1038\/nature10263","article-title":"Direct conversion of mouse fibroblasts to hepatocyte-like cells by defined factors","volume":"475","author":"Sekiya","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.stem.2026.04.007_bib46","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1038\/s41556-019-0359-5","article-title":"Modelling liver cancer initiation with organoids derived from directly reprogrammed human hepatocytes","volume":"21","author":"Sun","year":"2019","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.stem.2026.04.007_bib47","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-020-19041-z","article-title":"Direct reprogramming of human umbilical vein- and peripheral blood-derived endothelial cells into hepatic progenitor cells","volume":"11","author":"Inada","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.stem.2026.04.007_bib48","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.stemcr.2017.06.013","article-title":"Chemical Cocktails Enable Hepatic Reprogramming of Mouse Fibroblasts with a Single Transcription Factor","volume":"9","author":"Guo","year":"2017","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.stem.2026.04.007_bib49","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1002\/hep.32686","article-title":"Direct chemical induction of hepatocyte-like cells with capacity for liver repopulation","volume":"77","author":"Bai","year":"2023","journal-title":"Hepatology"},{"key":"10.1016\/j.stem.2026.04.007_bib50","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1016\/j.stemcr.2017.10.019","article-title":"Distinct Gene Expression and Epigenetic Signatures in Hepatocyte-like Cells Produced by Different Strategies from the Same Donor","volume":"9","author":"Gao","year":"2017","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.stem.2026.04.007_bib51","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1038\/s41422-019-0196-x","article-title":"A two-step lineage reprogramming strategy to generate functionally competent human hepatocytes from fibroblasts","volume":"29","author":"Xie","year":"2019","journal-title":"Cell Res."},{"key":"10.1016\/j.stem.2026.04.007_bib52","doi-asserted-by":"crossref","first-page":"3589","DOI":"10.1073\/pnas.73.10.3589","article-title":"Hormonal stimulation of DNA synthesis in primary cultures of adult rat hepatocytes","volume":"73","author":"Richman","year":"1976","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.stem.2026.04.007_bib53","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/0014-4827(87)90109-1","article-title":"Stimulation of growth of primary cultured adult rat hepatocytes without growth factors by coculture with nonparenchymal liver cells","volume":"172","author":"Shimaoka","year":"1987","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.stem.2026.04.007_bib54","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1002\/hep.1840130105","article-title":"Multiple cell cycles occur in rat hepatocytes cultured in the presence of nicotinamide and epidermal growth factor","volume":"13","author":"Mitaka","year":"1991","journal-title":"Hepatology"},{"key":"10.1016\/j.stem.2026.04.007_bib55","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1083\/jcb.132.6.1133","article-title":"Population expansion, clonal growth, and specific differentiation patterns in primary cultures of hepatocytes induced by HGF\/SF, EGF and TGF alpha in a chemically defined (HGM) medium","volume":"132","author":"Block","year":"1996","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.stem.2026.04.007_bib56","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1002\/jcp.1136","article-title":"Enhanced proliferation and differentiation of rat hepatocytes cultured with bone marrow stromal cells","volume":"189","author":"Mizuguchi","year":"2001","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.stem.2026.04.007_bib57","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1038\/nchembio.1270","article-title":"Identification of small molecules for human hepatocyte expansion and iPS differentiation","volume":"9","author":"Shan","year":"2013","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.stem.2026.04.007_bib58","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1101\/gad.207803.112","article-title":"Robust cellular reprogramming occurs spontaneously during liver regeneration","volume":"27","author":"Yanger","year":"2013","journal-title":"Genes Dev."},{"key":"10.1016\/j.stem.2026.04.007_bib59","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.stem.2014.04.010","article-title":"Stem\/progenitor cells in liver development, homeostasis, regeneration, and reprogramming","volume":"14","author":"Miyajima","year":"2014","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.stem.2026.04.007_bib60","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/j.stem.2014.09.008","article-title":"Bipotential adult liver progenitors are derived from chronically injured mature hepatocytes","volume":"15","author":"Tarlow","year":"2014","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.stem.2026.04.007_bib61","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1016\/j.cell.2014.03.060","article-title":"Hippo pathway activity influences liver cell fate","volume":"157","author":"Yimlamai","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.stem.2026.04.007_bib62","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1002\/hep.28774","article-title":"Wnt signaling regulates hepatobiliary repair following cholestatic liver injury in mice","volume":"64","author":"Okabe","year":"2016","journal-title":"Hepatology"},{"key":"10.1016\/j.stem.2026.04.007_bib63","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.stem.2019.06.008","article-title":"A Homeostatic Arid1a-Dependent Permissive Chromatin State Licenses Hepatocyte Responsiveness to Liver-Injury-Associated YAP Signaling","volume":"25","author":"Li","year":"2019","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.stem.2026.04.007_bib64","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.tcb.2020.01.007","article-title":"Cell Plasticity in Liver Regeneration","volume":"30","author":"Li","year":"2020","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.stem.2026.04.007_bib65","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1146\/annurev-pathol-020117-044010","article-title":"Wnt\/beta-Catenin Signaling in Liver Development, Homeostasis, and Pathobiology","volume":"13","author":"Russell","year":"2018","journal-title":"Annu. Rev. Pathol."},{"key":"10.1016\/j.stem.2026.04.007_bib66","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.stem.2023.01.009","article-title":"Kupffer-cell-derived IL-6 is repurposed for hepatocyte dedifferentiation via activating progenitor genes from injury-specific enhancers","volume":"30","author":"Li","year":"2023","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.stem.2026.04.007_bib67","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.stem.2016.10.007","article-title":"Conversion of Terminally Committed Hepatocytes to Culturable Bipotent Progenitor Cells with Regenerative Capacity","volume":"20","author":"Katsuda","year":"2017","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.stem.2026.04.007_bib68","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1038\/cr.2017.47","article-title":"Reversible transition between hepatocytes and liver progenitors for in vitro hepatocyte expansion","volume":"27","author":"Wu","year":"2017","journal-title":"Cell Res."},{"key":"10.1016\/j.stem.2026.04.007_bib69","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1038\/s41586-025-08861-y","article-title":"Generation of human adult hepatocyte organoids with metabolic functions","volume":"641","author":"Igarashi","year":"2025","journal-title":"Nature"},{"key":"10.1016\/j.stem.2026.04.007_bib70","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1002\/hep.32436","article-title":"Dedifferentiation-associated inflammatory factors of long-term expanded human hepatocytes exacerbate their elimination by macrophages during liver engraftment","volume":"76","author":"Wang","year":"2022","journal-title":"Hepatology"},{"key":"10.1016\/j.stem.2026.04.007_bib71","doi-asserted-by":"crossref","DOI":"10.1186\/s12864-023-09349-7","article-title":"Integration of ATAC-Seq and RNA-Seq reveals FOSL2 drives human liver progenitor-like cell aging by regulating inflammatory factors","volume":"24","author":"Ding","year":"2023","journal-title":"BMC Genomics"},{"key":"10.1016\/j.stem.2026.04.007_bib72","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1002\/hep.510290213","article-title":"Entry and integration of transplanted hepatocytes in rat liver plates occur by disruption of hepatic sinusoidal endothelium","volume":"29","author":"Gupta","year":"1999","journal-title":"Hepatology"},{"key":"10.1016\/j.stem.2026.04.007_bib73","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.3727\/096368916X691286","article-title":"Instant Blood-Mediated Inflammatory Reaction in Hepatocyte Transplantation: Current Status and Future Perspectives","volume":"25","author":"Lee","year":"2016","journal-title":"Cell Transplant."},{"key":"10.1016\/j.stem.2026.04.007_bib74","doi-asserted-by":"crossref","first-page":"S157","DOI":"10.1016\/j.jhep.2015.02.040","article-title":"Cell therapy for liver disease: From liver transplantation to cell factory","volume":"62","author":"Forbes","year":"2015","journal-title":"J. Hepatol."},{"key":"10.1016\/j.stem.2026.04.007_bib75","doi-asserted-by":"crossref","first-page":"11798","DOI":"10.1074\/jbc.M008503200","article-title":"alpha 1-Proteinase inhibitor, alpha 1-antichymotrypsin, and alpha 2-macroglobulin are the antiapoptotic factors of vascular smooth muscle cells","volume":"276","author":"Ikari","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.stem.2026.04.007_bib76","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1002\/hep.27232","article-title":"Etanercept blocks inflammatory responses orchestrated by TNF-alpha to promote transplanted cell engraftment and proliferation in rat liver","volume":"60","author":"Viswanathan","year":"2014","journal-title":"Hepatology"},{"key":"10.1016\/j.stem.2026.04.007_bib77","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1097\/TP.0000000000003461","article-title":"A Preconditioning Strategy to Augment Retention and Engraftment Rate of Donor Cells During Hepatocyte Transplantation","volume":"105","author":"Hsu","year":"2021","journal-title":"Transplantation"},{"key":"10.1016\/j.stem.2026.04.007_bib78","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2024.150278","article-title":"Magnetotactic hepatocytes promote liver repopulation after transplantation","volume":"486","author":"Shen","year":"2024","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.stem.2026.04.007_bib79","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1002\/hep.26005","article-title":"Directly acting drugs prostacyclin or nitroglycerine and endothelin receptor blocker bosentan improve cell engraftment in rodent liver","volume":"57","author":"Bahde","year":"2013","journal-title":"Hepatology"},{"key":"10.1016\/j.stem.2026.04.007_bib80","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1002\/hep.26766","article-title":"Endothelin-1 receptor A blocker darusentan decreases hepatic changes and improves liver repopulation after cell transplantation in rats","volume":"59","author":"Bahde","year":"2014","journal-title":"Hepatology"},{"key":"10.1016\/j.stem.2026.04.007_bib81","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1002\/hep.21937","article-title":"Hepatocyte transplantation and drug-induced perturbations in liver cell compartments","volume":"47","author":"Wu","year":"2008","journal-title":"Hepatology"},{"key":"10.1016\/j.stem.2026.04.007_bib82","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1002\/hep.22573","article-title":"Hepatic irradiation augments engraftment of donor cells following hepatocyte transplantation","volume":"49","author":"Yamanouchi","year":"2009","journal-title":"Hepatology"},{"key":"10.1016\/j.stem.2026.04.007_bib83","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1016\/j.jhep.2016.12.017","article-title":"Host conditioning and rejection monitoring in hepatocyte transplantation in humans","volume":"66","author":"Soltys","year":"2017","journal-title":"J. Hepatol."},{"key":"10.1016\/j.stem.2026.04.007_bib84","doi-asserted-by":"crossref","first-page":"1846","DOI":"10.1016\/j.ymthe.2023.02.018","article-title":"ROCK inhibition enhanced hepatocyte liver engraftment by retaining membrane CD59 and attenuating complement activation","volume":"31","author":"Ma","year":"2023","journal-title":"Mol. Ther."},{"key":"10.1016\/j.stem.2026.04.007_bib85","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1016\/j.ajt.2023.07.020","article-title":"CD47 and PD-L1 overexpression in proliferating human hepatocytes attenuated immune responses and ameliorated acute liver injury in mice","volume":"23","author":"Ma","year":"2023","journal-title":"Am. J. Transplant."},{"key":"10.1016\/j.stem.2026.04.007_bib86","article-title":"In vivo selection of hepatocytes","author":"Vonada","year":"2024","journal-title":"Hepatology"},{"key":"10.1016\/j.stem.2026.04.007_bib87","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.1002\/hep.31570","article-title":"Promoterless, Nuclease-Free Genome Editing Confers a Growth Advantage for Corrected Hepatocytes in Mice With Methylmalonic Acidemia","volume":"73","author":"Chandler","year":"2021","journal-title":"Hepatology"},{"key":"10.1016\/j.stem.2026.04.007_bib88","doi-asserted-by":"crossref","first-page":"2477","DOI":"10.1016\/j.ymthe.2017.09.020","article-title":"Survival Advantage of Both Human Hepatocyte Xenografts and Genome-Edited Hepatocytes for Treatment of alpha-1 Antitrypsin Deficiency","volume":"25","author":"Borel","year":"2017","journal-title":"Mol. Ther."},{"key":"10.1016\/j.stem.2026.04.007_bib89","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1006\/mthe.2001.0271","article-title":"Correction of liver disease following transplantation of normal rat hepatocytes into Long-Evans Cinnamon rats modeling Wilson's disease","volume":"3","author":"Irani","year":"2001","journal-title":"Mol. Ther."},{"key":"10.1016\/j.stem.2026.04.007_bib90","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1053\/gast.2000.20222","article-title":"Correction of liver disease by hepatocyte transplantation in a mouse model of progressive familial intrahepatic cholestasis","volume":"119","author":"De Vree","year":"2000","journal-title":"Gastroenterology"},{"key":"10.1016\/j.stem.2026.04.007_bib91","doi-asserted-by":"crossref","first-page":"2679","DOI":"10.1111\/j.1582-4934.2012.01586.x","article-title":"Hepatocyte transplantation in bile salt export pump-deficient mice: selective growth advantage of donor hepatocytes under bile acid stress","volume":"16","author":"Chen","year":"2012","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.stem.2026.04.007_bib92","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.2353\/ajpath.2009.090117","article-title":"Repopulation efficiencies of adult hepatocytes, fetal liver progenitor cells, and embryonic stem cell-derived hepatic cells in albumin-promoter-enhancer urokinase-type plasminogen activator mice","volume":"175","author":"Haridass","year":"2009","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.stem.2026.04.007_bib93","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1038\/73179","article-title":"Hepatocyte transplantation in a model of toxin-induced liver disease: variable therapeutic effect during replacement of damaged parenchyma by donor cells","volume":"6","author":"Braun","year":"2000","journal-title":"Nat. Med."},{"key":"10.1016\/j.stem.2026.04.007_bib94","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1053\/j.gastro.2011.01.001","article-title":"A humanized mouse model to study hepatitis C virus infection, immune response, and liver disease","volume":"140","author":"Washburn","year":"2011","journal-title":"Gastroenterology"},{"key":"10.1016\/j.stem.2026.04.007_bib95","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S0002-9440(10)65574-5","article-title":"Long-term, near-total liver replacement by transplantation of isolated hepatocytes in rats treated with retrorsine","volume":"153","author":"Laconi","year":"1998","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.stem.2026.04.007_bib96","doi-asserted-by":"crossref","first-page":"41","DOI":"10.3727\/000000005783983278","article-title":"Monocrotaline, an alternative to retrorsine-based hepatocyte transplantation in rodents","volume":"14","author":"Witek","year":"2005","journal-title":"Cell Transplant."},{"key":"10.1016\/j.stem.2026.04.007_bib97","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1016\/j.jhep.2019.01.010","article-title":"Radiation-primed hepatocyte transplantation in murine monogeneic dyslipidemia normalizes cholesterol and prevents atherosclerosis","volume":"70","author":"Barahman","year":"2019","journal-title":"J. Hepatol."},{"key":"10.1016\/j.stem.2026.04.007_bib98","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.jss.2023.08.015","article-title":"Irreversible Electroporation of the Liver Increases the Transplant Engraftment of Hepatocytes","volume":"293","author":"Han","year":"2024","journal-title":"J. Surg. Res."},{"key":"10.1016\/j.stem.2026.04.007_bib99","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.jhep.2024.12.039","article-title":"Host hepatocyte senescence determines the success of hepatocyte transplantation in a mouse model of liver injury","volume":"83","author":"Gadd","year":"2025","journal-title":"J. Hepatol."},{"key":"10.1016\/j.stem.2026.04.007_bib100","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1038\/2681","article-title":"Selective repopulation of normal mouse liver by Fas\/CD95-resistant hepatocytes","volume":"4","author":"Mignon","year":"1998","journal-title":"Nat. Med."},{"key":"10.1016\/j.stem.2026.04.007_bib101","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1002\/hep4.1278","article-title":"Genes and Pathways Promoting Long-Term Liver Repopulation by Ex Vivo hYAP-ERT2 Transduced Hepatocytes and Treatment of Jaundice in Gunn Rats","volume":"3","author":"Peterson","year":"2019","journal-title":"Hepatol. Commun."},{"key":"10.1016\/j.stem.2026.04.007_bib102","article-title":"Small molecule drugs promote repopulation of transplanted hepatocytes by stimulating cell dedifferentiation","volume":"5","author":"Jiang","year":"2023","journal-title":"JHEP Rep."},{"key":"10.1016\/j.stem.2026.04.007_bib103","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1002\/hep.32443","article-title":"Improving the repopulation capacity of elderly human hepatocytes by decoding aging-associated hepatocyte plasticity","volume":"76","author":"Nie","year":"2022","journal-title":"Hepatology"},{"key":"10.1016\/j.stem.2026.04.007_bib104","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1097\/HEP.0000000000000631","article-title":"Complete correction of murine phenylketonuria by selection-enhanced hepatocyte transplantation","volume":"79","author":"Vonada","year":"2024","journal-title":"Hepatology"},{"key":"10.1016\/j.stem.2026.04.007_bib108","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1097\/TP.0b013e31816de49e","article-title":"Correction of hyperoxaluria by liver repopulation with hepatocytes in a mouse model of primary hyperoxaluria type-1","volume":"85","author":"Jiang","year":"2008","journal-title":"Transplantation"},{"key":"10.1016\/j.stem.2026.04.007_bib105","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1111\/ajt.13487","article-title":"De Novo Donor-Specific HLA Antibody Formation in Two Patients With Crigler-Najjar Syndrome Type I Following Human Hepatocyte Transplantation With Partial Hepatectomy Preconditioning","volume":"16","author":"Jorns","year":"2016","journal-title":"Am. J. Transplant."},{"key":"10.1016\/j.stem.2026.04.007_bib109","first-page":"5871","article-title":"Amelioration of radiation-induced liver damage in partially hepatectomized rats by hepatocyte transplantation","volume":"59","author":"Guha","year":"1999","journal-title":"Cancer Res."},{"key":"10.1016\/j.stem.2026.04.007_bib110","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1053\/jhep.2002.34516","article-title":"Normal hepatocytes correct serum bilirubin after repopulation of Gunn rat liver subjected to irradiation\/partial resection","volume":"36","author":"Guha","year":"2002","journal-title":"Hepatology"},{"key":"10.1016\/j.stem.2026.04.007_bib106","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1053\/j.gastro.2006.01.008","article-title":"Sustained engraftment and tissue enzyme activity after liver cell transplantation for argininosuccinate lyase deficiency","volume":"130","author":"St\u00e9phenne","year":"2006","journal-title":"Gastroenterology"},{"key":"10.1016\/j.stem.2026.04.007_bib107","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1097\/01.TP.0000077420.81365.53","article-title":"Hepatocyte transplantation in a 4-year-old girl with peroxisomal biogenesis disease: technique, safety, and metabolic follow-up","volume":"76","author":"Sokal","year":"2003","journal-title":"Transplantation"},{"key":"10.1016\/j.stem.2026.04.007_bib111","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-024-49332-8","article-title":"Transient growth factor expression via mRNA in lipid nanoparticles promotes hepatocyte cell therapy in mice","volume":"15","author":"Smith","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.stem.2026.04.007_bib112","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1096\/fj.00-0892fje","article-title":"Selection of in vivo retrovirally transduced hepatocytes leads to efficient and predictable mouse liver repopulation","volume":"15","author":"Guidotti","year":"2001","journal-title":"FASEB J."},{"key":"10.1016\/j.stem.2026.04.007_bib113","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abg3047","article-title":"Therapeutic liver repopulation by transient acetaminophen selection of gene-modified hepatocytes","volume":"13","author":"Vonada","year":"2021","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.stem.2026.04.007_bib114","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1016\/j.cell.2018.11.012","article-title":"Inflammatory Cytokine TNFalpha Promotes the Long-Term Expansion of Primary Hepatocytes in 3D Culture","volume":"175","author":"Peng","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.stem.2026.04.007_bib115","doi-asserted-by":"crossref","DOI":"10.1177\/09636897211000014","article-title":"The Efficacy of the Hepatocyte Spheroids for Hepatocyte Transplantation","volume":"30","author":"Shibuya","year":"2021","journal-title":"Cell Transplant."},{"key":"10.1016\/j.stem.2026.04.007_bib116","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.surg.2018.04.012","article-title":"Hepatocyte spheroids as an alternative to single cells for transplantation after ex vivo gene therapy in mice and pig models","volume":"164","author":"Nicolas","year":"2018","journal-title":"Surgery"},{"key":"10.1016\/j.stem.2026.04.007_bib117","doi-asserted-by":"crossref","DOI":"10.1177\/0963689720964384","article-title":"Investigation of Clinical Safety of Human iPS Cell-Derived Liver Organoid Transplantation to Infantile Patients in Porcine Model","volume":"29","author":"Tsuchida","year":"2020","journal-title":"Cell Transplant."},{"key":"10.1016\/j.stem.2026.04.007_bib118","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2021.121067","article-title":"Patch grafting, strategies for transplantation of organoids into solid organs such as liver","volume":"277","author":"Zhang","year":"2021","journal-title":"Biomaterials"},{"key":"10.1016\/j.stem.2026.04.007_bib119","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2022.121647","article-title":"Patch grafting of organoids of stem\/progenitors into solid organs can correct genetic-based disease states","volume":"288","author":"Zhang","year":"2022","journal-title":"Biomaterials"},{"key":"10.1016\/j.stem.2026.04.007_bib120","first-page":"672","article-title":"Hormonally and chemically defined expansion conditions for organoids of biliary tree Stem Cells","volume":"41","author":"Zhang","year":"2024","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.stem.2026.04.007_bib121","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1053\/j.gastro.2010.11.006","article-title":"Rescue of lethal hepatic failure by hepatized lymph nodes in mice","volume":"140","author":"Hoppo","year":"2011","journal-title":"Gastroenterology"},{"key":"10.1016\/j.stem.2026.04.007_bib122","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1002\/hep.32277","article-title":"Fat-associated lymphoid clusters as expandable niches for ectopic liver development","volume":"76","author":"Han","year":"2022","journal-title":"Hepatology"},{"key":"10.1016\/j.stem.2026.04.007_bib123","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1016\/j.omtm.2020.07.009","article-title":"Ex Vivo Cell Therapy by Ectopic Hepatocyte Transplantation Treats the Porcine Tyrosinemia Model of Acute Liver Failure","volume":"18","author":"Nicolas","year":"2020","journal-title":"Mol. Ther. Methods Clin. Dev."},{"key":"10.1016\/j.stem.2026.04.007_bib124","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1002\/lt.25872","article-title":"Development of Ectopic Livers by Hepatocyte Transplantation Into Swine Lymph Nodes","volume":"26","author":"Fontes","year":"2020","journal-title":"Liver Transpl."},{"key":"10.1016\/j.stem.2026.04.007_bib125","article-title":"Transforming the spleen into a liver-like organ in vivo","volume":"6","author":"Wang","year":"2020","journal-title":"Sci. Adv."},{"key":"10.1016\/j.stem.2026.04.007_bib126","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/j.jhep.2019.12.002","article-title":"Alginate microencapsulated human hepatocytes for the treatment of acute liver failure in children","volume":"72","author":"Dhawan","year":"2020","journal-title":"J. Hepatol."},{"key":"10.1016\/j.stem.2026.04.007_bib127","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.stem.2024.02.005","article-title":"Preclinical efficacy and safety of encapsulated proliferating human hepatocyte organoids in treating liver failure","volume":"31","author":"Yuan","year":"2024","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.stem.2026.04.007_bib128","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1002\/lt.24986","article-title":"Extracorporeal cellular therapy (ELAD) in severe alcoholic hepatitis: A multinational, prospective, controlled, randomized trial","volume":"24","author":"Thompson","year":"2018","journal-title":"Liver Transpl."},{"key":"10.1016\/j.stem.2026.04.007_bib129","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1097\/01.sla.0000124298.74199.e5","article-title":"Prospective, randomized, multicenter, controlled trial of a bioartificial liver in treating acute liver failure","volume":"239","author":"Demetriou","year":"2004","journal-title":"Ann. Surg."},{"key":"10.1016\/j.stem.2026.04.007_bib130","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.jhep.2015.03.021","article-title":"Pivotal preclinical trial of the spheroid reservoir bioartificial liver","volume":"63","author":"Glorioso","year":"2015","journal-title":"J. Hepatol."},{"key":"10.1016\/j.stem.2026.04.007_bib131","doi-asserted-by":"crossref","first-page":"5562","DOI":"10.7150\/thno.26540","article-title":"Novel spheroid reservoir bioartificial liver improves survival of nonhuman primates in a toxin-induced model of acute liver failure","volume":"8","author":"Li","year":"2018","journal-title":"Theranostics"},{"key":"10.1016\/j.stem.2026.04.007_bib132","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1038\/cr.2016.6","article-title":"Improved survival of porcine acute liver failure by a bioartificial liver device implanted with induced human functional hepatocytes","volume":"26","author":"Shi","year":"2016","journal-title":"Cell Res."},{"key":"10.1016\/j.stem.2026.04.007_bib133","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.jhep.2025.08.038","article-title":"Reversal of ACLF and ALF using whole blood extracorporeal system combining HLA-depleted liver organoids with granulocyte-monocyte apheresis","volume":"84","author":"Yamaguchi","year":"2025","journal-title":"J. Hepatol."},{"key":"10.1016\/j.stem.2026.04.007_bib134","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aba5146","article-title":"An extracorporeal bioartificial liver embedded with 3D-layered human liver progenitor-like cells relieves acute liver failure in pigs","volume":"12","author":"Li","year":"2020","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.stem.2026.04.007_bib135","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1080\/14653240600855905","article-title":"Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement","volume":"8","author":"Dominici","year":"2006","journal-title":"Cytotherapy"},{"key":"10.1016\/j.stem.2026.04.007_bib136","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3727\/096368910X","article-title":"Mesenchymal stem cells","volume":"20","author":"Ding","year":"2011","journal-title":"Cell Transplant."},{"key":"10.1016\/j.stem.2026.04.007_bib137","first-page":"208","article-title":"Isolation, differentiation, and characterization of mesenchymal stem cells from human bone marrow","volume":"10","author":"Baghaei","year":"2017","journal-title":"Gastroenterol. Hepatol. Bed Bench"},{"key":"10.1016\/j.stem.2026.04.007_bib138","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.bbrc.2005.04.135","article-title":"Human adipose tissue-derived stem cells differentiate into endothelial cells in vitro and improve postnatal neovascularization in vivo","volume":"332","author":"Cao","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.stem.2026.04.007_bib139","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.cellbi.2006.03.009","article-title":"Isolation of mesenchymal stem cells from human placenta: comparison with human bone marrow mesenchymal stem cells","volume":"30","author":"Miao","year":"2006","journal-title":"Cell Biol. Int."},{"key":"10.1016\/j.stem.2026.04.007_bib140","first-page":"1017","article-title":"Isolation and characterization of human umbilical cord mesenchymal stem cells with hematopoiesis-supportive function and other potentials","volume":"91","author":"Lu","year":"2006","journal-title":"Haematologica"},{"key":"10.1016\/j.stem.2026.04.007_bib141","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1016\/j.jhep.2018.01.030","article-title":"Mesenchymal stromal cell therapy for liver diseases","volume":"68","author":"Alfaifi","year":"2018","journal-title":"J. Hepatol."},{"key":"10.1016\/j.stem.2026.04.007_bib142","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.stem.2017.07.011","article-title":"Mesenchymal Stem Cells in Fibrotic Disease","volume":"21","author":"El Agha","year":"2017","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.stem.2026.04.007_bib143","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1055\/s-0042-1755328","article-title":"Mesenchymal Stem Cell Transplantation in Liver Diseases","volume":"42","author":"Nevens","year":"2022","journal-title":"Semin. Liver Dis."},{"key":"10.1016\/j.stem.2026.04.007_bib144","doi-asserted-by":"crossref","DOI":"10.1186\/s41232-019-0107-z","article-title":"Mesenchymal stem cell therapies for liver cirrhosis: MSCs as \u201cconducting cells\u201d for improvement of liver fibrosis and regeneration","volume":"39","author":"Tsuchiya","year":"2019","journal-title":"Inflamm. Regen."},{"key":"10.1016\/j.stem.2026.04.007_bib145","doi-asserted-by":"crossref","DOI":"10.1186\/scrt459","article-title":"Peripheral vein infusion of autologous mesenchymal stem cells in Egyptian HCV-positive patients with end-stage liver disease","volume":"5","author":"Salama","year":"2014","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.stem.2026.04.007_bib146","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1002\/hep.29189","article-title":"Allogeneic bone marrow-derived mesenchymal stromal cells for hepatitis B virus-related acute-on-chronic liver failure: A randomized controlled trial","volume":"66","author":"Lin","year":"2017","journal-title":"Hepatology"},{"key":"10.1016\/j.stem.2026.04.007_bib147","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1111\/liv.12228","article-title":"Randomized placebo-controlled trial of mesenchymal stem cell transplantation in decompensated cirrhosis","volume":"33","author":"Mohamadnejad","year":"2013","journal-title":"Liver Int."},{"key":"10.1016\/j.stem.2026.04.007_bib148","doi-asserted-by":"crossref","DOI":"10.1186\/s13287-017-0541-2","article-title":"Autologous bone marrow-derived cell transplantation in decompensated alcoholic liver disease: what is the impact on liver histology and gene expression patterns?","volume":"8","author":"Lanthier","year":"2017","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.stem.2026.04.007_bib149","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1016\/j.immuni.2022.08.002","article-title":"Liver macrophages in health and disease","volume":"55","author":"Guilliams","year":"2022","journal-title":"Immunity"},{"key":"10.1016\/j.stem.2026.04.007_bib150","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1002\/hep.26429","article-title":"Hepatic macrophages but not dendritic cells contribute to liver fibrosis by promoting the survival of activated hepatic stellate cells in mice","volume":"58","author":"Pradere","year":"2013","journal-title":"Hepatology"},{"key":"10.1016\/j.stem.2026.04.007_bib151","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/s41423-020-00558-8","article-title":"Hepatic macrophages in liver homeostasis and diseases-diversity, plasticity and therapeutic opportunities","volume":"18","author":"Wen","year":"2021","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.stem.2026.04.007_bib152","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1016\/j.jcyt.2015.07.016","article-title":"Phenotypic and functional characterization of macrophages with therapeutic potential generated from human cirrhotic monocytes in a cohort study","volume":"17","author":"Moore","year":"2015","journal-title":"Cytotherapy"},{"key":"10.1016\/j.stem.2026.04.007_bib153","article-title":"Efficient, long term production of monocyte-derived macrophages from human pluripotent stem cells under partly-defined and fully-defined conditions","volume":"8","author":"van Wilgenburg","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.stem.2026.04.007_bib154","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.stemcr.2016.12.020","article-title":"Human Induced Pluripotent Stem Cell-Derived Macrophages Share Ontogeny with MYB-Independent Tissue-Resident Macrophages","volume":"8","author":"Buchrieser","year":"2017","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.stem.2026.04.007_bib155","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1038\/s41587-023-01784-x","article-title":"Hypoimmune induced pluripotent stem cells survive long term in fully immunocompetent, allogeneic rhesus macaques","volume":"42","author":"Hu","year":"2024","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.stem.2026.04.007_bib156","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1002\/hep.24315","article-title":"Macrophage therapy for murine liver fibrosis recruits host effector cells improving fibrosis, regeneration, and function","volume":"53","author":"Thomas","year":"2011","journal-title":"Hepatology"},{"key":"10.1016\/j.stem.2026.04.007_bib157","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1016\/j.jhep.2017.05.022","article-title":"Cytotherapy with M1-polarized macrophages ameliorates liver fibrosis by modulating immune microenvironment in mice","volume":"67","author":"Ma","year":"2017","journal-title":"J. Hepatol."},{"key":"10.1016\/j.stem.2026.04.007_bib158","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/s41575-019-0125-y","article-title":"Cholangiocyte pathobiology","volume":"16","author":"Banales","year":"2019","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.stem.2026.04.007_bib159","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1038\/s41588-024-01687-w","article-title":"A spatiotemporal atlas of cholestatic injury and repair in mice","volume":"56","author":"Wu","year":"2024","journal-title":"Nat. Genet."},{"key":"10.1016\/j.stem.2026.04.007_bib160","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1038\/ncb3203","article-title":"Hepatic progenitor cells of biliary origin with liver repopulation capacity","volume":"17","author":"Lu","year":"2015","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.stem.2026.04.007_bib161","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/nature11826","article-title":"In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration","volume":"494","author":"Huch","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.stem.2026.04.007_bib162","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.cell.2014.11.050","article-title":"Long-term culture of genome-stable bipotent stem cells from adult human liver","volume":"160","author":"Huch","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.stem.2026.04.007_bib163","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.stem.2018.05.022","article-title":"Chronic Liver Injury Induces Conversion of Biliary Epithelial Cells into Hepatocytes","volume":"23","author":"Deng","year":"2018","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.stem.2026.04.007_bib164","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1038\/s41586-024-07465-2","article-title":"Acquisition of epithelial plasticity in human chronic liver disease","volume":"630","author":"Gribben","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.stem.2026.04.007_bib165","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1038\/s41588-023-01335-9","article-title":"Bipotent transitional liver progenitor cells contribute to liver regeneration","volume":"55","author":"Pu","year":"2023","journal-title":"Nat. Genet."},{"key":"10.1016\/j.stem.2026.04.007_bib166","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1016\/j.stem.2023.10.008","article-title":"VEGFA mRNA-LNP promotes biliary epithelial cell-to-hepatocyte conversion in acute and chronic liver diseases and reverses steatosis and fibrosis","volume":"30","author":"Rizvi","year":"2023","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.stem.2026.04.007_bib167","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1038\/nature23015","article-title":"Cholangiocytes act as facultative liver stem cells during impaired hepatocyte regeneration","volume":"547","author":"Raven","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.stem.2026.04.007_bib168","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1101\/gad.2029411","article-title":"Prospective isolation of a bipotential clonogenic liver progenitor cell in adult mice","volume":"25","author":"Dorrell","year":"2011","journal-title":"Genes Dev."},{"key":"10.1016\/j.stem.2026.04.007_bib169","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.stemcr.2017.06.003","article-title":"Adult Mouse Liver Contains Two Distinct Populations of Cholangiocytes","volume":"9","author":"Li","year":"2017","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.stem.2026.04.007_bib170","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-05858-0","article-title":"Cryopreservation protocol for human biliary tree stem\/progenitors, hepatic and pancreatic precursors","volume":"7","author":"Nevi","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.stem.2026.04.007_bib171","doi-asserted-by":"crossref","first-page":"1884","DOI":"10.1038\/s41596-019-0168-0","article-title":"Isolation and propagation of primary human cholangiocyte organoids for the generation of bioengineered biliary tissue","volume":"14","author":"Tysoe","year":"2019","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.stem.2026.04.007_bib172","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1038\/547171a","article-title":"Bioengineering: Bile ducts regenerated","volume":"547","author":"Zhang","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.stem.2026.04.007_bib173","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.stem.2022.02.006","article-title":"Human biliary epithelial cells from discarded donor livers rescue bile duct structure and function in a mouse model of biliary disease","volume":"29","author":"Hallett","year":"2022","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.stem.2026.04.007_bib174","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1126\/science.aaz6964","article-title":"Cholangiocyte organoids can repair bile ducts after transplantation in the human liver","volume":"371","author":"Sampaziotis","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.stem.2026.04.007_bib175","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0077255","article-title":"Production of factor VIII by human liver sinusoidal endothelial cells transplanted in immunodeficient uPA mice","volume":"8","author":"Fomin","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.stem.2026.04.007_bib176","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1111\/jth.12412","article-title":"Human liver sinusoidal endothelial cells but not hepatocytes contain factor VIII","volume":"12","author":"Shahani","year":"2014","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.stem.2026.04.007_bib177","doi-asserted-by":"crossref","DOI":"10.1098\/rsob.170108","article-title":"Human fetal liver cultures support multiple cell lineages that can engraft immunodeficient mice","volume":"7","author":"Fomin","year":"2017","journal-title":"Open Biol."},{"key":"10.1016\/j.stem.2026.04.007_bib178","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1038\/nbt.4231","article-title":"Paired-cell sequencing enables spatial gene expression mapping of liver endothelial cells","volume":"36","author":"Halpern","year":"2018","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.stem.2026.04.007_bib179","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.stem.2020.06.007","article-title":"Generation of Functional Liver Sinusoidal Endothelial Cells from Human Pluripotent Stem-Cell-Derived Venous Angioblasts","volume":"27","author":"Gage","year":"2020","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.stem.2026.04.007_bib180","doi-asserted-by":"crossref","first-page":"2022","DOI":"10.1111\/j.1538-7836.2005.01508.x","article-title":"Transplantation of endothelial cells corrects the phenotype in hemophilia A mice","volume":"3","author":"Kumaran","year":"2005","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.stem.2026.04.007_bib181","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1016\/j.stemcr.2018.10.012","article-title":"Patient-Specific iPSC-Derived Endothelial Cells Provide Long-Term Phenotypic Correction of Hemophilia A","volume":"11","author":"Olgasi","year":"2018","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.stem.2026.04.007_bib182","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.110759","article-title":"Therapeutic correction of hemophilia A by transplantation of hPSC-derived liver sinusoidal endothelial cell progenitors","volume":"39","author":"Gage","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.stem.2026.04.007_bib183","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1016\/j.bbrc.2018.01.186","article-title":"Billion-scale production of hepatocyte-like cells from human induced pluripotent stem cells","volume":"496","author":"Yamashita","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.stem.2026.04.007_bib184","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/j.jhep.2019.11.013","article-title":"Interleukin-22 ameliorates acute-on-chronic liver failure by reprogramming impaired regeneration pathways in mice","volume":"72","author":"Xiang","year":"2020","journal-title":"J. Hepatol."},{"key":"10.1016\/j.stem.2026.04.007_bib185","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1111\/ajt.12558","article-title":"Evidence for instant blood-mediated inflammatory reaction in clinical autologous islet transplantation","volume":"14","author":"Naziruddin","year":"2014","journal-title":"Am. J. Transplant."},{"key":"10.1016\/j.stem.2026.04.007_bib186","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.13467","article-title":"Ex vivo factor VIII-modified proliferating human hepatocytes therapy for haemophilia A","volume":"56","author":"Zhang","year":"2023","journal-title":"Cell Prolif."},{"key":"10.1016\/j.stem.2026.04.007_bib187","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1093\/stcltm\/szad084","article-title":"Human Hepatocyte Transplantation: Three Decades of Clinical Experience and Future Perspective","volume":"13","author":"Nulty","year":"2024","journal-title":"Stem Cells Transl. Med."},{"key":"10.1016\/j.stem.2026.04.007_bib188","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1111\/ajt.16835","article-title":"Donor-derived cell-free DNA levels predict graft injury in liver transplant recipients","volume":"22","author":"Levitsky","year":"2022","journal-title":"Am. J. Transplant."},{"key":"10.1016\/j.stem.2026.04.007_bib189","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1172\/JCI115288","article-title":"Phenotypes of apolipoprotein B and apolipoprotein E after liver transplantation","volume":"88","author":"Linton","year":"1991","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.stem.2026.04.007_bib190","doi-asserted-by":"crossref","first-page":"822","DOI":"10.4254\/wjh.v10.i11.822","article-title":"Bioengineered functional humanized livers: An emerging supportive modality to bridge the gap of organ transplantation for management of end-stage liver diseases","volume":"10","author":"Vishwakarma","year":"2018","journal-title":"World J. Hepatol."},{"key":"10.1016\/j.stem.2026.04.007_bib191","article-title":"Bioengineered omental transplant site promotes pancreatic islet allografts survival in non-human primates","volume":"4","author":"Deng","year":"2023","journal-title":"Cell Rep. Med."},{"key":"10.1016\/j.stem.2026.04.007_bib192","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1056\/NEJMoa2107454","article-title":"CRISPR-Cas9 In Vivo Gene Editing for Transthyretin Amyloidosis","volume":"385","author":"Gillmore","year":"2021","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.stem.2026.04.007_bib193","doi-asserted-by":"crossref","first-page":"2235","DOI":"10.1056\/NEJMoa2504747","article-title":"Patient-Specific In Vivo Gene Editing to Treat a Rare Genetic Disease","volume":"392","author":"Musunuru","year":"2025","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.stem.2026.04.007_bib194","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1038\/s41586-024-07266-7","article-title":"Interim analyses of a first-in-human phase 1\/2 mRNA trial for propionic acidaemia","volume":"628","author":"Koeberl","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.stem.2026.04.007_bib195","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1021\/acsptsci.2c00110","article-title":"Nedosiran, a Candidate siRNA Drug for the Treatment of Primary Hyperoxaluria: Design, Development, and Clinical Studies","volume":"5","author":"Liu","year":"2022","journal-title":"ACS Pharmacol. Transl. Sci."},{"key":"10.1016\/j.stem.2026.04.007_bib196","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1016\/j.stem.2024.04.022","article-title":"Efficient expansion and CRISPR-Cas9-mediated gene correction of patient-derived hepatocytes for treatment of inherited liver diseases","volume":"31","author":"Zhang","year":"2024","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.stem.2026.04.007_bib197","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1038\/s41586-025-08799-1","article-title":"Gene-modified pig-to-human liver xenotransplantation","volume":"641","author":"Tao","year":"2025","journal-title":"Nature"},{"key":"10.1016\/j.stem.2026.04.007_bib198","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.jhep.2025.08.044","article-title":"Genetically engineered pig-to-human liver xenotransplantation","volume":"84","author":"Zhang","year":"2025","journal-title":"J. Hepatol."},{"key":"10.1016\/j.stem.2026.04.007_bib199","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1038\/s41591-025-04196-3","article-title":"Extracorporeal liver cross-circulation using transgenic xenogeneic pig livers with brain-dead human decedents","volume":"32","author":"Shaked","year":"2026","journal-title":"Nat. Med."}],"container-title":["Cell Stem Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1934590926001475?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1934590926001475?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T16:48:57Z","timestamp":1783183737000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1934590926001475"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":199,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["S1934590926001475"],"URL":"https:\/\/doi.org\/10.1016\/j.stem.2026.04.007","relation":{},"ISSN":["1934-5909"],"issn-type":[{"value":"1934-5909","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Advancing hepatocyte-based therapies: A translational perspective","name":"articletitle","label":"Article Title"},{"value":"Cell Stem Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.stem.2026.04.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}