{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T12:54:39Z","timestamp":1791982479119,"version":"4.4.0"},"reference-count":68,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100007937","name":"Peking University","doi-asserted-by":"publisher","award":["JC202506"],"award-info":[{"award-number":["JC202506"]}],"id":[{"id":"10.13039\/501100007937","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004826","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["Z220014"],"award-info":[{"award-number":["Z220014"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004826","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["L252055"],"award-info":[{"award-number":["L252055"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004826","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["Z220011"],"award-info":[{"award-number":["Z220011"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100031233","name":"Michigan Medicine-PKUHSC Joint Institute for Translational and Clinical Research","doi-asserted-by":"publisher","award":["BMU2025JI003"],"award-info":[{"award-number":["BMU2025JI003"]}],"id":[{"id":"10.13039\/100031233","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013076","name":"National Major Science and Technology Projects of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013076","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018537","name":"National Science and Technology Major Project","doi-asserted-by":"publisher","award":["2026ZD0553603"],"award-info":[{"award-number":["2026ZD0553603"]}],"id":[{"id":"10.13039\/501100018537","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018537","name":"National Science and Technology Major Project","doi-asserted-by":"publisher","award":["2026ZD1804700"],"award-info":[{"award-number":["2026ZD1804700"]}],"id":[{"id":"10.13039\/501100018537","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["92459302"],"award-info":[{"award-number":["92459302"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U25A20139"],"award-info":[{"award-number":["U25A20139"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82325028"],"award-info":[{"award-number":["82325028"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Stem Cell"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.stem.2026.07.015","type":"journal-article","created":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:23:48Z","timestamp":1787239428000},"page":"1444-1458.e9","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Engineered mechanosensitive MSCs enable synthetic radiotheranostic targeting across tumor types"],"prefix":"10.1016","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-6215-2426","authenticated-orcid":false,"given":"Xiujie","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianze","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-3912-2175","authenticated-orcid":false,"given":"Rui","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoyi","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linyu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9722-6019","authenticated-orcid":false,"given":"Yuwen","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Da","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shixin","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-0115-2210","authenticated-orcid":false,"given":"Yang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunhong","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8718-8154","authenticated-orcid":false,"given":"Zhaofei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.stem.2026.07.015_bib1","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1038\/s41571-022-00652-y","article-title":"Radiotheranostics in oncology: current challenges and emerging opportunities","volume":"19","author":"Bodei","year":"2022","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.stem.2026.07.015_bib2","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1038\/s41573-020-0073-9","article-title":"Radiopharmaceutical therapy in cancer: clinical advances and challenges","volume":"19","author":"Sgouros","year":"2020","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.stem.2026.07.015_bib3","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1038\/s41587-024-02295-z","article-title":"Precision radiation opens a new window on cancer therapy","volume":"42","author":"Senior","year":"2024","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.stem.2026.07.015_bib4","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.annonc.2023.03.001","article-title":"Next generation radiotheranostics promoting precision medicine","volume":"34","author":"Pomykala","year":"2023","journal-title":"Ann. Oncol."},{"key":"10.1016\/j.stem.2026.07.015_bib5","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1056\/NEJMoa1607427","article-title":"Phase 3 trial of 177Lu-dotatate for midgut neuroendocrine tumors","volume":"376","author":"Strosberg","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.stem.2026.07.015_bib6","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1056\/NEJMoa2107322","article-title":"Lutetium-177-PSMA-617 for metastatic castration-resistant prostate cancer","volume":"385","author":"Sartor","year":"2021","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.stem.2026.07.015_bib7","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1038\/s41568-020-0290-x","article-title":"A compendium of mutational cancer driver genes","volume":"20","author":"Mart\u00ednez-Jim\u00e9nez","year":"2020","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.stem.2026.07.015_bib8","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1038\/nrclinonc.2016.66","article-title":"Triple-negative breast cancer: challenges and opportunities of a heterogeneous disease","volume":"13","author":"Bianchini","year":"2016","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.stem.2026.07.015_bib9","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1056\/NEJMra1404198","article-title":"Pancreatic adenocarcinoma","volume":"371","author":"Ryan","year":"2014","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.stem.2026.07.015_bib10","doi-asserted-by":"crossref","first-page":"eaaz0868","DOI":"10.1126\/science.aaz0868","article-title":"Physical traits of cancer","volume":"370","author":"Nia","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.stem.2026.07.015_bib11","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.1038\/s41592-024-02564-4","article-title":"Probing the physical hallmarks of cancer","volume":"22","author":"Nia","year":"2025","journal-title":"Nat. Methods"},{"key":"10.1016\/j.stem.2026.07.015_bib12","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1038\/nmat4009","article-title":"Extracellular matrix stiffness and composition jointly regulate the induction of malignant phenotypes in mammary epithelium","volume":"13","author":"Chaudhuri","year":"2014","journal-title":"Nat. Mater."},{"key":"10.1016\/j.stem.2026.07.015_bib13","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1038\/s41556-018-0131-2","article-title":"Mechanisms and impact of altered tumour mechanics","volume":"20","author":"Mohammadi","year":"2018","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.stem.2026.07.015_bib14","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/nature10137","article-title":"Role of YAP\/TAZ in mechanotransduction","volume":"474","author":"Dupont","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.stem.2026.07.015_bib15","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1038\/s41568-019-0168-y","article-title":"YAP and TAZ: a signalling hub of the tumour microenvironment","volume":"19","author":"Zanconato","year":"2019","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.stem.2026.07.015_bib16","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aan2966","article-title":"Mechanoresponsive stem cells to target cancer metastases through biophysical cues","volume":"9","author":"Liu","year":"2017","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.stem.2026.07.015_bib17","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1126\/science.abq6990","article-title":"The future of engineered immune cell therapies","volume":"378","author":"Irvine","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.stem.2026.07.015_bib18","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1038\/nnano.2012.167","article-title":"The nanomechanical signature of breast cancer","volume":"7","author":"Plodinec","year":"2012","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.stem.2026.07.015_bib19","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.actbio.2021.07.009","article-title":"Heterogeneous microenvironmental stiffness regulates pro-metastatic functions of breast cancer cells","volume":"131","author":"Liu","year":"2021","journal-title":"Acta Biomater."},{"key":"10.1016\/j.stem.2026.07.015_bib20","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1038\/s41587-019-0064-8","article-title":"Engineered immune cells as highly sensitive cancer diagnostics","volume":"37","author":"Aalipour","year":"2019","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.stem.2026.07.015_bib21","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1038\/s43018-023-00668-y","article-title":"Cytokine-armed dendritic cell progenitors for antigen-agnostic cancer immunotherapy","volume":"5","author":"Ghasemi","year":"2024","journal-title":"Nat. Cancer"},{"key":"10.1016\/j.stem.2026.07.015_bib22","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1002\/stem.81","article-title":"Trafficking mesenchymal stem cell engraftment and differentiation in tumor-bearing mice by bioluminescence imaging","volume":"27","author":"Wang","year":"2009","journal-title":"Stem Cells (Dayt. Ohio)"},{"key":"10.1016\/j.stem.2026.07.015_bib23","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1016\/j.stem.2021.09.006","article-title":"Mesenchymal stromal cells: putative microenvironmental modulators become cell therapy","volume":"28","author":"Krampera","year":"2021","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.stem.2026.07.015_bib24","article-title":"Stem cell-based therapy for human diseases","volume":"7","author":"Hoang","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.stem.2026.07.015_bib25","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.transproceed.2006.12.019","article-title":"Stem cell transplantation: the lung barrier","volume":"39","author":"Schrepfer","year":"2007","journal-title":"Transplant. Proc."},{"key":"10.1016\/j.stem.2026.07.015_bib26","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1146\/annurev-med-062117-073027","article-title":"Imaging of prostate-specific membrane antigen with small-molecule PET radiotracers: from the bench to advanced clinical applications","volume":"70","author":"Rowe","year":"2019","journal-title":"Annu. Rev. Med."},{"key":"10.1016\/j.stem.2026.07.015_bib27","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1038\/s41586-022-04924-6","article-title":"YAP\/TAZ activity in stromal cells prevents ageing by controlling cGAS-STING","volume":"607","author":"Sladitschek-Martens","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.stem.2026.07.015_bib28","doi-asserted-by":"crossref","DOI":"10.1186\/s13287-017-0499-0","article-title":"Effects of mesenchymal stem cells from human induced pluripotent stem cells on differentiation, maturation, and function of dendritic cells","volume":"8","author":"Gao","year":"2017","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.stem.2026.07.015_bib29","doi-asserted-by":"crossref","DOI":"10.1186\/s13045-021-01208-w","article-title":"Mesenchymal stem\/stromal cells in cancer therapy","volume":"14","author":"Lan","year":"2021","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.stem.2026.07.015_bib30","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.2967\/jnumed.115.161299","article-title":"The theranostic PSMA ligand PSMA-617 in the diagnosis of prostate cancer by PET\/CT: biodistribution in humans, radiation dosimetry, and first evaluation of tumor lesions","volume":"56","author":"Afshar-Oromieh","year":"2015","journal-title":"J. Nucl. Med."},{"key":"10.1016\/j.stem.2026.07.015_bib31","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.2967\/jnumed.118.221671","article-title":"Preclinical evaluation and pilot clinical study of Al18F-PSMA-BCH for prostate cancer PET imaging","volume":"60","author":"Liu","year":"2019","journal-title":"J. Nucl. Med."},{"key":"10.1016\/j.stem.2026.07.015_bib32","article-title":"The secretion profile of mesenchymal stem cells and potential applications in treating human diseases","volume":"7","author":"Han","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.stem.2026.07.015_bib33","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/nbt.2464","article-title":"Mass-encoded synthetic biomarkers for multiplexed urinary monitoring of disease","volume":"31","author":"Kwong","year":"2013","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.stem.2026.07.015_bib34","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1158\/1078-0432.CCR-22-1433","article-title":"Mesenchymal stem cell-mediated image-guided sodium iodide symporter (NIS) gene therapy improves survival of glioblastoma-bearing mice","volume":"29","author":"Kitzberger","year":"2023","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.stem.2026.07.015_bib35","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-01304-3","article-title":"Translation, but not transfection limits clinically relevant, exogenous mRNA based induction of alpha-4 integrin expression on human mesenchymal stem cells","volume":"7","author":"Nowakowski","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.stem.2026.07.015_bib36","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1038\/nrc3180","article-title":"Treating metastatic cancer with nanotechnology","volume":"12","author":"Schroeder","year":"2011","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.stem.2026.07.015_bib37","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.ccell.2023.02.016","article-title":"The evolving tumor microenvironment: from cancer initiation to metastatic outgrowth","volume":"41","author":"de Visser","year":"2023","journal-title":"Cancer Cell"},{"key":"10.1016\/j.stem.2026.07.015_bib38","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/j.cell.2009.10.027","article-title":"Matrix crosslinking forces tumor progression by enhancing integrin signaling","volume":"139","author":"Levental","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.stem.2026.07.015_bib39","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1038\/nrclinonc.2016.108","article-title":"Non-invasive metabolic imaging of brain tumours in the era of precision medicine","volume":"13","author":"Kim","year":"2016","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.stem.2026.07.015_bib40","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1016\/S1474-4422(10)70181-2","article-title":"Advanced MRI and PET imaging for assessment of treatment response in patients with gliomas","volume":"9","author":"Dhermain","year":"2010","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.stem.2026.07.015_bib41","doi-asserted-by":"crossref","first-page":"68","DOI":"10.2967\/jnumed.106.037200","article-title":"Skeletal PET with 18F-fluoride: applying new technology to an old tracer","volume":"49","author":"Grant","year":"2008","journal-title":"J. Nucl. Med."},{"key":"10.1016\/j.stem.2026.07.015_bib42","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1152\/physrev.00012.2019","article-title":"Bone metastasis: mechanisms, therapies, and biomarkers","volume":"101","author":"Cl\u00e9zardin","year":"2021","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.stem.2026.07.015_bib43","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.stem.2009.02.001","article-title":"Mesenchymal stem cell homing: the devil is in the details","volume":"4","author":"Karp","year":"2009","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.stem.2026.07.015_bib44","doi-asserted-by":"crossref","first-page":"521","DOI":"10.2967\/jnumed.120.250738","article-title":"177Lu-labeled albumin-binder-conjugated PSMA-targeting agents with extremely high tumor uptake and enhanced tumor-to-kidney absorbed dose ratio","volume":"62","author":"Kuo","year":"2021","journal-title":"J. Nucl. Med."},{"key":"10.1016\/j.stem.2026.07.015_bib45","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1161\/CIRCULATIONAHA.109.898312","article-title":"Functional mesenchymal stem cells derived from human induced pluripotent stem cells attenuate limb ischemia in mice","volume":"121","author":"Lian","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.stem.2026.07.015_bib46","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1038\/s41591-020-1050-x","article-title":"Production, safety and efficacy of iPSC-derived mesenchymal stromal cells in acute steroid-resistant graft versus host disease: a phase I, multicenter, open-label, dose-escalation study","volume":"26","author":"Bloor","year":"2020","journal-title":"Nat. Med."},{"key":"10.1016\/j.stem.2026.07.015_bib47","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1038\/s41571-022-00721-2","article-title":"Humanized mouse models for immuno-oncology research","volume":"20","author":"Chuprin","year":"2023","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.stem.2026.07.015_bib48","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1038\/s41591-025-03559-0","article-title":"Allogeneic mesenchymal stem cell therapy with laromestrocel in mild Alzheimer's disease: a randomized controlled phase 2a trial","volume":"31","author":"Rash","year":"2025","journal-title":"Nat. Med."},{"key":"10.1016\/j.stem.2026.07.015_bib49","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.molmed.2010.02.005","article-title":"Mesenchymal stem cell therapy: Two steps forward, one step back","volume":"16","author":"Ankrum","year":"2010","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.stem.2026.07.015_bib50","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1038\/nmat3889","article-title":"Mechanical memory and dosing influence stem cell fate","volume":"13","author":"Yang","year":"2014","journal-title":"Nat. Mater."},{"key":"10.1016\/j.stem.2026.07.015_bib51","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1016\/j.stem.2018.05.004","article-title":"Mesenchymal stromal cells: clinical challenges and therapeutic opportunities","volume":"22","author":"Galipeau","year":"2018","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.stem.2026.07.015_bib52","first-page":"255","article-title":"Radiotheranostics in oncology: making precision medicine possible","volume":"73","author":"Aboagye","year":"2023","journal-title":"CA: Cancer J. Clin."},{"key":"10.1016\/j.stem.2026.07.015_bib53","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.2967\/jnumed.123.265471","article-title":"Evaluation of the diagnostic accuracy of FAPI PET\/CT in oncologic studies: systematic review and metaanalysis","volume":"64","author":"Wass","year":"2023","journal-title":"J. Nucl. Med."},{"key":"10.1016\/j.stem.2026.07.015_bib54","doi-asserted-by":"crossref","first-page":"388","DOI":"10.52601\/bpr.2024.240022","article-title":"Current status of FAP-directed cancer theranostics: a bibliometric analysis","volume":"10","author":"Ruan","year":"2024","journal-title":"Biophys. Rep."},{"key":"10.1016\/j.stem.2026.07.015_bib55","doi-asserted-by":"crossref","first-page":"79S","DOI":"10.2967\/jnumed.115.170720","article-title":"The rise of PSMA ligands for diagnosis and therapy of prostate cancer","volume":"57","author":"Afshar-Oromieh","year":"2016","journal-title":"J. Nucl. Med."},{"key":"10.1016\/j.stem.2026.07.015_bib56","doi-asserted-by":"crossref","first-page":"e236","DOI":"10.1016\/S1470-2045(24)00030-5","article-title":"Recent advances and impending challenges for the radiopharmaceutical sciences in oncology","volume":"25","author":"Lapi","year":"2024","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.stem.2026.07.015_bib57","doi-asserted-by":"crossref","DOI":"10.1183\/16000617.0033-2018","article-title":"Matrix abnormalities in pulmonary fibrosis","volume":"27","author":"Upagupta","year":"2018","journal-title":"Eur. Respir. Rev."},{"key":"10.1016\/j.stem.2026.07.015_bib58","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1016\/j.jacc.2019.07.012","article-title":"Large-artery stiffness in health and disease: JACC state-of-the-art review","volume":"74","author":"Chirinos","year":"2019","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.stem.2026.07.015_bib59","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1161\/CIRCRESAHA.123.323365","article-title":"Sox9 accelerates vascular aging by regulating extracellular matrix composition and stiffness","volume":"134","author":"Faleeva","year":"2024","journal-title":"Circ. Res."},{"key":"10.1016\/j.stem.2026.07.015_bib60","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1001\/jama.2020.22171","article-title":"Diagnosis and treatment of hip and knee osteoarthritis: a review","volume":"325","author":"Katz","year":"2021","journal-title":"JAMA"},{"key":"10.1016\/j.stem.2026.07.015_bib61","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1126\/science.add7034","article-title":"Probiotic-guided CAR-T cells for solid tumor targeting","volume":"382","author":"Vincent","year":"2023","journal-title":"Science"},{"key":"10.1016\/j.stem.2026.07.015_bib68","doi-asserted-by":"crossref","DOI":"10.1186\/s13045-023-01455-z","article-title":"Leveraging CD16 fusion receptors to remodel the immune response for enhancing anti-tumor immunotherapy in iPSC-derived NK cells","volume":"16","author":"Meng","year":"2023","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.stem.2026.07.015_bib66","doi-asserted-by":"crossref","DOI":"10.1117\/1.JBO.19.1.016007","article-title":"Computational segmentation of collagen fibers from second-harmonic generation images of breast cancer","volume":"19","author":"Bredfeldt","year":"2014","journal-title":"J. Biomed. Opt."},{"key":"10.1016\/j.stem.2026.07.015_bib62","doi-asserted-by":"crossref","first-page":"5435","DOI":"10.1021\/acs.nanolett.5c00677","article-title":"A nanoradiosensitizer potentiates tumor radiotherapy through JFK inhibition and hypoxia alleviation","volume":"25","author":"Wang","year":"2025","journal-title":"Nano Lett."},{"key":"10.1016\/j.stem.2026.07.015_bib63","doi-asserted-by":"crossref","DOI":"10.1186\/s13059-017-1382-0","article-title":"SCANPY: large-scale single-cell gene expression data analysis","volume":"19","author":"Wolf","year":"2018","journal-title":"Genome Biol."},{"key":"10.1016\/j.stem.2026.07.015_bib64","doi-asserted-by":"crossref","first-page":"914","DOI":"10.2967\/jnumed.114.147413","article-title":"Preclinical evaluation of a tailor-made DOTA-conjugated PSMA inhibitor with optimized linker moiety for imaging and endoradiotherapy of prostate cancer","volume":"56","author":"Bene\u0161ov\u00e1","year":"2015","journal-title":"J. Nucl. Med."},{"key":"10.1016\/j.stem.2026.07.015_bib65","doi-asserted-by":"crossref","DOI":"10.1172\/JCI161065","article-title":"Noninvasive interrogation of CD8+ T cell effector function for monitoring early tumor responses to immunotherapy","volume":"132","author":"Zhou","year":"2022","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.stem.2026.07.015_bib67","doi-asserted-by":"crossref","first-page":"989","DOI":"10.2967\/jnumed.113.132969","article-title":"Integrin \u03b1v\u03b26-targeted SPECT imaging for pancreatic cancer detection","volume":"55","author":"Liu","year":"2014","journal-title":"J. Nucl. Med."}],"container-title":["Cell Stem Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1934590926002754?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1934590926002754?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T12:34:53Z","timestamp":1791981293000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1934590926002754"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":68,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["S1934590926002754"],"URL":"https:\/\/doi.org\/10.1016\/j.stem.2026.07.015","relation":{},"ISSN":["1934-5909"],"issn-type":[{"value":"1934-5909","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Engineered mechanosensitive MSCs enable synthetic radiotheranostic targeting across tumor types","name":"articletitle","label":"Article Title"},{"value":"Cell Stem Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.stem.2026.07.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.stem.2026.08.010","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}