{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T21:31:19Z","timestamp":1792704679222,"version":"4.5.0"},"reference-count":28,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T00:00:00Z","timestamp":1435708800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,5,2]],"date-time":"2015-05-02T00:00:00Z","timestamp":1430524800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Stem Cell Reports"],"published-print":{"date-parts":[[2015,7]]},"DOI":"10.1016\/j.stemcr.2015.04.017","type":"journal-article","created":{"date-parts":[[2015,6,13]],"date-time":"2015-06-13T22:47:36Z","timestamp":1434235656000},"page":"22-30","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":66,"title":["Amelioration of Hyperbilirubinemia in Gunn Rats after Transplantation of Human Induced Pluripotent Stem Cell-Derived Hepatocytes"],"prefix":"10.1016","volume":"5","author":[{"given":"Yong","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanfeng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Sauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chan-Jung","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatyana","family":"Tchaikovskaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yesim","family":"Avsar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edgar","family":"Tafaleng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanal","family":"Madhusudana\u00a0Girija","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krisztina","family":"Tar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zsuzsanna","family":"Polgar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Strom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric\u00a0E.","family":"Bouhassira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chandan","family":"Guha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ira\u00a0J.","family":"Fox","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jayanta","family":"Roy-Chowdhury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Namita","family":"Roy-Chowdhury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.stemcr.2015.04.017_bib1","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1177\/145749691110000104","article-title":"Long-term results of liver transplantation","volume":"100","author":"\u00c5berg","year":"2011","journal-title":"Scand. J. Surg."},{"key":"10.1016\/j.stemcr.2015.04.017_bib2","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1053\/j.gastro.2008.10.047","article-title":"Differentiation and transplantation of human embryonic stem cell-derived hepatocytes","volume":"136","author":"Basma","year":"2009","journal-title":"Gastroenterology"},{"key":"10.1016\/j.stemcr.2015.04.017_bib3","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/s10815-008-9233-2","article-title":"Preimplantation HLA haplotyping using tri-, tetra-, and pentanucleotide short tandem repeats for HLA matching","volume":"25","author":"Bick","year":"2008","journal-title":"J.\u00a0Assist. Reprod. Genet."},{"key":"10.1016\/j.stemcr.2015.04.017_bib4","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1002\/hep.1840150531","article-title":"Sequence of exons and the flanking regions of human bilirubin-UDP-glucuronosyltransferase gene complex and identification of a genetic mutation in a patient with Crigler-Najjar syndrome, type I","volume":"15","author":"Bosma","year":"1992","journal-title":"Hepatology"},{"key":"10.1016\/j.stemcr.2015.04.017_bib5","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1002\/hep.21582","article-title":"Directed differentiation of human embryonic stem cells into functional hepatic cells","volume":"45","author":"Cai","year":"2007","journal-title":"Hepatology"},{"key":"10.1016\/j.stemcr.2015.04.017_bib6","doi-asserted-by":"crossref","first-page":"4953","DOI":"10.1172\/JCI75456","article-title":"Engrafted human stem cell-derived hepatocytes establish an infectious HCV murine model","volume":"124","author":"Carpentier","year":"2014","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.stemcr.2015.04.017_bib7","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.semradonc.2005.04.005","article-title":"Partial volume tolerance of the liver to radiation","volume":"15","author":"Dawson","year":"2005","journal-title":"Semin. Radiat. Oncol."},{"key":"10.1016\/j.stemcr.2015.04.017_bib8","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1002\/stem.315","article-title":"Differentiation and characterization of metabolically functioning hepatocytes from human embryonic stem cells","volume":"28","author":"Duan","year":"2010","journal-title":"Stem Cells"},{"key":"10.1016\/j.stemcr.2015.04.017_bib9","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1097\/01.tp.0000231689.44266.ac","article-title":"Human hepatocyte transplantation: worldwide results","volume":"82","author":"Fisher","year":"2006","journal-title":"Transplantation"},{"key":"10.1016\/j.stemcr.2015.04.017_bib10","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1056\/NEJM199805143382004","article-title":"Treatment of the Crigler-Najjar syndrome type I with hepatocyte transplantation","volume":"338","author":"Fox","year":"1998","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.stemcr.2015.04.017_bib11","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1053\/jhep.2002.34516","article-title":"Normal hepatocytes correct serum bilirubin after repopulation of Gunn rat liver subjected to irradiation\/partial resection","volume":"36","author":"Guha","year":"2002","journal-title":"Hepatology"},{"key":"10.1016\/j.stemcr.2015.04.017_bib12","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1111\/j.1432-0436.2004.07205002.x","article-title":"Differentiation and isolation of hepatic-like cells from human embryonic stem cells","volume":"72","author":"Lavon","year":"2004","journal-title":"Differentiation"},{"key":"10.1016\/j.stemcr.2015.04.017_bib13","doi-asserted-by":"crossref","first-page":"82ra39","DOI":"10.1126\/scitranslmed.3002376","article-title":"In\u00a0vivo liver regeneration potential of human induced pluripotent stem cells from diverse origins","volume":"3","author":"Liu","year":"2011","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.stemcr.2015.04.017_bib14","doi-asserted-by":"crossref","first-page":"3464","DOI":"10.3748\/wjg.14.3464","article-title":"Liver cell transplantation for Crigler-Najjar syndrome type I: update and perspectives","volume":"14","author":"Lysy","year":"2008","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.stemcr.2015.04.017_bib15","doi-asserted-by":"crossref","first-page":"807","DOI":"10.2144\/000112761","article-title":"A quantitative real-time PCR method for absolute telomere length","volume":"44","author":"O\u2019Callaghan","year":"2008","journal-title":"Biotechniques"},{"key":"10.1016\/j.stemcr.2015.04.017_bib16","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1056\/NEJM196707272770406","article-title":"\u201cPhysiologic\u201d hyperbilirubinemia in the neonatal period","volume":"277","author":"Odell","year":"1967","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.stemcr.2015.04.017_bib17","doi-asserted-by":"crossref","first-page":"2875","DOI":"10.1016\/j.transproceed.2009.07.025","article-title":"Living related liver transplantation in Crigler-Najjar syndrome type 1","volume":"41","author":"Oz\u00e7ay","year":"2009","journal-title":"Transplant. Proc."},{"key":"10.1016\/j.stemcr.2015.04.017_bib18","doi-asserted-by":"crossref","first-page":"18294","DOI":"10.1016\/S0021-9258(18)55268-6","article-title":"Molecular basis for the lack of bilirubin-specific and 3-methylcholanthrene-inducible UDP-glucuronosyltransferase activities in Gunn rats. The two isoforms are encoded by distinct mRNA species that share an identical single base deletion","volume":"266","author":"Roy-Chowdhury","year":"1991","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.stemcr.2015.04.017_bib19","series-title":"Animal Models in Liver Research","first-page":"149","article-title":"The Gunn rat: an animal model for inherited deficiency of bilirubin glucuronidation","author":"Roy-Chowdhury","year":"1993"},{"key":"10.1016\/j.stemcr.2015.04.017_bib20","series-title":"Text Book of Gastroenterology","first-page":"2432","article-title":"Experimental Therapies: Hepatocytes transplantation, gene therapy, and liver assist devices","author":"Roy-Chowdhury","year":"2009"},{"key":"10.1016\/j.stemcr.2015.04.017_bib21","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1089\/scd.2005.14.643","article-title":"Defined conditions for development of functional hepatic cells from human embryonic stem cells","volume":"14","author":"Schwartz","year":"2005","journal-title":"Stem Cells Dev."},{"key":"10.1016\/j.stemcr.2015.04.017_bib22","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1002\/hep.23354","article-title":"Highly efficient generation of human hepatocyte-like cells from induced pluripotent stem cells","volume":"51","author":"Si-Tayeb","year":"2010","journal-title":"Hepatology"},{"key":"10.1016\/j.stemcr.2015.04.017_bib23","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1038\/cr.2009.107","article-title":"Efficient generation of hepatocyte-like cells from human induced pluripotent stem cells","volume":"19","author":"Song","year":"2009","journal-title":"Cell Res."},{"key":"10.1016\/j.stemcr.2015.04.017_bib24","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.cell.2006.07.024","article-title":"Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors","volume":"126","author":"Takahashi","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.stemcr.2015.04.017_bib25","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1002\/hep.22573","article-title":"Hepatic irradiation augments engraftment of donor cells following hepatocyte transplantation","volume":"49","author":"Yamanouchi","year":"2009","journal-title":"Hepatology"},{"key":"10.1016\/j.stemcr.2015.04.017_bib26","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.yjmcc.2010.10.026","article-title":"iPS cells: a source of cardiac regeneration","volume":"50","author":"Yoshida","year":"2011","journal-title":"J.\u00a0Mol. Cell. Cardiol."},{"key":"10.1016\/j.stemcr.2015.04.017_bib27","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1126\/science.1151526","article-title":"Induced pluripotent stem cell lines derived from human somatic cells","volume":"318","author":"Yu","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.stemcr.2015.04.017_bib28","doi-asserted-by":"crossref","first-page":"e46775","DOI":"10.1371\/journal.pone.0046775","article-title":"Single liver lobe repopulation with wildtype hepatocytes using regional hepatic irradiation cures jaundice in Gunn rats","volume":"7","author":"Zhou","year":"2012","journal-title":"PLoS ONE"}],"container-title":["Stem Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213671115001290?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213671115001290?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,5,13]],"date-time":"2022-05-13T01:53:40Z","timestamp":1652406820000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213671115001290"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7]]},"references-count":28,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,7]]}},"alternative-id":["S2213671115001290"],"URL":"https:\/\/doi.org\/10.1016\/j.stemcr.2015.04.017","relation":{},"ISSN":["2213-6711"],"issn-type":[{"value":"2213-6711","type":"print"}],"subject":[],"published":{"date-parts":[[2015,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Amelioration of Hyperbilirubinemia in Gunn Rats after Transplantation of Human Induced Pluripotent Stem Cell-Derived Hepatocytes","name":"articletitle","label":"Article Title"},{"value":"Stem Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.stemcr.2015.04.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}