{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T11:24:45Z","timestamp":1790767485283,"version":"4.1.0"},"reference-count":28,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T00:00:00Z","timestamp":1435708800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,5,29]],"date-time":"2015-05-29T00:00:00Z","timestamp":1432857600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Stem Cell Reports"],"published-print":{"date-parts":[[2015,7]]},"DOI":"10.1016\/j.stemcr.2015.05.016","type":"journal-article","created":{"date-parts":[[2015,6,25]],"date-time":"2015-06-25T17:59:17Z","timestamp":1435255157000},"page":"10-21","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":51,"title":["Histone Demethylases KDM4A and KDM4C Regulate Differentiation of Embryonic Stem Cells to Endothelial Cells"],"prefix":"10.1016","volume":"5","author":[{"given":"Liangtang","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kishore\u00a0K.","family":"Wary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergei","family":"Revskoy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaopei","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kitman","family":"Tsang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulia\u00a0A.","family":"Komarova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jalees","family":"Rehman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asrar\u00a0B.","family":"Malik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.stemcr.2015.05.016_bib1","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/j.cell.2007.05.009","article-title":"High-resolution profiling of histone methylations in the human genome","volume":"129","author":"Barski","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.stemcr.2015.05.016_bib2","doi-asserted-by":"crossref","first-page":"2936","DOI":"10.1158\/0008-5472.CAN-12-4300","article-title":"KDM4\/JMJD2 histone demethylases: epigenetic regulators in cancer cells","volume":"73","author":"Berry","year":"2013","journal-title":"Cancer Res."},{"key":"10.1016\/j.stemcr.2015.05.016_bib3","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.molcel.2012.11.006","article-title":"Histone lysine methylation dynamics: establishment, regulation, and biological impact","volume":"48","author":"Black","year":"2012","journal-title":"Mol. Cell"},{"key":"10.1016\/j.stemcr.2015.05.016_bib4","first-page":"5","article-title":"Endothelial differentiation of embryonic stem cells","volume":"Chapter 1","author":"Blancas","year":"2008","journal-title":"Curr. Protoc. Stem Cell Biol."},{"key":"10.1016\/j.stemcr.2015.05.016_bib5","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/nature04837","article-title":"The putative oncogene GASC1 demethylates tri- and dimethylated lysine 9 on histone H3","volume":"442","author":"Cloos","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.stemcr.2015.05.016_bib6","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1101\/gad.1652908","article-title":"Erasing the methyl mark: histone demethylases at the center of cellular differentiation and disease","volume":"22","author":"Cloos","year":"2008","journal-title":"Genes Dev."},{"key":"10.1016\/j.stemcr.2015.05.016_bib7","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1038\/nsmb1273","article-title":"Specificity and mechanism of JMJD2A, a trimethyllysine-specific histone demethylase","volume":"14","author":"Couture","year":"2007","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.stemcr.2015.05.016_bib8","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.vph.2012.03.007","article-title":"Vascular differentiation from embryonic stem cells: novel technologies and therapeutic promises","volume":"56","author":"Descamps","year":"2012","journal-title":"Vascul. Pharmacol."},{"key":"10.1016\/j.stemcr.2015.05.016_bib9","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.sbi.2010.09.006","article-title":"Structural insights into histone lysine demethylation","volume":"20","author":"Hou","year":"2010","journal-title":"Curr. Opin. Struct. Biol."},{"key":"10.1016\/j.stemcr.2015.05.016_bib10","doi-asserted-by":"crossref","first-page":"6975","DOI":"10.1182\/blood-2011-05-352658","article-title":"Etv2\/ER71 induces vascular mesoderm from Flk1+PDGFR\u03b1+ primitive mesoderm","volume":"118","author":"Kataoka","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.stemcr.2015.05.016_bib11","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1002\/aja.1002030302","article-title":"Stages of embryonic development of the zebrafish","volume":"203","author":"Kimmel","year":"1995","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.stemcr.2015.05.016_bib12","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1038\/nrg1945","article-title":"JmjC-domain-containing proteins and histone demethylation","volume":"7","author":"Klose","year":"2006","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.stemcr.2015.05.016_bib13","doi-asserted-by":"crossref","first-page":"e85549","DOI":"10.1371\/journal.pone.0085549","article-title":"Flk1+ and VE-cadherin+ endothelial cells derived from iPSCs recapitulates vascular development during differentiation and display similar angiogenic potential as ESC-derived cells","volume":"8","author":"Kohler","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1016\/j.stemcr.2015.05.016_bib14","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1038\/nrm3327","article-title":"Molecular mechanisms and potential functions of histone demethylases","volume":"13","author":"Kooistra","year":"2012","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.stemcr.2015.05.016_bib15","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.1161\/CIRCULATIONAHA.114.009727","article-title":"Expanding the pool of stem cell therapy for lung growth and repair","volume":"129","author":"Kourembanas","year":"2014","journal-title":"Circulation"},{"key":"10.1016\/j.stemcr.2015.05.016_bib16","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.cell.2007.02.005","article-title":"Chromatin modifications and their function","volume":"128","author":"Kouzarides","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.stemcr.2015.05.016_bib17","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.stem.2008.03.008","article-title":"ER71 acts downstream of BMP, Notch, and Wnt signaling in blood and vessel progenitor specification","volume":"2","author":"Lee","year":"2008","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.stemcr.2015.05.016_bib18","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1161\/CIRCULATIONAHA.109.881441","article-title":"Stem cell therapy for vascular regeneration: adult, embryonic, and induced pluripotent stem cells","volume":"122","author":"Leeper","year":"2010","journal-title":"Circulation"},{"issue":"Suppl","key":"10.1016\/j.stemcr.2015.05.016_bib19","first-page":"I46","article-title":"Differentiation, survival, and function of embryonic stem cell derived endothelial cells for ischemic heart disease","volume":"116","author":"Li","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.stemcr.2015.05.016_bib20","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1161\/CIRCRESAHA.113.300506","article-title":"Regulation of endothelial cell differentiation and specification","volume":"112","author":"Marcelo","year":"2013","journal-title":"Circ. Res."},{"key":"10.1016\/j.stemcr.2015.05.016_bib21","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1038\/nature05971","article-title":"Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity","volume":"448","author":"Ng","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.stemcr.2015.05.016_bib22","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1161\/CIRCRESAHA.111.247304","article-title":"Epigenetic regulation of endothelial lineage committed genes in pro-angiogenic hematopoietic and endothelial progenitor cells","volume":"109","author":"Ohtani","year":"2011","journal-title":"Circ. Res."},{"key":"10.1016\/j.stemcr.2015.05.016_bib23","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1161\/CIRCRESAHA.113.301078","article-title":"Transcriptional regulation of endothelial cell and vascular development","volume":"112","author":"Park","year":"2013","journal-title":"Circ. Res."},{"key":"10.1016\/j.stemcr.2015.05.016_bib24","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.molmed.2007.07.003","article-title":"Chromatin remodeling and cancer, Part I: Covalent histone modifications","volume":"13","author":"Wang","year":"2007","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.stemcr.2015.05.016_bib25","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1101\/gad.9.17.2105","article-title":"Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse","volume":"9","author":"Winnier","year":"1995","journal-title":"Genes Dev."},{"key":"10.1016\/j.stemcr.2015.05.016_bib26","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/35040568","article-title":"Flk1-positive cells derived from embryonic stem cells serve as vascular progenitors","volume":"408","author":"Yamashita","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.stemcr.2015.05.016_bib27","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.stem.2012.04.009","article-title":"Histone demethylases KDM4B and KDM6B promotes osteogenic differentiation of human MSCs","volume":"11","author":"Ye","year":"2012","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.stemcr.2015.05.016_bib28","doi-asserted-by":"crossref","first-page":"a006692","DOI":"10.1101\/cshperspect.a006692","article-title":"Human endothelial progenitor cells","volume":"2","author":"Yoder","year":"2012","journal-title":"Cold Spring Harb Perspect Med"}],"container-title":["Stem Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213671115001599?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213671115001599?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,27]],"date-time":"2019-08-27T18:30:38Z","timestamp":1566930638000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213671115001599"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7]]},"references-count":28,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,7]]}},"alternative-id":["S2213671115001599"],"URL":"https:\/\/doi.org\/10.1016\/j.stemcr.2015.05.016","relation":{},"ISSN":["2213-6711"],"issn-type":[{"value":"2213-6711","type":"print"}],"subject":[],"published":{"date-parts":[[2015,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Histone Demethylases KDM4A and KDM4C Regulate Differentiation of Embryonic Stem Cells to Endothelial Cells","name":"articletitle","label":"Article Title"},{"value":"Stem Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.stemcr.2015.05.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}