{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T22:51:21Z","timestamp":1791413481245,"version":"4.3.3"},"reference-count":43,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2016,5,21]],"date-time":"2016-05-21T00:00:00Z","timestamp":1463788800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002426","name":"Fondazione Telethon","doi-asserted-by":"publisher","award":["GGP09227"],"award-info":[{"award-number":["GGP09227"]}],"id":[{"id":"10.13039\/501100002426","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000016","name":"U.S. Department of Health and Human Services","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000016","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003407","name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004271","name":"Sapienza Universit\u00e0 di Roma","doi-asserted-by":"publisher","award":["DFG - KO2119\/8-1"],"award-info":[{"award-number":["DFG - KO2119\/8-1"]}],"id":[{"id":"10.13039\/501100004271","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004271","name":"Sapienza Universit\u00e0 di Roma","doi-asserted-by":"publisher","award":["TCP07004"],"award-info":[{"award-number":["TCP07004"]}],"id":[{"id":"10.13039\/501100004271","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004588","name":"Istituto Pasteur-Fondazione Cenci Bolognetti","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004588","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001708","name":"International Foundation for Research in Paraplegia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Stem Cell Reports"],"published-print":{"date-parts":[[2016,6]]},"DOI":"10.1016\/j.stemcr.2016.05.011","type":"journal-article","created":{"date-parts":[[2016,6,14]],"date-time":"2016-06-14T15:46:27Z","timestamp":1465919187000},"page":"897-913","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":404,"title":["No Identical \u201cMesenchymal Stem Cells\u201d at Different Times and Sites: Human Committed Progenitors of Distinct Origin and Differentiation Potential Are Incorporated as Adventitial Cells in Microvessels"],"prefix":"10.1016","volume":"6","author":[{"given":"Benedetto","family":"Sacchetti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessia","family":"Funari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Remoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Giannicola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gesine","family":"Kogler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie","family":"Liedtke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulio","family":"Cossu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Serafini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurilio","family":"Sampaolesi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Tagliafico","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Tenedini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabella","family":"Saggio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela G.","family":"Robey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mara","family":"Riminucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Bianco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.stemcr.2016.05.011_bib1","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/978-3-662-44608-9_4","article-title":"Mechanisms of myogenic specification and patterning","volume":"56","author":"Applebaum","year":"2015","journal-title":"Results Probl. Cell Differ."},{"key":"10.1016\/j.stemcr.2016.05.011_bib2","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.devcel.2011.07.001","article-title":"Pericytes: developmental, physiological, and pathological perspectives, problems, and promises","volume":"21","author":"Armulik","year":"2011","journal-title":"Dev. Cell"},{"key":"10.1016\/j.stemcr.2016.05.011_bib3","doi-asserted-by":"crossref","first-page":"5281","DOI":"10.1182\/blood-2011-01-315069","article-title":"Bone and the hematopoietic niche: a tale of two stem cells","volume":"117","author":"Bianco","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.stemcr.2016.05.011_bib4","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1146\/annurev-cellbio-100913-013132","article-title":"\u201cMesenchymal\u201d stem cells","volume":"30","author":"Bianco","year":"2014","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.stemcr.2016.05.011_bib5","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1242\/dev.102210","article-title":"Skeletal stem cells","volume":"142","author":"Bianco","year":"2015","journal-title":"Development"},{"key":"10.1016\/j.stemcr.2016.05.011_bib6","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.stem.2008.03.002","article-title":"Mesenchymal stem cells: revisiting history, concepts, and assays","volume":"2","author":"Bianco","year":"2008","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.stemcr.2016.05.011_bib7","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/nm.3028","article-title":"The meaning, the sense and the significance: translating the science of mesenchymal stem cells into medicine","volume":"19","author":"Bianco","year":"2013","journal-title":"Nat. Med."},{"key":"10.1016\/j.stemcr.2016.05.011_bib8","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1089\/scd.2011.0414","article-title":"Distinct differentiation potential of \u201cMSC\u201d derived from cord blood and umbilical cord: are cord-derived cells true mesenchymal stromal cells?","volume":"21","author":"Bosch","year":"2012","journal-title":"Stem Cells Dev."},{"key":"10.1016\/j.stemcr.2016.05.011_bib9","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1002\/jor.1100090504","article-title":"Mesenchymal stem cells","volume":"9","author":"Caplan","year":"1991","journal-title":"J.\u00a0Orthop. Res."},{"key":"10.1016\/j.stemcr.2016.05.011_bib10","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.stem.2008.08.008","article-title":"All MSCs are pericytes?","volume":"3","author":"Caplan","year":"2008","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.stemcr.2016.05.011_bib11","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.stem.2011.06.008","article-title":"The MSC: an injury drugstore","volume":"9","author":"Caplan","year":"2011","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.stemcr.2016.05.011_bib12","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.stem.2008.07.003","article-title":"A perivascular origin for mesenchymal stem cells in multiple human organs","volume":"3","author":"Crisan","year":"2008","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.stemcr.2016.05.011_bib13","doi-asserted-by":"crossref","first-page":"2204","DOI":"10.1242\/jcs.02932","article-title":"Mesenchymal stem cells reside in virtually all post-natal organs and tissues","volume":"119","author":"da Silva Meirelles","year":"2006","journal-title":"J.\u00a0Cell Sci."},{"key":"10.1016\/j.stemcr.2016.05.011_bib14","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/ncb1542","article-title":"Pericytes of human skeletal muscle are myogenic precursors distinct from satellite cells","volume":"9","author":"Dellavalle","year":"2007","journal-title":"Nat. Cell Biol"},{"key":"10.1016\/j.stemcr.2016.05.011_bib15","first-page":"909","article-title":"Pericytes. Morphofunction, interactions and pathology in a quiescent and activated mesenchymal cell niche","volume":"24","author":"Diaz-Flores","year":"2009","journal-title":"Histol. Histopathol."},{"key":"10.1016\/j.stemcr.2016.05.011_bib16","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1080\/14653240600855905","article-title":"Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement","volume":"8","author":"Dominici","year":"2006","journal-title":"Cytotherapy"},{"key":"10.1016\/j.stemcr.2016.05.011_bib17","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1242\/dev.02226","article-title":"Smooth muscle of the dorsal aorta shares a common clonal origin with skeletal muscle of the myotome","volume":"133","author":"Esner","year":"2006","journal-title":"Development"},{"key":"10.1016\/j.stemcr.2016.05.011_bib18","first-page":"217","article-title":"Marrow microenvironment transfer by heterotopic transplantation of freshly isolated and cultured cells in porous sponges","volume":"10","author":"Friedenstein","year":"1982","journal-title":"Exp. Hematol."},{"key":"10.1016\/j.stemcr.2016.05.011_bib19","doi-asserted-by":"crossref","first-page":"3047","DOI":"10.1242\/dev.126.14.3047","article-title":"Role of PDGF-B and PDGFR-beta in recruitment of vascular smooth muscle cells and pericytes during embryonic blood vessel formation in the mouse","volume":"126","author":"Hellstrom","year":"1999","journal-title":"Development"},{"key":"10.1016\/j.stemcr.2016.05.011_bib20","doi-asserted-by":"crossref","first-page":"31079","DOI":"10.1074\/jbc.M602296200","article-title":"Oxygen tension regulates chondrocyte differentiation and function during endochondral ossification","volume":"281","author":"Hirao","year":"2006","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.stemcr.2016.05.011_bib21","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/S0008-6363(96)00063-6","article-title":"Pericytes in the microvasculature","volume":"32","author":"Hirschi","year":"1996","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.stemcr.2016.05.011_bib22","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1038\/nm0603-685","article-title":"Molecular regulation of vessel maturation","volume":"9","author":"Jain","year":"2003","journal-title":"Nat. Med."},{"key":"10.1016\/j.stemcr.2016.05.011_bib23","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/ncb2015","article-title":"Muscle injury activates resident fibro\/adipogenic progenitors that facilitate myogenesis","volume":"12","author":"Joe","year":"2010","journal-title":"Nat. Cell Biol"},{"key":"10.1016\/j.stemcr.2016.05.011_bib24","doi-asserted-by":"crossref","first-page":"2419","DOI":"10.1634\/stemcells.2008-0304","article-title":"In\u00a0vivo osteoprogenitor potency of human stromal cells from different tissues does not correlate with expression of POU5F1 or its pseudogenes","volume":"26","author":"Kaltz","year":"2008","journal-title":"Stem Cells"},{"key":"10.1016\/j.stemcr.2016.05.011_bib25","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1089\/scd.2010.0070","article-title":"DLK-1 as a marker to distinguish unrestricted somatic stem cells and mesenchymal stromal cells in cord blood","volume":"19","author":"Kluth","year":"2010","journal-title":"Stem Cells Dev."},{"key":"10.1016\/j.stemcr.2016.05.011_bib26","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1084\/jem.20040440","article-title":"A new human somatic stem cell from placental cord blood with intrinsic pluripotent differentiation potential","volume":"200","author":"Kogler","year":"2004","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.stemcr.2016.05.011_bib27","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1097\/00007890-199704270-00003","article-title":"Bone formation in\u00a0vivo: comparison of osteogenesis by transplanted mouse and human marrow stromal fibroblasts","volume":"65","author":"Krebsbach","year":"1997","journal-title":"Transplantation"},{"key":"10.1016\/j.stemcr.2016.05.011_bib28","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.scr.2010.03.004","article-title":"The HOX Code as a \u201cbiological fingerprint\u201d to distinguish functionally distinct stem cell populations derived from cord blood","volume":"5","author":"Liedtke","year":"2010","journal-title":"Stem Cell Res."},{"key":"10.1016\/j.stemcr.2016.05.011_bib29","article-title":"Low oxygen tension reveals distinct HOX codes in human cord blood-derived stromal cells associated with specific endochondral ossification capacities in\u00a0vitro and in\u00a0vivo","author":"Liedtke","year":"2016","journal-title":"J.\u00a0Tissue Eng. Regen. Med."},{"key":"10.1016\/j.stemcr.2016.05.011_bib30","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1126\/science.277.5323.242","article-title":"Pericyte loss and microaneurysm formation in PDGF-B-deficient mice","volume":"277","author":"Lindahl","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.stemcr.2016.05.011_bib31","doi-asserted-by":"crossref","first-page":"2773","DOI":"10.1242\/dev.129.11.2773","article-title":"The meso-angioblast: a multipotent, self-renewing cell that originates from the dorsal aorta and differentiates into most mesodermal tissues","volume":"129","author":"Minasi","year":"2002","journal-title":"Development"},{"key":"10.1016\/j.stemcr.2016.05.011_bib32","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1038\/ncb2025","article-title":"Identification and characterization of a non-satellite cell muscle resident progenitor during postnatal development","volume":"12","author":"Mitchell","year":"2010","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.stemcr.2016.05.011_bib33","doi-asserted-by":"crossref","first-page":"2064","DOI":"10.1126\/science.1114758","article-title":"Direct isolation of satellite cells for skeletal muscle regeneration","volume":"309","author":"Montarras","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.stemcr.2016.05.011_bib34","doi-asserted-by":"crossref","first-page":"867","DOI":"10.5966\/sctm.2013-0154","article-title":"Directed differentiation of human induced pluripotent stem cells toward bone and cartilage: in\u00a0vitro versus in\u00a0vivo assays","volume":"3","author":"Phillips","year":"2014","journal-title":"Stem Cells Transl. Med."},{"key":"10.1016\/j.stemcr.2016.05.011_bib35","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1359\/jbmr.091036","article-title":"Transfer, analysis, and reversion of the fibrous dysplasia cellular phenotype in human skeletal progenitors","volume":"25","author":"Piersanti","year":"2010","journal-title":"J.\u00a0Bone Miner. Res."},{"key":"10.1016\/j.stemcr.2016.05.011_bib36","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1126\/science.284.5411.143","article-title":"Multilineage potential of adult human mesenchymal stem cells","volume":"284","author":"Pittenger","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.stemcr.2016.05.011_bib37","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1016\/j.yexcr.2013.04.002","article-title":"Differential microRNA signature of human mesenchymal stem cells from different sources reveals an \u201cenvironmental-niche memory\u201d for bone marrow stem cells","volume":"319","author":"Ragni","year":"2013","journal-title":"Exp. Cell Res"},{"key":"10.1016\/j.stemcr.2016.05.011_bib38","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1182\/blood-2014-04-572255","article-title":"Epigenetic and in\u00a0vivo comparison of diverse MSC sources reveals an endochondral signature for human hematopoietic niche formation","volume":"125","author":"Reinisch","year":"2015","journal-title":"Blood"},{"key":"10.1016\/j.stemcr.2016.05.011_bib39","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.cell.2007.08.025","article-title":"Self-renewing osteoprogenitors in bone marrow sinusoids can organize a hematopoietic microenvironment","volume":"131","author":"Sacchetti","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.stemcr.2016.05.011_bib40","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.cell.2004.10.021","article-title":"Isolation of adult mouse myogenic progenitors: functional heterogeneity of cells within and engrafting skeletal muscle","volume":"119","author":"Sherwood","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.stemcr.2016.05.011_bib41","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1002\/(SICI)1096-9896(199909)189:1<4::AID-PATH332>3.0.CO;2-P","article-title":"The role of CD146 (Mel-CAM) in biology and pathology","volume":"189","author":"Shih","year":"1999","journal-title":"J.\u00a0Pathol."},{"key":"10.1016\/j.stemcr.2016.05.011_bib42","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.stemcr.2016.05.011_bib43","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1002\/mus.880181212","article-title":"Myogenic cells derived from rat bone marrow mesenchymal stem cells exposed to 5-azacytidine","volume":"18","author":"Wakitani","year":"1995","journal-title":"Muscle Nerve"}],"container-title":["Stem Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213671116300662?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213671116300662?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T09:38:29Z","timestamp":1761989909000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213671116300662"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6]]},"references-count":43,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,6]]}},"alternative-id":["S2213671116300662"],"URL":"https:\/\/doi.org\/10.1016\/j.stemcr.2016.05.011","relation":{},"ISSN":["2213-6711"],"issn-type":[{"value":"2213-6711","type":"print"}],"subject":[],"published":{"date-parts":[[2016,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"No Identical \u201cMesenchymal Stem Cells\u201d at Different Times and Sites: Human Committed Progenitors of Distinct Origin and Differentiation Potential Are Incorporated as Adventitial Cells in Microvessels","name":"articletitle","label":"Article Title"},{"value":"Stem Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.stemcr.2016.05.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 The Authors.","name":"copyright","label":"Copyright"}]}}