{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T09:44:46Z","timestamp":1789983886223,"version":"4.0.1"},"reference-count":44,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,1,13]],"date-time":"2017-01-13T00:00:00Z","timestamp":1484265600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Edinger Foundation"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Stem Cell Reports"],"published-print":{"date-parts":[[2017,3]]},"DOI":"10.1016\/j.stemcr.2017.01.009","type":"journal-article","created":{"date-parts":[[2017,2,16]],"date-time":"2017-02-16T18:52:30Z","timestamp":1487271150000},"page":"701-714","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"title":["Astrocytic Calcium Waves Signal Brain Injury to Neural Stem and\u00a0Progenitor\u00a0Cells"],"prefix":"10.1016","volume":"8","author":[{"given":"Anna","family":"Kraft","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo Rosales","family":"Jubal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth","family":"von Laer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"D\u00f6ring","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Rocha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moyo","family":"Grebbin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Zenke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helmut","family":"Kettenmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albrecht","family":"Stroh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Momma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.stemcr.2017.01.009_bib1","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1038\/nm747","article-title":"Neuronal replacement from endogenous precursors in the adult brain after stroke","volume":"8","author":"Arvidsson","year":"2002","journal-title":"Nat. Med."},{"key":"10.1016\/j.stemcr.2017.01.009_bib2","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1126\/science.1411526","article-title":"Intercellular propagation of calcium waves mediated by inositol trisphosphate","volume":"258","author":"Boitano","year":"1992","journal-title":"Science"},{"key":"10.1016\/j.stemcr.2017.01.009_bib3","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/nn.2268","article-title":"Forebrain ependymal cells are Notch-dependent and generate neuroblasts and astrocytes after stroke","volume":"12","author":"Carl\u00e9n","year":"2009","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.stemcr.2017.01.009_bib4","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1093\/brain\/awq128","article-title":"Bone morphogenetic protein-7 release from endogenous neural precursor cells suppresses the tumourigenicity of stem-like glioblastoma cells","volume":"133","author":"Chirasani","year":"2010","journal-title":"Brain"},{"key":"10.1016\/j.stemcr.2017.01.009_bib5","doi-asserted-by":"crossref","first-page":"15735","DOI":"10.1073\/pnas.95.26.15735","article-title":"Connexins regulate calcium signaling by controlling ATP release","volume":"95","author":"Cotrina","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.stemcr.2017.01.009_bib6","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.nbd.2005.01.020","article-title":"Increased number of neural progenitors in human temporal lobe epilepsy","volume":"19","author":"Crespel","year":"2005","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.stemcr.2017.01.009_bib7","doi-asserted-by":"crossref","first-page":"9023","DOI":"10.1073\/pnas.1532244100","article-title":"Increased cell proliferation and neurogenesis in the adult human Huntington\u2019s disease brain","volume":"100","author":"Curtis","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.stemcr.2017.01.009_bib8","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1093\/nar\/30.1.207","article-title":"Gene Expression Omnibus: NCBI gene expression and hybridization array data repository","volume":"30","author":"Edgar","year":"2002","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.stemcr.2017.01.009_bib9","doi-asserted-by":"crossref","first-page":"e1002045","DOI":"10.1371\/journal.pbio.1002045","article-title":"Adult neurogenesis in humans\u2014common and unique traits in mammals","volume":"13","author":"Ernst","year":"2015","journal-title":"PLoS Biol."},{"key":"10.1016\/j.stemcr.2017.01.009_bib10","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1016\/j.cell.2014.01.044","article-title":"Neurogenesis in the striatum of the adult human brain","volume":"156","author":"Ernst","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.stemcr.2017.01.009_bib11","doi-asserted-by":"crossref","first-page":"4359","DOI":"10.1523\/JNEUROSCI.1898-05.2006","article-title":"Neural stem\/progenitor cells participate in the regenerative response to perinatal hypoxia\/ischemia","volume":"26","author":"Felling","year":"2006","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.stemcr.2017.01.009_bib12","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1093\/cercor\/bhu336","article-title":"Cytoarchitecture-dependent decrease in propagation velocity of cortical spreading depression in the rat insular cortex revealed by optical imaging","volume":"26","author":"Fujita","year":"2016","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.stemcr.2017.01.009_bib13","doi-asserted-by":"crossref","first-page":"2637","DOI":"10.1523\/JNEUROSCI.5118-04.2005","article-title":"Glioblastoma-induced attraction of endogenous neural precursor cells is associated with improved survival","volume":"25","author":"Glass","year":"2005","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.stemcr.2017.01.009_bib14","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1523\/JNEUROSCI.19-02-00520.1999","article-title":"ATP released from astrocytes mediates glial calcium waves","volume":"19","author":"Guthrie","year":"1999","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.stemcr.2017.01.009_bib15","doi-asserted-by":"crossref","first-page":"16267","DOI":"10.1073\/pnas.242435499","article-title":"Monitoring of implanted stem cell migration in\u00a0vivo: a highly resolved in\u00a0vivo magnetic resonance imaging investigation of experimental stroke in rat","volume":"99","author":"Hoehn","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"Suppl 1","key":"10.1016\/j.stemcr.2017.01.009_bib16","doi-asserted-by":"crossref","first-page":"S96","DOI":"10.1093\/bioinformatics\/18.suppl_1.S96","article-title":"Variance stabilization applied to microarray data calibration and to the quantification of differential expression","volume":"18","author":"Huber","year":"2002","journal-title":"Bioinformatics"},{"key":"10.1016\/j.stemcr.2017.01.009_bib17","doi-asserted-by":"crossref","first-page":"18117","DOI":"10.1073\/pnas.0408258102","article-title":"Directed migration of neural stem cells to sites of CNS injury by the stromal cell-derived factor 1alpha\/CXC chemokine receptor 4 pathway","volume":"101","author":"Imitola","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.stemcr.2017.01.009_bib18","doi-asserted-by":"crossref","first-page":"13198","DOI":"10.1073\/pnas.0603512103","article-title":"Evidence for stroke-induced neurogenesis in the human brain","volume":"103","author":"Jin","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.stemcr.2017.01.009_bib19","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0092-8674(00)80956-3","article-title":"Identification of a neural stem cell in the adult mammalian central nervous system","volume":"96","author":"Johansson","year":"1999","journal-title":"Cell"},{"key":"10.1016\/j.stemcr.2017.01.009_bib20","doi-asserted-by":"crossref","first-page":"3129","DOI":"10.1101\/gad.10.24.3129","article-title":"Single factors direct the differentiation of stem cells from the fetal and adult central nervous system","volume":"10","author":"Johe","year":"1996","journal-title":"Genes Dev."},{"key":"10.1016\/j.stemcr.2017.01.009_bib21","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.neulet.2005.01.005","article-title":"Changes in the expression of Hes5 and Mash1 mRNA in the adult rat dentate gyrus after transient forebrain ischemia","volume":"380","author":"Kawai","year":"2005","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.stemcr.2017.01.009_bib22","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1111\/j.1460-9568.2011.07901.x","article-title":"Gap junction-mediated calcium waves define communication networks among murine postnatal neural progenitor cells","volume":"34","author":"Lacar","year":"2011","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.stemcr.2017.01.009_bib23","doi-asserted-by":"crossref","first-page":"16435","DOI":"10.1523\/JNEUROSCI.1457-12.2012","article-title":"Neural progenitor cells regulate capillary blood flow in the postnatal subventricular zone","volume":"32","author":"Lacar","year":"2012","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.stemcr.2017.01.009_bib24","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.ydbio.2006.09.017","article-title":"Purinergic signaling regulates neural progenitor cell expansion and neurogenesis","volume":"302","author":"Lin","year":"2007","journal-title":"Dev. Biol."},{"key":"10.1016\/j.stemcr.2017.01.009_bib25","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1038\/nature04960","article-title":"Stem cells for the treatment of neurological disorders","volume":"441","author":"Lindvall","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.stemcr.2017.01.009_bib26","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1634\/stemcells.2007-0867","article-title":"Enumeration of neural stem and progenitor cells in the neural colony-forming cell assay","volume":"26","author":"Louis","year":"2008","journal-title":"Stem Cells"},{"key":"10.1016\/j.stemcr.2017.01.009_bib27","doi-asserted-by":"crossref","first-page":"13114","DOI":"10.1523\/JNEUROSCI.4667-06.2006","article-title":"Increased generation of neuronal progenitors after ischemic injury in the aged adult human forebrain","volume":"26","author":"Macas","year":"2006","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.stemcr.2017.01.009_bib28","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1002\/stem.1581","article-title":"Generation of neuronal progenitor cells in response to tumors in the human brain","volume":"32","author":"Macas","year":"2014","journal-title":"Stem Cells"},{"key":"10.1016\/j.stemcr.2017.01.009_bib29","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1126\/science.346.6206.237","article-title":"A latent neurogenic program in astrocytes regulated by Notch signaling in the mouse","volume":"346","author":"Magnusson","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.stemcr.2017.01.009_bib30","doi-asserted-by":"crossref","first-page":"5374","DOI":"10.1523\/JNEUROSCI.18-14-05374.1998","article-title":"Patterns of intracellular calcium fluctuation in precursor cells of the neocortical ventricular zone","volume":"18","author":"Owens","year":"1998","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.stemcr.2017.01.009_bib31","doi-asserted-by":"crossref","first-page":"9888","DOI":"10.1523\/JNEUROSCI.23-30-09888.2003","article-title":"Different mechanisms promote astrocyte Ca2+ waves and spreading depression in the mouse neocortex","volume":"23","author":"Peters","year":"2003","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.stemcr.2017.01.009_bib32","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/nmeth758","article-title":"Neural stem cells and neurospheres\u2014re-evaluating the relationship","volume":"2","author":"Reynolds","year":"2005","journal-title":"Nat. Methods"},{"key":"10.1016\/j.stemcr.2017.01.009_bib33","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1002\/glia.20374","article-title":"Astrocyte calcium waves: what they are and what they do","volume":"54","author":"Scemes","year":"2006","journal-title":"Glia"},{"key":"10.1016\/j.stemcr.2017.01.009_bib34","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1096\/fj.01-0514fje","article-title":"Astrocyte Ca2+ waves trigger responses in microglial cells in brain slices","volume":"16","author":"Schipke","year":"2002","journal-title":"FASEB J."},{"key":"10.1016\/j.stemcr.2017.01.009_bib35","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1016\/j.devcel.2012.04.012","article-title":"Long-range Ca2+ waves transmit brain-damage signals to microglia","volume":"22","author":"Sieger","year":"2012","journal-title":"Dev. Cell"},{"key":"10.1016\/j.stemcr.2017.01.009_bib36","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1093\/cercor\/bhi101","article-title":"Activity-dependent ATP-waves in the mouse neocortex are independent from astrocytic calcium waves","volume":"16","author":"S\u00f6hl","year":"2006","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.stemcr.2017.01.009_bib37","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1016\/j.cell.2013.05.002","article-title":"Dynamics of hippocampal neurogenesis in adult humans","volume":"153","author":"Spalding","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.stemcr.2017.01.009_bib38","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1002\/stem.558","article-title":"Tracking stem cell differentiation in the setting of automated optogenetic stimulation","volume":"29","author":"Stroh","year":"2011","journal-title":"Stem Cells"},{"key":"10.1016\/j.stemcr.2017.01.009_bib39","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1016\/j.neuron.2013.01.031","article-title":"Making waves: initiation and propagation of corticothalamic Ca2+ waves in\u00a0vivo","volume":"77","author":"Stroh","year":"2013","journal-title":"Neuron"},{"key":"10.1016\/j.stemcr.2017.01.009_bib40","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1097\/00004647-200203000-00007","article-title":"Increased proliferation of neural progenitor cells but reduced survival of newborn cells in the contralateral hippocampus after focal cerebral ischemia in rats","volume":"22","author":"Takasawa","year":"2002","journal-title":"J.\u00a0Cereb. Blood Flow Metab."},{"key":"10.1016\/j.stemcr.2017.01.009_bib41","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1016\/j.neuroscience.2008.10.064","article-title":"The Notch pathway mediates expansion of a progenitor pool and neuronal differentiation in adult neural progenitor cells after stroke","volume":"158","author":"Wang","year":"2009","journal-title":"Neuroscience"},{"key":"10.1016\/j.stemcr.2017.01.009_bib42","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1038\/jcbfm.2009.83","article-title":"Involvement of Notch1 signaling in neurogenesis in the subventricular zone of normal and ischemic rat brain in\u00a0vivo","volume":"29","author":"Wang","year":"2009","journal-title":"J.\u00a0Cereb. Blood Flow Metab."},{"key":"10.1016\/j.stemcr.2017.01.009_bib43","doi-asserted-by":"crossref","first-page":"5810","DOI":"10.1523\/JNEUROSCI.1109-04.2004","article-title":"Stroke transiently increases subventricular zone cell division from asymmetric to symmetric and increases neuronal differentiation in the adult rat","volume":"24","author":"Zhang","year":"2004","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.stemcr.2017.01.009_bib44","doi-asserted-by":"crossref","first-page":"3157","DOI":"10.1523\/JNEUROSCI.4969-06.2007","article-title":"Neuroblast division during migration toward the ischemic striatum: a study of dynamic migratory and proliferative characteristics of neuroblasts from the subventricular zone","volume":"27","author":"Zhang","year":"2007","journal-title":"J.\u00a0Neurosci."}],"container-title":["Stem Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213671117300243?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213671117300243?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,4]],"date-time":"2018-09-04T03:58:50Z","timestamp":1536033530000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213671117300243"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3]]},"references-count":44,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["S2213671117300243"],"URL":"https:\/\/doi.org\/10.1016\/j.stemcr.2017.01.009","relation":{},"ISSN":["2213-6711"],"issn-type":[{"value":"2213-6711","type":"print"}],"subject":[],"published":{"date-parts":[[2017,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Astrocytic Calcium Waves Signal Brain Injury to Neural Stem and\u00a0Progenitor\u00a0Cells","name":"articletitle","label":"Article Title"},{"value":"Stem Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.stemcr.2017.01.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 The Author(s).","name":"copyright","label":"Copyright"}]}}