{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T02:30:38Z","timestamp":1790303438805,"version":"4.1.0"},"reference-count":48,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2017,5,1]],"date-time":"2017-05-01T00:00:00Z","timestamp":1493596800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,5,1]],"date-time":"2017-05-01T00:00:00Z","timestamp":1493596800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2017,4,6]],"date-time":"2017-04-06T00:00:00Z","timestamp":1491436800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009330","name":"Medical Science and Technology Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2016A020214019"],"award-info":[{"award-number":["2016A020214019"]}],"id":[{"id":"10.13039\/501100009330","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010256","name":"Guangzhou Municipal Science and Technology Project","doi-asserted-by":"publisher","award":["201707010231"],"award-info":[{"award-number":["201707010231"]}],"id":[{"id":"10.13039\/501100010256","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81371217"],"award-info":[{"award-number":["81371217"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81470205"],"award-info":[{"award-number":["81470205"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81472999"],"award-info":[{"award-number":["81472999"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81473014"],"award-info":[{"award-number":["81473014"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81501014"],"award-info":[{"award-number":["81501014"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2015A030311038"],"award-info":[{"award-number":["2015A030311038"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Stem Cell Reports"],"published-print":{"date-parts":[[2017,5]]},"DOI":"10.1016\/j.stemcr.2017.04.006","type":"journal-article","created":{"date-parts":[[2017,5,9]],"date-time":"2017-05-09T14:58:56Z","timestamp":1494341936000},"page":"1256-1269","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":71,"title":["PI3K\/AKT\/mTOR Signaling Mediates Valproic Acid-Induced Neuronal Differentiation of Neural Stem Cells through Epigenetic Modifications"],"prefix":"10.1016","volume":"8","author":[{"given":"Xi","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaosong","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingqing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuejian","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenri","family":"Ou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuo","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dahong","family":"Long","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhua","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weidong","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aiguo","family":"Xuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.stemcr.2017.04.006_bib1","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.cell.2006.02.041","article-title":"A bivalent chromatin structure marks key developmental genes in embryonic stem cells","volume":"125","author":"Bernstein","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.stemcr.2017.04.006_bib2","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1038\/nn.4213","article-title":"KIF1A inhibition immortalizes brain stem cells but blocks BDNF-mediated neuronal migration","volume":"19","author":"Carabalona","year":"2016","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.stemcr.2017.04.006_bib3","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.stem.2008.11.011","article-title":"Chromatin signatures in multipotent human hematopoietic stem cells indicate the fate of bivalent genes during differentiation","volume":"4","author":"Cui","year":"2009","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.stemcr.2017.04.006_bib4","doi-asserted-by":"crossref","first-page":"27586","DOI":"10.1074\/jbc.M303740200","article-title":"Valproate induces replication-independent active DNA demethylation","volume":"278","author":"Detich","year":"2003","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.stemcr.2017.04.006_bib5","doi-asserted-by":"crossref","first-page":"730","DOI":"10.4161\/epi.5.8.13053","article-title":"Valproate induces DNA demethylation in nuclear extracts from adult mouse brain","volume":"5","author":"Dong","year":"2010","journal-title":"Epigenetics"},{"key":"10.1016\/j.stemcr.2017.04.006_bib6","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1002\/dvdy.24173","article-title":"Valproic acid, a histone deacetylase inhibitor, regulates cell proliferation in the adult zebrafish optic tectum","volume":"243","author":"Dozawa","year":"2014","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.stemcr.2017.04.006_bib7","doi-asserted-by":"crossref","first-page":"ra80","DOI":"10.1126\/scisignal.2001462","article-title":"DNMT1 stability is regulated by proteins coordinating deubiquitination and acetylation-driven ubiquitination","volume":"3","author":"Du","year":"2010","journal-title":"Sci. Signal."},{"key":"10.1016\/j.stemcr.2017.04.006_bib8","doi-asserted-by":"crossref","first-page":"5107","DOI":"10.1074\/jbc.M807745200","article-title":"Cdc42-mTOR signaling pathway controls Hes5 and Pax6 expression in retinoic acid-dependent neural differentiation","volume":"284","author":"Endo","year":"2009","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.stemcr.2017.04.006_bib9","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1038\/ncb3147","article-title":"The histone deacetylase SIRT6 controls embryonic stem cell fate via TET-mediated production of 5-hydroxymethylcytosine","volume":"17","author":"Etchegaray","year":"2015","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.stemcr.2017.04.006_bib10","doi-asserted-by":"crossref","first-page":"3345","DOI":"10.1242\/dev.01912","article-title":"DNA methylation controls the timing of astrogliogenesis through regulation of JAK-STAT signaling","volume":"132","author":"Fan","year":"2005","journal-title":"Development"},{"key":"10.1016\/j.stemcr.2017.04.006_bib11","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1080\/15592294.2015.1055441","article-title":"Epigenetic landscape of amphetamine and methamphetamine addiction in rodents","volume":"10","author":"Godino","year":"2015","journal-title":"Epigenetics"},{"key":"10.1016\/j.stemcr.2017.04.006_bib12","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/j.neuropharm.2010.10.021","article-title":"Epigenetic GABAergic targets in schizophrenia and bipolar disorder","volume":"60","author":"Guidotti","year":"2011","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.stemcr.2017.04.006_bib13","doi-asserted-by":"crossref","first-page":"999","DOI":"10.2353\/ajpath.2009.080537","article-title":"Valproic acid activates the PI3K\/AKT\/mTOR pathway in muscle and ameliorates pathology in a mouse model of Duchenne muscular dystrophy","volume":"174","author":"Gurpur","year":"2009","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.stemcr.2017.04.006_bib14","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.celrep.2013.01.011","article-title":"Dynamics of 5-hydroxymethylcytosine and chromatin marks in mammalian neurogenesis","volume":"3","author":"Hahn","year":"2013","journal-title":"Cell Rep."},{"key":"10.1016\/j.stemcr.2017.04.006_bib15","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.mcn.2008.06.003","article-title":"Mammalian target of rapamycin (mTOR) is involved in the neuronal differentiation of neural progenitors induced by insulin","volume":"39","author":"Han","year":"2008","journal-title":"Mol. Cell Neurosci."},{"key":"10.1016\/j.stemcr.2017.04.006_bib16","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1002\/stem.1932","article-title":"Vitamin C facilitates dopamine neuron differentiation in fetal midbrain through TET1- and JMJD3-dependent epigenetic control manner","volume":"33","author":"He","year":"2015","journal-title":"Stem Cells"},{"key":"10.1016\/j.stemcr.2017.04.006_bib17","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1038\/ng1966","article-title":"Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome","volume":"39","author":"Heintzman","year":"2007","journal-title":"Nat. Genet."},{"key":"10.1016\/j.stemcr.2017.04.006_bib18","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/nrn2810","article-title":"Epigenetic control of neural\u00a0precursor cell fate during development","volume":"11","author":"Hirabayashi","year":"2010","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.stemcr.2017.04.006_bib19","doi-asserted-by":"crossref","first-page":"16659","DOI":"10.1073\/pnas.0407643101","article-title":"Histone deacetylase inhibition-mediated neuronal differentiation of multipotent adult neural progenitor cells","volume":"101","author":"Hsieh","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.stemcr.2017.04.006_bib20","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1038\/nature15713","article-title":"Structural insight into substrate preference for TET-mediated oxidation","volume":"527","author":"Hu","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.stemcr.2017.04.006_bib21","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1016\/j.celrep.2016.01.035","article-title":"5-Hydroxymethylcytosine marks sites of DNA damage and promotes genome stability","volume":"14","author":"Kafer","year":"2016","journal-title":"Cell Rep."},{"key":"10.1016\/j.stemcr.2017.04.006_bib22","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1093\/hmg\/ddt453","article-title":"Dynamic changes in DNA methylation and hydroxymethylation when hES cells undergo differentiation toward a neuronal lineage","volume":"23","author":"Kim","year":"2014","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.stemcr.2017.04.006_bib23","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1126\/science.1169786","article-title":"The nuclear DNA base 5-hydroxymethylcytosine is present in Purkinje neurons and the brain","volume":"324","author":"Kriaucionis","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.stemcr.2017.04.006_bib24","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1124\/mol.108.051763","article-title":"The reelin and GAD67 promoters are activated by epigenetic drugs that facilitate the disruption of local repressor complexes","volume":"75","author":"Kundakovic","year":"2009","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.stemcr.2017.04.006_bib25","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1073\/pnas.1523645113","article-title":"Promoting axon regeneration in the adult CNS by modulation of the melanopsin\/GPCR signaling","volume":"113","author":"Li","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.stemcr.2017.04.006_bib26","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1111\/jcmm.12299","article-title":"Cross-communication between histone H3 and H4 acetylation and AKT-mTOR signalling in prostate cancer cells","volume":"18","author":"Makarevi\u0107","year":"2014","journal-title":"J.\u00a0Cell Mol. Med."},{"key":"10.1016\/j.stemcr.2017.04.006_bib27","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.nbd.2011.02.004","article-title":"Adult neural precursors isolated from post mortem brain yield mostly neurons: an erythropoietin-dependent process","volume":"43","author":"Marfia","year":"2011","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.stemcr.2017.04.006_bib28","doi-asserted-by":"crossref","first-page":"71","DOI":"10.4161\/epi.7.1.18750","article-title":"Role of DNMT3B in the regulation of early neural and neural crest specifiers","volume":"7","author":"Martins-Taylor","year":"2012","journal-title":"Epigenetics"},{"key":"10.1016\/j.stemcr.2017.04.006_bib29","doi-asserted-by":"crossref","first-page":"e04235","DOI":"10.7554\/eLife.04235","article-title":"Polycomb- and REST-associated histone deacetylases are independent pathways toward a mature neuronal phenotype","volume":"3","author":"McGann","year":"2014","journal-title":"Elife"},{"key":"10.1016\/j.stemcr.2017.04.006_bib30","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1146\/annurev.biochem.78.070907.103946","article-title":"Reversal of histone methylation: biochemical and molecular mechanisms of histone demethylases","volume":"79","author":"Mosammaparast","year":"2010","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.stemcr.2017.04.006_bib31","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s40478-015-0184-4","article-title":"Decreased mTOR signaling pathway in human idiopathic autism and in rats exposed to valproic acid","volume":"3","author":"Nicolini","year":"2015","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.stemcr.2017.04.006_bib32","doi-asserted-by":"crossref","first-page":"5018","DOI":"10.1073\/pnas.1604365113","article-title":"Tissue-specific DNA demethylation is required for proper B-cell differentiation and function","volume":"113","author":"Orlanski","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.stemcr.2017.04.006_bib33","doi-asserted-by":"crossref","first-page":"2739","DOI":"10.1242\/jcs.03012","article-title":"Modulation of the PI 3-kinase-AKT signalling pathway by IGF-I and PTEN regulates the differentiation of neural stem\/precursor cells","volume":"119","author":"Otaegi","year":"2006","journal-title":"J.\u00a0Cell Sci."},{"issue":"Suppl 1","key":"10.1016\/j.stemcr.2017.04.006_bib34","doi-asserted-by":"crossref","first-page":"S77","DOI":"10.1016\/S0140-6736(15)60392-0","article-title":"Phosphoinositide 3-kinase-related overgrowth: cellular phenotype and future therapeutic options","volume":"385","author":"Parker","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.stemcr.2017.04.006_bib35","doi-asserted-by":"crossref","first-page":"2508","DOI":"10.1074\/jbc.M114.603761","article-title":"Dual roles of histone H3 lysine 9 acetylation in human embryonic stem cell pluripotency and neural differentiation","volume":"290","author":"Qiao","year":"2015","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.stemcr.2017.04.006_bib36","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.mcn.2016.06.004","article-title":"Valproic acid exposure sequentially activates Wnt and mTOR pathways in rats","volume":"75","author":"Qin","year":"2016","journal-title":"Mol. Cell Neurosci."},{"key":"10.1016\/j.stemcr.2017.04.006_bib37","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.cell.2013.09.011","article-title":"Mapping human epigenomes","volume":"155","author":"Rivera","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.stemcr.2017.04.006_bib38","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1002\/cbin.10179","article-title":"Inhibition of mTOR signalling potentiates the effects of trichostatin A in human gastric cancer cell lines by promoting histone acetylation","volume":"38","author":"Sun","year":"2014","journal-title":"Cell Biol. Int."},{"key":"10.1016\/j.stemcr.2017.04.006_bib39","doi-asserted-by":"crossref","first-page":"3806","DOI":"10.1242\/dev.082198","article-title":"Essential roles of the histone methyltransferase ESET in the epigenetic control of neural progenitor cells during development","volume":"139","author":"Tan","year":"2012","journal-title":"Development"},{"key":"10.1016\/j.stemcr.2017.04.006_bib40","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.mce.2013.12.008","article-title":"Valproic acid enhances Oct4 promoter activity through PI3K\/AKT\/mTOR pathway activated nuclear receptors","volume":"383","author":"Teng","year":"2014","journal-title":"Mol. Cell Endocrinol."},{"key":"10.1016\/j.stemcr.2017.04.006_bib41","doi-asserted-by":"crossref","first-page":"13259","DOI":"10.1523\/JNEUROSCI.2334-14.2014","article-title":"The timing of upper-layer neurogenesis is conferred by sequential derepression and negative feedback from deep-layer neurons","volume":"34","author":"Toma","year":"2014","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.stemcr.2017.04.006_bib42","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.immuni.2008.12.009","article-title":"Global mapping of H3K4me3 and H3K27me3 reveals specificity and plasticity in lineage fate determination of differentiating CD4+ T\u00a0cells","volume":"30","author":"Wei","year":"2009","journal-title":"Immunity"},{"key":"10.1016\/j.stemcr.2017.04.006_bib43","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/s10549-014-2877-y","article-title":"mTORC1\/C2 and pan-HDAC inhibitors synergistically impair breast cancer growth by convergent AKT and polysome inhibiting mechanisms","volume":"144","author":"Wilson-Edell","year":"2014","journal-title":"Breast Cancer Res. Treat."},{"key":"10.1016\/j.stemcr.2017.04.006_bib44","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1126\/science.1190485","article-title":"Dnmt3a-dependent nonpromoter DNA methylation facilitates transcription of neurogenic genes","volume":"329","author":"Wu","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.stemcr.2017.04.006_bib45","doi-asserted-by":"crossref","first-page":"1826","DOI":"10.3892\/ol.2016.4880","article-title":"Valproic acid induces autophagy by suppressing the AKT\/mTOR pathway in human prostate cancer cells","volume":"12","author":"Xia","year":"2016","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.stemcr.2017.04.006_bib46","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.neuropharm.2008.09.019","article-title":"Valproic acid promotes neuronal differentiation by induction of proneural factors in association with H4 acetylation","volume":"56","author":"Yu","year":"2009","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.stemcr.2017.04.006_bib47","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.stem.2013.05.006","article-title":"Tet1 regulates adult hippocampal neurogenesis and cognition","volume":"13","author":"Zhang","year":"2013","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.stemcr.2017.04.006_bib48","doi-asserted-by":"crossref","first-page":"5605","DOI":"10.1073\/pnas.0910578107","article-title":"Epigenetic alterations regulate estradiol-induced enhancement of memory consolidation","volume":"107","author":"Zhao","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"}],"container-title":["Stem Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213671117301601?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213671117301601?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T09:39:43Z","timestamp":1761989983000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213671117301601"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5]]},"references-count":48,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,5]]}},"alternative-id":["S2213671117301601"],"URL":"https:\/\/doi.org\/10.1016\/j.stemcr.2017.04.006","relation":{},"ISSN":["2213-6711"],"issn-type":[{"value":"2213-6711","type":"print"}],"subject":[],"published":{"date-parts":[[2017,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"PI3K\/AKT\/mTOR Signaling Mediates Valproic Acid-Induced Neuronal Differentiation of Neural Stem Cells through Epigenetic Modifications","name":"articletitle","label":"Article Title"},{"value":"Stem Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.stemcr.2017.04.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 The Authors.","name":"copyright","label":"Copyright"}]}}