{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T12:30:25Z","timestamp":1770813025908,"version":"3.50.1"},"reference-count":42,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T00:00:00Z","timestamp":1501545600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T00:00:00Z","timestamp":1501545600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2017,6,27]],"date-time":"2017-06-27T00:00:00Z","timestamp":1498521600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK2011029"],"award-info":[{"award-number":["BK2011029"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20140366"],"award-info":[{"award-number":["BK20140366"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20140964"],"award-info":[{"award-number":["BK20140964"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010257","name":"Collaborative Innovation Center for Cardiovascular Disease Translational Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010257","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["R01AA022377"],"award-info":[{"award-number":["R01AA022377"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2016YFC1306703"],"award-info":[{"award-number":["2016YFC1306703"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000965","name":"American Federation for Aging Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000965","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001391","name":"Whitehall Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001391","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31530091"],"award-info":[{"award-number":["31530091"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81370033"],"award-info":[{"award-number":["81370033"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81571269"],"award-info":[{"award-number":["81571269"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81572891"],"award-info":[{"award-number":["81572891"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["91232304"],"award-info":[{"award-number":["91232304"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Stem Cell Reports"],"published-print":{"date-parts":[[2017,8]]},"DOI":"10.1016\/j.stemcr.2017.06.014","type":"journal-article","created":{"date-parts":[[2017,7,27]],"date-time":"2017-07-27T14:32:09Z","timestamp":1501165929000},"page":"543-556","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":40,"title":["Hippocampal TERT Regulates Spatial Memory Formation through Modulation of Neural Development"],"prefix":"10.1016","volume":"9","author":[{"given":"Qi-Gang","family":"Zhou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng-Ying","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han-Woong","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fuyuki","family":"Ishikawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sushil","family":"Devkota","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin-Ru","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hai-Yin","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhigang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xun","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hai-Hui","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun Jeoung","family":"Ro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Hui","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hoonkyo","family":"Suh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong-Ya","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.stemcr.2017.06.014_bib1","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.cell.2006.12.021","article-title":"Trekking across the brain: the journey of neuronal migration","volume":"128","author":"Ayala","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.stemcr.2017.06.014_bib2","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/S0092-8674(01)00492-5","article-title":"Switching and signaling at the telomere","volume":"106","author":"Blackburn","year":"2001","journal-title":"Cell"},{"key":"10.1016\/j.stemcr.2017.06.014_bib3","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1515\/REVNEURO.2007.18.2.93","article-title":"Adult hippocampal neurogenesis, synaptic plasticity and memory: facts and hypotheses","volume":"18","author":"Bruel-Jungerman","year":"2007","journal-title":"Rev. Neurosci."},{"key":"10.1016\/j.stemcr.2017.06.014_bib4","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.conb.2010.12.002","article-title":"Wnt signaling during synaptic development and plasticity","volume":"21","author":"Budnik","year":"2011","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.stemcr.2017.06.014_bib5","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1006\/dbio.2002.0828","article-title":"Properties of a fetal multipotent neural stem cell (NEP cell)","volume":"251","author":"Cai","year":"2002","journal-title":"Dev. Biol."},{"key":"10.1016\/j.stemcr.2017.06.014_bib6","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/S1044-7431(03)00103-9","article-title":"Telomerase activity in the subventricular zone of adult mice","volume":"23","author":"Caporaso","year":"2003","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.stemcr.2017.06.014_bib7","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/S0165-0173(01)00067-4","article-title":"Applications of the Morris water maze in the study of learning and memory","volume":"36","author":"D'Hooge","year":"2001","journal-title":"Brain Res. Brain Res. Rev."},{"key":"10.1016\/j.stemcr.2017.06.014_bib8","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1038\/nrn2822","article-title":"New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory?","volume":"11","author":"Deng","year":"2010","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.stemcr.2017.06.014_bib9","doi-asserted-by":"crossref","first-page":"8233","DOI":"10.1073\/pnas.0601992103","article-title":"Fluoxetine targets early progenitor cells in the adult brain","volume":"103","author":"Encinas","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.stemcr.2017.06.014_bib10","doi-asserted-by":"crossref","first-page":"4059","DOI":"10.1242\/dev.01215","article-title":"Telomere shortening and chromosomal instability abrogates proliferation of adult but not embryonic neural stem cells","volume":"131","author":"Ferron","year":"2004","journal-title":"Development"},{"key":"10.1016\/j.stemcr.2017.06.014_bib11","doi-asserted-by":"crossref","first-page":"14394","DOI":"10.1523\/JNEUROSCI.3836-09.2009","article-title":"Telomere shortening in neural stem cells disrupts neuronal differentiation and neuritogenesis","volume":"29","author":"Ferron","year":"2009","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.stemcr.2017.06.014_bib12","doi-asserted-by":"crossref","first-page":"14317","DOI":"10.1523\/JNEUROSCI.3206-07.2007","article-title":"Conditional knock-out of beta-catenin in postnatal-born dentate gyrus granule neurons results in dendritic malformation","volume":"27","author":"Gao","year":"2007","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.stemcr.2017.06.014_bib13","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/nature07925","article-title":"HDAC2 negatively regulates memory formation and synaptic plasticity","volume":"459","author":"Guan","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.stemcr.2017.06.014_bib14","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1038\/nrc2275","article-title":"Telomerase and cancer therapeutics","volume":"8","author":"Harley","year":"2008","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.stemcr.2017.06.014_bib15","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1126\/science.1218370","article-title":"Wnt\/beta-catenin signaling regulates telomerase in stem cells and cancer cells","volume":"336","author":"Hoffmeyer","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.stemcr.2017.06.014_bib16","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0079-6123(07)63006-4","article-title":"Mossy fiber synaptic transmission: communication from the dentate gyrus to area CA3","volume":"163","author":"Jaffe","year":"2007","journal-title":"Prog. Brain Res."},{"key":"10.1016\/j.stemcr.2017.06.014_bib17","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1038\/nature09603","article-title":"Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice","volume":"469","author":"Jaskelioff","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.stemcr.2017.06.014_bib18","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1002\/jnr.21829","article-title":"Chronic fluoxetine treatment improves ischemia-induced spatial cognitive deficits through increasing hippocampal neurogenesis after stroke","volume":"87","author":"Li","year":"2009","journal-title":"J.\u00a0Neurosci. Res."},{"key":"10.1016\/j.stemcr.2017.06.014_bib19","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/nrn1867","article-title":"Adult neurogenesis and functional plasticity in neuronal circuits","volume":"7","author":"Lledo","year":"2006","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.stemcr.2017.06.014_bib20","doi-asserted-by":"crossref","first-page":"1872","DOI":"10.1111\/j.1471-4159.2007.04915.x","article-title":"Reduced neuronal nitric oxide synthase is involved in ischemia-induced hippocampal neurogenesis by up-regulating inducible nitric oxide synthase expression","volume":"103","author":"Luo","year":"2007","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.stemcr.2017.06.014_bib21","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.neuron.2011.05.001","article-title":"Adult neurogenesis in the mammalian brain: significant answers and significant questions","volume":"70","author":"Ming","year":"2011","journal-title":"Neuron"},{"key":"10.1016\/j.stemcr.2017.06.014_bib22","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1073\/pnas.1013004108","article-title":"Mouse telomerase reverse transcriptase (mTert) expression marks slowly cycling intestinal stem cells","volume":"108","author":"Montgomery","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.stemcr.2017.06.014_bib23","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.cell.2012.01.046","article-title":"Young dentate granule cells mediate pattern separation, whereas old granule cells facilitate pattern completion","volume":"149","author":"Nakashiba","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.stemcr.2017.06.014_bib24","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/nrm3505","article-title":"Finding the end: recruitment of telomerase to telomeres","volume":"14","author":"Nandakumar","year":"2013","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.stemcr.2017.06.014_bib25","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1038\/nrn2303","article-title":"Synaptic plasticity, memory and the hippocampus: a neural network approach to causality","volume":"9","author":"Neves","year":"2008","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.stemcr.2017.06.014_bib26","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1038\/nprot.2013.094","article-title":"Design and generation of recombinant rabies virus vectors","volume":"8","author":"Osakada","year":"2013","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.stemcr.2017.06.014_bib27","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.neuron.2011.07.005","article-title":"New rabies virus variants for monitoring and manipulating activity and gene expression in defined neural circuits","volume":"71","author":"Osakada","year":"2011","journal-title":"Neuron"},{"key":"10.1016\/j.stemcr.2017.06.014_bib28","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1038\/nature08137","article-title":"Telomerase modulates Wnt signalling by association with target gene chromatin","volume":"460","author":"Park","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.stemcr.2017.06.014_bib29","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1084\/jem.190.2.157","article-title":"Telomere fluorescence measurements in granulocytes and T lymphocyte subsets point to a high turnover of hematopoietic stem cells and memory T\u00a0cells in early childhood","volume":"190","author":"Rufer","year":"1999","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.stemcr.2017.06.014_bib30","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1038\/nature08982","article-title":"Linking functional decline of telomeres, mitochondria and stem cells during ageing","volume":"464","author":"Sahin","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.stemcr.2017.06.014_bib31","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1126\/science.1083328","article-title":"Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants","volume":"301","author":"Santarelli","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.stemcr.2017.06.014_bib32","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1038\/nature03836","article-title":"Conditional telomerase induction causes proliferation of hair follicle stem cells","volume":"436","author":"Sarin","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.stemcr.2017.06.014_bib33","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1126\/science.1174519","article-title":"Molecular and cellular approaches to memory allocation in neural circuits","volume":"326","author":"Silva","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.stemcr.2017.06.014_bib34","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1162\/jocn.1992.4.3.232","article-title":"Declarative and nondeclarative memory: multiple brain systems supporting learning and memory","volume":"4","author":"Squire","year":"1992","journal-title":"J.\u00a0Cogn. Neurosci."},{"key":"10.1016\/j.stemcr.2017.06.014_bib35","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1037\/0033-295X.99.2.195","article-title":"Memory and the hippocampus: a synthesis from findings with rats, monkeys, and humans","volume":"99","author":"Squire","year":"1992","journal-title":"Psychol. Rev."},{"key":"10.1016\/j.stemcr.2017.06.014_bib36","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1126\/science.2506642","article-title":"Synapsins: mosaics of shared and individual domains in a family of synaptic vesicle phosphoproteins","volume":"245","author":"Sudhof","year":"1989","journal-title":"Science"},{"key":"10.1016\/j.stemcr.2017.06.014_bib37","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1038\/ncomms2101","article-title":"Monosynaptic inputs to new neurons in the dentate gyrus","volume":"3","author":"Vivar","year":"2012","journal-title":"Nat. Commun."},{"key":"10.1016\/j.stemcr.2017.06.014_bib38","doi-asserted-by":"crossref","first-page":"31","DOI":"10.2174\/157488807779317062","article-title":"Telomerase activation in\u00a0liver regeneration and hepatocarcinogenesis: Dr. Jekyll or Mr.\u00a0Hyde?","volume":"2","author":"Wege","year":"2007","journal-title":"Curr. Stem Cell Res. Ther."},{"key":"10.1016\/j.stemcr.2017.06.014_bib39","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1046\/j.1365-2443.1999.00284.x","article-title":"Presence of telomeric G-strand tails in the telomerase catalytic subunit TERT knockout mice","volume":"4","author":"Yuan","year":"1999","journal-title":"Genes Cells"},{"key":"10.1016\/j.stemcr.2017.06.014_bib40","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.cell.2008.01.033","article-title":"Mechanisms and functional implications of adult neurogenesis","volume":"132","author":"Zhao","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.stemcr.2017.06.014_bib41","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.cell.2009.05.026","article-title":"Telomere extension occurs at most chromosome ends and is uncoupled from fill-in in human cancer cells","volume":"138","author":"Zhao","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.stemcr.2017.06.014_bib42","doi-asserted-by":"crossref","first-page":"12258","DOI":"10.1523\/JNEUROSCI.0805-11.2011","article-title":"Hippocampal telomerase is involved in the modulation of depressive behaviors","volume":"31","author":"Zhou","year":"2011","journal-title":"J.\u00a0Neurosci."}],"container-title":["Stem Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213671117302771?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213671117302771?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T09:39:45Z","timestamp":1761989985000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213671117302771"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8]]},"references-count":42,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,8]]}},"alternative-id":["S2213671117302771"],"URL":"https:\/\/doi.org\/10.1016\/j.stemcr.2017.06.014","relation":{},"ISSN":["2213-6711"],"issn-type":[{"value":"2213-6711","type":"print"}],"subject":[],"published":{"date-parts":[[2017,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hippocampal TERT Regulates Spatial Memory Formation through Modulation of Neural Development","name":"articletitle","label":"Article Title"},{"value":"Stem Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.stemcr.2017.06.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 The Authors.","name":"copyright","label":"Copyright"}]}}