{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T13:57:25Z","timestamp":1787579845442,"version":"build-2736575974"},"reference-count":31,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2017,8,28]],"date-time":"2017-08-28T00:00:00Z","timestamp":1503878400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100017357","name":"Science and Technology Projects of Fujian Province","doi-asserted-by":"publisher","award":["20140520013JH"],"award-info":[{"award-number":["20140520013JH"]}],"id":[{"id":"10.13039\/100017357","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81200397"],"award-info":[{"award-number":["81200397"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81273334"],"award-info":[{"award-number":["81273334"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81422026"],"award-info":[{"award-number":["81422026"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81501279"],"award-info":[{"award-number":["81501279"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81570145"],"award-info":[{"award-number":["81570145"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81571798"],"award-info":[{"award-number":["81571798"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002338","name":"Ministry of Education of the People's Republic of China","doi-asserted-by":"publisher","award":["IRT1133"],"award-info":[{"award-number":["IRT1133"]}],"id":[{"id":"10.13039\/501100002338","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["2013CB966900"],"award-info":[{"award-number":["2013CB966900"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["2014AA021601"],"award-info":[{"award-number":["2014AA021601"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["2015CB964400"],"award-info":[{"award-number":["2015CB964400"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P01AI045897"],"award-info":[{"award-number":["P01AI045897"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AI064569"],"award-info":[{"award-number":["R01AI064569"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Stem Cell Reports"],"published-print":{"date-parts":[[2017,10]]},"DOI":"10.1016\/j.stemcr.2017.08.018","type":"journal-article","created":{"date-parts":[[2017,9,29]],"date-time":"2017-09-29T01:07:05Z","timestamp":1506647225000},"page":"1034-1042","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"title":["Complement Depletion Improves Human Red Blood Cell Reconstitution in Immunodeficient Mice"],"prefix":"10.1016","volume":"9","author":[{"given":"Bing","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siwen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang","family":"Shu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoqing","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianmeng","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-Guang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.stemcr.2017.08.018_bib1","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.2337\/diab.42.11.1574","article-title":"Complement lytic activity has no role in the pathogenesis of autoimmune diabetes in NOD mice","volume":"42","author":"Baxter","year":"1993","journal-title":"Diabetes"},{"key":"10.1016\/j.stemcr.2017.08.018_bib2","doi-asserted-by":"crossref","first-page":"21783","DOI":"10.1073\/pnas.0912274106","article-title":"Expression of human cytokines dramatically improves reconstitution of specific human-blood lineage cells in humanized mice","volume":"106","author":"Chen","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.stemcr.2017.08.018_bib3","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.blre.2013.04.003","article-title":"Hereditary spherocytosis, elliptocytosis, and other red cell membrane disorders","volume":"27","author":"Da Costa","year":"2013","journal-title":"Blood Rev."},{"issue":"Pt 3","key":"10.1016\/j.stemcr.2017.08.018_bib4","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1242\/jcs.108.3.967","article-title":"Phagocytosis of apoptotic bodies by liver endothelial cells","volume":"108","author":"Dini","year":"1995","journal-title":"J.\u00a0Cell Sci."},{"key":"10.1016\/j.stemcr.2017.08.018_bib5","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1182\/blood.V96.3.823","article-title":"Erythropoietin, iron, and erythropoiesis","volume":"96","author":"Goodnough","year":"2000","journal-title":"Blood"},{"key":"10.1016\/j.stemcr.2017.08.018_bib6","doi-asserted-by":"crossref","first-page":"2977","DOI":"10.4049\/jimmunol.152.6.2977","article-title":"Immunoreactivity and function of oligosaccharides in cobra venom factor","volume":"152","author":"Gowda","year":"1994","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.stemcr.2017.08.018_bib7","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.4049\/jimmunol.182.3.1756","article-title":"Anti-endothelial antibodies interfere in apoptotic cell clearance and promote thrombosis in patients with antiphospholipid syndrome","volume":"182","author":"Graham","year":"2009","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.stemcr.2017.08.018_bib8","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.molimm.2012.01.010","article-title":"Complement regulator C4BP binds to Staphylococcus aureus and decreases opsonization","volume":"50","author":"Hair","year":"2012","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.stemcr.2017.08.018_bib9","doi-asserted-by":"crossref","first-page":"5938","DOI":"10.1182\/blood-2010-11-321414","article-title":"Macrophages prevent human red blood cell reconstitution in immunodeficient mice","volume":"118","author":"Hu","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.stemcr.2017.08.018_bib10","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/cmi.2011.63","article-title":"Human lymphohematopoietic reconstitution and immune function in immunodeficient mice receiving cotransplantation of human thymic tissue and CD34+ cells","volume":"9","author":"Hu","year":"2012","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.stemcr.2017.08.018_bib11","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1182\/blood-2012-01-407890","article-title":"Full reconstitution of human platelets in humanized mice after macrophage depletion","volume":"120","author":"Hu","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.stemcr.2017.08.018_bib12","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1038\/cmi.2015.92","article-title":"Antithymocyte globulin treatment at the time of transplantation impairs donor hematopoietic stem cell engraftment","volume":"14","author":"Jin","year":"2017","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.stemcr.2017.08.018_bib13","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1172\/JCI36088","article-title":"C3b deposition on human erythrocytes induces the formation of a membrane skeleton-linked protein complex","volume":"119","author":"Karnchanaphanurach","year":"2009","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.stemcr.2017.08.018_bib14","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1182\/blood-2005-11-4388","article-title":"Reconstitution of a functional human immune system in immunodeficient mice through combined human fetal thymus\/liver and CD34+ cell transplantation","volume":"108","author":"Lan","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.stemcr.2017.08.018_bib15","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1128\/IAI.00613-07","article-title":"Defining targets for complement components C4b and C3b on the pathogenic neisseriae","volume":"76","author":"Lewis","year":"2008","journal-title":"Infect. Immun."},{"key":"10.1016\/j.stemcr.2017.08.018_bib16","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1084\/jem.184.4.1225","article-title":"Interaction between complement proteins C5b-7 and erythrocyte membrane sialic acid","volume":"184","author":"Marshall","year":"1996","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.stemcr.2017.08.018_bib17","doi-asserted-by":"crossref","first-page":"3044","DOI":"10.4049\/jimmunol.173.5.3044","article-title":"Opsonization with C1q and mannose-binding lectin targets apoptotic cells to dendritic cells","volume":"173","author":"Nauta","year":"2004","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.stemcr.2017.08.018_bib18","doi-asserted-by":"crossref","first-page":"3","DOI":"10.3389\/fphys.2014.00003","article-title":"Primitive and definitive erythropoiesis in mammals","volume":"5","author":"Palis","year":"2014","journal-title":"Front. Physiol."},{"key":"10.1016\/j.stemcr.2017.08.018_bib19","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1172\/JCI111472","article-title":"Increased efficiency of binding of nascent C3b to the erythrocytes of chronic cold agglutinin disease","volume":"74","author":"Parker","year":"1984","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.stemcr.2017.08.018_bib20","doi-asserted-by":"crossref","first-page":"4628","DOI":"10.1091\/mbc.e08-02-0223","article-title":"Membrane ruffles capture C3bi-opsonized particles in activated macrophages","volume":"19","author":"Patel","year":"2008","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.stemcr.2017.08.018_bib21","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/1475-2875-10-91","article-title":"Automated counting for Plasmodium falciparum cytoadherence experiments","volume":"10","author":"Paton","year":"2011","journal-title":"Malar. J."},{"key":"10.1016\/j.stemcr.2017.08.018_bib22","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.stemcr.2016.08.005","article-title":"Improved human erythropoiesis and platelet formation in humanized NSGW41 mice","volume":"7","author":"Rahmig","year":"2016","journal-title":"Stem Cell Reports"},{"key":"10.1016\/j.stemcr.2017.08.018_bib23","doi-asserted-by":"crossref","first-page":"2018","DOI":"10.1016\/S0140-6736(10)61029-X","article-title":"Sickle-cell disease","volume":"376","author":"Rees","year":"2010","journal-title":"Lancet"},{"key":"10.1016\/j.stemcr.2017.08.018_bib24","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1146\/annurev-immunol-032712-095921","article-title":"Human hemato-lymphoid system mice: current use and future potential for medicine","volume":"31","author":"Rongvaux","year":"2013","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.stemcr.2017.08.018_bib25","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/nm.3814","article-title":"Anemia: progress in molecular mechanisms and therapies","volume":"21","author":"Sankaran","year":"2015","journal-title":"Nat. Med."},{"key":"10.1016\/j.stemcr.2017.08.018_bib26","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1038\/nature20565","article-title":"In\u00a0vivo genome editing via CRISPR\/Cas9 mediated homology-independent targeted integration","volume":"540","author":"Suzuki","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.stemcr.2017.08.018_bib27","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1038\/ni1527","article-title":"Polymorphism in Sirpa modulates engraftment of human hematopoietic stem cells","volume":"8","author":"Takenaka","year":"2007","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.stemcr.2017.08.018_bib28","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1182\/blood.V95.2.683","article-title":"Loxosceles intermedia spider envenomation induces activation of an endogenous metalloproteinase, resulting in cleavage of glycophorins from the erythrocyte surface and facilitating complement-mediated lysis","volume":"95","author":"Tambourgi","year":"2000","journal-title":"Blood"},{"key":"10.1016\/j.stemcr.2017.08.018_bib29","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/0022-1759(94)90012-4","article-title":"Liposome mediated depletion of macrophages: mechanism of action, preparation of liposomes and applications","volume":"174","author":"Van Rooijen","year":"1994","journal-title":"J.\u00a0Immunol. Methods"},{"key":"10.1016\/j.stemcr.2017.08.018_bib30","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/nri2099","article-title":"Xenotransplantation: current status and a perspective on the future","volume":"7","author":"Yang","year":"2007","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.stemcr.2017.08.018_bib31","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/cmi2015.34","article-title":"Neutrophil sensing of cytoplasmic, pathogenic DNA in a cGAS-STING-independent manner","volume":"13","author":"Yu","year":"2016","journal-title":"Cell. Mol. Immunol."}],"container-title":["Stem Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213671117303752?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213671117303752?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T09:38:48Z","timestamp":1761989928000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213671117303752"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10]]},"references-count":31,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["S2213671117303752"],"URL":"https:\/\/doi.org\/10.1016\/j.stemcr.2017.08.018","relation":{},"ISSN":["2213-6711"],"issn-type":[{"value":"2213-6711","type":"print"}],"subject":[],"published":{"date-parts":[[2017,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Complement Depletion Improves Human Red Blood Cell Reconstitution in Immunodeficient Mice","name":"articletitle","label":"Article Title"},{"value":"Stem Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.stemcr.2017.08.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 The Authors.","name":"copyright","label":"Copyright"}]}}