{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:40:47Z","timestamp":1792784447327,"version":"4.5.0"},"reference-count":67,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,8,29]],"date-time":"2017-08-29T00:00:00Z","timestamp":1503964800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01AG036884"],"award-info":[{"award-number":["R01AG036884"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01AG051390"],"award-info":[{"award-number":["R01AG051390"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["K08EY023610"],"award-info":[{"award-number":["K08EY023610"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["K01AG046374"],"award-info":[{"award-number":["K01AG046374"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Rainwater Foundation"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Stem Cell Reports"],"published-print":{"date-parts":[[2017,10]]},"DOI":"10.1016\/j.stemcr.2017.08.019","type":"journal-article","created":{"date-parts":[[2017,9,29]],"date-time":"2017-09-29T01:07:59Z","timestamp":1506647279000},"page":"1221-1233","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":446,"title":["Scalable Production of iPSC-Derived Human Neurons to Identify Tau-Lowering Compounds by High-Content Screening"],"prefix":"10.1016","volume":"9","author":[{"given":"Chao","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael E.","family":"Ward","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tara E.","family":"Tracy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter Dongmin","family":"Sohn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Connor","family":"Ludwig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anke","family":"Meyer-Franke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celeste M.","family":"Karch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Gan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.stemcr.2017.08.019_bib1","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.biopsych.2013.02.027","article-title":"Allosteric heat shock protein 70 inhibitors rapidly rescue synaptic plasticity deficits by reducing aberrant tau","volume":"74","author":"Abisambra","year":"2013","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.stemcr.2017.08.019_bib2","doi-asserted-by":"crossref","first-page":"745","DOI":"10.2174\/1386207043328256","article-title":"High throughput screening of beta-amyloid secretion inhibitors using homogenous time-resolved fluorescence","volume":"7","author":"Albrecht","year":"2004","journal-title":"Comb. Chem. High Throughput Screen."},{"key":"10.1016\/j.stemcr.2017.08.019_bib3","doi-asserted-by":"crossref","first-page":"1239882","DOI":"10.1126\/science.1239882","article-title":"Development-inspired reprogramming of the mammalian central nervous system","volume":"343","author":"Amamoto","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.stemcr.2017.08.019_bib4","doi-asserted-by":"crossref","first-page":"5446","DOI":"10.1523\/JNEUROSCI.4637-04.2005","article-title":"Cell-cycle reentry and cell death in transgenic mice expressing nonmutant human tau isoforms","volume":"25","author":"Andorfer","year":"2005","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.stemcr.2017.08.019_bib5","doi-asserted-by":"crossref","first-page":"13707","DOI":"10.1523\/JNEUROSCI.4040-10.2010","article-title":"Apolipoprotein E4 causes age- and Tau-dependent impairment of GABAergic interneurons, leading to learning and memory deficits in mice","volume":"30","author":"Andrews-Zwilling","year":"2010","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.stemcr.2017.08.019_bib6","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1093\/hmg\/8.4.711","article-title":"Association of an extended haplotype in the tau gene with progressive supranuclear palsy","volume":"8","author":"Baker","year":"1999","journal-title":"Hum. Mol. Genet."},{"issue":"Suppl 2","key":"10.1016\/j.stemcr.2017.08.019_bib7","doi-asserted-by":"crossref","first-page":"127","DOI":"10.3233\/JAD-2011-110161","article-title":"Tau transgenic mice as models for cerebrospinal fluid tau biomarkers","volume":"24","author":"Barten","year":"2011","journal-title":"J.\u00a0Alzheimers Dis."},{"key":"10.1016\/j.stemcr.2017.08.019_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-3-319-12679-1_1","article-title":"Neuroanatomy and pathology of sporadic Alzheimer's disease","volume":"215","author":"Braak","year":"2015","journal-title":"Adv. Anat. Embryol. Cell Biol."},{"key":"10.1016\/j.stemcr.2017.08.019_bib9","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1097\/NEN.0b013e318232a379","article-title":"Stages of the pathologic process in Alzheimer disease: age categories from 1 to 100 years","volume":"70","author":"Braak","year":"2011","journal-title":"J.\u00a0Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.stemcr.2017.08.019_bib10","doi-asserted-by":"crossref","first-page":"2726","DOI":"10.1016\/j.neurobiolaging.2014.06.011","article-title":"Administration of a selective beta2 adrenergic receptor antagonist exacerbates neuropathology and cognitive deficits in a mouse model of Alzheimer's disease","volume":"35","author":"Branca","year":"2014","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.stemcr.2017.08.019_bib11","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1177\/1087057103258285","article-title":"Improved statistical methods for hit selection in high-throughput screening","volume":"8","author":"Brideau","year":"2003","journal-title":"J.\u00a0Biomol. Screen."},{"key":"10.1016\/j.stemcr.2017.08.019_bib12","doi-asserted-by":"crossref","first-page":"393","DOI":"10.3233\/JAD-2008-14406","article-title":"Evidence that non-fibrillar tau causes pathology linked to neurodegeneration and behavioral impairments","volume":"14","author":"Brunden","year":"2008","journal-title":"J.\u00a0Alzheimers Dis."},{"key":"10.1016\/j.stemcr.2017.08.019_bib13","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1038\/nrd2959","article-title":"Advances in tau-focused drug discovery for Alzheimer's disease and related tauopathies","volume":"8","author":"Brunden","year":"2009","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.stemcr.2017.08.019_bib14","doi-asserted-by":"crossref","first-page":"760","DOI":"10.15252\/msb.20145508","article-title":"Rapid neurogenesis through transcriptional activation in human stem cells","volume":"10","author":"Busskamp","year":"2014","journal-title":"Mol. Syst. Biol."},{"key":"10.1016\/j.stemcr.2017.08.019_bib15","doi-asserted-by":"crossref","first-page":"e0116032","DOI":"10.1371\/journal.pone.0116032","article-title":"Transcription activator-like effector nuclease (TALEN)-mediated CLYBL targeting enables enhanced transgene expression and one-step generation of dual reporter human induced pluripotent stem cell (iPSC) and neural stem cell (NSC) lines","volume":"10","author":"Cerbini","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.stemcr.2017.08.019_bib16","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.stemcr.2014.05.020","article-title":"Generation of induced neuronal cells by the single reprogramming factor ASCL1","volume":"3","author":"Chanda","year":"2014","journal-title":"Stem Cell Reports"},{"key":"10.1016\/j.stemcr.2017.08.019_bib17","doi-asserted-by":"crossref","first-page":"609","DOI":"10.4161\/auto.19048","article-title":"Methylthioninium chloride (methylene blue) induces autophagy and attenuates tauopathy in\u00a0vitro and in\u00a0vivo","volume":"8","author":"Congdon","year":"2012","journal-title":"Autophagy"},{"key":"10.1016\/j.stemcr.2017.08.019_bib18","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1080\/15476278.2015.1011921","article-title":"Large-scale generation of human iPSC-derived neural stem cells\/early neural progenitor cells and their neuronal differentiation","volume":"10","author":"D'Aiuto","year":"2014","journal-title":"Organogenesis"},{"key":"10.1016\/j.stemcr.2017.08.019_bib19","doi-asserted-by":"crossref","first-page":"679","DOI":"10.2174\/15672050113109990143","article-title":"A high-throughput screening assay for determining cellular levels of total tau protein","volume":"10","author":"Dehdashti","year":"2013","journal-title":"Curr. Alzheimer Res."},{"key":"10.1016\/j.stemcr.2017.08.019_bib20","doi-asserted-by":"crossref","first-page":"12887","DOI":"10.1523\/JNEUROSCI.2107-13.2013","article-title":"Antisense reduction of tau in adult mice protects against seizures","volume":"33","author":"DeVos","year":"2013","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.stemcr.2017.08.019_bib21","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1750-1326-1-6","article-title":"Pharmacologic reductions of total tau levels; implications for the role of microtubule dynamics in regulating tau expression","volume":"1","author":"Dickey","year":"2006","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.stemcr.2017.08.019_bib22","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1111\/bph.12201","article-title":"Identification through high-throughput screening of 4\u2032-methoxyflavone and 3\u2032,4\u2032-dimethoxyflavone as novel neuroprotective inhibitors of parthanatos","volume":"169","author":"Fatokun","year":"2013","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.stemcr.2017.08.019_bib23","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1073\/pnas.85.4.1292","article-title":"Norepinephrine inhibits gamma-interferon-induced major histocompatibility class II (Ia) antigen expression on cultured astrocytes via beta-2-adrenergic signal transduction mechanisms","volume":"85","author":"Frohman","year":"1988","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.stemcr.2017.08.019_bib24","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1111\/nan.12192","article-title":"Invited review: drug development for tauopathies","volume":"41","author":"Gruninger","year":"2015","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"10.1016\/j.stemcr.2017.08.019_bib25","doi-asserted-by":"crossref","first-page":"6","DOI":"10.2174\/2213988501509010006","article-title":"A facile method for simultaneously measuring neuronal cell viability and neurite outgrowth","volume":"9","author":"K Hancock","year":"2015","journal-title":"Curr. Chem. Genom. Transl. Med."},{"key":"10.1016\/j.stemcr.2017.08.019_bib26","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.neuro.2012.10.013","article-title":"Use of high content image analyses to detect chemical-mediated effects on neurite sub-populations in primary rat cortical neurons","volume":"34","author":"Harrill","year":"2013","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.stemcr.2017.08.019_bib27","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1038\/mt.2011.135","article-title":"Rapid and efficient generation of functional motor neurons from human pluripotent stem cells using gene delivered transcription factor codes","volume":"19","author":"Hester","year":"2011","journal-title":"Mol. Ther."},{"key":"10.1016\/j.stemcr.2017.08.019_bib28","doi-asserted-by":"crossref","first-page":"e52389","DOI":"10.1371\/journal.pone.0052389","article-title":"Methylene blue reduced abnormal tau accumulation in P301L tau transgenic mice","volume":"7","author":"Hosokawa","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.stemcr.2017.08.019_bib29","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.cell.2010.06.036","article-title":"Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer's disease mouse models","volume":"142","author":"Ittner","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.stemcr.2017.08.019_bib30","first-page":"e3452","article-title":"High content screening in neurodegenerative diseases","author":"Jain","year":"2012","journal-title":"J.\u00a0Vis. Exp."},{"key":"10.1016\/j.stemcr.2017.08.019_bib31","doi-asserted-by":"crossref","first-page":"2352","DOI":"10.1074\/jbc.270.5.2352","article-title":"AnkyrinG. A new ankyrin gene with neural-specific isoforms localized at the axonal initial segment and node of Ranvier","volume":"270","author":"Kordeli","year":"1995","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.stemcr.2017.08.019_bib32","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.neuron.2016.09.022","article-title":"Reduction of Nuak1 decreases tau and reverses phenotypes in a tauopathy mouse model","volume":"92","author":"Lasagna-Reeves","year":"2016","journal-title":"Neuron"},{"key":"10.1016\/j.stemcr.2017.08.019_bib33","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/j.neuron.2012.12.040","article-title":"Environmental novelty activates beta2-adrenergic signaling to prevent the impairment of hippocampal LTP by Abeta oligomers","volume":"77","author":"Li","year":"2013","journal-title":"Neuron"},{"key":"10.1016\/j.stemcr.2017.08.019_bib34","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1002\/1531-8249(200003)47:3<374::AID-ANA15>3.0.CO;2-8","article-title":"Corticobasal degeneration shares a common genetic background with progressive supranuclear palsy","volume":"47","author":"Di Maria","year":"2000","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.stemcr.2017.08.019_bib35","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.tics.2016.01.001","article-title":"The locus coeruleus: essential for maintaining cognitive function and the aging brain","volume":"20","author":"Mather","year":"2016","journal-title":"Trends Cogn. Sci."},{"key":"10.1016\/j.stemcr.2017.08.019_bib36","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1177\/1087057116638029","article-title":"Development of a scalable, high-throughput-compatible assay to detect Tau aggregates using iPSC-derived cortical neurons maintained in a three-dimensional culture format","volume":"21","author":"Medda","year":"2016","journal-title":"J.\u00a0Biomol. Screen."},{"key":"10.1016\/j.stemcr.2017.08.019_bib37","doi-asserted-by":"crossref","first-page":"e76523","DOI":"10.1371\/journal.pone.0076523","article-title":"Characterization of novel CSF Tau and ptau biomarkers for Alzheimer's disease","volume":"8","author":"Meredith","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.stemcr.2017.08.019_bib38","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1038\/nm.3951","article-title":"Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits","volume":"21","author":"Min","year":"2015","journal-title":"Nat. Med."},{"key":"10.1016\/j.stemcr.2017.08.019_bib39","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1038\/nmeth.2840","article-title":"Isolation of single-base genome-edited human iPS cells without antibiotic selection","volume":"11","author":"Miyaoka","year":"2014","journal-title":"Nat. Methods"},{"key":"10.1016\/j.stemcr.2017.08.019_bib40","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1016\/j.neurobiolaging.2012.12.003","article-title":"Age-appropriate cognition and subtle dopamine-independent motor deficits in aged tau knockout mice","volume":"34","author":"Morris","year":"2013","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.stemcr.2017.08.019_bib41","doi-asserted-by":"crossref","first-page":"e105807","DOI":"10.1371\/journal.pone.0105807","article-title":"Comparison and optimization of hiPSC forebrain cortical differentiation protocols","volume":"9","author":"Muratore","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.stemcr.2017.08.019_bib42","doi-asserted-by":"crossref","first-page":"2399","DOI":"10.1093\/hmg\/ddi241","article-title":"The H1c haplotype at the MAPT locus is associated with Alzheimer's disease","volume":"14","author":"Myers","year":"2005","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.stemcr.2017.08.019_bib43","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.nbd.2006.10.018","article-title":"The MAPT H1c risk haplotype is associated with increased expression of tau and especially of 4 repeat containing transcripts","volume":"25","author":"Myers","year":"2007","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.stemcr.2017.08.019_bib44","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1097\/NEN.0b013e31825018f7","article-title":"Correlation of Alzheimer disease neuropathologic changes with cognitive status: a review of the literature","volume":"71","author":"Nelson","year":"2012","journal-title":"J.\u00a0Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.stemcr.2017.08.019_bib45","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1038\/nm1485","article-title":"Activation of beta2-adrenergic receptor stimulates gamma-secretase activity and accelerates amyloid plaque formation","volume":"12","author":"Ni","year":"2006","journal-title":"Nat. Med."},{"key":"10.1016\/j.stemcr.2017.08.019_bib46","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.stem.2013.04.005","article-title":"Functional maturation of hPSC-derived forebrain interneurons requires an extended timeline and mimics human neural development","volume":"12","author":"Nicholas","year":"2013","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.stemcr.2017.08.019_bib47","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1038\/nature10202","article-title":"Induction of human neuronal cells by defined transcription factors","volume":"476","author":"Pang","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.stemcr.2017.08.019_bib48","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.2217\/imt-2016-0019","article-title":"Tau-based therapeutics for Alzheimer's disease: active and passive immunotherapy","volume":"8","author":"Panza","year":"2016","journal-title":"Immunotherapy"},{"key":"10.1016\/j.stemcr.2017.08.019_bib49","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/0304-3940(92)90614-D","article-title":"Loss of high-affinity alpha 2-adrenoceptors in Alzheimer's disease: an autoradiographic study in frontal cortex and hippocampus","volume":"142","author":"Pascual","year":"1992","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.stemcr.2017.08.019_bib50","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1126\/science.1141736","article-title":"Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model","volume":"316","author":"Roberson","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.stemcr.2017.08.019_bib51","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1523\/JNEUROSCI.4152-10.2011","article-title":"Amyloid-beta\/Fyn-induced synaptic, network, and cognitive impairments depend on tau levels in multiple mouse models of Alzheimer's disease","volume":"31","author":"Roberson","year":"2011","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.stemcr.2017.08.019_bib52","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1126\/science.1113694","article-title":"Tau suppression in a neurodegenerative mouse model improves memory function","volume":"309","author":"Santacruz","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.stemcr.2017.08.019_bib53","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1742-2094-7-2","article-title":"Norepinephrine enhances the LPS-induced expression of COX-2 and secretion of PGE2 in primary rat microglia","volume":"7","author":"Schlachetzki","year":"2010","journal-title":"J.\u00a0Neuroinflammation"},{"key":"10.1016\/j.stemcr.2017.08.019_bib54","doi-asserted-by":"crossref","first-page":"10216","DOI":"10.1038\/ncomms10216","article-title":"Toxic tau oligomer formation blocked by capping of cysteine residues with 1,2-dihydroxybenzene groups","volume":"6","author":"Soeda","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.stemcr.2017.08.019_bib55","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1007\/s12031-011-9566-7","article-title":"Are tangles as toxic as they look?","volume":"45","author":"Spires-Jones","year":"2011","journal-title":"J.\u00a0Mol. Neurosci."},{"key":"10.1016\/j.stemcr.2017.08.019_bib56","doi-asserted-by":"crossref","first-page":"2153","DOI":"10.1016\/S0002-9440(10)65533-2","article-title":"Prominent axonopathy in the brain and spinal cord of transgenic mice overexpressing four-repeat human tau protein","volume":"155","author":"Spittaels","year":"1999","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.stemcr.2017.08.019_bib57","doi-asserted-by":"crossref","first-page":"2511","DOI":"10.1523\/JNEUROSCI.5245-10.2011","article-title":"Tau-induced defects in synaptic plasticity, learning, and memory are reversible in transgenic mice after switching off the toxic Tau mutant","volume":"31","author":"Sydow","year":"2011","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.stemcr.2017.08.019_bib58","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1046\/j.1365-2567.1997.00137.x","article-title":"Isoproterenol regulates tumour necrosis factor, interleukin-10, interleukin-6 and nitric oxide production and protects against the development of\u00a0vascular hyporeactivity in endotoxaemia","volume":"90","author":"Szabo","year":"1997","journal-title":"Immunology"},{"key":"10.1016\/j.stemcr.2017.08.019_bib59","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0304-3940(97)00715-5","article-title":"Characterization of tau proteins in human neuroblastoma SH-SY5Y cell line","volume":"235","author":"Uberti","year":"1997","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.stemcr.2017.08.019_bib60","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1126\/science.1194653","article-title":"Tau reduction prevents Abeta-induced defects in axonal transport","volume":"330","author":"Vossel","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.stemcr.2017.08.019_bib61","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/nrn.2015.1","article-title":"Tau in physiology and pathology","volume":"17","author":"Wang","year":"2016","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.stemcr.2017.08.019_bib62","doi-asserted-by":"crossref","first-page":"4024","DOI":"10.1093\/hmg\/ddu116","article-title":"Genetic suppression of beta2-adrenergic receptors ameliorates tau pathology in a mouse model of tauopathies","volume":"23","author":"Wisely","year":"2014","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.stemcr.2017.08.019_bib63","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1126\/science.1062382","article-title":"Tauopathy in Drosophila: neurodegeneration without neurofibrillary tangles","volume":"293","author":"Wittmann","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.stemcr.2017.08.019_bib64","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.brainres.2008.03.019","article-title":"Polymorphisms at the beta2-adrenergic receptor gene influence Alzheimer's disease susceptibility","volume":"1210","author":"Yu","year":"2008","journal-title":"Brain Res."},{"key":"10.1016\/j.stemcr.2017.08.019_bib65","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1177\/108705719900400206","article-title":"A simple statistical parameter for use in evaluation and validation of high throughput screening assays","volume":"4","author":"Zhang","year":"1999","journal-title":"J.\u00a0Biomol. Screen."},{"key":"10.1016\/j.stemcr.2017.08.019_bib66","doi-asserted-by":"crossref","first-page":"299","DOI":"10.2217\/14622416.7.3.299","article-title":"Robust statistical methods for hit selection in RNA interference high-throughput screening experiments","volume":"7","author":"Zhang","year":"2006","journal-title":"Pharmacogenomics"},{"key":"10.1016\/j.stemcr.2017.08.019_bib67","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/j.neuron.2013.05.029","article-title":"Rapid single-step induction of functional neurons from human pluripotent stem cells","volume":"78","author":"Zhang","year":"2013","journal-title":"Neuron"}],"container-title":["Stem Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213671117303764?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213671117303764?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,10,3]],"date-time":"2019-10-03T22:32:00Z","timestamp":1570141920000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213671117303764"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10]]},"references-count":67,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["S2213671117303764"],"URL":"https:\/\/doi.org\/10.1016\/j.stemcr.2017.08.019","relation":{},"ISSN":["2213-6711"],"issn-type":[{"value":"2213-6711","type":"print"}],"subject":[],"published":{"date-parts":[[2017,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Scalable Production of iPSC-Derived Human Neurons to Identify Tau-Lowering Compounds by High-Content Screening","name":"articletitle","label":"Article Title"},{"value":"Stem Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.stemcr.2017.08.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 The Author(s).","name":"copyright","label":"Copyright"}]}}