{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T05:36:32Z","timestamp":1790228192331,"version":"4.1.0"},"reference-count":42,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,1,18]],"date-time":"2018-01-18T00:00:00Z","timestamp":1516233600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004336","name":"Novartis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004336","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002241","name":"Japan Science and Technology Agency","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002241","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008373","name":"Takeda Pharmaceutical Company","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008373","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004095","name":"Kyowa Hakko Kirin","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004095","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010793","name":"Pfizer Japan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010793","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004948","name":"Astellas Pharma","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004948","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011313","name":"Tokyo Biochemical Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011313","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005612","name":"Shionogi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005612","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002491","name":"Bristol-Myers Squibb","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002491","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006062","name":"Foundation for Promotion of Cancer Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["14J02953"],"award-info":[{"award-number":["14J02953"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["16K19568"],"award-info":[{"award-number":["16K19568"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012832","name":"Okinaka Memorial Institute for Medical Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012832","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Stem Cell Reports"],"published-print":{"date-parts":[[2018,3]]},"DOI":"10.1016\/j.stemcr.2018.01.015","type":"journal-article","created":{"date-parts":[[2018,2,8]],"date-time":"2018-02-08T11:38:27Z","timestamp":1518089907000},"page":"1115-1130","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":36,"title":["ADAM8 Is an Antigen of Tyrosine Kinase Inhibitor-Resistant Chronic Myeloid Leukemia Cells Identified by Patient-Derived Induced Pluripotent Stem Cells"],"prefix":"10.1016","volume":"10","author":[{"given":"Masashi","family":"Miyauchi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junji","family":"Koya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunya","family":"Arai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sho","family":"Yamazaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Honda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keisuke","family":"Kataoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihide","family":"Yoshimi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuki","family":"Taoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiki","family":"Kumano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mineo","family":"Kurokawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.stemcr.2018.01.015_bib1","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1038\/nature18288","article-title":"Dual targeting of p53 and c-MYC selectively eliminates leukaemic stem cells","volume":"534","author":"Abraham","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.stemcr.2018.01.015_bib2","doi-asserted-by":"crossref","first-page":"e71596","DOI":"10.1371\/journal.pone.0071596","article-title":"Variable behavior of iPSCs derived from CML patients for response to TKI and hematopoietic differentiation","volume":"8","author":"Bedel","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.stemcr.2018.01.015_bib3","doi-asserted-by":"crossref","first-page":"4039","DOI":"10.1182\/blood-2009-07-231845","article-title":"Generation of iPSCs from cultured human malignant cells","volume":"115","author":"Carette","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.stemcr.2018.01.015_bib4","doi-asserted-by":"crossref","first-page":"5565","DOI":"10.1182\/blood-2010-12-327437","article-title":"Persistence of leukemia stem cells in chronic myelogenous leukemia patients in prolonged remission with imatinib treatment","volume":"118","author":"Chu","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.stemcr.2018.01.015_bib5","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1182\/blood-2013-05-501072","article-title":"Personalized synthetic lethality induced by targeting RAD52 in leukemias identified by gene mutation and expression profile","volume":"122","author":"Cramer-Morales","year":"2013","journal-title":"Blood"},{"key":"10.1016\/j.stemcr.2018.01.015_bib6","doi-asserted-by":"crossref","first-page":"33016","DOI":"10.18632\/oncotarget.9108","article-title":"Quantitative assessment of the CD26+ leukemic stem cell compartment in chronic myeloid leukemia: patient-subgroups, prognostic impact, and technical aspects","volume":"7","author":"Culen","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.stemcr.2018.01.015_bib7","doi-asserted-by":"crossref","first-page":"7622","DOI":"10.1073\/pnas.102583199","article-title":"A murine model of CML blast\u00a0crisis induced by cooperation between BCR\/ABL and NUP98\/HOXA9","volume":"99","author":"Dash","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.stemcr.2018.01.015_bib8","doi-asserted-by":"crossref","first-page":"3436","DOI":"10.1002\/eji.201141764","article-title":"The metalloprotease ADAM8 is associated with and regulates the function of the adhesion receptor PSGL-1 through ERM proteins","volume":"41","author":"Dom\u00ednguez-Luis","year":"2011","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.stemcr.2018.01.015_bib9","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1093\/neuonc\/nov042","article-title":"The metalloprotease-disintegrin ADAM8 contributes to temozolomide chemoresistance and enhanced invasiveness of human glioblastoma cells","volume":"17","author":"Dong","year":"2015","journal-title":"Neuro Oncol."},{"key":"10.1016\/j.stemcr.2018.01.015_bib10","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1056\/NEJM200104053441402","article-title":"Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome","volume":"344","author":"Druker","year":"2001","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.stemcr.2018.01.015_bib11","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1182\/blood.V99.1.319","article-title":"Primitive, quiescent, Philadelphia-positive stem cells from patients with chronic myeloid leukemia are insensitive to STI571 in\u00a0vitro","volume":"99","author":"Graham","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.stemcr.2018.01.015_bib12","doi-asserted-by":"crossref","first-page":"3951","DOI":"10.1182\/blood-2013-10-536078","article-title":"Dipeptidylpeptidase IV (CD26) defines leukemic stem cells (LSC) in chronic myeloid leukemia","volume":"123","author":"Herrmann","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.stemcr.2018.01.015_bib13","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.jim.2009.06.008","article-title":"ELDA: extreme limiting dilution analysis for comparing depleted and enriched populations in stem cell and other assays","volume":"347","author":"Hu","year":"2009","journal-title":"J.\u00a0Immunol. Methods"},{"key":"10.1016\/j.stemcr.2018.01.015_bib14","doi-asserted-by":"crossref","first-page":"e109","DOI":"10.1182\/blood-2010-07-298331","article-title":"Efficient generation of transgene-free induced pluripotent stem cells from normal and neoplastic bone marrow and cord blood mononuclear cells","volume":"117","author":"Hu","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.stemcr.2018.01.015_bib15","doi-asserted-by":"crossref","first-page":"e528","DOI":"10.1016\/S2352-3026(15)00196-9","article-title":"Discontinuation of dasatinib in patients with chronic myeloid leukaemia who have maintained deep molecular response for longer than 1 year (DADI trial): a multicentre phase 2 trial","volume":"2","author":"Imagawa","year":"2015","journal-title":"Lancet Haematol."},{"key":"10.1016\/j.stemcr.2018.01.015_bib16","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.stem.2015.07.011","article-title":"A TIM-3\/Gal-9 autocrine stimulatory loop drives self-renewal of human myeloid leukemia stem cells and leukemic progression","volume":"17","author":"Kikushige","year":"2015","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.stemcr.2018.01.015_bib17","doi-asserted-by":"crossref","first-page":"2540","DOI":"10.1182\/blood-2013-07-517847","article-title":"The IL-2\/CD25 axis maintains distinct subsets of chronic myeloid leukemia-initiating cells","volume":"123","author":"Kobayashi","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.stemcr.2018.01.015_bib18","doi-asserted-by":"crossref","first-page":"6234","DOI":"10.1182\/blood-2011-07-367441","article-title":"Generation of induced pluripotent stem cells from primary chronic myelogenous leukemia patient samples","volume":"119","author":"Kumano","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.stemcr.2018.01.015_bib19","doi-asserted-by":"crossref","first-page":"2669","DOI":"10.1158\/0008-5472.CAN-13-2797","article-title":"BCR-ABL-induced deregulation of the IL-33\/ST2 pathway in CD34+ progenitors from chronic myeloid leukemia patients","volume":"74","author":"Levescot","year":"2014","journal-title":"Cancer Res."},{"key":"10.1016\/j.stemcr.2018.01.015_bib20","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.ccr.2011.12.020","article-title":"Activation of p53 by SIRT1 inhibition enhances elimination of CML leukemia stem cells in combination with imatinib","volume":"21","author":"Li","year":"2012","journal-title":"Cancer Cell"},{"key":"10.1016\/j.stemcr.2018.01.015_bib21","doi-asserted-by":"crossref","first-page":"252ra121","DOI":"10.1126\/scitranslmed.3009073","article-title":"A therapeutically targetable mechanism of BCR-ABL-independent imatinib resistance in chronic myeloid leukemia","volume":"6","author":"Ma","year":"2014","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.stemcr.2018.01.015_bib22","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1016\/S1470-2045(10)70233-3","article-title":"Discontinuation of imatinib in patients with chronic myeloid leukaemia who have maintained complete molecular remission for at least 2 years: the prospective, multicentre Stop Imatinib (STIM) trial","volume":"11","author":"Mahon","year":"2010","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.stemcr.2018.01.015_bib23","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1016\/j.bcp.2005.02.021","article-title":"Relative importance of apoptosis and cell cycle blockage in the synergistic effect of combined R115777 and imatinib treatment in BCR\/ABL-positive cell lines","volume":"69","author":"Miyoshi","year":"2005","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.stemcr.2018.01.015_bib24","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1182\/blood-2012-05-431403","article-title":"Role of SOX17 in hematopoietic development from human embryonic stem cells","volume":"121","author":"Nakajima-Takagi","year":"2013","journal-title":"Blood"},{"key":"10.1016\/j.stemcr.2018.01.015_bib25","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/nrc3184","article-title":"Cancer stem cells: an evolving concept","volume":"12","author":"Nguyen","year":"2012","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.stemcr.2018.01.015_bib26","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1111\/bjh.12726","article-title":"Single-cell gene expression analysis reveals clonal architecture of blast-phase chronic myeloid leukaemia","volume":"165","author":"Nukina","year":"2014","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.stemcr.2018.01.015_bib27","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1038\/nrc3317","article-title":"Pushing the limits of targeted therapy in chronic myeloid leukaemia","volume":"12","author":"O'Hare","year":"2012","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.stemcr.2018.01.015_bib28","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1634\/stemcells.21-3-315","article-title":"Analysis of gene expression profiles in an imatinib-resistant cell line, KCL22\/SR","volume":"21","author":"Ohmine","year":"2003","journal-title":"Stem Cells"},{"key":"10.1016\/j.stemcr.2018.01.015_bib29","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1038\/nmeth.1591","article-title":"A more efficient method to generate integration-free human iPS cells","volume":"8","author":"Okita","year":"2011","journal-title":"Nat. Methods"},{"key":"10.1016\/j.stemcr.2018.01.015_bib30","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1002\/stem.1293","article-title":"An efficient nonviral method to generate integration-free human-induced pluripotent stem cells from cord blood and peripheral blood cells","volume":"31","author":"Okita","year":"2013","journal-title":"Stem Cells"},{"key":"10.1016\/j.stemcr.2018.01.015_bib31","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1038\/sj.leu.2402963","article-title":"Patterns of BCR\/ABL gene rearrangements by interphase fluorescence in\u00a0situ hybridization (FISH) in BCR\/ABL+ leukemias: incidence and underlying genetic abnormalities","volume":"17","author":"Primo","year":"2003","journal-title":"Leukemia"},{"key":"10.1016\/j.stemcr.2018.01.015_bib32","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.1158\/1078-0432.CCR-15-0767","article-title":"Identification of CD25 as STAT5-dependent\u00a0growth regulator of leukemic stem cells in Ph+ CML","volume":"22","author":"Sadovnik","year":"2016","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.stemcr.2018.01.015_bib33","doi-asserted-by":"crossref","first-page":"5028","DOI":"10.1038\/onc.2014.108","article-title":"Evi1 defines leukemia-initiating capacity and tyrosine\u00a0kinase inhibitor resistance in chronic myeloid leukemia","volume":"33","author":"Sato","year":"2014","journal-title":"Oncogene"},{"key":"10.1016\/j.stemcr.2018.01.015_bib34","doi-asserted-by":"crossref","first-page":"6175","DOI":"10.1038\/ncomms7175","article-title":"ADAM8 as a drug target in pancreatic cancer","volume":"6","author":"Schlomann","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.stemcr.2018.01.015_bib35","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/j.scr.2015.10.015","article-title":"Discovery of survival factor for primitive chronic myeloid leukemia cells using induced pluripotent stem cells","volume":"15","author":"Suknuntha","year":"2015","journal-title":"Stem Cell Res."},{"key":"10.1016\/j.stemcr.2018.01.015_bib36","doi-asserted-by":"crossref","first-page":"5298","DOI":"10.1182\/blood-2007-10-117622","article-title":"Generation of functional platelets from human embryonic stem cells in\u00a0vitro via ES-sacs, VEGF-promoted structures that concentrate hematopoietic progenitors","volume":"111","author":"Takayama","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.stemcr.2018.01.015_bib37","doi-asserted-by":"crossref","first-page":"2817","DOI":"10.1084\/jem.20100844","article-title":"Transient activation of c-MYC expression is critical for efficient platelet generation from human induced pluripotent stem cells","volume":"207","author":"Takayama","year":"2010","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.stemcr.2018.01.015_bib38","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1038\/nrc3368","article-title":"Cancer stem cell definitions and terminology: the devil is in the details","volume":"12","author":"Valent","year":"2012","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.stemcr.2018.01.015_bib39","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1172\/JCI0214151","article-title":"P-selectin glycoprotein ligand-1-deficient mice have impaired leukocyte tethering to E-selectin under flow","volume":"109","author":"Xia","year":"2002","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.stemcr.2018.01.015_bib40","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1182\/blood-2009-12-259556","article-title":"E-selectin engages PSGL-1 and CD44 through a common signaling pathway to induce integrin alphaLbeta2-mediated slow leukocyte rolling","volume":"116","author":"Yago","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.stemcr.2018.01.015_bib41","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1046\/j.1365-2141.2000.02003.x","article-title":"Expression of the NUP98\/HOXA9 fusion transcript in the blast crisis of Philadelphia chromosome-positive chronic myelogenous leukaemia with t(7;11)(p15;p15)","volume":"109","author":"Yamamoto","year":"2000","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.stemcr.2018.01.015_bib42","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/j.immuni.2007.04.011","article-title":"Spleen tyrosine kinase Syk is necessary for E-selectin-induced alpha(L)beta(2) integrin-mediated rolling on intercellular adhesion molecule-1","volume":"26","author":"Zarbock","year":"2007","journal-title":"Immunity"}],"container-title":["Stem Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213671118300419?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213671118300419?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T09:42:28Z","timestamp":1761990148000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213671118300419"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3]]},"references-count":42,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,3]]}},"alternative-id":["S2213671118300419"],"URL":"https:\/\/doi.org\/10.1016\/j.stemcr.2018.01.015","relation":{},"ISSN":["2213-6711"],"issn-type":[{"value":"2213-6711","type":"print"}],"subject":[],"published":{"date-parts":[[2018,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"ADAM8 Is an Antigen of Tyrosine Kinase Inhibitor-Resistant Chronic Myeloid Leukemia Cells Identified by Patient-Derived Induced Pluripotent Stem Cells","name":"articletitle","label":"Article Title"},{"value":"Stem Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.stemcr.2018.01.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 The Authors.","name":"copyright","label":"Copyright"}]}}