{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T11:51:02Z","timestamp":1775044262370,"version":"3.50.1"},"reference-count":22,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,1,31]],"date-time":"2018-01-31T00:00:00Z","timestamp":1517356800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004082","name":"Korean Foundation for Cancer Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004082","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004920","name":"Royan Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004920","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2017M3A9B402814"],"award-info":[{"award-number":["2017M3A9B402814"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010421","name":"Iranian Council of Stem Cell Research and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010421","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Stem Cell Reports"],"published-print":{"date-parts":[[2018,3]]},"DOI":"10.1016\/j.stemcr.2018.01.037","type":"journal-article","created":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T12:50:54Z","timestamp":1519908654000},"page":"848-859","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"title":["Prospective Isolation of ISL1+ Cardiac Progenitors from Human ESCs for\u00a0Myocardial Infarction Therapy"],"prefix":"10.1016","volume":"10","author":[{"given":"Zaniar","family":"Ghazizadeh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faranak","family":"Fattahi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehdi","family":"Mirzaei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Delger","family":"Bayersaikhan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaesuk","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sehyun","family":"Chae","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daehee","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyunghee","family":"Byun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehdi Sharifi","family":"Tabar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Taleahmad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shahab","family":"Mirshahvaladi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Parisa","family":"Shabani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hananeh","family":"Fonoudi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul A.","family":"Haynes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hossein","family":"Baharvand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nasser","family":"Aghdami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Todd","family":"Evans","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bonghee","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ghasem Hosseini","family":"Salekdeh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.stemcr.2018.01.037_bib1","doi-asserted-by":"crossref","first-page":"3405","DOI":"10.1073\/pnas.1220832110","article-title":"Prospective isolation of human embryonic stem cell-derived cardiovascular progenitors that integrate into human fetal heart tissue","volume":"110","author":"Ardehali","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.stemcr.2018.01.037_bib2","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1093\/bioinformatics\/19.2.185","article-title":"A comparison of normalization methods for high density oligonucleotide array data based on variance and bias","volume":"19","author":"Bolstad","year":"2003","journal-title":"Bioinformatics"},{"key":"10.1016\/j.stemcr.2018.01.037_bib3","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/nature08191","article-title":"Human ISL1 heart progenitors generate diverse multipotent cardiovascular cell lineages","volume":"460","author":"Bu","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.stemcr.2018.01.037_bib4","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1038\/nrg1710","article-title":"Building the mammalian heart from two sources of myocardial cells","volume":"6","author":"Buckingham","year":"2005","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.stemcr.2018.01.037_bib5","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/S1534-5807(03)00363-0","article-title":"Isl1 identifies a cardiac progenitor population that proliferates prior to differentiation and contributes a majority of cells to the heart","volume":"5","author":"Cai","year":"2003","journal-title":"Dev. Cell"},{"key":"10.1016\/j.stemcr.2018.01.037_bib6","doi-asserted-by":"crossref","first-page":"rs4","DOI":"10.1126\/scisignal.2003266","article-title":"A systems approach for decoding mitochondrial retrograde signaling pathways","volume":"6","author":"Chae","year":"2013","journal-title":"Sci. Signal."},{"key":"10.1016\/j.stemcr.2018.01.037_bib7","doi-asserted-by":"crossref","first-page":"3931","DOI":"10.1242\/dev.01256","article-title":"Mef2c is a direct transcriptional target of ISL1 and GATA factors in the anterior heart field during mouse embryonic development","volume":"131","author":"Dodou","year":"2004","journal-title":"Development"},{"key":"10.1016\/j.stemcr.2018.01.037_bib8","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1038\/nbt.2239","article-title":"Isolation of primitive endoderm, mesoderm, vascular endothelial and trophoblast progenitors from human pluripotent stem cells","volume":"30","author":"Drukker","year":"2012","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.stemcr.2018.01.037_bib9","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1038\/nbt.2005","article-title":"SIRPA is a specific cell-surface marker for isolating cardiomyocytes derived from human pluripotent stem cells","volume":"29","author":"Dubois","year":"2011","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.stemcr.2018.01.037_bib10","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.stemcr.2015.09.011","article-title":"Comparison of human embryonic stem cell-derived cardiomyocytes, cardiovascular progenitors, and bone marrow mononuclear cells for cardiac repair","volume":"5","author":"Fernandes","year":"2015","journal-title":"Stem Cell Reports"},{"key":"10.1016\/j.stemcr.2018.01.037_bib11","doi-asserted-by":"crossref","first-page":"e55577","DOI":"10.1371\/journal.pone.0055577","article-title":"ISL1 protein transduction promotes cardiomyocyte differentiation from human embryonic stem cells","volume":"8","author":"Fonoudi","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.stemcr.2018.01.037_bib12","doi-asserted-by":"crossref","first-page":"17296","DOI":"10.1073\/pnas.0508647102","article-title":"A data integration methodology for systems biology","volume":"102","author":"Hwang","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.stemcr.2018.01.037_bib13","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1038\/ncb1906","article-title":"A regulatory pathway involving Notch1\/beta-catenin\/Isl1 determines cardiac progenitor cell fate","volume":"11","author":"Kwon","year":"2009","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.stemcr.2018.01.037_bib14","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1038\/nbt1327","article-title":"Cardiomyocytes derived from human embryonic stem cells in pro-survival factors enhance function of infarcted rat hearts","volume":"25","author":"Laflamme","year":"2007","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.stemcr.2018.01.037_bib15","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1038\/nature03215","article-title":"Postnatal isl1+ cardioblasts enter fully differentiated cardiomyocyte lineages","volume":"433","author":"Laugwitz","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.stemcr.2018.01.037_bib16","doi-asserted-by":"crossref","first-page":"3256","DOI":"10.1172\/JCI68257","article-title":"Transcription factor ISL1 is essential for pacemaker development and function","volume":"125","author":"Liang","year":"2015","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.stemcr.2018.01.037_bib17","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1093\/cvr\/cvs185","article-title":"High-purity enrichment of functional cardiovascular cells from human iPS cells","volume":"95","author":"Lin","year":"2012","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.stemcr.2018.01.037_bib18","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1161\/CIRCRESAHA.113.301283","article-title":"Embryonic stem cell-derived CD166+ precursors develop into fully functional sinoatrial-like cells","volume":"113","author":"Scavone","year":"2013","journal-title":"Circ. Res."},{"key":"10.1016\/j.stemcr.2018.01.037_bib19","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.ydbio.2006.12.048","article-title":"Islet 1 is expressed in distinct cardiovascular lineages, including pacemaker and coronary vascular cells","volume":"304","author":"Sun","year":"2007","journal-title":"Dev. Biol."},{"key":"10.1016\/j.stemcr.2018.01.037_bib20","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.cell.2008.02.002","article-title":"Origins and fates of cardiovascular progenitor cells","volume":"132","author":"Wu","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.stemcr.2018.01.037_bib21","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/S0002-9440(10)64242-3","article-title":"Regulation of angiogenesis by vascular endothelial growth factor and angiopoietin-1 in the rat aorta model: distinct temporal patterns of intracellular signaling correlate with induction of angiogenic sprouting","volume":"161","author":"Zhu","year":"2002","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.stemcr.2018.01.037_bib22","doi-asserted-by":"crossref","first-page":"2339","DOI":"10.1021\/pr060161n","article-title":"Statistical analysis of membrane proteome expression changes in Saccharomyces cerevisiae","volume":"5","author":"Zybailov","year":"2006","journal-title":"J.\u00a0Proteome Res."}],"updated-by":[{"DOI":"10.1016\/j.stemcr.2021.01.012","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2021,3,9]],"date-time":"2021-03-09T00:00:00Z","timestamp":1615248000000}}],"container-title":["Stem Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213671118300638?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213671118300638?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T09:42:31Z","timestamp":1761990151000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213671118300638"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3]]},"references-count":22,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,3]]}},"alternative-id":["S2213671118300638"],"URL":"https:\/\/doi.org\/10.1016\/j.stemcr.2018.01.037","relation":{},"ISSN":["2213-6711"],"issn-type":[{"value":"2213-6711","type":"print"}],"subject":[],"published":{"date-parts":[[2018,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prospective Isolation of ISL1+ Cardiac Progenitors from Human ESCs for\u00a0Myocardial Infarction Therapy","name":"articletitle","label":"Article Title"},{"value":"Stem Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.stemcr.2018.01.037","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 The Authors.","name":"copyright","label":"Copyright"}]}}