{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:20:45Z","timestamp":1790554845674,"version":"4.1.0"},"reference-count":49,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,3,30]],"date-time":"2018-03-30T00:00:00Z","timestamp":1522368000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["MOP-102709"],"award-info":[{"award-number":["MOP-102709"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000156","name":"Fonds de Recherche du Qu\u00e9bec - Sant\u00e9","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000156","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011255","name":"Warren H. and Clara Cole Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011255","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000196","name":"Canada Foundation for Innovation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019683","name":"Cole Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019683","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Stem Cell Reports"],"published-print":{"date-parts":[[2018,6]]},"DOI":"10.1016\/j.stemcr.2018.03.025","type":"journal-article","created":{"date-parts":[[2018,4,26]],"date-time":"2018-04-26T11:41:03Z","timestamp":1524742863000},"page":"1721-1733","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"title":["INK4a\/ARF Expression Impairs Neurogenesis in the Brain of Irradiated Mice"],"prefix":"10.1016","volume":"10","author":[{"given":"Oanh","family":"Le","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Palacio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilbert","family":"Bernier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ines","family":"Batinic-Haberle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilles","family":"Hickson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Beaus\u00e9jour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.stemcr.2018.03.025_bib1","doi-asserted-by":"crossref","first-page":"1846","DOI":"10.1016\/j.freeradbiomed.2010.08.021","article-title":"Consequences of ionizing radiation-induced damage in human neural stem cells","volume":"49","author":"Acharya","year":"2010","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.stemcr.2018.03.025_bib2","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1038\/nature16932","article-title":"Naturally occurring p16(Ink4a)-positive cells shorten healthy lifespan","volume":"530","author":"Baker","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.stemcr.2018.03.025_bib3","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1016\/j.celrep.2013.03.028","article-title":"p21 both attenuates and drives senescence and aging in BubR1 progeroid mice","volume":"3","author":"Baker","year":"2013","journal-title":"Cell Rep."},{"key":"10.1016\/j.stemcr.2018.03.025_bib4","doi-asserted-by":"crossref","first-page":"2372","DOI":"10.1089\/ars.2012.5147","article-title":"SOD therapeutics: latest insights into their structure-activity relationships and impact on the cellular redox-based signaling pathways","volume":"20","author":"Batinic-Haberle","year":"2014","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.stemcr.2018.03.025_bib5","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.redox.2015.01.017","article-title":"An educational overview of the chemistry, biochemistry and therapeutic aspects of Mn porphyrins\u2013from superoxide dismutation to H2O2-driven pathways","volume":"5","author":"Batinic-Haberle","year":"2015","journal-title":"Redox Biol."},{"key":"10.1016\/j.stemcr.2018.03.025_bib6","doi-asserted-by":"crossref","first-page":"2853","DOI":"10.1371\/journal.pbio.0060301","article-title":"Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor","volume":"6","author":"Coppe","year":"2008","journal-title":"PLoS Biol."},{"key":"10.1016\/j.stemcr.2018.03.025_bib7","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.scr.2013.02.008","article-title":"Quiescent neural stem cells exit dormancy upon alteration of GABAAR signaling following radiation damage","volume":"11","author":"Daynac","year":"2013","journal-title":"Stem Cell Res."},{"key":"10.1016\/j.stemcr.2018.03.025_bib8","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1016\/j.devcel.2014.11.012","article-title":"An essential role for senescent cells in optimal wound healing through secretion of PDGF-AA","volume":"31","author":"Demaria","year":"2014","journal-title":"Dev. Cell"},{"key":"10.1016\/j.stemcr.2018.03.025_bib9","doi-asserted-by":"crossref","first-page":"e73206","DOI":"10.1371\/journal.pone.0073206","article-title":"Loss of the osteogenic differentiation potential during senescence is limited to bone progenitor cells and is dependent on p53","volume":"8","author":"Despars","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.stemcr.2018.03.025_bib10","doi-asserted-by":"crossref","first-page":"13632","DOI":"10.1073\/pnas.2234031100","article-title":"Inflammation is detrimental for neurogenesis in adult brain","volume":"100","author":"Ekdahl","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.stemcr.2018.03.025_bib11","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/ncb2466","article-title":"Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation","volume":"14","author":"Fumagalli","year":"2012","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.stemcr.2018.03.025_bib12","doi-asserted-by":"crossref","first-page":"2705","DOI":"10.1001\/jama.297.24.2705","article-title":"Medical assessment of adverse health outcomes in long-term survivors of childhood cancer","volume":"297","author":"Geenen","year":"2007","journal-title":"JAMA"},{"key":"10.1016\/j.stemcr.2018.03.025_bib13","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1016\/j.bcp.2012.09.010","article-title":"N-Acetylcysteine ethyl ester (NACET): a novel lipophilic cell-permeable cysteine derivative with an unusual pharmacokinetic feature and remarkable antioxidant potential","volume":"84","author":"Giustarini","year":"2012","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.stemcr.2018.03.025_bib14","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1634\/stemcells.2008-0732","article-title":"Differential recovery of neural stem cells in the subventricular zone and dentate gyrus after ionizing radiation","volume":"27","author":"Hellstrom","year":"2009","journal-title":"Stem Cells"},{"key":"10.1016\/j.stemcr.2018.03.025_bib15","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1016\/j.mcn.2011.02.001","article-title":"Unique gene expression patterns indicate microglial contribution to neural stem cell recovery following irradiation","volume":"46","author":"Hellstrom","year":"2011","journal-title":"Mol. Cell Neurosci."},{"key":"10.1016\/j.stemcr.2018.03.025_bib16","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1038\/nature02989","article-title":"Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells","volume":"431","author":"Ito","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.stemcr.2018.03.025_bib17","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1038\/nm1388","article-title":"Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells","volume":"12","author":"Ito","year":"2006","journal-title":"Nat. Med."},{"key":"10.1016\/j.stemcr.2018.03.025_bib18","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/nature05092","article-title":"p16INK4a induces an age-dependent decline in islet regenerative potential","volume":"443","author":"Krishnamurthy","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.stemcr.2018.03.025_bib19","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1172\/JCI22475","article-title":"Ink4a\/Arf expression is a biomarker of aging","volume":"114","author":"Krishnamurthy","year":"2004","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.stemcr.2018.03.025_bib20","doi-asserted-by":"crossref","first-page":"4407","DOI":"10.1200\/JCO.2012.48.2315","article-title":"Neurocognitive outcomes decades after treatment for childhood acute lymphoblastic leukemia: a report from the St Jude lifetime cohort study","volume":"31","author":"Krull","year":"2013","journal-title":"J.\u00a0Clin. Oncol."},{"key":"10.1016\/j.stemcr.2018.03.025_bib21","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1016\/j.cell.2008.03.039","article-title":"Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network","volume":"133","author":"Kuilman","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.stemcr.2018.03.025_bib22","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1111\/j.1474-9726.2010.00567.x","article-title":"Ionizing radiation-induced long-term expression of senescence markers in mice is independent of p53 and immune status","volume":"9","author":"Le","year":"2010","journal-title":"Aging Cell"},{"key":"10.1016\/j.stemcr.2018.03.025_bib23","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.bbi.2012.09.010","article-title":"Absence of CCL2 is sufficient to restore hippocampal neurogenesis following cranial irradiation","volume":"30","author":"Lee","year":"2013","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.stemcr.2018.03.025_bib24","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.freeradbiomed.2011.04.016","article-title":"Mn(III) meso-tetrakis-(N-ethylpyridinium-2-yl) porphyrin mitigates total body irradiation-induced long-term bone marrow suppression","volume":"51","author":"Li","year":"2011","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.stemcr.2018.03.025_bib25","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1667\/RR3112","article-title":"Radiation response of neural precursor cells: linking cellular sensitivity to cell cycle checkpoints, apoptosis and oxidative stress","volume":"161","author":"Limoli","year":"2004","journal-title":"Radiat. Res."},{"key":"10.1016\/j.stemcr.2018.03.025_bib26","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1667\/RR0591.1","article-title":"Time-dependent neurosphere-forming ability of adult rat spinal cord after irradiation","volume":"168","author":"Lu","year":"2007","journal-title":"Radiat. Res."},{"key":"10.1016\/j.stemcr.2018.03.025_bib27","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1186\/1748-717X-8-252","article-title":"Expression of the senescence marker p16INK4a in skin biopsies of acute lymphoblastic leukemia survivors: a pilot study","volume":"8","author":"Marcoux","year":"2013","journal-title":"Radiat. Oncol."},{"key":"10.1016\/j.stemcr.2018.03.025_bib28","first-page":"4021","article-title":"Extreme sensitivity of adult neurogenesis to low doses of X-irradiation","volume":"63","author":"Mizumatsu","year":"2003","journal-title":"Cancer Res."},{"key":"10.1016\/j.stemcr.2018.03.025_bib29","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1038\/nature05091","article-title":"Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing","volume":"443","author":"Molofsky","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.stemcr.2018.03.025_bib30","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.bbr.2011.05.012","article-title":"Cognitive side effects of cancer therapy demonstrate a functional role for adult neurogenesis","volume":"227","author":"Monje","year":"2012","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.stemcr.2018.03.025_bib31","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1038\/nm749","article-title":"Irradiation induces neural precursor-cell dysfunction","volume":"8","author":"Monje","year":"2002","journal-title":"Nat. Med."},{"key":"10.1016\/j.stemcr.2018.03.025_bib32","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1126\/science.1088417","article-title":"Inflammatory blockade restores adult hippocampal neurogenesis","volume":"302","author":"Monje","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.stemcr.2018.03.025_bib33","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1667\/RR2587.1","article-title":"Cranial irradiation leads to acute and persistent neuroinflammation with delayed increases in T-cell infiltration and CD11c expression in C57BL\/6 mouse brain","volume":"176","author":"Moravan","year":"2011","journal-title":"Radiat. Res."},{"key":"10.1016\/j.stemcr.2018.03.025_bib34","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1056\/NEJMsa060185","article-title":"Chronic health conditions in adult survivors of childhood cancer","volume":"355","author":"Oeffinger","year":"2006","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.stemcr.2018.03.025_bib35","first-page":"362ra144","article-title":"Senescence-associated secretory phenotype\u00a0contributes to pathological angiogenesis in retinopathy","volume":"8","author":"Oubaha","year":"2016","journal-title":"Sci.\u00a0Transl. Med."},{"key":"10.1016\/j.stemcr.2018.03.025_bib36","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1007\/s11060-011-0582-9","article-title":"Therapeutic doses of cranial irradiation induce hippocampus-dependent cognitive deficits in young mice","volume":"105","author":"Rao","year":"2011","journal-title":"J.\u00a0Neurooncol."},{"key":"10.1016\/j.stemcr.2018.03.025_bib37","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1038\/nrc3634","article-title":"Survivors of childhood and adolescent cancer: life-long risks and responsibilities","volume":"14","author":"Robison","year":"2014","journal-title":"Nat.\u00a0Rev. Cancer"},{"key":"10.1016\/j.stemcr.2018.03.025_bib38","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1038\/ncb1909","article-title":"Persistent DNA damage signalling triggers senescence-associated\u00a0inflammatory cytokine secretion","volume":"11","author":"Rodier","year":"2009","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.stemcr.2018.03.025_bib39","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.expneurol.2004.05.005","article-title":"Radiation-induced impairment of hippocampal neurogenesis is associated with cognitive deficits in young mice","volume":"188","author":"Rola","year":"2004","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.stemcr.2018.03.025_bib40","doi-asserted-by":"crossref","first-page":"14532","DOI":"10.1038\/ncomms14532","article-title":"Cellular senescence mediates fibrotic pulmonary disease","volume":"8","author":"Schafer","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.stemcr.2018.03.025_bib41","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/35092592","article-title":"Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis","volume":"413","author":"Sharpless","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.stemcr.2018.03.025_bib42","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1006\/exnr.1999.7172","article-title":"Long-term impairment of subependymal repopulation following damage by ionizing irradiation","volume":"160","author":"Tada","year":"1999","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.stemcr.2018.03.025_bib43","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1038\/nature13193","article-title":"The role of senescent cells in ageing","volume":"509","author":"van Deursen","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.stemcr.2018.03.025_bib44","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/nature10357","article-title":"The ageing systemic milieu negatively regulates neurogenesis and cognitive function","volume":"477","author":"Villeda","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.stemcr.2018.03.025_bib45","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.freeradbiomed.2009.11.005","article-title":"Total body irradiation causes residual bone marrow injury by induction of persistent oxidative stress in murine hematopoietic stem cells","volume":"48","author":"Wang","year":"2010","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.stemcr.2018.03.025_bib46","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1182\/blood-2005-04-1418","article-title":"Total body irradiation selectively induces murine hematopoietic stem cell senescence","volume":"107","author":"Wang","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.stemcr.2018.03.025_bib47","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.freeradbiomed.2013.01.006","article-title":"Comprehensive pharmacokinetic studies and oral bioavailability of two Mn porphyrin-based SOD mimics, MnTE-2-PyP5+ and MnTnHex-2-PyP5+","volume":"58","author":"Weitner","year":"2013","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.stemcr.2018.03.025_bib48","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1002\/hipo.20158","article-title":"Irradiation as an experimental tool in studies of adult neurogenesis","volume":"16","author":"Wojtowicz","year":"2006","journal-title":"Hippocampus"},{"key":"10.1016\/j.stemcr.2018.03.025_bib49","doi-asserted-by":"crossref","first-page":"21522","DOI":"10.1073\/pnas.1216913110","article-title":"Extracellular superoxide dismutase is important for hippocampal neurogenesis and preservation of cognitive functions after irradiation","volume":"109","author":"Zou","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"}],"container-title":["Stem Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213671118301528?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213671118301528?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T09:40:58Z","timestamp":1761990058000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213671118301528"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6]]},"references-count":49,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["S2213671118301528"],"URL":"https:\/\/doi.org\/10.1016\/j.stemcr.2018.03.025","relation":{},"ISSN":["2213-6711"],"issn-type":[{"value":"2213-6711","type":"print"}],"subject":[],"published":{"date-parts":[[2018,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"INK4a\/ARF Expression Impairs Neurogenesis in the Brain of Irradiated Mice","name":"articletitle","label":"Article Title"},{"value":"Stem Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.stemcr.2018.03.025","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 The Author(s).","name":"copyright","label":"Copyright"}]}}