{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T22:43:56Z","timestamp":1790721836875,"version":"4.1.0"},"reference-count":50,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,5,25]],"date-time":"2018-05-25T00:00:00Z","timestamp":1527206400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2017B030311014"],"award-info":[{"award-number":["2017B030311014"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["81561128007"],"award-info":[{"award-number":["81561128007"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004000","name":"Guangzhou Science and Technology Program key projects","doi-asserted-by":"publisher","award":["201707010452"],"award-info":[{"award-number":["201707010452"]}],"id":[{"id":"10.13039\/501100004000","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011711","name":"Department of Agriculture of Guangdong Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013069","name":"Leading Talents Program of Guangdong Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013137","name":"Guangdong Province Higher Vocational Colleges and Schools Pearl River Scholar Funded Scheme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013137","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012540","name":"Guangdong Province Introduction of Innovative R&amp;D Team","doi-asserted-by":"publisher","award":["2009010058"],"award-info":[{"award-number":["2009010058"]}],"id":[{"id":"10.13039\/100012540","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013314","name":"Higher Education Discipline Innovation Project","doi-asserted-by":"publisher","award":["B12003"],"award-info":[{"award-number":["B12003"]}],"id":[{"id":"10.13039\/501100013314","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["201508020256"],"award-info":[{"award-number":["201508020256"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["US NIH"],"award-info":[{"award-number":["US NIH"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81561128007"],"award-info":[{"award-number":["81561128007"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81590765"],"award-info":[{"award-number":["81590765"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81771665"],"award-info":[{"award-number":["81771665"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["91542112"],"award-info":[{"award-number":["91542112"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81742002"],"award-info":[{"award-number":["81742002"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81571520"],"award-info":[{"award-number":["81571520"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010871","name":"Recruitment Program of Global Experts","doi-asserted-by":"publisher","award":["WQ2014440O204"],"award-info":[{"award-number":["WQ2014440O204"]}],"id":[{"id":"10.13039\/501100010871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Stem Cell Reports"],"published-print":{"date-parts":[[2018,7]]},"DOI":"10.1016\/j.stemcr.2018.05.016","type":"journal-article","created":{"date-parts":[[2018,6,21]],"date-time":"2018-06-21T11:01:25Z","timestamp":1529578885000},"page":"258-273","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":47,"title":["ICAM-1 Deficiency in the Bone Marrow Niche Impairs Quiescence and\u00a0Repopulation of Hematopoietic Stem Cells"],"prefix":"10.1016","volume":"11","author":[{"given":"Yu-feng","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shao-ying","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying-ying","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lai","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang-zheng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dmitry I.","family":"Gabrilovich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.stemcr.2018.05.016_bib1","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/35004599","article-title":"A\u00a0clonogenic common myeloid progenitor that gives rise to all myeloid lineages","volume":"404","author":"Akashi","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.stemcr.2018.05.016_bib2","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.cell.2004.07.004","article-title":"Tie2\/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche","volume":"118","author":"Arai","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.stemcr.2018.05.016_bib3","doi-asserted-by":"crossref","first-page":"5465","DOI":"10.1073\/pnas.1000834107","article-title":"Functionally distinct hematopoietic stem cells modulate hematopoietic lineage potential during aging by a mechanism of clonal expansion","volume":"107","author":"Beerman","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.stemcr.2018.05.016_bib4","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1084\/jem.20161616","article-title":"CXCR1 remodels the vascular niche to promote hematopoietic stem and progenitor cell engraftment","volume":"214","author":"Blaser","year":"2017","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.stemcr.2018.05.016_bib5","doi-asserted-by":"crossref","first-page":"3095","DOI":"10.1073\/pnas.85.9.3095","article-title":"Intercellular adhesion molecule 1 (ICAM-1) has a central role in\u00a0cell-cell contact-mediated immune mechanisms","volume":"85","author":"Boyd","year":"1988","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.stemcr.2018.05.016_bib6","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1038\/leu.2008.392","article-title":"The hematopoietic stem cell in chronic phase CML is characterized by a transcriptional profile resembling normal myeloid progenitor cells and reflecting loss of quiescence","volume":"23","author":"Bruns","year":"2009","journal-title":"Leukemia"},{"key":"10.1016\/j.stemcr.2018.05.016_bib7","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1038\/nm1274","article-title":"Rac GTPases differentially integrate signals regulating hematopoietic stem cell localization","volume":"11","author":"Cancelas","year":"2005","journal-title":"Nat. Med."},{"key":"10.1016\/j.stemcr.2018.05.016_bib8","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/S1074-7613(04)00105-0","article-title":"LFA-1\/ICAM-1 interaction lowers the threshold of B\u00a0cell activation by facilitating B cell adhesion and synapse formation","volume":"20","author":"Carrasco","year":"2004","journal-title":"Immunity"},{"key":"10.1016\/j.stemcr.2018.05.016_bib9","doi-asserted-by":"crossref","first-page":"e201","DOI":"10.1371\/journal.pbio.0050201","article-title":"Aging hematopoietic stem cells decline in function and exhibit epigenetic dysregulation","volume":"5","author":"Chambers","year":"2007","journal-title":"PLoS Biol."},{"key":"10.1016\/j.stemcr.2018.05.016_bib10","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1242\/dev.083139","article-title":"Adhesion in the stem cell niche: biological roles and regulation","volume":"140","author":"Chen","year":"2013","journal-title":"Development"},{"key":"10.1016\/j.stemcr.2018.05.016_bib11","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.1126\/science.287.5459.1804","article-title":"Hematopoietic stem cell quiescence maintained by p21cip1\/waf1","volume":"287","author":"Cheng","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.stemcr.2018.05.016_bib12","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1182\/blood-2014-03-565721","article-title":"CD166 regulates human and murine hematopoietic stem cells and the hematopoietic niche","volume":"124","author":"Chitteti","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.stemcr.2018.05.016_bib13","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1038\/nri.2017.53","article-title":"Adult haematopoietic stem cell niches","volume":"17","author":"Crane","year":"2017","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.stemcr.2018.05.016_bib14","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.stem.2012.01.006","article-title":"Hematopoiesis: a human perspective","volume":"10","author":"Doulatov","year":"2012","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.stemcr.2018.05.016_bib15","doi-asserted-by":"crossref","first-page":"2691","DOI":"10.1084\/jem.20111490","article-title":"Clonal analysis reveals multiple functional defects of aged murine hematopoietic stem cells","volume":"208","author":"Dykstra","year":"2011","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.stemcr.2018.05.016_bib16","doi-asserted-by":"crossref","first-page":"2500","DOI":"10.1182\/blood-2011-11-391730","article-title":"Rantes\/Ccl5 influences hematopoietic stem cell subtypes and causes myeloid skewing","volume":"119","author":"Ergen","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.stemcr.2018.05.016_bib17","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.coi.2014.05.002","article-title":"Hematopoietic stem cell aging","volume":"29","author":"Geiger","year":"2014","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.stemcr.2018.05.016_bib18","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1016\/j.cell.2016.06.042","article-title":"Angiogenin promotes hematopoietic regeneration by dichotomously regulating quiescence of stem and progenitor cells","volume":"166","author":"Goncalves","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.stemcr.2018.05.016_bib19","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1038\/nature11926","article-title":"CXCL12 in early mesenchymal progenitors is required for haematopoietic stem-cell maintenance","volume":"495","author":"Greenbaum","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.stemcr.2018.05.016_bib20","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1182\/blood-2010-09-307843","article-title":"SDF-1 keeps HSC quiescent at home","volume":"117","author":"Itkin","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.stemcr.2018.05.016_bib21","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1002\/stem.1309","article-title":"Alcam regulates long-term hematopoietic stem cell engraftment and self-renewal","volume":"31","author":"Jeannet","year":"2013","journal-title":"Stem Cells"},{"key":"10.1016\/j.stemcr.2018.05.016_bib22","doi-asserted-by":"crossref","first-page":"6342","DOI":"10.1182\/blood-2008-12-192054","article-title":"Prospective isolation and molecular characterization of hematopoietic stem cells with durable self-renewal potential","volume":"113","author":"Kent","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.stemcr.2018.05.016_bib23","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.devcel.2013.04.016","article-title":"Deficiency of lipid phosphatase SHIP enables long-term reconstitution of hematopoietic inductive bone marrow microenvironment","volume":"25","author":"Liang","year":"2013","journal-title":"Dev. Cell"},{"key":"10.1016\/j.stemcr.2018.05.016_bib24","doi-asserted-by":"crossref","first-page":"5021","DOI":"10.4049\/jimmunol.1100646","article-title":"ICAM-1: getting a grip on leukocyte adhesion","volume":"186","author":"Long","year":"2011","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.stemcr.2018.05.016_bib25","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1038\/nm.3647","article-title":"Hematopoietic stem cell niche maintenance during homeostasis and regeneration","volume":"20","author":"Mendelson","year":"2014","journal-title":"Nat. Med."},{"key":"10.1016\/j.stemcr.2018.05.016_bib26","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1084\/jem.20091318","article-title":"Heterogeneity and\u00a0hierarchy within the most primitive hematopoietic stem cell compartment","volume":"207","author":"Morita","year":"2010","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.stemcr.2018.05.016_bib27","doi-asserted-by":"crossref","first-page":"4656","DOI":"10.1242\/dev.106575","article-title":"The analysis, roles and regulation of quiescence in hematopoietic stem cells","volume":"141","author":"Nakamura-Ishizu","year":"2014","journal-title":"Development"},{"key":"10.1016\/j.stemcr.2018.05.016_bib28","doi-asserted-by":"crossref","first-page":"2293","DOI":"10.1182\/blood.V97.8.2293","article-title":"Spatial localization of transplanted hemopoietic stem cells: inferences for the localization of stem cell niches","volume":"97","author":"Nilsson","year":"2001","journal-title":"Blood"},{"key":"10.1016\/j.stemcr.2018.05.016_bib29","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1038\/nrg2269","article-title":"Deconstructing stem cell self-renewal: genetic insights into cell-cycle regulation","volume":"9","author":"Orford","year":"2008","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.stemcr.2018.05.016_bib30","doi-asserted-by":"crossref","first-page":"9374","DOI":"10.1073\/pnas.90.20.9374","article-title":"Peripheralization of hemopoietic progenitors in primates treated with anti-VLA4 integrin","volume":"90","author":"Papayannopoulou","year":"1993","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.stemcr.2018.05.016_bib31","doi-asserted-by":"crossref","first-page":"9647","DOI":"10.1073\/pnas.92.21.9647","article-title":"The VLA4\/VCAM-1 adhesion pathway defines contrasting mechanisms of lodgement of transplanted murine hemopoietic progenitors between bone marrow and spleen","volume":"92","author":"Papayannopoulou","year":"1995","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.stemcr.2018.05.016_bib32","doi-asserted-by":"crossref","first-page":"3289","DOI":"10.1182\/blood.V95.11.3289","article-title":"The chemokine SDF-1 activates the integrins LFA-1, VLA-4, and VLA-5 on immature human CD34(+) cells: role in transendothelial\/stromal\u00a0migration and engraftment of NOD\/SCID mice","volume":"95","author":"Peled","year":"2000","journal-title":"Blood"},{"key":"10.1016\/j.stemcr.2018.05.016_bib33","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.1182\/blood-2003-09-3033","article-title":"Lack of the adhesion molecules P-selectin and intercellular adhesion molecule-1 accelerate the development of BCR\/ABL-induced chronic myeloid leukemia-like myeloproliferative disease in mice","volume":"104","author":"Pelletier","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.stemcr.2018.05.016_bib34","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1083\/jcb.201102131","article-title":"Cell cycle regulation in hematopoietic stem cells","volume":"195","author":"Pietras","year":"2011","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.stemcr.2018.05.016_bib35","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1189\/jlb.69.3.307","article-title":"Regulation of hematopoiesis through adhesion receptors","volume":"69","author":"Prosper","year":"2001","journal-title":"J.\u00a0Leukoc. Biol."},{"key":"10.1016\/j.stemcr.2018.05.016_bib36","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.immuni.2016.08.007","article-title":"Hematopoietic stem cells are the major source of multilineage hematopoiesis in adult animals","volume":"45","author":"Sawai","year":"2016","journal-title":"Immunity"},{"key":"10.1016\/j.stemcr.2018.05.016_bib37","doi-asserted-by":"crossref","first-page":"3425","DOI":"10.1182\/blood-2011-11-395418","article-title":"Activated Gs signaling in osteoblastic cells alters the hematopoietic stem cell niche in mice","volume":"120","author":"Schepers","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.stemcr.2018.05.016_bib38","first-page":"7","article-title":"The relationship between the spleen colony-forming cell and the haemopoietic stem cell","volume":"4","author":"Schofield","year":"1978","journal-title":"Blood Cells"},{"key":"10.1016\/j.stemcr.2018.05.016_bib39","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.immuni.2007.12.016","article-title":"Intercellular adhesion molecule-1-dependent stable interactions between T\u00a0cells and dendritic cells determine CD8+ T\u00a0cell memory","volume":"28","author":"Scholer","year":"2008","journal-title":"Immunity"},{"key":"10.1016\/j.stemcr.2018.05.016_bib40","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/S0950-3536(97)80022-4","article-title":"Adhesion molecules in haemopoiesis","volume":"10","author":"Simmons","year":"1997","journal-title":"Baillieres Clin. Haematol."},{"key":"10.1016\/j.stemcr.2018.05.016_bib41","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.it.2005.06.006","article-title":"Hematopoietic stem cells and their niche","volume":"26","author":"Suda","year":"2005","journal-title":"Trends Immunol."},{"key":"10.1016\/j.stemcr.2018.05.016_bib42","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1182\/blood-2008-09-179788","article-title":"Cell-nonautonomous function of Id1 in the hematopoietic progenitor cell niche","volume":"114","author":"Suh","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.stemcr.2018.05.016_bib43","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/BF00202069","article-title":"Intercellular adhesion molecule-1","volume":"74","author":"van de Stolpe","year":"1996","journal-title":"J.\u00a0Mol. Med. (Berl.)"},{"key":"10.1016\/j.stemcr.2018.05.016_bib44","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1182\/blood.V92.3.894","article-title":"Role of adhesion molecules in the homing and mobilization of murine hematopoietic stem and progenitor cells","volume":"92","author":"Vermeulen","year":"1998","journal-title":"Blood"},{"key":"10.1016\/j.stemcr.2018.05.016_bib45","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/nri1779","article-title":"Bone-marrow haematopoietic-stem-cell niches","volume":"6","author":"Wilson","year":"2006","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.stemcr.2018.05.016_bib46","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1016\/j.cell.2008.10.048","article-title":"Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair","volume":"135","author":"Wilson","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.stemcr.2018.05.016_bib47","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.gde.2009.08.005","article-title":"Balancing dormant and self-renewing hematopoietic stem cells","volume":"19","author":"Wilson","year":"2009","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1016\/j.stemcr.2018.05.016_bib48","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1038\/nm.2969","article-title":"Vascular niche\u00a0E-selectin regulates hematopoietic stem cell dormancy, self renewal and chemoresistance","volume":"18","author":"Winkler","year":"2012","journal-title":"Nat. Med."},{"key":"10.1016\/j.stemcr.2018.05.016_bib49","doi-asserted-by":"crossref","first-page":"2190","DOI":"10.1182\/blood-2005-12-010272","article-title":"Increased hematopoietic stem cell mobilization in aged mice","volume":"108","author":"Xing","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.stemcr.2018.05.016_bib50","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1038\/nm1342","article-title":"Angiopoietin-like proteins stimulate ex\u00a0vivo expansion of hematopoietic stem cells","volume":"12","author":"Zhang","year":"2006","journal-title":"Nat. Med."}],"container-title":["Stem Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213671118302340?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213671118302340?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T15:17:47Z","timestamp":1778858267000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213671118302340"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7]]},"references-count":50,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,7]]}},"alternative-id":["S2213671118302340"],"URL":"https:\/\/doi.org\/10.1016\/j.stemcr.2018.05.016","relation":{},"ISSN":["2213-6711"],"issn-type":[{"value":"2213-6711","type":"print"}],"subject":[],"published":{"date-parts":[[2018,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"ICAM-1 Deficiency in the Bone Marrow Niche Impairs Quiescence and\u00a0Repopulation of Hematopoietic Stem Cells","name":"articletitle","label":"Article Title"},{"value":"Stem Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.stemcr.2018.05.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 The Author(s).","name":"copyright","label":"Copyright"}]}}