{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T18:21:33Z","timestamp":1790619693793,"version":"4.1.0"},"reference-count":50,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,10,8]],"date-time":"2018-10-08T00:00:00Z","timestamp":1538956800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["SP\/15\/9\/31605"],"award-info":[{"award-number":["SP\/15\/9\/31605"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["RG\/15\/6\/31436"],"award-info":[{"award-number":["RG\/15\/6\/31436"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["PG\/14\/59\/31000"],"award-info":[{"award-number":["PG\/14\/59\/31000"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["RG\/14\/1\/30588"],"award-info":[{"award-number":["RG\/14\/1\/30588"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["RM\/13\/30157"],"award-info":[{"award-number":["RM\/13\/30157"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["P47352\/CRM"],"award-info":[{"award-number":["P47352\/CRM"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Centre for the Replacement, Refinement & Reduction of Animals","award":["CRACK-IT:35911-259146"],"award-info":[{"award-number":["CRACK-IT:35911-259146"]}]},{"name":"National Centre for the Replacement, Refinement & Reduction of Animals","award":["NC\/K000225\/1"],"award-info":[{"award-number":["NC\/K000225\/1"]}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/M017354\/1"],"award-info":[{"award-number":["MR\/M017354\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Britain Israel Research and Academic Exchange Partnership","award":["04BX14CDLG"],"award-info":[{"award-number":["04BX14CDLG"]}]},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red"},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["CB16\/11\/00425 617"],"award-info":[{"award-number":["CB16\/11\/00425 617"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"FEDER","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Uni\u00f3n Europea"},{"name":"Una forma de hacer Europa"},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"publisher","award":["DFG-Es-88\/12-1, HA3423\/5-1"],"award-info":[{"award-number":["DFG-Es-88\/12-1, HA3423\/5-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010663","name":"European Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010447","name":"German Centre for Cardiovascular Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010447","id-type":"DOI","asserted-by":"publisher"}]},{"name":"German Ministry of Education and Research"},{"name":"Freie und Hansestadt Hamburg"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Stem Cell Reports"],"published-print":{"date-parts":[[2018,11]]},"DOI":"10.1016\/j.stemcr.2018.10.006","type":"journal-article","created":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T14:43:51Z","timestamp":1541083431000},"page":"1226-1243","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":69,"title":["Isogenic Pairs of hiPSC-CMs with Hypertrophic Cardiomyopathy\/LVNC-Associated ACTC1 E99K Mutation Unveil Differential Functional Deficits"],"prefix":"10.1016","volume":"11","author":[{"given":"James G.W.","family":"Smith","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Owen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamie R.","family":"Bhagwan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diogo","family":"Mosqueira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Scott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingra","family":"Mannhardt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asha","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Barriales-Villa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Monserrat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arne","family":"Hansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Eschenhagen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sian E.","family":"Harding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve","family":"Marston","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Denning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.stemcr.2018.10.006_bib1","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1093\/hmg\/ddm074","article-title":"Restriction landmark genome scanning identifies culture-induced DNA methylation instability in the human embryonic stem cell epigenome","volume":"16","author":"Allegrucci","year":"2007","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.stemcr.2018.10.006_bib2","doi-asserted-by":"crossref","first-page":"2027","DOI":"10.1038\/sj.mt.6300303","article-title":"Transgenic enrichment of cardiomyocytes from human embryonic stem cells","volume":"15","author":"Anderson","year":"2007","journal-title":"Mol. Ther."},{"key":"10.1016\/j.stemcr.2018.10.006_bib3","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.1093\/hmg\/11.20.2499","article-title":"Phenotypic diversity in hypertrophic cardiomyopathy","volume":"11","author":"Arad","year":"2002","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.stemcr.2018.10.006_bib4","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.yjmcc.2014.10.014","article-title":"The immediate effect of HCM causing actin mutants E99K and A230V on actin-Tm-myosin interaction in thin-filament reconstituted myocardium","volume":"79","author":"Bai","year":"2015","journal-title":"J.\u00a0Mol. Cell. Cardiol."},{"key":"10.1016\/j.stemcr.2018.10.006_bib5","doi-asserted-by":"crossref","first-page":"16777","DOI":"10.1074\/jbc.M512935200","article-title":"Functional consequences of a mutation in an expressed human alpha-cardiac actin at a site implicated in familial hypertrophic cardiomyopathy","volume":"281","author":"Bookwalter","year":"2006","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.stemcr.2018.10.006_bib6","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1038\/nprot.2017.033","article-title":"Differentiation of cardiomyocytes and generation of human engineered heart tissue","volume":"12","author":"Breckwoldt","year":"2017","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.stemcr.2018.10.006_bib7","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1177\/1087057113500812","article-title":"Phenotypic screening with human iPS cell-derived cardiomyocytes: HTS-compatible assays for interrogating cardiac hypertrophy","volume":"18","author":"Carlson","year":"2013","journal-title":"J.\u00a0Biomol. Screen"},{"key":"10.1016\/j.stemcr.2018.10.006_bib8","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1161\/CIRCULATIONAHA.112.134932","article-title":"Late sodium current inhibition reverses electro-mechanical dysfunction in human hypertrophic cardiomyopathy","volume":"127","author":"Coppini","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.stemcr.2018.10.006_bib9","doi-asserted-by":"crossref","first-page":"8590","DOI":"10.1038\/s41598-017-08713-4","article-title":"Distinct carbon sources affect structural and functional maturation of cardiomyocytes derived from human pluripotent stem cells","volume":"7","author":"Correia","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.stemcr.2018.10.006_bib10","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.yjmcc.2009.09.014","article-title":"Human actin mutations associated with hypertrophic and dilated cardiomyopathies demonstrate distinct thin filament regulatory properties in\u00a0vitro","volume":"48","author":"Debold","year":"2010","journal-title":"J.\u00a0Mol. Cell. Cardiol."},{"key":"10.1016\/j.stemcr.2018.10.006_bib11","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1016\/j.bbamcr.2015.10.014","article-title":"Cardiomyocytes from human pluripotent stem cells: from laboratory curiosity to industrial biomedical platform","volume":"1863","author":"Denning","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.stemcr.2018.10.006_bib12","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1161\/CIRCRESAHA.117.310355","article-title":"Calcium signaling and transcriptional regulation in cardiomyocytes","volume":"121","author":"Dewenter","year":"2017","journal-title":"Circ. Res."},{"key":"10.1016\/j.stemcr.2018.10.006_bib13","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.tig.2014.03.003","article-title":"Random monoallelic expression: regulating gene expression one allele at a time","volume":"30","author":"Eckersley-Maslin","year":"2014","journal-title":"Trends Genet."},{"key":"10.1016\/j.stemcr.2018.10.006_bib14","doi-asserted-by":"crossref","first-page":"H133","DOI":"10.1152\/ajpheart.00007.2012","article-title":"Physiological aspects of cardiac tissue engineering","volume":"303","author":"Eschenhagen","year":"2012","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.stemcr.2018.10.006_bib15","doi-asserted-by":"crossref","first-page":"H1250","DOI":"10.1152\/ajpheart.00779.2011","article-title":"Calsequestrin 2 and arrhythmias","volume":"302","author":"Faggioni","year":"2012","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.stemcr.2018.10.006_bib16","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/S1043-2760(03)00113-9","article-title":"Natriuretic peptides: markers or modulators of cardiac hypertrophy?","volume":"14","author":"Gardner","year":"2003","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.stemcr.2018.10.006_bib17","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.stem.2017.06.005","article-title":"The evolving roles of human iPSC-derived cardiomyocytes in drug safety and discovery","volume":"21","author":"Gintant","year":"2017","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.stemcr.2018.10.006_bib18","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1016\/j.yjmcc.2010.01.011","article-title":"'Increased myofilament Ca2+-sensitivity and arrhythmia susceptibility'","volume":"48","author":"Huke","year":"2010","journal-title":"J.\u00a0Mol. Cell. Cardiol."},{"key":"10.1016\/j.stemcr.2018.10.006_bib19","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1002\/emmm.201100194","article-title":"Dantrolene rescues arrhythmogenic RYR2 defect in a patient-specific stem cell model of catecholaminergic polymorphic ventricular tachycardia","volume":"4","author":"Jung","year":"2012","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.stemcr.2018.10.006_bib20","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/j.stem.2016.02.005","article-title":"Age-related accumulation of somatic mitochondrial DNA mutations in adult-derived human iPSCs","volume":"18","author":"Kang","year":"2016","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.stemcr.2018.10.006_bib21","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1161\/CIRCGENETICS.108.821314","article-title":"Prevalence of sarcomere protein gene mutations in preadolescent children with hypertrophic cardiomyopathy","volume":"2","author":"Kaski","year":"2009","journal-title":"Circ. Cardiovasc. Genet."},{"key":"10.1016\/j.stemcr.2018.10.006_bib22","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1089\/scd.2017.0268","article-title":"Simplified footprint-free Cas9\/CRISPR editing of cardiac-associated genes in human pluripotent stem cells","volume":"27","author":"Kondrashov","year":"2018","journal-title":"Stem Cells Dev."},{"key":"10.1016\/j.stemcr.2018.10.006_bib23","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1161\/CIRCRESAHA.116.309804","article-title":"Hypertrophic cardiomyopathy: cell-to-cell imbalance in gene expression and contraction force as trigger for disease phenotype development","volume":"119","author":"Kraft","year":"2016","journal-title":"Circ. Res."},{"key":"10.1016\/j.stemcr.2018.10.006_bib24","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.stem.2012.10.010","article-title":"Abnormal calcium handling properties underlie familial hypertrophic cardiomyopathy pathology in patient-specific induced pluripotent stem cells","volume":"12","author":"Lan","year":"2013","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.stemcr.2018.10.006_bib25","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.stemcr.2016.04.011","article-title":"Human engineered heart tissue: analysis of contractile force","volume":"7","author":"Mannhardt","year":"2016","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.stemcr.2018.10.006_bib26","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/S0735-1097(01)01389-4","article-title":"On genetic and phenotypic variability of hypertrophic cardiomyopathy: nature versus nurture","volume":"38","author":"Marian","year":"2001","journal-title":"J.\u00a0Am. Coll. Cardiol."},{"key":"10.1016\/j.stemcr.2018.10.006_bib27","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1161\/CIRCULATIONAHA.106.174287","volume":"113","author":"Maron","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.stemcr.2018.10.006_bib28","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s12265-011-9266-2","article-title":"How do mutations in contractile proteins cause the primary familial cardiomyopathies?","volume":"4","author":"Marston","year":"2011","journal-title":"J.\u00a0Cardiovasc. Transl. Res."},{"key":"10.1016\/j.stemcr.2018.10.006_bib29","doi-asserted-by":"crossref","first-page":"R39","DOI":"10.1172\/JCI6460","article-title":"Alpha-cardiac actin is a novel disease gene in familial hypertrophic cardiomyopathy","volume":"103","author":"Mogensen","year":"1999","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.stemcr.2018.10.006_bib30","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1093\/eurheartj\/ehm239","article-title":"Mutation in the alpha-cardiac actin gene associated with apical hypertrophic cardiomyopathy, left ventricular non-compaction, and septal defects","volume":"28","author":"Monserrat","year":"2007","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.stemcr.2018.10.006_bib31","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1056\/NEJMoa075463","article-title":"Shared genetic causes of cardiac hypertrophy in children and adults","volume":"358","author":"Morita","year":"2008","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.stemcr.2018.10.006_bib32","doi-asserted-by":"crossref","DOI":"10.1093\/eurheartj\/ehy249","article-title":"CRISPR\/Cas9 editing in human pluripotent stem cell-cardiomyocytes highlights arrhythmias, hypocontractility, and energy depletion as potential therapeutic targets for hypertrophic cardiomyopathy","author":"Mosqueira","year":"2018","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.stemcr.2018.10.006_bib33","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1016\/j.bbrc.2018.01.181","article-title":"CaMKII-mediated phosphorylation of RyR2 plays a crucial role in aberrant Ca(2+) release as an arrhythmogenic substrate in cardiac troponin T-related familial hypertrophic cardiomyopathy","volume":"496","author":"Okuda","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.stemcr.2018.10.006_bib34","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/S0025-6196(11)60890-2","article-title":"Myofilament protein gene mutation screening and outcome of patients with hypertrophic cardiomyopathy","volume":"83","author":"Olivotto","year":"2008","journal-title":"Mayo Clin. Proc."},{"key":"10.1016\/j.stemcr.2018.10.006_bib35","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1126\/science.280.5364.750","article-title":"Actin mutations in dilated cardiomyopathy, a heritable form of heart failure","volume":"280","author":"Olson","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.stemcr.2018.10.006_bib36","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1006\/jmcc.2000.1204","article-title":"Inherited and de novo mutations in the cardiac actin gene cause hypertrophic cardiomyopathy","volume":"32","author":"Olson","year":"2000","journal-title":"J.\u00a0Mol. Cell. Cardiol."},{"key":"10.1016\/j.stemcr.2018.10.006_bib37","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1113\/expphysiol.2011.057612","article-title":"Angiotensin II-induced dilated cardiomyopathy in Balb\/c but not C57BL\/6J mice","volume":"96","author":"Peng","year":"2011","journal-title":"Exp. Physiol."},{"key":"10.1016\/j.stemcr.2018.10.006_bib38","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1093\/toxsci\/kfw069","article-title":"Cardiac non-myocyte cells show enhanced pharmacological function suggestive of contractile maturity in stem cell derived cardiomyocyte microtissues","volume":"152","author":"Ravenscroft","year":"2016","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.stemcr.2018.10.006_bib39","doi-asserted-by":"crossref","first-page":"10487","DOI":"10.1074\/jbc.RA118.002081","article-title":"Hypertrophic cardiomyopathy mutations increase myofilament Ca2+ buffering, alter intracellular Ca2+ handling and stimulate Ca2+ dependent signalling","volume":"293","author":"Robinson","year":"2018","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.stemcr.2018.10.006_bib40","doi-asserted-by":"crossref","first-page":"H1213","DOI":"10.1152\/ajpheart.00244.2017","article-title":"Age and strain related aberrant Ca(2+) release is associated with sudden cardiac death in the ACTC E99K mouse model of hypertrophic cardiomyopathy","volume":"313","author":"Rowlands","year":"2017","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.stemcr.2018.10.006_bib41","doi-asserted-by":"crossref","first-page":"11354","DOI":"10.1016\/S0021-9258(17)44425-5","article-title":"NH2-terminal processing of Drosophila melanogaster actin. Sequential removal of two amino acids","volume":"258","author":"Rubenstein","year":"1983","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.stemcr.2018.10.006_bib42","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/978-1-4939-1047-2_11","article-title":"Generation of strip-format fibrin-based engineered heart tissue (EHT)","volume":"1181","author":"Schaaf","year":"2014","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.stemcr.2018.10.006_bib43","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1007\/s00392-017-1155-5","article-title":"Clinical outcomes associated with sarcomere mutations in hypertrophic cardiomyopathy: a meta-analysis on 7675 individuals","volume":"107","author":"Sedaghat-Hamedani","year":"2018","journal-title":"Clin. Res. Cardiol."},{"key":"10.1016\/j.stemcr.2018.10.006_bib44","doi-asserted-by":"crossref","DOI":"10.3791\/52628-v","article-title":"Derivation of highly purified cardiomyocytes from human induced pluripotent stem cells using small molecule-modulated differentiation and subsequent glucose starvation","author":"Sharma","year":"2015","journal-title":"J.\u00a0Vis. Exp."},{"key":"10.1016\/j.stemcr.2018.10.006_bib45","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1126\/science.7350644","article-title":"Intraclonal variation in proliferative potential of human diploid fibroblasts: stochastic mechanism for cellular aging","volume":"207","author":"Smith","year":"1980","journal-title":"Science"},{"key":"10.1016\/j.stemcr.2018.10.006_bib46","doi-asserted-by":"crossref","first-page":"27582","DOI":"10.1074\/jbc.M111.252320","article-title":"Molecular mechanism of the Glu99lys mutation in cardiac actin (ACTC gene) that causes apical hypertrophy in man and mouse","volume":"286","author":"Song","year":"2011","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.stemcr.2018.10.006_bib47","doi-asserted-by":"crossref","first-page":"H1513","DOI":"10.1152\/ajpheart.00951.2012","article-title":"Mechanical and energetic properties of papillary muscle from ACTC E99K transgenic mouse models of hypertrophic cardiomyopathy","volume":"304","author":"Song","year":"2013","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.stemcr.2018.10.006_bib48","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1016\/j.bpj.2014.02.011","article-title":"Hypertrophic and dilated cardiomyopathy: four decades of basic research on muscle lead to potential therapeutic approaches to these devastating genetic diseases","volume":"106","author":"Spudich","year":"2014","journal-title":"Biophys. J."},{"key":"10.1016\/j.stemcr.2018.10.006_bib49","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.ymeth.2015.11.005","article-title":"Biowire platform for maturation of human pluripotent stem cell-derived cardiomyocytes","volume":"101","author":"Sun","year":"2016","journal-title":"Methods"},{"key":"10.1016\/j.stemcr.2018.10.006_bib50","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1002\/path.1311","article-title":"Alpha-actin isoform distribution in normal and failing human heart: a morphological, morphometric, and biochemical study","volume":"199","author":"Suurmeijer","year":"2003","journal-title":"J.\u00a0Pathol."}],"container-title":["Stem Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213671118304296?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213671118304296?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,2]],"date-time":"2024-06-02T17:50:56Z","timestamp":1717350656000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213671118304296"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11]]},"references-count":50,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,11]]}},"alternative-id":["S2213671118304296"],"URL":"https:\/\/doi.org\/10.1016\/j.stemcr.2018.10.006","relation":{},"ISSN":["2213-6711"],"issn-type":[{"value":"2213-6711","type":"print"}],"subject":[],"published":{"date-parts":[[2018,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Isogenic Pairs of hiPSC-CMs with Hypertrophic Cardiomyopathy\/LVNC-Associated ACTC1 E99K Mutation Unveil Differential Functional Deficits","name":"articletitle","label":"Article Title"},{"value":"Stem Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.stemcr.2018.10.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 The Author(s).","name":"copyright","label":"Copyright"}]}}