{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T18:52:14Z","timestamp":1792176734112,"version":"4.4.0"},"reference-count":37,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,4,9]],"date-time":"2021-04-09T00:00:00Z","timestamp":1617926400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 HL123968"],"award-info":[{"award-number":["R01 HL123968"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 HL132875"],"award-info":[{"award-number":["R01 HL132875"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 HL141851"],"award-info":[{"award-number":["R01 HL141851"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32 HL098049"],"award-info":[{"award-number":["T32 HL098049"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014549","name":"Stanford Cancer Institute","doi-asserted-by":"publisher","award":["1R01CA222969"],"award-info":[{"award-number":["1R01CA222969"]}],"id":[{"id":"10.13039\/100014549","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014549","name":"Stanford Cancer Institute","doi-asserted-by":"publisher","award":["1U54CA209971"],"award-info":[{"award-number":["1U54CA209971"]}],"id":[{"id":"10.13039\/100014549","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Stem Cell Reports"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1016\/j.stemcr.2021.04.004","type":"journal-article","created":{"date-parts":[[2021,5,6]],"date-time":"2021-05-06T16:11:18Z","timestamp":1620317478000},"page":"1468-1477","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":45,"title":["Antitumor effects of iPSC-based cancer vaccine in pancreatic cancer"],"prefix":"10.1016","volume":"16","author":[{"given":"Xiaoming","family":"Ouyang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tzu-Tang","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bomi","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binbin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerriann M.","family":"Casey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nigel G.","family":"Kooreman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aida","family":"Habtezion","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edgar G.","family":"Engleman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph C.","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.stemcr.2021.04.004_bib1","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1073\/pnas.0707140104","article-title":"Booster vaccination of cancer patients with MAGE-A3 protein reveals long-term immunological memory or tolerance depending on priming","volume":"105","author":"Atanackovic","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"10.1016\/j.stemcr.2021.04.004_bib2","doi-asserted-by":"crossref","first-page":"4878","DOI":"10.4049\/jimmunol.167.9.4878","article-title":"Divergent therapeutic and immunologic effects of oligodeoxynucleotides with distinct CpG motifs","volume":"167","author":"Ballas","year":"2001","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.stemcr.2021.04.004_bib3","first-page":"3311","article-title":"Antigen-specific Tregs control T\u00a0cell responses against a limited repertoire of tumor antigens in patients with colorectal carcinoma","volume":"119","author":"Bonertz","year":"2009","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.stemcr.2021.04.004_bib4","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s13073-017-0424-2","article-title":"Analysis of 100,000 human cancer genomes reveals the landscape of tumor mutational burden","volume":"9","author":"Chalmers","year":"2017","journal-title":"Genome Med."},{"key":"10.1016\/j.stemcr.2021.04.004_bib5","doi-asserted-by":"crossref","first-page":"3520","DOI":"10.1158\/1078-0432.CCR-10-3126","article-title":"PROVENGE (Sipuleucel-T) in prostate cancer: the first FDA-approved therapeutic cancer vaccine","volume":"17","author":"Cheever","year":"2011","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.stemcr.2021.04.004_bib6","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1038\/s41587-019-0280-2","article-title":"Predicting HLA class II antigen presentation through integrated deep learning","volume":"37","author":"Chen","year":"2019","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.stemcr.2021.04.004_bib7","first-page":"717","article-title":"Induction and chemotherapeutic response of two transplantable ductal adenocarcinomas of the pancreas in C57BL\/6 mice","volume":"44","author":"Corbett","year":"1984","journal-title":"Cancer Res."},{"key":"10.1016\/j.stemcr.2021.04.004_bib8","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1038\/s41587-019-0016-3","article-title":"Hypoimmunogenic derivatives of induced pluripotent stem cells evade immune rejection in fully immunocompetent allogeneic recipients","volume":"37","author":"Deuse","year":"2019","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.stemcr.2021.04.004_bib42","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1007\/s00262-010-0899-9","article-title":"Administration of embryonic stem cells generates effective antitumor immunity in mice with minor and heavy tumor load. Cancer Immunol","volume":"59","author":"Dong","year":"2010","journal-title":"Immunother"},{"key":"10.1016\/j.stemcr.2021.04.004_bib45","doi-asserted-by":"crossref","first-page":"147","DOI":"10.3390\/vaccines8020147","article-title":"Novel genetic melanoma vaccines based on induced pluripotent stem cells or melanosphere-derived Stem-like cells display high efficacy in a murine tumor rejection model","volume":"8","author":"G\u0105bka-Buszek","year":"2020","journal-title":"Vaccines"},{"key":"10.1016\/j.stemcr.2021.04.004_bib10","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1002\/cyto.a.22625","article-title":"FlowSOM: using self-organizing maps for visualization and interpretation of cytometry data","volume":"87","author":"Gassen","year":"2015","journal-title":"Cytometry A"},{"key":"10.1016\/j.stemcr.2021.04.004_bib11","doi-asserted-by":"crossref","first-page":"2598","DOI":"10.1158\/1535-7163.MCT-17-0386","article-title":"Tumor mutational burden as an independent predictor of response to immunotherapy in diverse cancers","volume":"16","author":"Goodman","year":"2017","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.stemcr.2021.04.004_bib12","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1038\/nature11465","article-title":"Adenoma-linked barrier defects and microbial products drive IL-23\/IL-17-mediated tumour growth","volume":"491","author":"Grivennikov","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.stemcr.2021.04.004_bib13","doi-asserted-by":"crossref","first-page":"7424","DOI":"10.3390\/ijms12117424","article-title":"Distribution and clinical significance of Th17 cells in the tumor microenvironment and peripheral blood of pancreatic cancer patients","volume":"12","author":"He","year":"2011","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.stemcr.2021.04.004_bib14","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.ccell.2020.02.008","article-title":"Dendritic cell paucity leads to dysfunctional immune surveillance in pancreatic cancer","volume":"37","author":"Hegde","year":"2020","journal-title":"Cancer Cell"},{"key":"10.1016\/j.stemcr.2021.04.004_bib15","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.cell.2018.03.022","article-title":"Cell-of-origin patterns dominate the molecular classification of 10,000 tumors from 33 types of cancer","volume":"173","author":"Hoadley","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.stemcr.2021.04.004_bib16","doi-asserted-by":"crossref","first-page":"5117","DOI":"10.4049\/jimmunol.1501657","article-title":"Landscape of tumor antigens in T\u00a0cell immunotherapy","volume":"195","author":"Ilyas","year":"2015","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.stemcr.2021.04.004_bib19","doi-asserted-by":"crossref","first-page":"3360","DOI":"10.4049\/jimmunol.1700893","article-title":"NetMHCpan-4.0: improved peptide\u2013MHC class I interaction predictions integrating eluted ligand and peptide binding affinity data","volume":"199","author":"Jurtz","year":"2017","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.stemcr.2021.04.004_bib20","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.stem.2018.01.016","article-title":"Autologous iPSC-based vaccines elicit anti-tumor responses in\u00a0vivo","volume":"22","author":"Kooreman","year":"2018","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.stemcr.2021.04.004_bib21","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1513\/pats.200701-021AW","article-title":"Antiinfective applications of toll-like receptor 9 agonists","volume":"4","author":"Krieg","year":"2007","journal-title":"Proc. Am. Thorac. Soc."},{"key":"10.1016\/j.stemcr.2021.04.004_bib22","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1038\/374546a0","article-title":"CpG motifs in bacterial DNA trigger direct B-cell activation","volume":"374","author":"Krieg","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.stemcr.2021.04.004_bib23","doi-asserted-by":"crossref","first-page":"2154","DOI":"10.1002\/1521-4141(200107)31:7<2154::AID-IMMU2154>3.0.CO;2-U","article-title":"Identification of CpG oligonucleotide sequences with high induction of IFN-alpha\/beta in plasmacytoid dendritic cells","volume":"31","author":"Krug","year":"2001","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.stemcr.2021.04.004_bib47","doi-asserted-by":"crossref","first-page":"3103","DOI":"10.1002\/stem.234","article-title":"Vaccination with human pluripotent stem cells generates a broad spectrum of immunological and clinical responses against colon cancer","volume":"27","author":"Li","year":"2009","journal-title":"Stem Cells"},{"key":"10.1016\/j.stemcr.2021.04.004_bib24","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1093\/jnci\/89.6.442","article-title":"Hereditary pancreatitis and the risk of pancreatic cancer. International Hereditary Pancreatitis Study Group","volume":"89","author":"Lowenfels","year":"1997","journal-title":"J.\u00a0Natl. Cancer Inst."},{"key":"10.1016\/j.stemcr.2021.04.004_bib26","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.3389\/fimmu.2019.01510","article-title":"Induced pluripotent stem cell-based cancer vaccines","volume":"10","author":"Ouyang","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.stemcr.2021.04.004_bib27","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/ni1178","article-title":"Naturally arising Foxp3-expressing CD25+ CD4+ regulatory T\u00a0cells in immunological tolerance to self and non-self","volume":"6","author":"Sakaguchi","year":"2005","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.stemcr.2021.04.004_bib28","first-page":"432","article-title":"Screening for hepatocellular carcinoma in chronic carriers of hepatitis B virus: incidence and prevalence of hepatocellular carcinoma in a North American urban population","volume":"22","author":"Sherman","year":"1995","journal-title":"Hepatology"},{"key":"10.1016\/j.stemcr.2021.04.004_bib30","first-page":"7","article-title":"Cancer Statistics, 2019","volume":"69","author":"Siegel","year":"2019","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.stemcr.2021.04.004_bib32","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1002\/ags3.12176","article-title":"Immunotherapy for pancreatic cancer: barriers and breakthroughs","volume":"2","author":"Torphy","year":"2018","journal-title":"Ann. Gastroenterol. Surg."},{"key":"10.1016\/j.stemcr.2021.04.004_bib35","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1016\/S1470-2045(16)00099-1","article-title":"Efficacy of the MAGE-A3 cancer immunotherapeutic as adjuvant therapy in patients with resected MAGE-A3-positive non-small-cell lung cancer (MAGRIT): a randomised, double-blind, placebo-controlled, phase 3 trial","volume":"17","author":"Vansteenkiste","year":"2016","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.stemcr.2021.04.004_bib36","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1080\/14712598.2019.1650909","article-title":"Induced pluripotent stem cells as a novel cancer vaccine","volume":"19","author":"Wang","year":"2019","journal-title":"Expert Opin. Biol. Ther."},{"key":"10.1016\/j.stemcr.2021.04.004_bib43","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1111\/1759-7714.13440","article-title":"Expression levels of a gene signature in hiPSC associated with lung adenocarcinoma stem cells and its capability in eliciting specific antitumor immune-response in a humanized mice model","volume":"11","author":"Wang","year":"2020","journal-title":"Thoracic Cancer"},{"key":"10.1016\/j.stemcr.2021.04.004_bib37","doi-asserted-by":"crossref","first-page":"70","DOI":"10.3389\/fphys.2014.00070","article-title":"Pancreatic cancer risk in hereditary pancreatitis","volume":"5","author":"Weiss","year":"2014","journal-title":"Front. Physiol."},{"key":"10.1016\/j.stemcr.2021.04.004_bib38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/ncomms7744","article-title":"Whole-exome sequencing of pancreatic cancer defines genetic diversity and therapeutic targets","volume":"6","author":"Witkiewicz","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.stemcr.2021.04.004_bib44","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0042289","article-title":"Vaccination with Embryonic Stem Cells Protects against Lung Cancer: Is a Broad-Spectrum Prophylactic Vaccine against Cancer Possible?","volume":"7","author":"Yaddanapudi","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.stemcr.2021.04.004_bib39","doi-asserted-by":"crossref","first-page":"2500","DOI":"10.1056\/NEJMc1713444","article-title":"Tumor mutational burden and response rate to PD-1 inhibition","volume":"377","author":"Yarchoan","year":"2017","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.stemcr.2021.04.004_bib46","doi-asserted-by":"crossref","first-page":"4295","DOI":"10.7314\/APJCP.2012.13.9.4295","article-title":"Human embryonic stem cells--a potential vaccine for ovarian cancer","volume":"13","author":"Zhang","year":"2012","journal-title":"Asian Pac. J. Cancer Prev."}],"container-title":["Stem Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213671121001995?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213671121001995?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T09:45:33Z","timestamp":1761990333000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213671121001995"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6]]},"references-count":37,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["S2213671121001995"],"URL":"https:\/\/doi.org\/10.1016\/j.stemcr.2021.04.004","relation":{},"ISSN":["2213-6711"],"issn-type":[{"value":"2213-6711","type":"print"}],"subject":[],"published":{"date-parts":[[2021,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Antitumor effects of iPSC-based cancer vaccine in pancreatic cancer","name":"articletitle","label":"Article Title"},{"value":"Stem Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.stemcr.2021.04.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Author(s).","name":"copyright","label":"Copyright"}]}}