{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T23:46:17Z","timestamp":1792280777721,"version":"4.4.0"},"reference-count":61,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,7,27]],"date-time":"2021-07-27T00:00:00Z","timestamp":1627344000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004334","name":"Merck","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004334","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Stem Cell Reports"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1016\/j.stemcr.2021.07.016","type":"journal-article","created":{"date-parts":[[2021,8,26]],"date-time":"2021-08-26T10:37:02Z","timestamp":1629974222000},"page":"2364-2378","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":49,"title":["Assessing donor-to-donor variability in human intestinal organoid cultures"],"prefix":"10.1016","volume":"16","author":[{"given":"Sina","family":"Mohammadi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Morell-Perez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles W.","family":"Wright","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas P.","family":"Wyche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cory H.","family":"White","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodore R.","family":"Sana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda A.","family":"Lieberman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.stemcr.2021.07.016_bib1","doi-asserted-by":"crossref","first-page":"S63","DOI":"10.1093\/annonc\/12.suppl_2.S63","article-title":"The gut as the largest endocrine organ in the body","volume":"12","author":"Ahlman","year":"2001","journal-title":"Ann. Oncol."},{"key":"10.1016\/j.stemcr.2021.07.016_bib2","first-page":"125","article-title":"Inflammatory bowel disease pathobiology: the role of the interferon signature","volume":"33","author":"Andreou","year":"2020","journal-title":"Ann. Gastroenterol."},{"key":"10.1016\/j.stemcr.2021.07.016_bib3","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1038\/nature06196","article-title":"Identification of stem cells in small intestine and colon by marker gene Lgr5","volume":"449","author":"Barker","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.stemcr.2021.07.016_bib4","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.ydbio.2016.09.014","article-title":"Modeling infectious diseases and host-microbe interactions in gastrointestinal organoids","volume":"420","author":"Bartfeld","year":"2016","journal-title":"Dev. Biol."},{"key":"10.1016\/j.stemcr.2021.07.016_bib5","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1093\/jmcb\/mjaa034","article-title":"Intestinal organoids as tools for enriching and studying specific and rare cell types: advances and future directions","volume":"12","author":"Boonekamp","year":"2020","journal-title":"J.\u00a0Mol. Cell Biol."},{"key":"10.1016\/j.stemcr.2021.07.016_bib6","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1002\/jcp.20494","article-title":"Ki-67 protein is associated with ribosomal RNA transcription in quiescent and proliferating cells","volume":"206","author":"Bullwinkel","year":"2006","journal-title":"J.\u00a0Cell. Physiol."},{"key":"10.1016\/j.stemcr.2021.07.016_bib7","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.2741\/4669","article-title":"Glucose and amino acid in enterocyte: absorption, metabolism and maturation","volume":"23","author":"Chen","year":"2018","journal-title":"Front. Biosci. (Landmark Ed.)"},{"key":"10.1016\/j.stemcr.2021.07.016_bib8","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1146\/annurev-physiol-030212-183744","article-title":"Paneth cells: maestros of the small intestinal crypts","volume":"75","author":"Clevers","year":"2013","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.stemcr.2021.07.016_bib9","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1146\/annurev-cellbio-100814-125218","article-title":"Mini-gut organoids: reconstitution of the stem cell niche","volume":"31","author":"Date","year":"2015","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.stemcr.2021.07.016_bib10","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/978-3-642-14541-4_4","article-title":"Role of the intestinal bile acid transporters in bile acid and drug disposition","author":"Dawson","year":"2011","journal-title":"Handb. Exp. Pharmacol."},{"key":"10.1016\/j.stemcr.2021.07.016_bib11","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1038\/s41435-019-0057-0","article-title":"The many faces of tumor necrosis factor signaling in the intestinal epithelium","volume":"20","author":"Delgado","year":"2019","journal-title":"Genes Immun."},{"key":"10.1016\/j.stemcr.2021.07.016_bib12","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.cell.2016.08.030","article-title":"Epithelia use butyrophilin-like molecules to shape organ-specific gammadelta T\u00a0cell compartments","volume":"167","author":"Di Marco Barros","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.stemcr.2021.07.016_bib13","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.3389\/fimmu.2019.01499","article-title":"M cells: intelligent engineering of mucosal immune surveillance","volume":"10","author":"Dillon","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.stemcr.2021.07.016_bib14","doi-asserted-by":"crossref","first-page":"e54469","DOI":"10.7554\/eLife.54469","article-title":"R-spondins engage heparan sulfate proteoglycans to potentiate WNT signaling","volume":"9","author":"Dubey","year":"2020","journal-title":"eLife"},{"key":"10.1016\/j.stemcr.2021.07.016_bib15","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1210\/me.2015-1106","article-title":"Research resource: a chromogranin A reporter for serotonin and histamine secreting enteroendocrine cells","volume":"29","author":"Engelstoft","year":"2015","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.stemcr.2021.07.016_bib16","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1093\/jn\/121.1.72","article-title":"In\u00a0vivo kinetics of intestinal absorption of riboflavin in rats","volume":"121","author":"Feder","year":"1991","journal-title":"J.\u00a0Nutr."},{"key":"10.1016\/j.stemcr.2021.07.016_bib17","series-title":"StatPearls [Internet]","article-title":"Physiology, small bowel","author":"Fish","year":"2020"},{"key":"10.1016\/j.stemcr.2021.07.016_bib18","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1177\/2050640617737632","article-title":"Citrulline as a marker of intestinal function and absorption in clinical settings: a systematic review and meta-analysis","volume":"6","author":"Fragkos","year":"2018","journal-title":"United Eur. Gastroenterol. J."},{"key":"10.1016\/j.stemcr.2021.07.016_bib19","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/978-981-13-9589-5_2","article-title":"Cellular iron metabolism and regulation","volume":"1173","author":"Gao","year":"2019","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.stemcr.2021.07.016_bib20","doi-asserted-by":"crossref","first-page":"150","DOI":"10.4291\/wjgp.v8.i4.150","article-title":"Paneth cells in intestinal physiology and pathophysiology","volume":"8","author":"Gassler","year":"2017","journal-title":"World J. Gastrointest. Pathophysiol."},{"key":"10.1016\/j.stemcr.2021.07.016_bib21","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/s41575-018-0081-y","article-title":"Tales from the crypt: new insights into intestinal stem cells","volume":"16","author":"Gehart","year":"2019","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.stemcr.2021.07.016_bib22","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.cell.2007.02.006","article-title":"Epigenetics: a landscape takes shape","volume":"128","author":"Goldberg","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.stemcr.2021.07.016_bib23","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1038\/s41574-019-0168-8","article-title":"Function and mechanisms of enteroendocrine cells and gut hormones in metabolism","volume":"15","author":"Gribble","year":"2019","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.stemcr.2021.07.016_bib24","doi-asserted-by":"crossref","first-page":"1702","DOI":"10.1093\/jn\/113.9.1702","article-title":"Riboflavin uptake by isolated enterocytes of Guinea pigs","volume":"113","author":"Hegazy","year":"1983","journal-title":"J.\u00a0Nutr."},{"key":"10.1016\/j.stemcr.2021.07.016_bib25","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1002\/j.2040-4603.2018.tb00031.x","article-title":"Mechanisms and regulation of intestinal phosphate absorption","volume":"8","author":"Hernando","year":"2018","journal-title":"Compr. Physiol."},{"key":"10.1016\/j.stemcr.2021.07.016_bib26","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1097\/MOL.0000000000000084","article-title":"Intestinal lipid absorption and lipoprotein formation","volume":"25","author":"Hussain","year":"2014","journal-title":"Curr. Opin. Lipidol."},{"key":"10.1016\/j.stemcr.2021.07.016_bib27","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/nrd3028","article-title":"Membrane transporters in drug development","volume":"9","author":"International Transporter","year":"2010","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.stemcr.2021.07.016_bib28","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1128\/MCB.22.4.1172-1183.2002","article-title":"Wnt\/beta-catenin\/Tcf signaling induces the transcription of Axin2, a negative regulator of the signaling pathway","volume":"22","author":"Jho","year":"2002","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.stemcr.2021.07.016_bib29","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1038\/nrgastro.2013.35","article-title":"The gastrointestinal mucus system in health and disease","volume":"10","author":"Johansson","year":"2013","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.stemcr.2021.07.016_bib30","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1124\/dmd.31.12.1520","article-title":"The small intestine as a xenobiotic-metabolizing organ","volume":"31","author":"Kaminsky","year":"2003","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.stemcr.2021.07.016_bib31","doi-asserted-by":"crossref","first-page":"87","DOI":"10.2133\/dmpk.23.87","article-title":"Intestinal first-pass metabolism of CYP3A4 substrates","volume":"23","author":"Kato","year":"2008","journal-title":"Drug Metab. Pharmacokinet."},{"key":"10.1016\/j.stemcr.2021.07.016_bib32","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/s41575-019-0250-7","article-title":"Regulation of intestinal lipid metabolism: current concepts and relevance to disease","volume":"17","author":"Ko","year":"2020","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.stemcr.2021.07.016_bib33","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1002\/dvdy.24423","article-title":"Heterogeneity in readouts of canonical wnt pathway activity within intestinal crypts","volume":"245","author":"Li","year":"2016","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.stemcr.2021.07.016_bib34","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1038\/nature16460","article-title":"Interleukin-22 promotes intestinal-stem-cell-mediated epithelial regeneration","volume":"528","author":"Lindemans","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.stemcr.2021.07.016_bib35","doi-asserted-by":"crossref","first-page":"R1","DOI":"10.1530\/JOE-19-0399","article-title":"Mechanisms controlling hormone secretion in human gut and its relevance to metabolism","volume":"244","author":"Martin","year":"2019","journal-title":"J.\u00a0Endocrinol."},{"key":"10.1016\/j.stemcr.2021.07.016_bib36","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1038\/nrgastro.2013.105","article-title":"Serotonin signalling in the gut--functions, dysfunctions and therapeutic targets","volume":"10","author":"Mawe","year":"2013","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.stemcr.2021.07.016_bib37","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1136\/gut.36.2.259","article-title":"Characterisation of CYP3A gene subfamily expression in human gastrointestinal tissues","volume":"36","author":"McKinnon","year":"1995","journal-title":"Gut"},{"key":"10.1016\/j.stemcr.2021.07.016_bib38","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/s12915-018-0527-2","article-title":"Harnessing single-cell genomics to improve the physiological fidelity of organoid-derived cell types","volume":"16","author":"Mead","year":"2018","journal-title":"BMC Biol."},{"key":"10.1016\/j.stemcr.2021.07.016_bib39","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1016\/j.stem.2020.04.003","article-title":"Pooled in\u00a0vitro and in\u00a0vivo CRISPR-cas9 screening identifies tumor suppressors in human colon organoids","volume":"26","author":"Michels","year":"2020","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.stemcr.2021.07.016_bib40","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1002\/stem.1655","article-title":"Adult stem cells in the small intestine are intrinsically programmed with their location-specific function","volume":"32","author":"Middendorp","year":"2014","journal-title":"Stem Cells"},{"key":"10.1016\/j.stemcr.2021.07.016_bib41","doi-asserted-by":"crossref","first-page":"2471","DOI":"10.1038\/nprot.2013.153","article-title":"In\u00a0vitro expansion and genetic modification of gastrointestinal stem cells in spheroid culture","volume":"8","author":"Miyoshi","year":"2013","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.stemcr.2021.07.016_bib42","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1083\/jcb.111.2.567","article-title":"Identification of protein IT of the intestinal cytoskeleton as a novel type I cytokeratin with unusual properties and expression patterns","volume":"111","author":"Moll","year":"1990","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.stemcr.2021.07.016_bib43","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1038\/s41590-019-0415-0","article-title":"Targeting immune cell circuits and trafficking in inflammatory bowel disease","volume":"20","author":"Neurath","year":"2019","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.stemcr.2021.07.016_bib44","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.imlet.2019.02.003","article-title":"Tuft cells: from the mucosa to the thymus","volume":"210","author":"Nevo","year":"2019","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.stemcr.2021.07.016_bib45","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/s41586-019-0992-y","article-title":"Colonic epithelial cell diversity in health and inflammatory bowel disease","volume":"567","author":"Parikh","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.stemcr.2021.07.016_bib46","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/imr.12182","article-title":"The mucus and mucins of the goblet cells and enterocytes provide the first defense line of the gastrointestinal tract and interact with the immune system","volume":"260","author":"Pelaseyed","year":"2014","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.stemcr.2021.07.016_bib47","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.stem.2020.02.007","article-title":"Genome-scale CRISPR screening in human intestinal organoids identifies drivers of TGF-beta resistance","volume":"26","author":"Ringel","year":"2020","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.stemcr.2021.07.016_bib48","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.1053\/j.gastro.2011.07.050","article-title":"Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and Barrett's epithelium","volume":"141","author":"Sato","year":"2011","journal-title":"Gastroenterology"},{"key":"10.1016\/j.stemcr.2021.07.016_bib49","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/nature09637","article-title":"Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts","volume":"469","author":"Sato","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.stemcr.2021.07.016_bib50","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1038\/nature07935","article-title":"Single Lgr5 stem cells build crypt-villus structures in\u00a0vitro without a mesenchymal niche","volume":"459","author":"Sato","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.stemcr.2021.07.016_bib51","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1146\/annurev-pathmechdis-012419-032611","article-title":"Human organoids: tools for understanding biology and treating diseases","volume":"15","author":"Schutgens","year":"2020","journal-title":"Annu. Rev. Pathol."},{"key":"10.1016\/j.stemcr.2021.07.016_bib52","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/j.cell.2019.06.029","article-title":"Intra- and inter-cellular rewiring of the human colon during ulcerative colitis","volume":"178","author":"Smillie","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.stemcr.2021.07.016_bib53","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1038\/nrgastro.2017.51","article-title":"Non-conventional features of peripheral serotonin signalling\u2014the gut and beyond","volume":"14","author":"Spohn","year":"2017","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.stemcr.2021.07.016_bib54","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.cell.2020.06.022","article-title":"RNA sensing by gut Piezo1 is essential for systemic serotonin synthesis","volume":"182","author":"Sugisawa","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.stemcr.2021.07.016_bib55","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1203\/00006450-199210000-00019","article-title":"Characteristics of L-citrulline transport across rat small intestine in\u00a0vitro","volume":"32","author":"Vadgama","year":"1992","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.stemcr.2021.07.016_bib56","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/j.cell.2009.01.031","article-title":"Transcription factor achaete scute-like 2 controls intestinal stem cell fate","volume":"136","author":"van der Flier","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.stemcr.2021.07.016_bib57","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1111\/joim.13075","article-title":"Airway organoids as models of human disease","volume":"289","author":"van der Vaart","year":"2020","journal-title":"J.\u00a0Intern. Med."},{"key":"10.1016\/j.stemcr.2021.07.016_bib58","doi-asserted-by":"crossref","first-page":"e20191130","DOI":"10.1084\/jem.20191130","article-title":"Single-cell transcriptome analysis reveals differential nutrient absorption functions in human intestine","volume":"217","author":"Wang","year":"2020","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.stemcr.2021.07.016_bib59","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/mi.2017.73","article-title":"Enteroendocrine cells-sensory sentinels of the intestinal environment and orchestrators of mucosal immunity","volume":"11","author":"Worthington","year":"2018","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.stemcr.2021.07.016_bib60","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/nmeth.2737","article-title":"Niche-independent high-purity cultures of Lgr5+ intestinal stem cells and their progeny","volume":"11","author":"Yin","year":"2014","journal-title":"Nat. Methods"},{"key":"10.1016\/j.stemcr.2021.07.016_bib61","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1038\/oby.2006.77","article-title":"Peptide YY and proglucagon mRNA expression patterns and regulation in the gut","volume":"14","author":"Zhou","year":"2006","journal-title":"Obesity (Silver Spring)"}],"container-title":["Stem Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213671121003829?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213671121003829?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T09:49:27Z","timestamp":1761990567000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213671121003829"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":61,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["S2213671121003829"],"URL":"https:\/\/doi.org\/10.1016\/j.stemcr.2021.07.016","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2021.07.23.453590","asserted-by":"object"}]},"ISSN":["2213-6711"],"issn-type":[{"value":"2213-6711","type":"print"}],"subject":[],"published":{"date-parts":[[2021,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Assessing donor-to-donor variability in human intestinal organoid cultures","name":"articletitle","label":"Article Title"},{"value":"Stem Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.stemcr.2021.07.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors.","name":"copyright","label":"Copyright"}]}}