{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:09:02Z","timestamp":1792796942016,"version":"4.5.0"},"reference-count":70,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,11,23]],"date-time":"2021-11-23T00:00:00Z","timestamp":1637625600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R44AG058330"],"award-info":[{"award-number":["R44AG058330"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["R44TR001326"],"award-info":[{"award-number":["R44TR001326"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Stem Cell Reports"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1016\/j.stemcr.2021.11.009","type":"journal-article","created":{"date-parts":[[2021,12,22]],"date-time":"2021-12-22T10:43:38Z","timestamp":1640169818000},"page":"96-109","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":79,"title":["A functional hiPSC-cortical neuron differentiation and maturation model and its application to neurological disorders"],"prefix":"10.1016","volume":"17","author":[{"given":"Kaveena","family":"Autar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiufang","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John W.","family":"Rumsey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher J.","family":"Long","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nesar","family":"Akanda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max","family":"Jackson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narasimhan S.","family":"Narasimhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julbert","family":"Caneus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dave","family":"Morgan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1621-3006","authenticated-orcid":false,"given":"James J.","family":"Hickman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.stemcr.2021.11.009_bib1","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1002\/(SICI)1098-1063(1997)7:2<137::AID-HIPO3>3.0.CO;2-K","article-title":"Induction and reversal of long-term potentiation by repeated high-frequency stimulation in rat hippocampal slices","volume":"7","author":"Abraham","year":"1997","journal-title":"Hippocampus"},{"key":"10.1016\/j.stemcr.2021.11.009_bib2","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1089\/neu.2011.1923","article-title":"Endogenous GFAP-positive neural stem\/progenitor cells in the postnatal mouse cortex are activated following traumatic brain injury","volume":"29","author":"Ahmed","year":"2012","journal-title":"J.\u00a0Neurotrauma"},{"key":"10.1016\/j.stemcr.2021.11.009_bib3","doi-asserted-by":"crossref","first-page":"14302","DOI":"10.1038\/s41598-020-70510-3","article-title":"Skeletal muscle model derived from familial ALS patient iPSCs recapitulates hallmarks of disease progression","volume":"10","author":"Badu-Mensah","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.stemcr.2021.11.009_bib4","doi-asserted-by":"crossref","first-page":"E2725","DOI":"10.1073\/pnas.1504393112","article-title":"Neuronal medium that supports basic synaptic functions and activity of human neurons in\u00a0vitro","volume":"112","author":"Bardy","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"10.1016\/j.stemcr.2021.11.009_bib5","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/j.stemcr.2018.01.019","article-title":"GDNF\/GFR\u03b11 complex abrogates self-renewing activity of cortical neural precursors inducing their differentiation","volume":"10","author":"Bonafina","year":"2018","journal-title":"Stem Cell Reports"},{"key":"10.1016\/j.stemcr.2021.11.009_bib6","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.eplepsyres.2018.07.008","article-title":"In\u00a0vitro and in\u00a0vivo experimental models employed in the discovery and development of antiepileptic drugs for pharmacoresistant epilepsy","volume":"146","author":"Campos","year":"2018","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.stemcr.2021.11.009_bib7","doi-asserted-by":"crossref","first-page":"e12029","DOI":"10.1002\/trc2.12029","article-title":"A human induced pluripotent stem cell-derived cortical neuron human-on-a chip system to study A\u03b242 and tau-induced pathophysiological effects on long-term potentiation","volume":"6","author":"Caneus","year":"2020","journal-title":"Alzheimers Dement. (N Y)"},{"key":"10.1016\/j.stemcr.2021.11.009_bib8","doi-asserted-by":"crossref","first-page":"3282","DOI":"10.1038\/s41598-017-03519-w","article-title":"Enhanced derivation of human pluripotent stem cell-derived cortical glutamatergic neurons by a small molecule","volume":"7","author":"Cao","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.stemcr.2021.11.009_bib9","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.jgg.2012.04.006","article-title":"Pluripotent stem cells models for Huntington's disease: prospects and challenges","volume":"39","author":"Carter","year":"2012","journal-title":"J.\u00a0Genet. Genomics"},{"key":"10.1016\/j.stemcr.2021.11.009_bib10","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/nbt.1529","article-title":"Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling","volume":"27","author":"Chambers","year":"2009","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.stemcr.2021.11.009_bib11","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1002\/(SICI)1098-1063(1998)8:3<289::AID-HIPO10>3.0.CO;2-X","article-title":"Effects of GABA(A) inhibition on the expression of long-term potentiation in CA1 pyramidal cells are dependent on tetanization parameters","volume":"8","author":"Chapman","year":"1998","journal-title":"Hippocampus"},{"key":"10.1016\/j.stemcr.2021.11.009_bib12","doi-asserted-by":"crossref","first-page":"369","DOI":"10.4196\/kjpp.2012.16.6.369","article-title":"Synaptic plasticity in mouse models of autism spectrum disorders","volume":"16","author":"Chung","year":"2012","journal-title":"Korean J. Physiol. Pharmacol."},{"key":"10.1016\/j.stemcr.2021.11.009_bib13","doi-asserted-by":"crossref","first-page":"5643","DOI":"10.1016\/j.biomaterials.2004.01.020","article-title":"Long-term culture of embryonic rat cardiomyocytes on an organosilane surface in a serum free medium","volume":"25","author":"Das","year":"2004","journal-title":"Biomaterials"},{"key":"10.1016\/j.stemcr.2021.11.009_bib14","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/S1059-1311(95)80003-4","article-title":"Mechanisms of action of antiepileptic drugs","volume":"4","author":"Davies","year":"1995","journal-title":"Seizure"},{"key":"10.1016\/j.stemcr.2021.11.009_bib15","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/S0896-6273(03)00465-3","article-title":"Place representation within hippocampal networks is modified by long-term potentiation","volume":"39","author":"Dragoi","year":"2003","journal-title":"Neuron"},{"key":"10.1016\/j.stemcr.2021.11.009_bib16","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1021\/cn300206k","article-title":"Two cell circuits of oriented adult hippocampal neurons on self-assembled monolayers for use in the study of neuronal communication in a defined system","volume":"4","author":"Edwards","year":"2013","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.stemcr.2021.11.009_bib17","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.neuron.2018.10.033","article-title":"Best practices for translational disease modeling using human iPSC-derived neurons","volume":"100","author":"Engle","year":"2018","journal-title":"Neuron"},{"key":"10.1016\/j.stemcr.2021.11.009_bib18","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.neuron.2012.12.011","article-title":"Pyramidal neurons derived from human pluripotent stem cells integrate efficiently into mouse brain circuits in\u00a0vivo","volume":"77","author":"Espuny-Camacho","year":"2013","journal-title":"Neuron"},{"key":"10.1016\/j.stemcr.2021.11.009_bib19","first-page":"54900","article-title":"Rapid neuronal differentiation of induced pluripotent stem cells for measuring network activity on micro-electrode arrays","volume":"119","author":"Frega","year":"2017","journal-title":"JoVE"},{"key":"10.1016\/j.stemcr.2021.11.009_bib20","doi-asserted-by":"crossref","first-page":"e50333","DOI":"10.7554\/eLife.50333","article-title":"Mechanisms of hyperexcitability in Alzheimer\u2019s disease hiPSC-derived neurons and cerebral organoids vs isogenic controls","volume":"8","author":"Ghatak","year":"2019","journal-title":"eLife"},{"key":"10.1016\/j.stemcr.2021.11.009_bib21","doi-asserted-by":"crossref","first-page":"2756","DOI":"10.1021\/acschemneuro.8b00682","article-title":"Polarity induced in human stem cell derived motoneurons on patterned self-assembled monolayers","volume":"10","author":"Gonzalez","year":"2019","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.stemcr.2021.11.009_bib22","doi-asserted-by":"crossref","first-page":"6856","DOI":"10.1523\/JNEUROSCI.23-17-06856.2003","article-title":"Brain-derived neurotrophic factor is required for the maintenance of cortical dendrites","volume":"23","author":"Gorski","year":"2003","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.stemcr.2021.11.009_bib23","doi-asserted-by":"crossref","first-page":"590","DOI":"10.3389\/fnins.2018.00590","article-title":"In\u00a0vitro models for seizure-liability testing using induced pluripotent stem cells","volume":"12","author":"Grainger","year":"2018","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.stemcr.2021.11.009_bib24","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1038\/mp.2017.56","article-title":"A simplified protocol for differentiation of electrophysiologically mature neuronal networks from human induced pluripotent stem cells","volume":"23","author":"Gunhanlar","year":"2018","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.stemcr.2021.11.009_bib25","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1002\/term.223","article-title":"Characterization of a human fetal spinal cord stem cell line NSI-566RSC and its induction to functional motoneurons","volume":"4","author":"Guo","year":"2010","journal-title":"J.\u00a0Tissue Eng. Regen. Med."},{"key":"10.1016\/j.stemcr.2021.11.009_bib26","doi-asserted-by":"crossref","first-page":"13974","DOI":"10.1038\/s41598-020-70876-4","article-title":"Multicoding in neural information transfer suggested by mathematical analysis of the frequency-dependent synaptic plasticity in\u00a0vivo","volume":"10","author":"Hata","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.stemcr.2021.11.009_bib27","doi-asserted-by":"crossref","first-page":"29152","DOI":"10.1038\/srep29152","article-title":"The reemergence of long-term potentiation in aged Alzheimer's disease mouse model","volume":"6","author":"Huh","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.stemcr.2021.11.009_bib28","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/s13041-017-0338-3","article-title":"Restoring synaptic plasticity and memory in mouse models of Alzheimer\u2019s disease by PKR inhibition","volume":"10","author":"Hwang","year":"2017","journal-title":"Mol. Brain"},{"key":"10.1016\/j.stemcr.2021.11.009_bib29","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1111\/bph.12127","article-title":"Advantages of an antagonist: bicuculline and other GABA antagonists","volume":"169","author":"Johnston","year":"2013","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.stemcr.2021.11.009_bib30","doi-asserted-by":"crossref","first-page":"593","DOI":"10.3233\/JAD-2012-120532","article-title":"Impaired LTP- but not LTD-like cortical plasticity in Alzheimer's disease patients","volume":"31","author":"Koch","year":"2012","journal-title":"J.\u00a0Alzheimer's Dis."},{"key":"10.1016\/j.stemcr.2021.11.009_bib31","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.neulet.2014.03.066","article-title":"Valproic acid selectively suppresses the formation of inhibitory synapses in cultured cortical neurons","volume":"569","author":"Kumamaru","year":"2014","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.stemcr.2021.11.009_bib32","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3389\/fnagi.2011.00007","article-title":"Long-term potentiation at CA3\u2013CA1 hippocampal synapses with special emphasis on aging, disease, and stress","volume":"3","author":"Kumar","year":"2011","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.stemcr.2021.11.009_bib33","doi-asserted-by":"crossref","first-page":"e0169506","DOI":"10.1371\/journal.pone.0169506","article-title":"Functional maturation of human stem cell-derived neurons in long-term cultures","volume":"12","author":"Lam","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.stemcr.2021.11.009_bib34","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.neuron.2013.01.011","article-title":"GABAergic interneurons shape the functional maturation of the cortex","volume":"77","author":"Le Magueresse","year":"2013","journal-title":"Neuron"},{"key":"10.1016\/j.stemcr.2021.11.009_bib35","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.expneurol.2016.04.010","article-title":"NBQX, a highly selective competitive antagonist of AMPA and KA ionotropic glutamate receptors, increases seizures and mortality following picornavirus infection","volume":"280","author":"Libbey","year":"2016","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.stemcr.2021.11.009_bib36","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.1111\/j.1530-0277.2012.01792.x","article-title":"Pilot study of iPS-derived neural cells to examine biologic effects of alcohol on human neurons in\u00a0vitro","volume":"36","author":"Lieberman","year":"2012","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.stemcr.2021.11.009_bib37","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.seizure.2011.01.003","article-title":"Critical review of current animal models of seizures and epilepsy used in the discovery and development of new antiepileptic drugs","volume":"20","author":"Loscher","year":"2011","journal-title":"Seizure"},{"key":"10.1016\/j.stemcr.2021.11.009_bib38","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1038\/s41390-018-0214-6","article-title":"Cortical interneuron function in autism spectrum condition","volume":"85","author":"Lunden","year":"2019","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.stemcr.2021.11.009_bib39","doi-asserted-by":"crossref","first-page":"778","DOI":"10.3389\/fphar.2019.00778","article-title":"Targeting synaptic plasticity in experimental models of Alzheimer's disease","volume":"10","author":"Mango","year":"2019","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.stemcr.2021.11.009_bib40","doi-asserted-by":"crossref","first-page":"2343","DOI":"10.1523\/JNEUROSCI.21-07-02343.2001","article-title":"GABA expression dominates neuronal lineage progression in the embryonic rat neocortex and facilitates neurite outgrowth via GABA(A) autoreceptor\/Cl- channels","volume":"21","author":"Maric","year":"2001","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.stemcr.2021.11.009_bib41","doi-asserted-by":"crossref","first-page":"980941","DOI":"10.1155\/2012\/980941","article-title":"Stem cells as in\u00a0vitro model of Parkinson's disease","volume":"2012","author":"Mart\u00ednez-Morales","year":"2012","journal-title":"Stem Cells Int."},{"key":"10.1016\/j.stemcr.2021.11.009_bib42","doi-asserted-by":"crossref","first-page":"e0178533","DOI":"10.1371\/journal.pone.0178533","article-title":"Multi-level characterization of balanced inhibitory-excitatory cortical neuron network derived from human pluripotent stem cells","volume":"12","author":"Nadadhur","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.stemcr.2021.11.009_bib43","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/j.neuron.2007.10.033","article-title":"Long-term potentiation in rat hippocampal neurons is accompanied by spatially widespread changes in intrinsic oscillatory dynamics and excitability","volume":"56","author":"Narayanan","year":"2007","journal-title":"Neuron"},{"key":"10.1016\/j.stemcr.2021.11.009_bib44","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1021\/cn300029t","article-title":"DMH1, a highly selective small molecule BMP inhibitor promotes neurogenesis of hiPSCs: comparison of PAX6 and SOX1 expression during neural induction","volume":"3","author":"Neely","year":"2012","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.stemcr.2021.11.009_bib45","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1002\/stem.1462","article-title":"Embryonic stem cells neural differentiation qualifies the role of Wnt\/\u03b2-catenin signals in human telencephalic specification and regionalization","volume":"31","author":"Nicoleau","year":"2013","journal-title":"Stem Cells"},{"key":"10.1016\/j.stemcr.2021.11.009_bib46","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.neuron.2016.12.015","article-title":"A brief history of long-term potentiation","volume":"93","author":"Nicoll","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/j.stemcr.2021.11.009_bib47","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/0006-8993(82)90913-1","article-title":"GABA and bicuculline actions on mouse spinal cord and cortical neurons in cell culture","volume":"244","author":"Nowak","year":"1982","journal-title":"Brain Res."},{"key":"10.1016\/j.stemcr.2021.11.009_bib48","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fnins.2014.00423","article-title":"Revealing neuronal function through microelectrode array recordings","volume":"8","author":"Obien","year":"2015","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.stemcr.2021.11.009_bib49","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1016\/j.bbrc.2015.12.087","article-title":"Induction of long-term potentiation and depression phenomena in human induced pluripotent stem cell-derived cortical neurons","volume":"469","author":"Odawara","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.stemcr.2021.11.009_bib50","doi-asserted-by":"crossref","first-page":"26181","DOI":"10.1038\/srep26181","article-title":"Physiological maturation and drug responses of human induced pluripotent stem cell-derived cortical neuronal networks in long-term culture","volume":"6","author":"Odawara","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.stemcr.2021.11.009_bib51","doi-asserted-by":"crossref","first-page":"10416","DOI":"10.1038\/s41598-018-28835-7","article-title":"Toxicological evaluation of convulsant and anticonvulsant drugs in human induced pluripotent stem cell-derived cortical neuronal networks using an MEA system","volume":"8","author":"Odawara","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.stemcr.2021.11.009_bib52","doi-asserted-by":"crossref","first-page":"1805792","DOI":"10.1002\/adfm.201805792","article-title":"Long-term electrical and mechanical function monitoring of a human-on-a-chip system","volume":"29","author":"Oleaga","year":"2019","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.stemcr.2021.11.009_bib53","doi-asserted-by":"crossref","first-page":"33069","DOI":"10.1002\/btpr.3069","article-title":"A functional long-term serum-free human hepatic in\u00a0vitro system for drug evaluation","volume":"37","author":"Oleaga","year":"2021","journal-title":"Biotechnol. Prog."},{"key":"10.1016\/j.stemcr.2021.11.009_bib54","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1097\/00000542-200407000-00018","article-title":"Lidocaine increases intracellular sodium concentration through voltage-dependent sodium channels in an identified lymnaea neuron","volume":"101","author":"Onizuka","year":"2004","journal-title":"Anesthesiology"},{"key":"10.1016\/j.stemcr.2021.11.009_bib55","doi-asserted-by":"crossref","first-page":"17796","DOI":"10.1038\/srep17796","article-title":"Learning-induced synaptic potentiation in implanted neural precursor cell-derived neurons","volume":"5","author":"Park","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.stemcr.2021.11.009_bib56","doi-asserted-by":"crossref","first-page":"2615","DOI":"10.1021\/acschemneuro.0c00287","article-title":"Myelination and node of Ranvier formation in a human motoneuron\u2013Schwann cell serum-free coculture","volume":"11","author":"Patel","year":"2020","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.stemcr.2021.11.009_bib57","doi-asserted-by":"crossref","first-page":"e103418","DOI":"10.1371\/journal.pone.0103418","article-title":"A time course analysis of the electrophysiological properties of neurons differentiated from human induced pluripotent stem cells (iPSCs)","volume":"9","author":"Pr\u00e8","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.stemcr.2021.11.009_bib58","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1097\/ALN.0b013e31822ddf08","article-title":"Lidocaine blocks the hyperpolarization-activated mixed cation current, I h, in rat thalamocortical neurons","volume":"115","author":"Putrenko","year":"2011","journal-title":"Anesthesiology"},{"key":"10.1016\/j.stemcr.2021.11.009_bib59","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1038\/nbt.3777","article-title":"Combined small-molecule inhibition accelerates the derivation of functional, early-born, cortical neurons from human pluripotent stem cells","volume":"35","author":"Qi","year":"2017","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.stemcr.2021.11.009_bib60","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1002\/dneu.22057","article-title":"\u03b22 and \u03b33 laminins are critical cortical basement membrane components: ablation of Lamb2 and Lamc3 genes disrupts cortical lamination and produces dysplasia","volume":"73","author":"Radner","year":"2013","journal-title":"Dev. Neurobiol."},{"key":"10.1016\/j.stemcr.2021.11.009_bib61","doi-asserted-by":"crossref","first-page":"81","DOI":"10.3389\/fncir.2018.00081","article-title":"Robust network inhibition and decay of early-phase LTP in the hippocampal CA1 subfield of the Amazon rodent Proechimys","volume":"12","author":"Reyes-Garcia","year":"2018","journal-title":"Front. Neural Circuits"},{"key":"10.1016\/j.stemcr.2021.11.009_bib62","doi-asserted-by":"crossref","first-page":"209","DOI":"10.5500\/wjt.v5.i4.209","article-title":"Induced pluripotent stem cells for modeling neurological disorders","volume":"5","author":"Russo","year":"2015","journal-title":"World J. Transpl."},{"key":"10.1016\/j.stemcr.2021.11.009_bib63","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1080\/01926230701748305","article-title":"Mesial temporal lobe epilepsy: pathogenesis, induced rodent models and lesions","volume":"35","author":"Sharma","year":"2007","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.stemcr.2021.11.009_bib64","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.biomaterials.2015.04.035","article-title":"A phenotypic in\u00a0vitro model for the main determinants of human whole heart function","volume":"60","author":"Stancescu","year":"2015","journal-title":"Biomaterials"},{"key":"10.1016\/j.stemcr.2021.11.009_bib65","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1152\/jn.1999.81.4.1559","article-title":"Inhibitory control of LTP and LTD: stability of synapse strength","volume":"81","author":"Steele","year":"1999","journal-title":"J.\u00a0Neurophysiol."},{"key":"10.1016\/j.stemcr.2021.11.009_bib66","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.conb.2014.04.010","article-title":"Dual-transmitter neurons: functional implications of co-release and co-transmission","volume":"29","author":"Vaaga","year":"2014","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.stemcr.2021.11.009_bib67","doi-asserted-by":"crossref","first-page":"e8643","DOI":"10.1371\/journal.pone.0008643","article-title":"A new target for amyloid beta toxicity validated by standard and high-throughput electrophysiology","volume":"5","author":"Varghese","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.stemcr.2021.11.009_bib68","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1113\/jphysiol.2008.167635","article-title":"Defining the role of GABA in cortical development","volume":"587","author":"Wang","year":"2009","journal-title":"J.\u00a0Physiol."},{"key":"10.1016\/j.stemcr.2021.11.009_bib69","doi-asserted-by":"crossref","first-page":"333ra348","DOI":"10.1126\/scitranslmed.aad0623","article-title":"Cultured networks of excitatory projection neurons and inhibitory interneurons for studying human cortical neurotoxicity","volume":"8","author":"Xu","year":"2016","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.stemcr.2021.11.009_bib70","doi-asserted-by":"crossref","first-page":"3667","DOI":"10.1111\/j.1460-9568.2007.05598.x","article-title":"Impaired single cell firing and long-term potentiation parallels memory impairment following recurrent seizures","volume":"25","author":"Zhou","year":"2007","journal-title":"Eur. J. Neurosci."}],"container-title":["Stem Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213671121005907?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213671121005907?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T09:48:33Z","timestamp":1761990513000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213671121005907"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":70,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["S2213671121005907"],"URL":"https:\/\/doi.org\/10.1016\/j.stemcr.2021.11.009","relation":{},"ISSN":["2213-6711"],"issn-type":[{"value":"2213-6711","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A functional hiPSC-cortical neuron differentiation and maturation model and its application to neurological disorders","name":"articletitle","label":"Article Title"},{"value":"Stem Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.stemcr.2021.11.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors.","name":"copyright","label":"Copyright"}]}}