{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T16:22:26Z","timestamp":1792167746590,"version":"4.4.0"},"reference-count":37,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,6,27]],"date-time":"2022-06-27T00:00:00Z","timestamp":1656288000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100001116","name":"Foundation Fighting Blindness","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001116","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001395","name":"Wisconsin Alumni Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001395","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001818","name":"Research to Prevent Blindness","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001818","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008091","name":"University of Rochester","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008091","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013779","name":"Retina Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013779","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["F30EY031230"],"award-info":[{"award-number":["F30EY031230"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01EY06855"],"award-info":[{"award-number":["R01EY06855"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U24EY029890"],"award-info":[{"award-number":["U24EY029890"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Stem Cell Reports"],"published-print":{"date-parts":[[2022,8]]},"DOI":"10.1016\/j.stemcr.2022.06.009","type":"journal-article","created":{"date-parts":[[2022,7,28]],"date-time":"2022-07-28T10:33:03Z","timestamp":1659004383000},"page":"1824-1841","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":37,"title":["Systemic immunosuppression promotes survival and integration of subretinally implanted human ESC-derived photoreceptor precursors in dogs"],"prefix":"10.1016","volume":"17","author":[{"given":"Ana","family":"Ripolles-Garcia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Dolgova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Joseph","family":"Phillips","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svetlana","family":"Savina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison L.","family":"Ludwig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara A.","family":"Stuedemann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uchenna","family":"Nlebedum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John H.","family":"Wolfe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver A.","family":"Garden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arvydas","family":"Maminishkis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Amaral","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kapil","family":"Bharti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Gamm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo D.","family":"Aguirre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7132-2491","authenticated-orcid":false,"given":"William A.","family":"Beltran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.stemcr.2022.06.009_bib1","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.stemcr.2020.06.019","article-title":"Imaging transplanted photoreceptors in living nonhuman primates with single-cell resolution","volume":"15","author":"Aboualizadeh","year":"2020","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.stemcr.2022.06.009_bib2","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/bs.pbr.2017.01.001","article-title":"Pluripotent stem cells and their utility in treating photoreceptor degenerations","volume":"231","author":"Aghaizu","year":"2017","journal-title":"Prog. Brain Res."},{"key":"10.1016\/j.stemcr.2022.06.009_bib3","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1007\/s12015-016-9670-8","article-title":"Cellular GFP toxicity and immunogenicity: potential confounders in in\u00a0vivo cell tracking experiments","volume":"12","author":"Ansari","year":"2016","journal-title":"Stem Cell Rev. Rep."},{"key":"10.1016\/j.stemcr.2022.06.009_bib4","doi-asserted-by":"crossref","first-page":"29784","DOI":"10.1038\/srep29784","article-title":"Function of human pluripotent stem cell-derived photoreceptor progenitors in blind mice","volume":"6","author":"Barnea-Cramer","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.stemcr.2022.06.009_bib5","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.1016\/j.ymthe.2017.05.004","article-title":"Optimization of retinal gene therapy for X-linked retinitis pigmentosa due to RPGR mutations","volume":"25","author":"Beltran","year":"2017","journal-title":"Mol. Ther."},{"key":"10.1016\/j.stemcr.2022.06.009_bib6","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1007\/s00439-019-01999-6","article-title":"Natural models for retinitis pigmentosa: progressive retinal atrophy in dog breeds","volume":"138","author":"Bunel","year":"2019","journal-title":"Hum. Genet."},{"key":"10.1016\/j.stemcr.2022.06.009_bib7","first-page":"171686","article-title":"Reproducibility and staging of 3D human retinal organoids across multiple pluripotent stem cell lines","volume":"146","author":"Capowski","year":"2019","journal-title":"Development"},{"key":"10.1016\/j.stemcr.2022.06.009_bib8","doi-asserted-by":"crossref","first-page":"4524","DOI":"10.1038\/s41467-019-12330-2","article-title":"Restoration of visual function by transplantation of optogenetically engineered photoreceptors","volume":"10","author":"Garita-Hernandez","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.stemcr.2022.06.009_bib9","doi-asserted-by":"crossref","first-page":"e85408","DOI":"10.1371\/journal.pone.0085408","article-title":"Up-regulation of tumor necrosis factor superfamily genes in early phases of photoreceptor degeneration","volume":"8","author":"Genini","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.stemcr.2022.06.009_bib10","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1016\/j.stemcr.2017.07.022","article-title":"Recapitulation of human retinal development from human pluripotent stem cells generates transplantable populations of cone photoreceptors","volume":"9","author":"Gonzalez-Cordero","year":"2017","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.stemcr.2022.06.009_bib11","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1007\/978-3-319-17121-0_77","article-title":"Gliosis can impede integration following photoreceptor transplantation into the diseased retina","volume":"854","author":"Hippert","year":"2016","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.stemcr.2022.06.009_bib12","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.advms.2015.09.005","article-title":"Effect of enzymatic and mechanical methods of dissociation on neural progenitor cells derived from induced pluripotent stem cells","volume":"61","author":"Jager","year":"2016","journal-title":"Adv. Med. Sci."},{"key":"10.1016\/j.stemcr.2022.06.009_bib13","doi-asserted-by":"crossref","first-page":"e1803550","DOI":"10.1002\/adma.201803550","article-title":"3D microstructured scaffolds to support photoreceptor polarization and maturation","volume":"30","author":"Jung","year":"2018","journal-title":"Adv. Mater."},{"key":"10.1016\/j.stemcr.2022.06.009_bib14","doi-asserted-by":"crossref","first-page":"983","DOI":"10.3727\/096368917X694697","article-title":"Early subretinal allograft rejection is characterized by innate immune activity","volume":"26","author":"Kennelly","year":"2017","journal-title":"Cell Transpl."},{"key":"10.1016\/j.stemcr.2022.06.009_bib15","doi-asserted-by":"crossref","first-page":"eabf0344","DOI":"10.1126\/sciadv.abf0344","article-title":"Ultrathin micromolded 3D scaffolds for high-density photoreceptor layer reconstruction","volume":"7","author":"Lee","year":"2021","journal-title":"Sci. Adv."},{"key":"10.1016\/j.stemcr.2022.06.009_bib16","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1167\/tvst.10.10.15","article-title":"Outer retinal cell replacement: putting the pieces together","volume":"10","author":"Ludwig","year":"2021","journal-title":"Transl Vis. Sci. Technol."},{"key":"10.1016\/j.stemcr.2022.06.009_bib17","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1167\/iovs.17-22467","article-title":"Allogeneic iPSC-derived RPE cell graft failure following transplantation into the subretinal space in nonhuman primates","volume":"59","author":"McGill","year":"2018","journal-title":"Invest Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.stemcr.2022.06.009_bib18","first-page":"183","article-title":"The outer limiting membrane (OLM) revisited: clinical implications","volume":"4","author":"Omri","year":"2010","journal-title":"Clin. Ophthalmol."},{"key":"10.1016\/j.stemcr.2022.06.009_bib19","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1002\/stem.2552","article-title":"A reinterpretation of cell transplantation: GFP transfer from donor to host photoreceptors","volume":"35","author":"Ortin-Martinez","year":"2017","journal-title":"Stem Cells"},{"key":"10.1016\/j.stemcr.2022.06.009_bib20","doi-asserted-by":"crossref","first-page":"487","DOI":"10.3727\/096368909X486057","article-title":"Targeted disruption of outer limiting membrane junctional proteins (Crb1 and ZO-1) increases integration of transplanted photoreceptor precursors into the adult wild-type and degenerating retina","volume":"19","author":"Pearson","year":"2010","journal-title":"Cell Transpl."},{"key":"10.1016\/j.stemcr.2022.06.009_bib21","doi-asserted-by":"crossref","first-page":"621007","DOI":"10.3389\/fimmu.2021.621007","article-title":"Immunologic rejection of transplanted retinal pigmented epithelium: mechanisms and strategies for prevention","volume":"12","author":"Petrash","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.stemcr.2022.06.009_bib22","doi-asserted-by":"crossref","first-page":"2370","DOI":"10.1038\/s41598-018-20813-3","article-title":"Generation of a rod-specific NRL reporter line in human pluripotent stem cells","volume":"8","author":"Phillips","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.stemcr.2022.06.009_bib23","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1002\/stem.2755","article-title":"A novel approach to single cell RNA-sequence analysis facilitates in\u00a0silico gene reporting of human pluripotent stem cell-derived retinal cell types","volume":"36","author":"Phillips","year":"2018","journal-title":"Stem Cells"},{"key":"10.1016\/j.stemcr.2022.06.009_bib24","doi-asserted-by":"crossref","first-page":"109022","DOI":"10.1016\/j.celrep.2021.109022","article-title":"Restoration of visual function in advanced disease after transplantation of purified human pluripotent stem cell-derived cone photoreceptors","volume":"35","author":"Ribeiro","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.stemcr.2022.06.009_bib25","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1002\/sctm.18-0210","article-title":"Optimizing donor cellular dissociation and subretinal injection parameters for stem cell-based treatments","volume":"8","author":"Scruggs","year":"2019","journal-title":"Stem Cell translational Med."},{"key":"10.1016\/j.stemcr.2022.06.009_bib26","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1007\/s00417-014-2638-y","article-title":"A new immunodeficient pigmented retinal degenerate rat strain to study transplantation of human cells without immunosuppression","volume":"252","author":"Seiler","year":"2014","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"10.1016\/j.stemcr.2022.06.009_bib27","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1007\/s12015-018-9802-4","article-title":"Pluripotent stem cells for retinal tissue engineering: current status and future prospects","volume":"14","author":"Singh","year":"2018","journal-title":"Stem Cell Rev. Rep."},{"key":"10.1016\/j.stemcr.2022.06.009_bib28","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.ebiom.2018.11.028","article-title":"Medium- to long-term survival and functional examination of human iPSC-derived retinas in rat and primate models of retinal degeneration","volume":"39","author":"Tu","year":"2019","journal-title":"EBioMedicine"},{"key":"10.1016\/j.stemcr.2022.06.009_bib29","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.stemcr.2017.12.008","article-title":"Transplanted donor- or stem cell-derived cone photoreceptors can both integrate and undergo material transfer in an environment-dependent manner","volume":"10","author":"Waldron","year":"2018","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.stemcr.2022.06.009_bib30","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1038\/s41419-020-02955-3","article-title":"Stem\/progenitor cell-based transplantation for retinal degeneration: a review of clinical trials","volume":"11","author":"Wang","year":"2020","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.stemcr.2022.06.009_bib31","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.1002\/stem.520","article-title":"Long-term survival of photoreceptors transplanted into the adult murine neural retina requires immune modulation","volume":"28","author":"West","year":"2010","journal-title":"Stem Cells"},{"key":"10.1016\/j.stemcr.2022.06.009_bib32","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.exer.2008.01.004","article-title":"Pharmacological disruption of the outer limiting membrane leads to increased retinal integration of transplanted photoreceptor precursors","volume":"86","author":"West","year":"2008","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.stemcr.2022.06.009_bib33","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1111\/j.1748-5827.2011.01024.x","article-title":"Immunomodulatory drugs and their application to the management of canine immune-mediated disease","volume":"52","author":"Whitley","year":"2011","journal-title":"J.\u00a0Small Anim. Pract."},{"key":"10.1016\/j.stemcr.2022.06.009_bib34","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1023\/A:1002143802926","article-title":"The role of carbonic anhydrase inhibitors in the management of macular edema","volume":"97","author":"Wolfensberger","year":"1999","journal-title":"Doc Ophthalmol."},{"key":"10.1016\/j.stemcr.2022.06.009_bib35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13287-015-0167-1","article-title":"The immune response of stem cells in subretinal transplantation","volume":"6","author":"Xian","year":"2015","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.stemcr.2022.06.009_bib36","doi-asserted-by":"crossref","first-page":"108283","DOI":"10.1016\/j.exer.2020.108283","article-title":"The road to restore vision with photoreceptor regeneration","volume":"202","author":"Zhang","year":"2021","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.stemcr.2022.06.009_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.stem.2016.11.019","article-title":"Immunosuppression via loss of IL2r\u03b3 enhances long-term functional integration of hESC-derived photoreceptors in the mouse retina","volume":"20","author":"Zhu","year":"2017","journal-title":"Cell Stem Cell"}],"container-title":["Stem Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213671122003253?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213671122003253?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T09:47:35Z","timestamp":1761990455000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213671122003253"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8]]},"references-count":37,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2022,8]]}},"alternative-id":["S2213671122003253"],"URL":"https:\/\/doi.org\/10.1016\/j.stemcr.2022.06.009","relation":{},"ISSN":["2213-6711"],"issn-type":[{"value":"2213-6711","type":"print"}],"subject":[],"published":{"date-parts":[[2022,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Systemic immunosuppression promotes survival and integration of subretinally implanted human ESC-derived photoreceptor precursors in dogs","name":"articletitle","label":"Article Title"},{"value":"Stem Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.stemcr.2022.06.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Author(s).","name":"copyright","label":"Copyright"}]}}